Partial restoration of T-cell function in aged mice by in vitro blockade of the PD-1/PD-L1 pathway

Aging Cell

Volumn 9, Issue 5, 2010, Pages 785-798

  Lages, Celine S ^a   Lewkowich, Ian ^b   Sproles, Alyssa ^b   Wills Karp, Marsha ^b   Chougnet, Claire ^a  

^a Division of Molecular Immunology   (United States)

^b UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

Author keywords

Aging; Dendritic cells; Programmed cell death 1 (PD 1) ligands; T cells

Indexed keywords

CD28 ANTIGEN; CD69 ANTIGEN; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 13; INTERLEUKIN 2 RECEPTOR ALPHA; INTERLEUKIN 7 RECEPTOR; PROGRAMMED DEATH 1 LIGAND 1; PROGRAMMED DEATH 1 RECEPTOR;

AGED; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL PROLIFERATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DENDRITIC CELL; EFFECTOR CELL; IN VITRO STUDY; INFECTION; LUNG; LYMPH NODE; MEMORY T LYMPHOCYTE; MOUSE; NONHUMAN; PEYER PATCH; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; SPLEEN; T LYMPHOCYTE; UPREGULATION;

AGING; ANIMALS; ANTIGENS, CD80; ANTIGENS, SURFACE; APOPTOSIS REGULATORY PROTEINS; CELL PROLIFERATION; CYTOKINES; FLOW CYTOMETRY; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED C57BL; PEPTIDES; T-LYMPHOCYTES;

MUS;

EID: 78349286392     PISSN: 14749718     EISSN: 14749726     Source Type: Journal    
DOI: 10.1111/j.1474-9726.2010.00611.x     Document Type: Article

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