Intra-Abdominal Activation of a Local Inflammatory Response Within the Human Muscularis Externa during Laparotomy

Annals of Surgery

Volumn 237, Issue 3, 2003, Pages 301-315

  Kalff, Jörg C ^a   Türler, Andreas ^a   Schwarz, Nicolas T ^a   Schraut, Wolfgang H ^a   Lee, Kenneth K W ^a   Tweardy, David J ^a   Billiar, Timothy R ^a   Simmons, Richard L ^a   Bauer, Anthony J ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; CYTOKINE; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 6; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 1; NITRIC OXIDE; NITRIC OXIDE SYNTHASE INHIBITOR; PROSTAGLANDIN; S [2 (1 IMINOETHYLAMINO)ETHYL]HOMOCYSTEINE; STAT PROTEIN; TRANSCRIPTION FACTOR; TUMOR NECROSIS FACTOR ALPHA ANTIBODY; UNCLASSIFIED DRUG; ACUTE PHASE PROTEIN; AUTACOID; DNA BINDING PROTEIN; INTERLEUKIN 1; ISOENZYME; MEMBRANE PROTEIN; NITRIC OXIDE SYNTHASE; NOS2A PROTEIN, HUMAN; PROSTAGLANDIN SYNTHASE; PTGS2 PROTEIN, HUMAN; STAT3 PROTEIN; STAT3 PROTEIN, HUMAN; TRANSACTIVATOR PROTEIN; TUMOR NECROSIS FACTOR ALPHA;

ABDOMINAL SURGERY; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; ELECTROPHORETIC MOBILITY; HISTOCHEMISTRY; HUMAN; HUMAN TISSUE; ILEUS; IMMUNOHISTOCHEMISTRY; IMMUNOMODULATION; INFLAMMATION; INTESTINE MUSCLE; INTRAOPERATIVE PERIOD; JEJUNUM; LAPAROTOMY; MACROPHAGE; POSTOPERATIVE COMPLICATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; REVIEW; SMOOTH MUSCLE; ARTICLE; CYTOLOGY; GEL MOBILITY SHIFT ASSAY; IMMUNOLOGY; IN VITRO STUDY; MACROPHAGE ACTIVATION; METABOLISM; MUSCLE CONTRACTION; PATHOPHYSIOLOGY; POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION;

ACUTE-PHASE PROTEINS; CYCLOOXYGENASE 2; CYTOKINES; DNA-BINDING PROTEINS; ELECTROPHORETIC MOBILITY SHIFT ASSAY; HUMANS; IMMUNOHISTOCHEMISTRY; INFLAMMATION MEDIATORS; INTERLEUKIN-1; ISOENZYMES; JEJUNUM; LAPAROTOMY; MACROPHAGE ACTIVATION; MACROPHAGES; MEMBRANE PROTEINS; MUSCLE CONTRACTION; MUSCLE, SMOOTH; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; POLYMERASE CHAIN REACTION; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR; TRANS-ACTIVATORS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0037364505     PISSN: 00034932     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000658-200303000-00003     Document Type: Review

References (55)

1. Hall MJ, Popovic JR. summary: national hospital discharge survey. Advance Data. 2000;1998;316:1-17.
2. Hall MJ, Lawrence L. Ambulatory surgery in the United States, 1996. Advance Data. 1998;300:1-16.
3. Holte K, Kehlet H. Postoperative ileus: a preventable event. Br J Surg. 2000;87:1480-1493.
4. Thompson JS, Quigley EM. Prokinetic agents in the surgical patient. Am J Surg. 1999;177:508-514.
5. Kehlet H. Postoperative ileus. Gut. 2000;47(Suppl 4):iv85-iv86.
6. Prasad M, Matthews JB. Deflating postoperative ileus. Gastroenterology. 1999;117:489-492.
7. Livingston EH, Passaro EP. Postoperative ileus. Dig Dis Sci. 1990;35: 121-132.
8. Kalff JC, Schraut WH, Simmons RL, et al. Surgical manipulation of the gut elicits an intestinal muscularis inflammatory response resulting in paralytic ileus. Ann Surg. 1998;228:652-663.
9. Kalff JC, Carlos TM, Schraut WH, et al. Surgically induced leukocytic infiltrates within the rat intestinal muscularis mediate postoperative ileus. Gastroenterology. 1999;117:378-387.
10. Kalff JC, Schraut WH, Billiar TR, et al. Role of inducible nitric oxide synthase in postoperative intestinal smooth muscle dysfunction in rodents. Gastroenterology. 2000;118:316-327.
11. Eskandari MK, Kalff JC, Billiar TR, et al. Lipopolysaccharide activates the muscularis macrophage network and suppresses circular smooth muscle activity. Am J Physiol. 1997;273:G727-G734.
12. Wan Y, Freeswick PD, Khemlani LS, et al. Role of lipopolysaccharide (LPS), interieukin-1, interleukin-6, tumor necrosis factor, and dexamethasone in regulation of LPS-binding protein expression in normal hepatocytes and hepatocytes from LPS-treated rats. Infect Immun. 1995;63:2435-2442.
13. Tuerler A, Schwarz NT, Tuerler E, et al. Rat intestinal monocyte chemoattractant protein-1 initiates leukocyte recruitment and smooth muscle dysfunction in endotoxemic ileus. Am J Physiol. 2002;282: G145-155.
14. Schmittgen TD, Zakrajsek BA, Mills AG, et al. Quantitative reverse transcription-polymerase chain reaction to study mRNA decay: comparison of endpoint and real-time methods. Anal Biochem. 2000;285: 194-204.
15. Hierholzer C, Kalff JC, Audolfsson G, et al. Molecular and functional contractile sequelae of rat intestinal ischemia/reperfusion injury. Transplantation. 1999;68:1244-1254.
16. Wagner BJ, Hayes TE, Hoban CJ, et al. The SIF binding element confers sis/PDGF inducibility onto the c-fos promoter. EMBO J. 1990;9:4477-4484.
17. Chakraborty A, White SM, Schaefer TS, et al. Granulocyte colony-stimulating factor activation of Stat3-α and Stat3β in immature normal and leukemic human myeloid cells. Blood. 1996;88:2442-2449.
18. Türler A, Moore BA, Pezzone MA, et al. Colonic postoperative inflammatory ileus in the rat. Ann Surg. 2002.
19. Hamilton TA, Adams DO. Molecular mechanisms of signal transduction in macrophages. Immunol Today. 1987;8:151-158.
20. Nathan CF. Secretory products of macrophages. J Clin Invest. 1987; 79:319-326.
21. Khan I, Collins SM. Expression of cytokines in the longitudinal muscle myenteric plexus of the inflamed intestine of rat. Gastroenterology. 1994;107:691-700.
22. Sredni-Kenigsbuch D, Kambayashi T, Strassmann G. Neutrophils augment the release of TNF-alpha from LPS-stimulated macrophages via hydrogen peroxide. Immunol Lett. 2000;71:97-102.
23. Vulcano M, Alves Rosa MF, Minnucci FS, et al. N-formyl-methionylleucyl-phenylalanine (fMLP) inhibits tumour necrosis factor-alpha (TNF-alpha) production on lipopolysaccharide (LPS)-stimulated human neutrophils. Clin Exp Immunol. 1998;113:39-47.
24. Schwarz NT, Kalff JC, Engel BM, et al. Prostanoid production via COX-2 as a causative mechanism of rodent postoperative ileus. Gastroenterology. 2001;121:1354-1371.
25. Kalff JC, Eskandari MK, Hierholzer C, et al. Biphasic response to gut manipulation and temporal correlation of cellular infiltrates and muscle dysfunction in rat. Surgery. 1999;126:498-509.
26. Bueno L, Ferre JP, Ruckebusch Y. Effects of anesthesia and surgical procedures on intestinal myoelectric activity in rats. Dig Dis Sci. 1978;23:690-695.
27. De Winter BY, Boeckxstaens GE, De Man JG, et al. Effect of adrenergic and nitrergic blockade on experimental ileus in rats. Br J Pharmacol. 1997;120:464-468.
28. Barquist E, Zinner M, Rivier J, et al. Abdominal surgery-induced delayed gastric emptying in rats: role of CRF and sensory neurons. Am J Physiol. 1992;262:G616-G620.
29. Tache Y, Monnikes H, Bonaz B, et al. Role of CRF in stress-related alterations of gastric and colonic motor function. Ann NY Acad Sci. 1993;697:233-243.
30. Nozu T, Martinez V, Rivier J, et al. Peripheral urocortin delays gastric emptying: role of CRF receptor 2. Am J Physiol. 1999;276:G867-G874.
31. Zittel TT, Lloyd KC, Rothenhofer I, et al. Calcitonin gene-related peptide and spinal afferents partly mediate postoperative colonic ileus in the rat. Surgery. 1998;123:518-527.
32. Boeckxstaens GE, Pelckmans PA, Herman AG, et al. Involvement of nitric oxide in the inhibitory innervation of the human isolated colon. Gastroenterology. 1993;104:690-697.
33. Seenu V, Goel AK. Early oral feeding after elective colorectal surgery: is it safe? Trop Gastroenterology. 1995;16:72-73.
34. Reissman P, Agachan F, Wexner, SD. Outcome of laparoscopic colorectal surgery in older patients. Am Surgeon. 1996;62:1060-1063.
35. Mikkelsen HB. Macrophages in the external muscle layers of mammalian intestines. Histol Histopathol. 1995;10:719-736.
36. Kalff JC, Schwarz NT, Walgenbach KJ, et al. Leukocytes of the intestinal muscularis externa: their phenotype and isolation. J Leukoc Biol. 1998;63:683-691.
37. Mikkelsen HB, Rumessen JJ. Characterization of macrophage-like cells in the external layers of human small and large intestine. Cell Tissue Res. 1992;270:273-279.
38. Collins SM. The immunomodulation of enteric neuromuscular function: implications for motility and inflammatory disorders. Gastroenterology. 1996;111:1683-1699.
39. Lodato RF, Khan AR, Zembowicz MJ, et al. Roles of IL-1 and TNF in the decreased ileal muscle contractility induced by lipopolysaccharide. Am J Physiol. 1999;276:G1356-G1362.
40. Sanders KM. Endogenous prostaglandin E and contractile activity of isolated ileal smooth muscle. Am J Physiol. 1978;234:E209-E212.
41. Thor P, Konturek JW, Konturek SJ, et al. Role of prostaglandins in control of intestinal motility. Am J Physiol. 1985;248:G353-G359.
42. Eberhart CE, Dubois RN. Eicosanoids and the gastrointestinal tract. Gastroenterology. 1995;109:285-301.
43. Hori M, Kita M, Torihashi S, et al. Upregulation of iNOS by COX-2 in muscularis resident macrophage of rat intestine stimulated with LPS. Am J Physiol Gastrointest Liver Physiol. 2001;280: G930-G938.
44. Stark MB, Bauer AJ, Szurszewski JH. Effect of nitric oxide on circular muscle of the canine small intestine. J Physiol. 1991;444:743-761.
45. Billiar TR. Nitric oxide: novel biology with clinical relevance. Ann Surg. 1995;221:339-349.
46. Moojen TM, Van Gulik TM, Hoek FJ, et al. Possible role of nitric oxide in postoperative ileus: a comparative study. Neurogastroenterology Motil. 1999;11:403-408.
47. Eskandari MK, Kalff JC, Billiar TR, et al. LPS-induced muscularis macrophage nitric oxide suppresses rat jejunal circular muscle activity. Am J Physiol. 1999;277:G478-G486.
48. Hassoun HT, Weisbrodt NW, Mercer DW, et al. Inducible nitric oxide synthase mediates gut ischemia/reperfusion-induced ileus only after severe insults. J Surg Res. 2001;97:150-154.
49. Cullen JJ, Mercer D, Hinkhouse M, et al. Effects of endotoxin on regulation of intestinal smooth muscle nitric oxide synthase and intestinal transit. Surgery. 1999;125:339-344.
50. Weisbrodt NW, Pressley TA, Li YF, et al. Decreased ileal muscle contractility and increased NOS II expression induced by lipopolysaccharide. Am J Physiol. 1996;271:G454-G460.
51. Deitch EA, Xu D, Franko L, et al. Evidence favoring the role of the gut as a cytokine-generating organ in rats subjected to hemorrhagic shock. Shock. 1994;1:141-145.
52. Mainous MR, Ertel W, Chaudry IH, et al. The gut: a cytokine-generating organ in systemic inflammation. Shock. 1995;4:193-199.
53. Michalsky MP, Deitch EA, Ding J, et al. Interleukin-6 and tumor necrosis factor production in an enterocyte cell model (Caco-2) during exposure to Escherichia coli. Shock. 1997;7:139-146.
54. Auger MJ, Ross JA. The biology of the macrophage. In: Lewis CE, McGee JO, eds. The Macrophage. New York: Oxford University Press, 1992:3-74.
55. van Furth R. Origin and turnover of monocytes and macrophages. In: Iversen OH, ed. Current Topics in Pathology. Heidelberg: Springer, 1989:125-150.