Effect of adrenergic and nitrergic blockade on experimental ileus in rats

British Journal of Pharmacology

Volumn 120, Issue 3, 1997, Pages 464-468

  De Winter, Benedicte Y ^b   Boeckxstaens, Guy E ^a   De Man, Joris G ^b   Moreels, Tom G ^b   Herman, Arnold G ^b   Pelckmans, Paul A ^b  

^a ACADEMIC MEDICAL CENTER   (Netherlands)

^b UNIVERSITY OF ANTWERP   (Belgium)

Author keywords

Adrenergic pathways; Ileus; Intestinal transit; NANC (non adrenergic non cholinergic); Nitric oxide synthase

Indexed keywords

ALKALOID; AMINOGUANIDINE; NITRIC OXIDE SYNTHASE INHIBITOR; RESERPINE;

ADRENERGIC TRANSMISSION; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ILEUS; INTESTINE TRANSIT TIME; LAPAROTOMY; MALE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; RAT;

ADRENERGIC ANTAGONISTS; ADRENERGIC UPTAKE INHIBITORS; ANESTHESIA, GENERAL; ANIMALS; ARGININE; AUTONOMIC PATHWAYS; ENZYME INHIBITORS; GASTROINTESTINAL TRANSIT; GUANIDINES; INTESTINAL OBSTRUCTION; ISOTHIURONIUM; MALE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITROARGININE; RATS; RATS, WISTAR; RESERPINE;

EID: 0031026843     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0700913     Document Type: Article

References (30)

1. ABRAHAMSSON, H., GLISE, H. & GLISE, K. (1979). Reflex suppression of gastric motility during laparotomy and gastroduodenal nociceptive stimulation. Scand. J. Gastroenterol., 14, 101-106.
2. ARANOW, J.S., ZHUANG, H., WANG, H., LARKIN, V., SMITH, M. & FINK, M.P. (1996). A selective inhibitor of inducible nitric oxide synthase prolongs survival in a rat model of bacterial peritonitis; comparison with two nonselective strategies. Shock, 5, 116-121.
3. BOECKXSTAENS, G.E. & PELCKMANS, P.A. (1996). Nitric oxide and the inhibitory non-adrenergic non-cholinergic innervation. Comp. Biochem. Physiol., (in press).
4. BOECKXSTAENS, G.E., PELCKMANS, P.A., BULT, H., DE MAN, J.G., HERMAN, A.G. & VAN MAERCKE, Y.M. (1990). Non-adrenergic non-cholinergic relaxation mediated by nitric oxide in the canine ileocolonic junction. Eur. J. Pharmacol., 190, 239-246.
5. BOJÖ, L., CASSUTO, J. & NELLGÅRD, P. (1992). Pain-induced inhibition of gastric motility is mediated by adrenergic and vagal non-adrenergic reflexes in the rat. Acta Physiol. Scand., 146, 377-383.
6. BUENO, L., FERRE, J.-P. & RUCKEBUSCH, Y. (1978). Effects of anesthesia and surgical procedures on intestinal myoelectric activity in rats. Am. J. Dig. Dis., 23, 690-695.
7. BULT, H., BOECKXSTAENS, G.E., PELCKMANS, P.A., JORDAENS, F.H., VAN MAERCKE, Y.M. & HERMAN, A.G. (1990). Nitric oxide as an inhibitory non-adrenergic non-cholinergic neurotransmitter. Nature, 345, 346-347.
8. BURNSTOCK, G. & COSTA, M. (1973). Inhibitory innervation of the gut. Gastroenterology, 64, 141-144.
9. CATCHPOLE, B.N. (1969). Ileus: use of sympathetic blocking agents in its treatment. Surgery, 66, 811-820.
10. CHENG, G., CASSISSI, C., DREXLER, P.G., VOGEL, S.B., SNINSKY, C.A. & HOCKING, M.P. (1996). Salsalate, morphine and postoperative ileus. Am. J. Surg., 171, 85-89.
11. DUBOIS, A. (1988). Mechanical gastrointestinal obstruction and paralytic ileus. In An Illustrated Guide to Gastrointestinal Motility. ed. Kumar, D. & Gustavsson, S. pp. 365-382. London: John Wiley & Sons.
12. DUBOIS, A., WEISE, V.K. & KOPIN, I.J. (1973). Postoperative ileus in the rat: physiopathology, etiology and treatment. Ann. Surg., 178, 781-786.
13. FURNESS, J.B. & COSTA, M. (1974). Adynamic ileus, its pathogenesis and treatment. Med. Biol., 52, 82-89.
14. GLISE, H. & ABRAHAMSSON, H. (1980). Reflex vagal inhibition of gastric motility by intestinal nociceptive stimulation in the cat. Scand. J. Gastroenterol., 15, 769-774.
15. GOYAL, R.K. & HIRANO, I. (1996). The enteric nervous system. N. Engl. J. Med., 334, 1106-1115.
16. HEIMBACH, D.M. & CROUT, J.R. (1971). Treatment of paralytic ileus with adrenergic neuronal blocking drugs. Surgery, 69, 582-587.
17. KNOWLES, R.G., MERRETT, M., SALTER, M. & MONCADA, S. (1990). Differential induction of brain, lung and liver nitric oxide synthase by endotoxin in the rat. Biochem. J., 270, 833-836.
18. LÁSZLÓ, F., WHITTLE, B.J.R., EVANS, S.M. & MONCADA, S. (1995). Association of microvascular leakage with induction of nitric oxide synthase: effects of nitric oxide synthase inhibitors in various organs. Eur. J. Pharmacol., 283, 47-53.
19. LIVINGSTON, E.H. & PASSARO, E.P. (1990). Postoperative ileus. Dig. Dis. Sci., 35, 121-132.
20. MILLER, M.J.S., CHOTINARUEMOL, S., SADOWSKA-KROWICKA, H., KAKKIS, J.L., MUNSHI, U.K., ZHANG, X.-J. & CLARCK, D.A. (1993). Nitric oxide: the Jekyll and Hyde of gut inflammation. Agents Actions, 39, C180-C182.
21. RAND, M.J. & LI, C.G. (1995). Nitric oxide as a neurotransmitter in peripheral nerves: nature of transmitter and mechanism of transmission. Ann. Rev. Physiol., 57, 659-682.
22. SALZMAN, A.L. (1995). Nitric oxide in the gut. New Horiz., 3, 33-45.
23. SEAGO, N.D., THOMPSON, J.H., ZHANG, X.-J., ELOBY-CHILDRESS, S., SADOWSKA-KROWICKA, H., ROSSI, J.L., CURRIE, M.G., MANNING, P.T., CLARK, D.A. & MILLER, M.J.S. (1995). Inducible nitric oxide synthase and guinea-pig ileitis induced by adjuvant. Mediators of Inflammation, 4, 19-24.
24. SMITH, J., KELLY, K.A. & WEINSHILBOUM, R.M. (1977). Pathophysiology of postoperative ileus. Arch. Surg., 112, 203-209.
25. SOUTHAN, G.J., SZABO, C. & THIEMERMANN, C. (1995). Isothioureas: potent inhibitors of nitric oxide synthases with variable isoform selectivity. Br. J. Pharmacol., 114, 510-516.
26. STARK, M.E. & SZURSZEWSKI, J.H. (1992). Role of nitric oxide in gastrointestinal and hepatic function and disease. Gastroenterology, 103, 1928-1949.
27. SZABÓ, C., SOUTHAN, G.J. & THIEMERMANN, C. (1994). Beneficial effects and improved survival in rodent models of septic shock with S-methylisothiourea sulfate, a potent and selective inhibitor of inducible nitric oxide synthase. Proc. Natl. Acad. Sci. U.S.A., 91, 12472-12476.
28. 2-adrenergic drugs in the rat. Gastroenterology, 104, 819-824.
29. WU, C.-C., CHEN, S.-J., SZABO, C. THIEMERMANN, C. & VANE, J.R. (1995). Aminoguanidine attenuates the delayed circulatory failure and improves survival in rodent models of endotoxic shock. Br. J. Pharmacol., 114, 1666-1672.
30. ω-nitro-L-arginine methyl ester on the multiple organ dysfunction caused by endotoxaemia in the rat. Eur. J. Pharmacol., 300, 99-104.