T-cell receptor ligation induces distinct signaling pathways in naïve vs. antigen-experienced T cells

Proceedings of the National Academy of Sciences of the United States of America

Volumn 108, Issue 4, 2011, Pages 1549-1554

  Adachi, Keishi ^a,b   Davisa, Mark M ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NAGASAKI UNIVERSITY   (Japan)

Author keywords

T cell signaling

Indexed keywords

ANTIGEN; CD3 ANTIGEN; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN DISC LARGE; PROTEIN KINASE ZAP 70; PROTEIN SLP 76; SIGNAL TRANSDUCING ADAPTOR PROTEIN; SYNAPTOPHYSIN; T LYMPHOCYTE RECEPTOR; UNCLASSIFIED DRUG;

ARTICLE; CALCIUM TRANSPORT; CONTROLLED STUDY; HUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN INTERACTION; PROTEIN PHOSPHORYLATION; T LYMPHOCYTE;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANTIGENS; BLOTTING, WESTERN; BUTADIENES; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; DENDRITIC CELLS; ENTEROTOXINS; ENZYME INHIBITORS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HUMANS; IMIDAZOLES; INTERFERON-GAMMA; LYMPHOCYTE ACTIVATION; MEMBRANE PROTEINS; NITRILES; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PYRIDINES; RECEPTORS, ANTIGEN, T-CELL; SIGNAL TRANSDUCTION; T-LYMPHOCYTES;

EID: 79952180387     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1017340108     Document Type: Article

References (49)

1. Smith-Garvin JE, Koretzky GA, Jordan MS (2009) T cell activation. Annu Rev Immunol 27:591-619.
2. Wange RL (2004) TCR signaling: another Abl-bodied kinase joins the cascade. Curr Biol 14:R562-R564.
3. van Oers NS (1999) T cell receptor-mediated signs and signals governing T cell development. Semin Immunol 11:227-237.
4. Alberola-Ila J, Takaki S, Kerner JD, Perlmutter RM (1997) Differential signaling by lymphocyte antigen receptors. Annu Rev Immunol 15:125-154. (Pubitemid 27169277)
5. Cantrell D (1996) T cell antigen receptor signal transduction pathways. Annu Rev Immunol 14:259-274.
6. Hoshi N, Langeberg LK, Scott JD (2005) Distinct enzyme combinations in AKAP signalling complexes permit functional diversity. Nat Cell Biol 7:1066-1073.
7. Ptashne M, Gann A (2003) Signal transduction. Imposing specificity on kinases. Science 299:1025-1027.
8. Burack WR, Shaw AS (2000) Signal transduction: Hanging on a scaffold. Curr Opin Cell Biol 12:211-216. (Pubitemid 30142568)
9. Jordan MS, Singer AL, Koretzky GA (2003) Adaptors as central mediators of signal transduction in immune cells. Nat Immunol 4:110-116. (Pubitemid 36193011)
10. Round JL, et al. (2005) Dlgh1 coordinates actin polymerization, synaptic T cell receptor and lipid raft aggregation, and effector function in T cells. J Exp Med 201: 419-430. (Pubitemid 40229416)
11. Ludford-Menting MJ, et al. (2005) A network of PDZ-containing proteins regulates T cell polarity and morphology during migration and immunological synapse formation. Immunity 22:737-748. (Pubitemid 40814504)
12. da Silva AJ, et al. (1997) Cloning of a novel T-cell protein FYB that binds FYN and SH2- domain-containing leukocyte protein 76 and modulates interleukin 2 production. Proc Natl Acad Sci USA 94:7493-7498.
13. Geng L, Rudd CE (2002) Signalling scaffolds and adaptors in T-cell immunity. Br J Haematol 116:19-27.
14. 2+/ calcineurin-NFAT-mediated signaling. Mol Cells 18:1-9.
15. Serfling E, et al. (2004) NFAT and NF-kappaB factors - the distant relatives. Int J Biochem Cell Biol 36:1166-1170. (Pubitemid 38515658)
16. Tybulewicz VL (2005) Vav-family proteins in T-cell signalling. Curr Opin Immunol 17: 267-274.
17. Mor A, Philips MR (2006) Compartmentalized Ras/MAPK signaling. Annu Rev Immunol 24:771-800.
18. Dong C, Davis RJ, Flavell RA (2002) MAP kinases in the immune response. Annu Rev Immunol 20:55-72. (Pubitemid 34293420)
19. Yamashita M, et al. (1999) T cell antigen receptor-mediated activation of the Ras/ mitogen-activated protein kinase pathway controls interleukin 4 receptor function and type-2 helper T cell differentiation. Proc Natl Acad Sci USA 96:1024-1029. (Pubitemid 29072177)
20. Rincón M, Flavell RA, Davis RA (2000) The JNK and P38 MAP kinase signaling pathways in T cell-mediated immune responses. Free Radic Biol Med 28:1328-1337. (Pubitemid 30621477)
21. + T cells. Immunol Rev 192:131-142.
22. Round JL, et al. (2007) Scaffold protein Dlgh1 coordinates alternative p38 kinase activation, directing T cell receptor signals toward NFAT but not NF-kappaB transcription factors. Nat Immunol 8:154-161. (Pubitemid 46152646)
23. Rebeaud F, Hailfinger S, Thome M (2007) Dlgh1 and Carma1 MAGUK proteins contribute to signal specificity downstream of TCR activation. Trends Immunol 28: 196-200. (Pubitemid 46654870)
24. Salvador JM, Mittelstadt PR, Belova GI, Fornace AJ, Jr., Ashwell JD (2005) The autoimmune suppressor Gadd45α inhibits the T cell alternative p38 activation pathway. Nat Immunol 6:396-402. (Pubitemid 41716780)
25. Yablonski D, Kadlecek T, Weiss A (2001) Identification of a phospholipase C-γ1 (PLC- γ1) SH3 domain-binding site in SLP-76 required for T-cell receptor-mediated activation of PLC-γ1 and NFAT. Mol Cell Biol 21:4208-4218. (Pubitemid 32565303)
26. Clements JL, Boerth NJ, Lee JR, Koretzky GA (1999) Integration of T cell receptor-dependent signaling pathways by adapter proteins. Annu Rev Immunol 17:89-108. (Pubitemid 29241120)
27. Salvador JM, et al. (2005) Alternative p38 activation pathway mediated by T cell receptor-proximal tyrosine kinases. Nat Immunol 6:390-395. (Pubitemid 41716779)
28. Matsuda S, et al. (2004) Negative feedback loop in T-cell activation through MAPK-catalyzed threonine phosphorylation of LAT. EMBO J 23:2577-2585. (Pubitemid 38988229)
29. Yablonski D, Kuhne MR, Kadlecek T, Weiss A (1998) Uncoupling of nonreceptor tyrosine kinases from PLC-γ1 in an SLP-76-deficient T cell. Science 281:413-416.
30. Lillemeier BF, Pfeiffer JR, Surviladze Z, Wilson BS, Davis MM (2006) Plasma membrane-associated proteins are clustered into islands attached to the cytoskeleton. Proc Natl Acad Sci USA 103:18992-18997. (Pubitemid 350002816)
31. Lillemeier BF, et al. (2010) TCR and Lat are expressed on separate protein islands on T cell membranes and concatenate during activation. Nat Immunol 11:90-96.
32. Dimitratos SD, Woods DF, Stathakis DG, Bryant PJ (1999) Signaling pathways are focused at specialized regions of the plasma membrane by scaffolding proteins of the MAGUK family. Bioessays 21:912-921. (Pubitemid 29530600)
33. Bilder D (2001) PDZ proteins and polarity: Functions from the fly. Trends Genet 17:511-519.
34. Wu H, Nash JE, Zamorano P, Garner CC (2002) Interaction of SAP97 with minus-end-directed actin motor myosin VI. Implications for AMPA receptor trafficking. J Biol Chem 277:30928-30934. (Pubitemid 34970794)
35. Patel VP, Moran M, Low TA, Miceli MC (2001) A molecular framework for two-step T cell signaling: Lck Src homology 3 mutations discriminate distinctly regulated lipid raft reorganization events. J Immunol 166:754-764. (Pubitemid 32060225)
36. Dupré L, et al. (2002) Wiskott-Aldrich syndrome protein regulates lipid raft dynamics during immunological synapse formation. Immunity 17:157-166. (Pubitemid 35245958)
37. Villalba M, et al. (2001) Vav1/Rac-dependent actin cytoskeleton reorganization is required for lipid raft clustering in T cells. J Cell Biol 155:331-338. (Pubitemid 34289325)
38. Cianferoni A, et al. (2005) Defective nuclear translocation of nuclear factor of activated T cells and extracellular signal-regulated kinase underlies deficient IL-2 gene expression in Wiskott-Aldrich syndrome. J Allergy Clin Immunol 116:1364-1371. (Pubitemid 41740950)
39. Macián F, et al. (2002) Transcriptional mechanisms underlying lymphocyte tolerance. Cell 109:719-731. (Pubitemid 34722268)
40. Macian F (2005) NFAT proteins: Key regulators of T-cell development and function. Nat Rev Immunol 5:472-484.
41. Singh K, et al. (2009) ERK-dependent T cell receptor threshold calibration in rheumatoid arthritis. J Immunol 183:8258-8267.
42. Stefanová I, et al. (2003) TCR ligand discrimination is enforced by competing ERK positive and SHP-1 negative feedback pathways. Nat Immunol 4:248-254. (Pubitemid 36322134)
43. Oh-hora M (2009) Calcium signaling in the development and function of T-lineage cells. Immunol Rev 231:210-224.
44. Alberola-Ila J, Hernández-Hoyos G (2003) The Ras/MAPK cascade and the control of positive selection. Immunol Rev 191:79-96. (Pubitemid 36398850)
45. Dumont FJ, Staruch MJ, Fischer P, DaSilva C, Camacho R (1998) Inhibition of T cell activation by pharmacologic disruption of the MEK1/ERK MAP kinase or calcineurin signaling pathways results in differential modulation of cytokine production. J Immunol 160:2579-2589.
46. Egerton M, Fitzpatrick DR, Catling AD, Kelso A (1996) Differential activation of T cell cytokine production by the extracellular signal-regulated kinase (ERK) signaling pathway. Eur J Immunol 26:2279-2285. (Pubitemid 26340924)
47. Sachs K, Perez O, Pe'er D, Lauffenburger DA, Nolan GP (2005) Causal protein-signaling networks derived from multiparameter single-cell data. Science 308:523-529. (Pubitemid 40570578)
48. von Essen MR, et al. (2010) Vitamin D controls T cell antigen receptor signaling and activation of human T cells. Nat Immunol 11:344-349.
49. Kersh EN, et al. (2003) TCR signal transduction in antigen-specific memory CD8 T cells. J Immunol 170:5455-5463. (Pubitemid 36617832)