Safety and efficacy of methylnaltrexone in shortening the duration of postoperative ileus following segmental colectomy: Results of two randomized, placebo-controlled phase 3 trials

Diseases of the Colon and Rectum

Volumn 54, Issue 5, 2011, Pages 570-578

  Yu, Chang Sik ^a,e   Chun, Ho Kyung ^b   Stambler, Nancy ^c   Carpenito, Jennifer ^c   Schulman, Seth ^d   Tzanis, Evan ^d   Randazzo, Bruce ^d  

^a University of Ulsan College of Medicine   (South Korea)

^b Samsung Medical Center   (South Korea)

^c A Subsidiary of Lantheus Holdings   (United States)

^d PFIZER INC   (United States)

^e Asan Medical Center   (South Korea)

Author keywords

Colectomy; Ileus; Methylnaltrexone; Postoperative period

Indexed keywords

17 METHYLNALTREXONE; 17 METHYLNALTREXONE BROMIDE; DICLOFENAC; FENTANYL; HYDROMORPHONE; KETOROLAC; MORPHINE; PLACEBO; DRUG DERIVATIVE; NALTREXONE; NARCOTIC ANTAGONIST; QUATERNARY AMMONIUM DERIVATIVE;

ABDOMINAL ABSCESS; ABDOMINAL DISTENSION; ABDOMINAL PAIN; ADULT; AGED; ANASTOMOSIS LEAKAGE; ANEMIA; ANXIETY; ARTICLE; ATELECTASIS; CLINICAL ASSESSMENT; COLON CANCER; COLON RESECTION; CONSTIPATION; CONTROLLED STUDY; CONVALESCENCE; DEEP VEIN THROMBOSIS; DIARRHEA; DISEASE DURATION; DIZZINESS; DRUG EFFICACY; DRUG SAFETY; DRUG TOLERABILITY; DRUG WITHDRAWAL; DYSPNEA; DYSURIA; FATIGUE; FEMALE; FEVER; HEADACHE; HEART ATRIUM FIBRILLATION; HOSPITAL DISCHARGE; HUMAN; HYPERGLYCEMIA; HYPERTENSION; HYPOKALEMIA; HYPOMAGNESEMIA; HYPOTENSION; ILEUS; INSOMNIA; LUNG EMBOLISM; LYMPHOCYTE COUNT; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY (TOPIC); NAUSEA; PARALLEL DESIGN; PATIENT COMPLIANCE; PELVIS ABSCESS; PERITONITIS; PHASE 3 CLINICAL TRIAL (TOPIC); PNEUMONIA; POSTOPERATIVE COMPLICATION; POSTOPERATIVE HEMORRHAGE; POSTOPERATIVE ILEUS; POSTOPERATIVE NAUSEA; POSTOPERATIVE PAIN; POSTOPERATIVE VOMITING; PRURITUS; RANDOMIZED CONTROLLED TRIAL (TOPIC); RESPIRATORY FAILURE; RETCHING; SEPSIS; SIDE EFFECT; SIGMOIDECTOMY; SMALL INTESTINE OBSTRUCTION; SYSTOLIC BLOOD PRESSURE; TACHYCARDIA; TREATMENT REFUSAL; TREATMENT WITHDRAWAL; URINARY TRACT INFECTION; URINE RETENTION; VOMITING; WOUND DEHISCENCE; WOUND INFECTION; ADOLESCENT; CLINICAL TRIAL; COMPARATIVE STUDY; CONTROLLED CLINICAL TRIAL; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; FOLLOW UP; INTRAVENOUS DRUG ADMINISTRATION; METHODOLOGY; MIDDLE AGED; MULTICENTER STUDY; PHASE 3 CLINICAL TRIAL; RANDOMIZED CONTROLLED TRIAL; RETROSPECTIVE STUDY; TREATMENT OUTCOME;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; COLECTOMY; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; FEMALE; FOLLOW-UP STUDIES; HUMANS; ILEUS; INJECTIONS, INTRAVENOUS; MALE; MIDDLE AGED; NALTREXONE; NARCOTIC ANTAGONISTS; POSTOPERATIVE COMPLICATIONS; QUATERNARY AMMONIUM COMPOUNDS; RETROSPECTIVE STUDIES; TREATMENT OUTCOME; YOUNG ADULT;

EID: 79957977065     PISSN: 00123706     EISSN: 15300358     Source Type: Journal    
DOI: 10.1007/DCR.0b013e3182092bde     Document Type: Article

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