New therapeutic strategies for postoperative ileus

Nature Reviews Gastroenterology and Hepatology

Volumn 9, Issue 11, 2012, Pages 675-683

  Van Bree, Sjoerd H W ^a   Nemethova, Andrea ^b   Cailotto, Cathy ^a   Gomez Pinilla, Pedro J ^b   Matteoli, Gianluca ^b   Boeckxstaens, Guy E ^b  

^a ACADEMIC MEDICAL CENTER   (Netherlands)

^b UNIVERSITY HOSPITALS LEUVEN   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

17 METHYLNALTREXONE; ALVIMOPAN; ANTISENSE OLIGONUCLEOTIDE; BISACODYL; CELECOXIB; CHOLECYSTOKININ; CISAPRIDE; CJ 033466; CYCLOOXYGENASE 2 INHIBITOR; DOPAMINE RECEPTOR BLOCKING AGENT; DOXANTRAZOLE; ERYTHROMYCIN; GELATINASE B; GLYCINE; GRANISETRON; IBUPROFEN; INTERCELLULAR ADHESION MOLECULE 1 ANTIBODY; KETOTIFEN; LIDOCAINE; MAGNESIUM OXIDE; METOCLOPRAMIDE; MOSAPRIDE; PLACEBO; PROTEIN KINASE SYK INHIBITOR; PRUCALOPRIDE; SEROTONIN 4 AGONIST; ULIMORELIN; UNCLASSIFIED DRUG; VALDECOXIB;

ADAPTIVE IMMUNITY; ANTIINFLAMMATORY ACTIVITY; CHEWING GUM; CONVALESCENCE; CYTOKINE RESPONSE; DRUG POTENCY; ENZYME INHIBITION; FUNCTIONAL TRAINING; HEALTH CARE PLANNING; HEALTH PROGRAM; HELPER CELL; HUMAN; IMMUNOMODULATION; INNATE IMMUNITY; LAPAROSCOPIC SURGERY; LENGTH OF STAY; MAST CELL; MASTICATION; MINIMALLY INVASIVE SURGERY; NAUSEA; NONHUMAN; PATHOGENESIS; POSTOPERATIVE CARE; POSTOPERATIVE ILEUS; PRIORITY JOURNAL; REVIEW; STOMACH PARESIS; VAGUS NERVE; VOMITING;

ADAPTIVE IMMUNITY; GHRELIN; HUMANS; ILEUS; IMMUNITY, INNATE; INFLAMMATION; NAPHTHOQUINONES; POSTOPERATIVE COMPLICATIONS; SEROTONIN 5-HT4 RECEPTOR AGONISTS;

EID: 84868521771     PISSN: 17595045     EISSN: 17595053     Source Type: Journal    
DOI: 10.1038/nrgastro.2012.134     Document Type: Review

References (114)

1. Koscielny, A. & Kalff, J. C. T helper cell type 1 memory cells and postoperative ileus in the entire gut. Curr. Opin. Gastroenterol. 27, 509-514 (2011).
2. Kehlet, H. Postoperative ileus-an update on preventive techniques. Nat. Clin. Pract. Gastroenterol. Hepatol. 5, 552-558 (2008).
3. Asgeirsson, T. et al. Postoperative ileus: it costs more than you expect. J. Am. Coll. Surg. 210, 228-231 (2010).
4. Bennett-Guerrero, E. et al. The use of a postoperative morbidity survey to evaluate patients with prolonged hospitalization after routine, moderate-risk, elective surgery. Anesth. Analg. 89, 514-519 (1999). (Pubitemid 29367746)
5. Grocott, M. P. et al. The Postoperative Morbidity Survey was validated and used to describe morbidity after major surgery. J. Clin. Epidemiol. 60, 919-928 (2007). (Pubitemid 47198447)
6. Iyer, S., Saunders, W. B. & Stemkowski, S. Economic burden of postoperative ileus associated with colectomy in the United States. J. Manag. Care Pharm. 15, 485-494 (2009).
7. Barquist, E. et al. Neuronal pathways involved in abdominal surgery-induced gastric ileus in rats. Am. J. Physiol. 270, R888-R894 (1996).
8. Bonaz, B. The cholinergic anti-inflammatory pathway and the gastrointestinal tract. Gastroenterology 133, 1370-1373 (2007). (Pubitemid 47494485)
9. Bonaz, B., Plourde, V. & Tache, Y. Abdominal surgery induces Fos immunoreactivity in the rat brain. J. Comp. Neurol. 349, 212-222 (1994). (Pubitemid 24331249)
10. Boeckxstaens, G. E. & de Jonge, W. J. Neuroimmune mechanisms in postoperative ileus. Gut 58, 1300-1311 (2009).
11. De Winter, B. Y. et al. Effect of adrenergic and nitrergic blockade on experimental ileus in rats. Br. J. Pharmacol. 120, 464-468 (1997). (Pubitemid 27052844)
12. Story, S. K. & Chamberlain, R. S. A comprehensive review of evidence-based strategies to prevent and treat postoperative ileus. Dig. Surg. 26, 265-275 (2009).
13. Kalff, J. C. et al. Surgically induced leukocytic infiltrates within the rat intestinal muscularis mediate postoperative ileus. Gastroenterology 117, 378-387 (1999). (Pubitemid 29352946)
14. Engel, D. R. et al. T helper type 1 memory cells disseminate postoperative ileus over the entire intestinal tract. Nat. Med. 16, 1407-1413 (2010).
15. Kalff, J. C. et al. Intra-abdominal activation of a local inflammatory response within the human muscularis externa during laparotomy. Ann. Surg. 237, 301-315 (2003). (Pubitemid 38176444)
16. The, F. O. et al. Intestinal handling-induced mast cell activation and inflammation in human postoperative ileus. Gut 57, 33-40 (2008).
17. Bauer, A. J. Two immune arms to stop one gut. Nat. Med. 16, 1378-1379 (2010).
18. Prasad, M. & Matthews, J. B. Deflating postoperative ileus. Gastroenterology 117, 489-492 (1999). (Pubitemid 29352957)
19. de Jonge, W. J. et al. Postoperative ileus is maintained by intestinal immune infiltrates that activate inhibitory neural pathways in mice. Gastroenterology 125, 1137-1147 (2003). (Pubitemid 37193460)
20. de Jonge, W. J. et al. Mast cell degranulation during abdominal surgery initiates postoperative ileus in mice. Gastroenterology 127, 535-545 (2004). (Pubitemid 39091902)
21. Kreiss, C., Birder, L. A., Kiss, S., Van Bibber, M. M. & Bauer, A. J. COX 2 dependent inflammation increases spinal Fos expression during rodent postoperative ileus. Gut 52, 527-534 (2003). (Pubitemid 36363406)
22. Borovikova, L. V. et al. Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin. Nature 405, 458-462 (2000). (Pubitemid 30367422)
23. Wang, H. et al. Nicotinic acetylcholine receptor α7 subunit is an essential regulator of inflammation. Nature 421, 384-388 (2003). (Pubitemid 36157937)
24. Tracey, K. J. The inflammatory reflex. Nature 420, 853-859 (2002). (Pubitemid 36019638)
25. de Jonge, W. J. et al. Stimulation of the vagus nerve attenuates macrophage activation by activating the Jak2-STAT3 signaling pathway. Nat. Immunol. 6, 844-851 (2005).
26. The, F. et al. Central activation of the cholinergic anti-inflammatory pathway reduces surgical inflammation in experimental post-operative ileus. Br. J. Pharmacol. 163, 1007-1016 (2011).
27. Pavlov, V. A. et al. Central muscarinic cholinergic regulation of the systemic inflammatory response during endotoxemia. Proc. Natl Acad. Sci. USA 103, 5219-5223 (2006).
28. Venkova, K., Fraser, G., Hoveyda, H. R. & Greenwood-Van Meerveld, B. Prokinetic effects of a new ghrelin receptor agonist TZP 101 in a rat model of postoperative ileus. Dig. Dis. Sci. 52, 2241-2248 (2007). (Pubitemid 47246531)
29. Pavlov, V. A. et al. Brain acetylcholinesterase activity controls systemic cytokine levels through the cholinergic anti-inflammatory pathway. Brain Behav. Immun. 23, 41-45 (2009).
30. Luyer, M. D. et al. Nutritional stimulation of cholecystokinin receptors inhibits inflammation via the vagus nerve. J. Exp. Med. 202, 1023-1029 (2005). (Pubitemid 41464495)
31. Lubbers, T. et al. Lipid-rich enteral nutrition reduces postoperative ileus in rats via activation of cholecystokinin-receptors. Ann. Surg. 249, 481-487 (2009).
32. Zhang, B., Cao, A., Zhou, J., Hu, Z. & Wu, D. Effect of jatrorrhizine on delayed gastrointestinal transit in rat postoperative ileus. J. Pharm. Pharmacol. 64, 413-419 (2012).
33. Cailotto, C. et al. Neuroanatomical evidence demonstrating the existence of the vagal anti-inflammatory reflex in the intestine. Neurogastroenterol. Motil. 24, 191-e93 (2011).
34. Mestas, J. & Hughes, C. C. Of mice and not men: differences between mouse and human immunology. J. Immunol. 172, 2731-2738 (2004). (Pubitemid 38263654)
35. van Bree, S. H. W. Which clinical symptoms reflect postoperative recovery of gastrointestinal motility? [abstract 864] Gastroenterology 138, (Suppl. 1), S-119 (2010).
36. Kehlet, H. Fast-track surgery-an update on physiological care principles to enhance recovery. Langenbecks Arch. Surg. 396, 585-590 (2011).
37. Kehlet, H. Surgery: Fast-track colonic surgery and the 'knowing-doing' gap. Nat. Rev. Gastroenterol. Hepatol. 8, 539-540 (2011).
38. Lassen, K. et al. Consensus review of optimal perioperative care in colorectal surgery: Enhanced Recovery After Surgery (ERAS) Group recommendations. Arch. Surg. 144, 961-969 (2009).
39. van Bree, S. et al. Faster recovery of gastrointestinal transit after laparoscopy and fast-track care in patients undergoing colonic surgery. Gastroenterology 141, 872-880 e1-4 (2011).
40. Basse, L., Madsen, J. L., Billesbolle, P., Bardram, L. & Kehlet, H. Gastrointestinal transit after laparoscopic versus open colonic resection. Surg. Endosc. 17, 1919-1922 (2003). (Pubitemid 38049903)
41. Delaney, C. P. et al. Gastrointestinal recovery after laparoscopic colectomy: results of a prospective, observational, multicenter study. Surg. Endosc. 24, 653-661 (2010).
42. Lacy, A. M. et al. Laparoscopy-assisted colectomy versus open colectomy for treatment of non-metastatic colon cancer: A randomised trial. Lancet 359, 2224-2229 (2002). (Pubitemid 34717975)
43. Milsom, J. W. et al. A prospective, randomized trial comparing laparoscopic versus conventional techniques in colorectal cancer surgery: A preliminary report. J. Am. Coll. Surg. 187, 46-54 (1998).
44. Schwenk, W., Bohm, B., Haase, O., Junghans, T. & Muller, J. M. Laparoscopic versus conventional colorectal resection: A prospective randomised study of postoperative ileus and early postoperative feeding. Langenbecks Arch. Surg. 383, 49-55 (1998). (Pubitemid 28226339)
45. Veldkamp, R. et al. Laparoscopic surgery versus open surgery for colon cancer: short-term outcomes of a randomised trial. Lancet Oncol. 6, 477-484 (2005). (Pubitemid 40903628)
46. Ohtani, H. et al. A meta-analysis of the short- and long-term results of randomized controlled trials that compared laparoscopy-assisted and open colectomy for colon cancer. J. Cancer 3, 49-57 (2012).
47. Augestad, K. M. Postoperative ileus: Impact of pharmacological treatment, laparoscopic surgery and enhanced recovery pathways. World J. Gastroenterol. 16, 2067-2074 (2010).
48. Delaney, C. P., Chang, E., Senagore, A. J. & Broder, M. Clinical outcomes and resource utilization associated with laparoscopic and open colectomy using a large national database. Ann. Surg. 247, 819-824 (2008). (Pubitemid 351591517)
49. Delaney, C. P. et al. Prospective, randomized, controlled trial between a pathway of controlled rehabilitation with early ambulation and diet and traditional postoperative care after laparotomy and intestinal resection. Dis. Colon Rectum 46, 851-859 (2003). (Pubitemid 36875478)
50. Zargar-Shoshtari, K., Connolly, A. B., Israel, L. H. & Hill, A. G. Fast-track surgery may reduce complications following major colonic surgery. Dis. Colon Rectum 51, 1633-1640 (2008).
51. Tsai, H. L. et al. Comparison of mini laparotomy with conventional laparotomy as the surgical approach in stage i iii colorectal cancer patients: appealing outcomes. Hepatogastroenterology http://dx.doi.org/10.5754/hge11953.
52. Traut, U. et al. Systemic prokinetic pharmacologic treatment for postoperative adynamic ileus following abdominal surgery in adults. Cochrane Database Systematic Reviews, Issue1. Art. No.: CD004930 http://dx.doi.org/10. 1002/14651858.CD004930.pub3.
53. Camilleri, M., Bharucha, A. E. & Farrugia, G. Epidemiology, mechanisms, and management of diabetic gastroparesis. Clin. Gastroenterol. Hepatol. 9, 5-12 (2011).
54. Chan, D. C. et al. Preventing prolonged post-operative ileus in gastric cancer patients undergoing gastrectomy and intra-peritoneal chemotherapy. World J. Gastroenterol. 11, 4776-4781 (2005).
55. Seta, M. L. & Kale-Pradhan, P. B. Efficacy of metoclopramide in postoperative ileus after exploratory laparotomy. Pharmacotherapy 21, 1181-1186 (2001). (Pubitemid 32939091)
56. Senagore, A. J. Pathogenesis and clinical and economic consequences of postoperative ileus. Clin. Exp. Gastroenterol. 3, 87-89 (2010).
57. Becker, G. & Blum, H. E. Novel opioid antagonists for opioid-induced bowel dysfunction and postoperative ileus. Lancet 373, 1198-1206 (2009).
58. Wolff, B. G. et al. Alvimopan, a novel, peripherally acting mu opioid antagonist: results of a multicenter, randomized, double-blind, placebo-controlled, phase III trial of major abdominal surgery and postoperative ileus. Ann. Surg. 240, 728-734 (2004).
59. Ludwig, K. et al. Gastrointestinal tract recovery in patients undergoing bowel resection: results of a randomized trial of alvimopan and placebo with a standardized accelerated postoperative care pathway. Arch. Surg. 143, 1098-1105 (2008).
60. Delaney, C. P. et al. Phase III trial of alvimopan, a novel, peripherally acting, mu opioid antagonist, for postoperative ileus after major abdominal surgery. Dis. Colon Rectum 48, 1114-1125 (2005).
61. Viscusi, E. R. et al. Alvimopan, a peripherally acting mu-opioid receptor antagonist, compared with placebo in postoperative ileus after major abdominal surgery: results of a randomized, double-blind, controlled study. Surg. Endosc. 20, 64-70 (2006). (Pubitemid 43097035)
62. Ludwig, K. et al. Alvimopan for the management of postoperative ileus after bowel resection: characterization of clinical benefit by pooled responder analysis. World J. Surg. 34, 2185-2190 (2010).
63. Büchler, M. W. et al. Clinical trial: alvimopan for the management of postoperative ileus after abdominal surgery: results of an international randomised, double-blind, multicentre, placebo-controlled clinical study. Aliment. Pharmacol. Ther. 28, 312-325 (2008).
64. Touchette, D. R., Yang, Y., Tiryaki, F. & Galanter, W. L. Economic analysis of alvimopan for prevention and management of postoperative ileus. Pharmacotherapy 32, 120-128 (2012).
65. Abodeely, A., Schechter, S., Klipfel, A., Vrees, M. & Lagares-Garcia, J. Does alvimopan enhance return of bowel function in laparoscopic right colectomy? Am. J. Surg. 77, 1460-1462 (2011).
66. Viscusi, E., Rathmell, J., Fichera, A, Gan, T. J. & Israel, R. J. A double blind, randomized placebo-controlled trial of methylnaltrexone (MNTX) for post-operative bowel dysfunction in segmental colectomy patients [abstract A893]. Anesthesiology 205, A893 (2005).
67. Viscusi, E. R. et al. Peripherally acting mu-opioid receptor antagonists and postoperative ileus: mechanisms of action and clinical applicability. Anesth. Analg. 108, 1811-1822 (2009).
68. Yu, C. S. et al. Safety and efficacy of methylnaltrexone in shortening the duration of postoperative ileus following segmental colectomy: results of two randomized, placebo-controlled phase 3 trials. Dis. Colon Rectum 54, 570-578 (2011).
69. Herroeder, S. et al. Systemic lidocaine shortens length of hospital stay after colorectal surgery: A double-blinded, randomized, placebo-controlled trial. Ann. Surg. 246, 192-200 (2007). (Pubitemid 47196515)
70. Wallin, G. et al. Effects of lidocaine infusion on the sympathetic response to abdominal surgery. Anesth. Analg. 66, 1008-1013 (1987). (Pubitemid 18007879)
71. Wood, J. D. Excitation of intestinal muscle by atropine, tetrodotoxin, and xylocaine. Am. J. Physiol. 222, 118-125 (1972).
72. Groudine, S. B. et al. Intravenous lidocaine speeds the return of bowel function, decreases postoperative pain, and shortens hospital stay in patients undergoing radical retropubic prostatectomy. Anesth. Analg. 86, 235-239 (1998). (Pubitemid 28079468)
73. Harvey, K. P., Adair, J. D., Isho, M. & Robinson, R. Can intravenous lidocaine decrease postsurgical ileus and shorten hospital stay in elective bowel surgery? A pilot study and literature review. Am. J. Surg. 198, 231-236 (2009).
74. Kuo, C. P. et al. Comparison of the effects of thoracic epidural analgesia and i.v. infusion with lidocaine on cytokine response, postoperative pain and bowel function in patients undergoing colonic surgery. Br. J. Anaesth. 97, 640-646 (2006). (Pubitemid 44593858)
75. Rimbäck, G., Cassuto, J. & Tollesson, P. O. Treatment of postoperative paralytic ileus by intravenous lidocaine infusion. Anesth. Analg. 70, 414-419 (1990). (Pubitemid 20261304)
76. Kaba, A. et al. Intravenous lidocaine infusion facilitates acute rehabilitation after laparoscopic colectomy. Anesthesiology 106, 11-18 (2007). (Pubitemid 46035398)
77. Wu, R. et al. Orexigenic hormone ghrelin ameliorates gut barrier dysfunction in sepsis in rats. Crit. Care Med. 37, 2421-2426 (2009).
78. Wu, R. et al. Ghrelin down-regulates proinflammatory cytokines in sepsis through activation of the vagus nerve. Ann. Surg. 245, 480-486 (2007). (Pubitemid 46673145)
79. Asakawa, A. et al. Peptide YY3-36 and pancreatic polypeptide suppress food intake. J. Gastroenterol. Hepatol 21, 1501-1502 (2006). (Pubitemid 44154729)
80. Tack, J. et al. Effect of erythromycin on gastric motility in controls and in diabetic gastroparesis. Gastroenterology 103, 72-79 (1992).
81. Trudel, L. et al. Ghrelin/motilin-related peptide is a potent prokinetic to reverse gastric postoperative ileus in rat. Am. J. Physiol. Gastrointest. Liver Physiol. 282, G948-G952 (2002). (Pubitemid 34651600)
82. Gonzalez-Rey, E., Chorny, A. & Delgado, M. Therapeutic action of ghrelin in a mouse model of colitis. Gastroenterology 130, 1707-1720 (2006). (Pubitemid 43668852)
83. Wu, R. et al. Orexigenic hormone ghrelin attenuates local and remote organ injury after intestinal ischemia-reperfusion. PLoS ONE 3, e2026 (2008).
84. Fraser, G. L., Venkova, K., Hoveyda, H. R., Thomas, H. & Greenwood-Van Meerveld, B. Effect of the ghrelin receptor agonist TZP 101 on colonic transit in a rat model of postoperative ileus. Eur. J. Pharmacol. 604, 132-137 (2009).
85. Popescu, I. et al. The Ghrelin agonist TZP 101 for management of postoperative ileus after partial colectomy: A randomized, dose-ranging, placebo-controlled clinical trial. Dis. Colon Rectum 53, 126-134 (2010).
86. Bochicchio, G., Charlton, P., Pezzullo, J. C., Kosutic, G. & Senagore, A. Ghrelin agonist TZP 101/ulimorelin accelerates gastrointestinal recovery independently of opioid use and surgery type: covariate analysis of phase 2 data. World J. Surg. 36, 39-45 (2012).
87. Gershon, M. D. Review article: serotonin receptors and transporters - roles in normal and abnormal gastrointestinal motility. Aliment. Pharmacol. Ther. 20 (Suppl. 7), 3-14 (2004). (Pubitemid 39657670)
88. De Winter, B. Y. et al. Effect of different prokinetic agents and a novel enterokinetic agent on postoperative ileus in rats. Gut 45, 713-718 (1999). (Pubitemid 29492144)
89. Zeinali, F., Stulberg, J. J. & Delaney, C. P. Pharmacological management of postoperative ileus. Can. J. Surg. 52, 153-157 (2009).
90. Narita, K. et al. Effect of mosapride on recovery of intestinal motility after hand-assisted laparoscopic colectomy for carcinoma. Dis. Colon Rectum 51, 1692-1695 (2008).
91. Toyomasu, Y. et al. Mosapride citrate improves postoperative ileus of patients with colectomy. J. Gastrointest. Surg. 15, 1361-1367 (2011).
92. Tsuchida, Y. et al. Neuronal stimulation with 5 hydroxytryptamine 4 receptor induces anti-inflammatory actions via α7nACh receptors on muscularis macrophages associated with postoperative ileus. Gut 60, 638-647 (2011).
93. Galandiuk, S., Beyens. G., Ausma, J. & Vandeplassche, L. Evaluation of the efficacy, safety and tolerability of prucalopride (Resolor®) given subcutaneously in patients undergoing elective partial colectomies. Gastroenterology 134 (Suppl. 1), A 138 (2008).
94. Schwarz, N. T. et al. Prostanoid production via COX 2 as a causative mechanism of rodent postoperative ileus. Gastroenterology 121, 1354-1371 (2001). (Pubitemid 33140453)
95. Bakkum-Gamez, J. N. et al. Incidence of and risk factors for postoperative ileus in women undergoing primary staging and debulking for epithelial ovarian carcinoma. Gynecol. Oncol. 125, 614-620 (2012).
96. Fearon, K. C. et al. Enhanced recovery after surgery: A consensus review of clinical care for patients undergoing colonic resection. Clin. Nutr. 24, 466-477 (2005).
97. Wattchow, D. A. et al. Clinical trial: the impact of cyclooxygenase inhibitors on gastrointestinal recovery after major surgery - a randomized double blind controlled trial of celecoxib or diclofenac vs. placebo. Aliment. Pharmacol. Ther. 30, 987-998 (2009).
98. Sim, R., Cheong, D. M., Wong, K. S., Lee, B. M. & Liew, Q. Y. Prospective randomized, double-blind, placebo-controlled study of pre- and postoperative administration of a COX 2 specific inhibitor as opioid-sparing analgesia in major colorectal surgery. Colorectal Dis. 9, 52-60 (2007). (Pubitemid 44869676)
99. Bahena-Aponte, J. A., Cardenas-Lailson, E., Chavez-Tapia, N. & Flores-Gama, F. Usefulness of chewing gum for the resolution of postoperative ileus in left colon resections [Spanish]. Rev. Gastroenterol. Mex. 75, 369-373 (2010).
100. Choi, H. et al. Chewing gum has a stimulatory effect on bowel motility in patients after open or robotic radical cystectomy for bladder cancer: A prospective randomized comparative study. Urology 77, 884-890 (2011).
101. Ngowe, M. N., Eyenga, V. C., Kengne, B. H., Bahebeck, J. & Sosso, A. M. Chewing gum reduces postoperative ileus after open appendectomy. Acta Chir. Belg. 110, 195-199 (2010).
102. Marwah, S., Singla, S. & Tinna, P. Role of gum chewing on the duration of postoperative ileus following ileostomy closure done for typhoid ileal perforation: A prospective randomized trial. Saudi J. Gastroenterol. 18, 111-117 (2012).
103. Noble, E. J., Harris, R., Hosie, K. B., Thomas, S. & Lewis, S. J. Gum chewing reduces postoperative ileus? A systematic review and meta-analysis. Int. J. Surg. 7, 100-105 (2009).
104. Fitzgerald, J. E. & Ahmed, I. Systematic review and meta-analysis of chewing-gum therapy in the reduction of postoperative paralytic ileus following gastrointestinal surgery. World J. Surg. 33, 2557-2566 (2009).
105. The, F. O. et al. The role of mast cell stabilization in treatment of postoperative ileus: A pilot study. Am. J. Gastroenterol. 104, 2257-2266 (2009).
106. Rivera, J. & Olivera, A. A current understanding of Fcε RI dependent mast cell activation. Curr. Allergy Asthma Rep. 8, 14-20 (2008). (Pubitemid 351459688)
107. Rossi, A. B. et al. Identification of the Syk kinase inhibitor R112 by a human mast cell screen. J. Allergy Clin. Immunol. 118, 749-755 (2006). (Pubitemid 44301399)
108. van Bree, S. H. W. Mast cell inhibition by a new spleen tyrosine kinase inhibitor in the treatment of postoperative ileus [abstract 40]. Gut 60 (Suppl. 3), OP172 (2011).
109. Long, E. O. ICAM 1: getting a grip on leukocyte adhesion. J. Immunol. 186, 5021-5023 (2011).
110. Rothlein, R. et al. Induction of intercellular adhesion molecule 1 on primary and continuous cell lines by pro-inflammatory cytokines. Regulation by pharmacologic agents and neutralizing antibodies. J. Immunol. 141, 1665-1669 (1988).
111. Stoolman, L. M. Adhesion molecules controlling lymphocyte migration. Cell 56, 907-910 (1989). (Pubitemid 19091002)
112. The, F. O., de Jonge, W. J., Bennink, R. J., van den Wijngaard, R. M. & Boeckxstaens, G. E. The ICAM 1 antisense oligonucleotide ISIS 3082 prevents the development of postoperative ileus in mice. Br. J. Pharmacol. 146, 252-258 (2005). (Pubitemid 43079965)
113. Stoffels, B. et al. Anti-inflammatory role of glycine in reducing rodent postoperative inflammatory ileus. Neurogastroenterol. Motil. 23, 76-87, e8 (2011).
114. Moore, B. A., Manthey, C. L., Johnson, D. L. & Bauer, A. J. Matrix metalloproteinase 9 inhibition reduces inflammation and improves motility in murine models of postoperative ileus. Gastroenterology 141, 1283-1292 e1-e4 (2011).