Prospective randomized, double-blind, placebo-controlled study of pre- and postoperative administration of a COX-2-specific inhibitor as opioid-sparing analgesia in major colorectal surgery

Colorectal Disease

Volumn 9, Issue 1, 2007, Pages 52-60

  Sim, Richard ^a   Cheong, D M ^a   Wong, K S ^b   Lee, B M K ^a   Liew, Q Y ^a  

^a TAN TOCK SENG HOSPITAL   (Singapore)

^b NATIONAL UNIVERSITY HOSPITAL   (Singapore)

Author keywords

Colorectal surgery; Perioperative treatment; Postoperative ileus; Preemptive analgesia

Indexed keywords

CYCLOOXYGENASE 2 INHIBITOR; MORPHINE; NARCOTIC ANALGESIC AGENT; PETHIDINE; PLACEBO; TRAMADOL; VALDECOXIB;

ADULT; AGED; ANESTHETIC RECOVERY; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; COLORECTAL SURGERY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CONVALESCENCE; COST OF ILLNESS; DOUBLE BLIND PROCEDURE; DRUG DOSE SEQUENCE; ELECTIVE SURGERY; FEMALE; HUMAN; ILEUS; INTERCOSTAL NERVE; INTESTINE SOUND; LENGTH OF STAY; MALE; MORBIDITY; NAUSEA; NERVE BLOCK; OPERATION DURATION; PATIENT CONTROLLED ANALGESIA; POSTOPERATIVE ANALGESIA; POSTOPERATIVE PAIN; PREOPERATIVE TREATMENT; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SEDATION; SIDE EFFECT;

ADULT; AGED; ANALGESIA, PATIENT-CONTROLLED; COLORECTAL SURGERY; CYCLOOXYGENASE 2 INHIBITORS; DOUBLE-BLIND METHOD; FEMALE; HUMANS; ILEUS; ISOXAZOLES; MALE; MIDDLE AGED; POSTOPERATIVE CARE; PREOPERATIVE CARE; PROSPECTIVE STUDIES; SULFONAMIDES;

EID: 33845292212     PISSN: 14628910     EISSN: 14631318     Source Type: Journal    
DOI: 10.1111/j.1463-1318.2006.00998.x     Document Type: Article

References (20)

1. Christensen T, Kehlet H. Postoperative fatigue. World J Surg 1993; 17: 220-5.
2. Basse L, Jakobsen DH, Bardram L, Billesbole P, Lund C, Morgensen T, Rosenberg J, Kehlet H. Functional recovery after open versus laparoscopic colonic resection: A randomized, blinded study. Ann Surg 2005; 241: 416-23.
3. Ferraz AA, Cowles VE, Condon RE, Carilli S, Ezberu F, Frantzides CT, Schulte WJ. Nonopioid analgesics shorten the duration of postoperative ileus. Am Surg 1995; 61: 1079-83.
4. Petros JG, Realica R, Ahmad S, Rimm EB, Robillard RJ. Patient-controlled analgesia and prolonged ileus after uncomplicated colectomy. Am J Surg 1995; 170: 371-4.
5. Bauer AJ, Boeckxstaens GE. Mechanisms of postoperative ileus. Neurogastroenterol Motil 2004; 16 (Suppl. 2): 54-60.
6. Kreiss C, Birder LA, Kiss S, VanBibber MM, Bauer AJ. COX-2-dependent inflammation increases spinal Fos expression during rodent postoperative ileus. Gut 2003; 52: 527-34.
7. Ong CK, Lirk P, Seymour RA, Jenkins BJ. The efficacy of preemptive analgesia for acute postoperative pain management: A meta-analysis. Anesth Analg 2005; 100: 757-73.
8. Horattas MC, Evans S, Sloan-Stakleff KD, Lee C, Snoke JW. Does preoperative rofecoxib (Vioxx) decrease postoperative pain with laparoscopic cholecystectomy? Am J Surg 2004; 188: 271-6.
9. Lohsiriwat V, Lert-akyamanee N, Rushatamukayanunt W. Efficacy of pre-incisional bupivacaine infiltration on postoperative pain relief after appendectomy: Prospective double-blind randomized trial. World J Surg 2004; 28: 947-50.
10. Cywinski JB, Parker BM, Xu M, Irefin SA. A comparison of postoperative pain control in patients after right lobe donor hepatectomy and major hepatic resection for tumor. Anesth Analg 2004; 99: 1747-52.
11. Bresalier RS, Sandler RS, Quan H et al. Cardiovascular events associated with rofecoxib in a colorectal adenoma chemoprevention trial. N Engl J Med 2005; 352: 1092-102.
12. Solomon SD, McMurray JJV, Pfeffer MA, Wittes J, Fowler R, Finn P, Anderson WF, Zauber A, Hawk E, Bertagnolli M, Adenoma Prevention with Celecoxib (APC) Study Investigators. Cardiovascular risk associated with celecoxib in a clinical trial for colorectal adenoma prevention. N Engl J Med 2005; 352: 1071-80.
13. Nussmeier NA, Whelton AA, Brown MT, Langford RM, Hoeft A, Parlow JL, Boyce SW, Verburg KM. Complications of the COX-2 inhibitors parecoxib and valdecoxib after cardiac surgery. N Engl J Med 2005; 352: 1081-91.
14. FDA Public Health Advisory. FDA Announces Important Changes and Additional Warnings for COX-2 Selective and Non-Selective Non-Steroidal Anti-Inflammatory Drugs (NSAIDs). http://www.fda.gov/cder/drug/advisory/ COX2.htm (accessed April 2005).
15. Psaty BM, Furberg CD. COX-2 inhibitors - lessons in drug safety. N Engl J Med 2005; 352: 1133-5.
16. Skelly MM, Hawkey CJ. Potential alternatives to COX-2 inhibitors. Br Med J 2002; 324: 1289-90.
17. Wolff BG, Michelassi F, Gerkin TM, Techner L, Gabriel K, Du W, Wallin BA, Alvimopan Postoperative Ileus Study Group. Alvimopan, a novel, peripherally acting mu opioid antagonist: Results of a multicenter, randomized, double-blind, placebo-controlled, phase III trial of major abdominal surgery and postoperative ileus. Ann Surg 2004; 240: 728-35.
18. Asao T, Kuwano H, Nakamura J, Morinaga N, Hirayama I, Ide M. Gum chewing enhances early recovery from postoperative ileus after laparoscopic colectomy. J Am Coll Surg 2002; 195: 30-2.
19. Le Blanc-Louvry I, Costaglioli B, Boulon C, Leroi AM, Ducrotte P. Does mechanical massage of the abdominal wall after colectomy reduce postoperative pain and shorten the duration of ileus? Results of a randomized study. J Gastrointest Surg 2002; 6: 43-9.
20. Walch JM, Rabin BS, Day R, Williams JN, Choi K, Kang JD. The effect of sunlight on postoperative analgesic medication use: A prospective study of patients undergoing spinal surgery. Psychosom Med 2005; 67: 156-63.