Economic burden of postoperative Ileus associated with colectomy in the United States

Journal of Managed Care Pharmacy

Volumn 15, Issue 6, 2009, Pages 485-494

  Iyer, Shrividya ^a   Saunders, William B ^b   Stemkowski, Stephen ^c  

^a PFIZER INC   (United States)

^b Premier Healthcare Informatics ^*

^c Premier Healthcare Informatics   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGED; ANASTOMOSIS; ARTICLE; CAUCASIAN; COHORT ANALYSIS; COLON RESECTION; CONTROLLED STUDY; DEPENDENT VARIABLE; DIGESTIVE SYSTEM DISEASE; DISEASE SEVERITY; ECONOMIC ASPECT; FEMALE; HEALTH CARE COST; HEALTH CARE UTILIZATION; HOSPITAL BED; HOSPITAL COST; HOSPITAL PATIENT; HOSPITALIZATION; HUMAN; ILEUS; INTESTINE FUNCTION; LENGTH OF STAY; MAJOR CLINICAL STUDY; MALE; MEDICAL RECORD; MORTALITY; MULTIVARIATE ANALYSIS; PARALYTIC ILEUS; POSTOPERATIVE COMPLICATION; RETROSPECTIVE STUDY; SEX DIFFERENCE; STATISTICAL SIGNIFICANCE; STUDENT T TEST; SURGICAL TECHNIQUE; UNITED STATES;

EID: 69149089004     PISSN: 10834087     EISSN: None     Source Type: Journal    
DOI: 10.18553/jmcp.2009.15.6.485     Document Type: Article

References (36)

1. Kehlet H, Holte K. Review of postoperative ileus. Am J Surg. 2001;182(5A Suppl):3S-10S.
2. Mattei P, Rombeau JL. Review of the pathophysiology and management of postoperative ileus. World J Surg. 2006;30(8):1382-1391 (Pubitemid 44421237)
3. Livingston EH, Passaro EP Jr. Postoperative ileus. Dig Dis Scl. 1990;35(l):121-132
4. Schuster TG, Montie JE. Postoperative ileus after abdominal surgery. Urology. 2002;59(4):465-471
5. Barquist E, Bonaz B, Martinez V, Rivier J, Zinner MJ, Taché Y. Neuronal pathways involved in abdominal surgery-induced gastric ileus in rats. Am J Physiol. 1996;270(4 Pt 2): R888-R894. (Pubitemid 126756663)
6. Bauer AJ, Boeckxstaens GE. Mechanisms of postoperative ileus. Neurogastroenterol Motil. 2004;16(Suppl 2):54-60.
7. Boeckxstaens GE, Hirsch DP, Kodde A, et al. Activation of an adrenergic and vagally-mediated NANC pathway in surgery-induced fundic relaxation in the rat. Neurogastroenterol Motil. 1999;ll(6):467-474
8. Barbara G, De Giorgio R, Deng Y, Vallance B, Blennerhassett P, Collins SM. Role of immunologic factors and cyclooxygenase 2 in persistent postinfective enteric muscle dysfunction in mice. Gastroenterology. 2001;120(7):1729-1736 (Pubitemid 32523491)
9. Kalff JC, Schraut WH, Billiar TR, Simmons RL, Bauer AJ. Role of inducible nitric oxide synthase in postoperative intestinal smooth muscle dysfunction in rodents. Gastroenterology. 2000;118(2):316-327 (Pubitemid 30067505)
10. Kalff JC, Schraut WH, Simmons RL, Bauer AJ. Surgical manipulation of the gut elicits an intestinal muscularis inflammatory response resulting in postsurgical ileus. Ann Surg. 1998;228(5):652-663 (Pubitemid 128719595)
11. Schwarz NT, Beer-Stolz D, Simmons RL, Bauer AJ. Pathogenesis of paralytic ileus: intestinal manipulation opens a transient pathway between the intestinal lumen and the leukocytic infiltrate of the jejunal muscularis. Ann Surg. 2002;235(l):31-40. (Pubitemid 34062397)
12. Bauer AJ, Sarr MG, Szurszewski JH. Opioids inhibit neuromuscular transmission in circular muscle of human and baboon jejunum. Gastroenterology. 1991;101(4):970-976
13. Delaney CP. Clinical perspective on postoperative ileus and the effect of opiates. Neurogastroenterol Motil. 2004;16(Suppl 2):61-66.
14. Carter S. The surgical team and outcomes management: focus on postoperative ileus. J Perianesthes Nurs. 2006;21(2A Suppl):S2-6.
15. Goldstein JL, Matuszewski KA, Delaney CP, et al. Inpatient economic burden of postoperative ileus associated with abdominal surgery in the United States. P&T. 2007;32(2):82-90. Available at: http://www.ptcommunity com/ptjournal/fulltext/32/2/PTJ3202082.pdf. Accessed June 17, 2009.
16. Miedema BW, Johnson JO. Methods for decreasing postoperative gut dysmotility. Lancet Oncol. 2003;4(6):365-372
17. Behrns KE, Kircher AP, Galanko JA, Brownstein MR, Koruda MJ. Prospective randomized trial of early initiation and hospital discharge on a liquid diet following elective intestinal surgery. J Gastrointest Surg. 2000;4(2):217-221
18. Stewart BT, Woods RJ, Collopy BT, Fink RJ, Mackay JR, Keck JO. Early feeding after elective open colorectal resections: a prospective randomized trial. Aust N Z J Surg. 1998,68(2):125-128
19. Abraham NS, Byrne CM, Young JM, Solomon MJ. Meta-analysis of non-randomized comparative studies of the short-term outcomes of laparoscopic resection for colorectal cancer. ANZ J Surg. 2007;77(7):508-516
20. Clinical Outcomes of Surgical Therapy Study Group. A comparison of laparoscopically assisted and open colectomy for colon cancer. N Engl J Med. 2004;350(20):2050-2059
21. Hinojosa MW, Murrell ZA, Konyalian VR, Mills S, Nguyen NT, Stamos MJ. Comparison of laparoscopic vs. open sigmoid colectomy for benign and malignant disease at academic medical centers. J Gastrointest Surg. 2007;ll(ll):1423-1429
22. Veldkamp R, Gholghesaei M, Bonjer HJ, et al. Laparoscopic resection of colon cancer: consensus of the European Association of Endoscopic Surgery (EAES). Surg Endosc. 2004;18(8):1163-1185 (Pubitemid 39014855)
23. Basse L, Jakobsen DH, Bardram L, et al. Functional recovery after open versus laparoscopic colonic resection: a randomized, blinded study. Ann Surg. 2005;241(3).416-423 (Pubitemid 40299717)
24. Basse L, Madsen JL, Kehlet H. Normal gastrointestinal transit after colonic resection using epidural analgesia, enforced oral nutrition and laxative. Br J Surg. 2001;88(11):1498-1500 (Pubitemid 32989471)
25. Tan EK, Cornish J, Darzi AW, Tekkis PP. Meta-analysis: alvimopan vs. placebo in the treatment of post-operative ileus. Aliment Pharmacol Ther. 2007;25(l):47-57.
26. Viscusi ER, Goldstein S, Witkowski T, et al. Alvimopan, a peripherally acting mu-opioid receptor antagonist, compared with placebo in postoperative ileus after major abdominal surgery: results of a randomized, double-blind, controlled study. Surg Endosc. 2006;20(l):64-70. (Pubitemid 43097035)
27. Wolff BG, Viscusi ER, Delaney CP, Du W, Techner L. Patterns of gastrointestinal recovery after bowel resection and total abdominal hysterectomy: pooled results from the placebo arms of alvimopan phase III North American clinical trials. J Am Coll Surg. 2007;205(1):43-51. (Pubitemid 47016955)
28. Lindenauer PK, Remus D, Roman S, et al. Public reporting and pay for performance in hospital quality improvement. N Engl J Med. 2007;356(5):486-96. Available at: http://content.nejm.org/cgi/reprint/356/5/486.pdf. Accessed June 17, 2009. (Pubitemid 46193076)
29. Agency for Healthcare Research and Quality. AHRQ Quality Indicators. Understanding the 3M™ All Patient Refined DRGs (APR DRGs). Available at: httpV/www.qualityindicators. ahrq.gov/%5Cdownloads%5Clistserv%5CUnde rstanding%20the%203M%20APR-DRG.pdf. Accessed June 21, 2009.
30. Averill RF, Goldfield N, Hughes JS, et al. All Patient Refined Diagnosis Related Groups (APR-DRGs), Version 20.0, Methodology Overview. Wallingford, CT: 3M Health Information Systems; July 2003. Available at: www.hcup-us. ahrq.gov/db/nation/nis/APR-DRGsV20MethodologyOverviewandBibliograph y.pdf. Accessed June 21, 2009.
31. Salvador CG, Sikirica M, Evans A, Pizzi L, Goldfarb N. Clinical and economic outcomes of prolonged postoperative ileus in patients undergoing hysterectomy and hemicolectomy. P&T. 2005;30(10):590-95. Available at: http://www.pharmscope.com/ptJournal/fulltext/30/10/PTJ3010590.pdf. Accessed June 21, 2009. (Pubitemid 41606996)
32. Sarawate CA, Lin S-J, Walton SM, Crawford SY, Goldstein JL. Economic burden of postoperative ileus (POI) in abdominal surgical procedures (abstract). Gastroenterology. 2003;124(Suppl 1):A828.
33. Poster presented at: Digestive Disease Week and the 104th Annual Meeting of the American Gastroenterological Association; May 17-22, 2003; Orlando, FL.
34. Benedict A, Davies A, Loftus J, Kirsch J. A comparative study of the burden of post-operative ileus (POI) on post-operative length,of stay (LOS) in European abdominal surgery (abstract). Colorectal Dis. 2004;6(Suppl 2):40.
35. Poster presented at: European Association of Coloproctology 5th Scientific and Annual General Meeting, European Council of Coloproctology 1st Annual Meeting; September 16-18, 2004; Geneva, Switzerland.
36. Kiran RP, Delaney CP, Senagore AJ, Steel M, Garafalo T, Fazio VW. Outcomes and prediction of hospital readmission after intestinal surgery. J Am Coll Surg. 2004;198(6):877-883 (Pubitemid 38759837)