메뉴 건너뛰기




Volumn 4, Issue 1, 2013, Pages 27-39

The essential adaptors of innate immune signaling

Author keywords

adaptor; innate immunity; STAT6; STING

Indexed keywords

ADAPTOR PROTEIN; CYTOKINE; INFLAMMASOME; INTERLEUKIN 1BETA CONVERTING ENZYME; MEMBRANE PROTEIN; MITOCHONDRIAL PROTEIN; MYELOID DIFFERENTIATION FACTOR 88; PROTEIN MAVS; PROTEIN STING; STAT6 PROTEIN; TOLL LIKE RECEPTOR ADAPTOR MOLECULE 1; UNCLASSIFIED DRUG;

EID: 84868130809     PISSN: 1674800X     EISSN: 16748018     Source Type: Journal    
DOI: 10.1007/s13238-012-2063-0     Document Type: Review
Times cited : (91)

References (63)
  • 2
    • 79951679142 scopus 로고    scopus 로고
    • Innate immune DNA sensing pathways: STING, AIMII and the regulation of interferon production and inflammatory responses
    • Barber, G. N. (2011). Innate immune DNA sensing pathways: STING, AIMII and the regulation of interferon production and inflammatory responses. Curr Opin Immunol 23, 10-20.
    • (2011) Curr Opin Immunol , vol.23 , pp. 10-20
    • Barber, G.N.1
  • 4
    • 30444458235 scopus 로고    scopus 로고
    • Stats: multifaceted regulators of transcription
    • Brierley, M. M., and Fish, E. N. (2005). Stats: multifaceted regulators of transcription. J Interf Cytok Res 25, 733-744.
    • (2005) J Interf Cytok Res , vol.25 , pp. 733-744
    • Brierley, M.M.1    Fish, E.N.2
  • 5
    • 79954577277 scopus 로고    scopus 로고
    • TLR-signaling networks: an integration of adaptor molecules, kinases, and cross-talk
    • Brown, J., Wang, H., Hajishengallis, G. N., and Martin, M. (2011). TLR-signaling networks: an integration of adaptor molecules, kinases, and cross-talk. J Dent Res 90, 417-427.
    • (2011) J Dent Res , vol.90 , pp. 417-427
    • Brown, J.1    Wang, H.2    Hajishengallis, G.N.3    Martin, M.4
  • 7
    • 0029865142 scopus 로고    scopus 로고
    • IRAK: a kinase associated with the interleukin-1 receptor
    • Cao, Z. D., Henzel, W. J., and Gao, X. (1996). IRAK: a kinase associated with the interleukin-1 receptor. Science 271, 1128-1131.
    • (1996) Science , vol.271 , pp. 1128-1131
    • Cao, Z.D.1    Henzel, W.J.2    Gao, X.3
  • 8
    • 77953991456 scopus 로고    scopus 로고
    • Regulation of the T helper cell type 2 (Th2)/T regulatory cell (Treg) balance by IL-4 and STAT6
    • Chapoval, S., Dasgupta, P., Dorsey, N. J., and Keegan, A. D. (2010). Regulation of the T helper cell type 2 (Th2)/T regulatory cell (Treg) balance by IL-4 and STAT6. J Leuk Biol 87, 1011-1018.
    • (2010) J Leuk Biol , vol.87 , pp. 1011-1018
    • Chapoval, S.1    Dasgupta, P.2    Dorsey, N.J.3    Keegan, A.D.4
  • 10
    • 23144449789 scopus 로고    scopus 로고
    • Ubiquitin signalling in the NF-κB pathway
    • Chen, Z. J. (2005). Ubiquitin signalling in the NF-κB pathway. Nat Cell Biol 7, 758-765.
    • (2005) Nat Cell Biol , vol.7 , pp. 758-765
    • Chen, Z.J.1
  • 13
    • 63649145255 scopus 로고    scopus 로고
    • AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA
    • Fernandes-Alnemri, T., Yu, J.-W., Datta, P., Wu, J. H., and Alnemri, E. S. (2009). AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA. Nature 458, 509-513.
    • (2009) Nature , vol.458 , pp. 509-513
    • Fernandes-Alnemri, T.1    Yu, J.-W.2    Datta, P.3    Wu, J.H.4    Alnemri, E.S.5
  • 16
    • 0035313367 scopus 로고    scopus 로고
    • STAT6 mediates eotaxin-1 expression in IL-4 or TNF-alpha-induced fibroblasts
    • Hoeck, J., and Woisetschläger, M. (2001). STAT6 mediates eotaxin-1 expression in IL-4 or TNF-alpha-induced fibroblasts. J Immunol 166, 4507-4515.
    • (2001) J Immunol , vol.166 , pp. 4507-4515
    • Hoeck, J.1    Woisetschläger, M.2
  • 17
    • 0035555301 scopus 로고    scopus 로고
    • TIRAP: an adaptor molecule in the Toll signaling pathway
    • Horng, T., Barton, G. M., and Medzhitov, R. (2001). TIRAP: an adaptor molecule in the Toll signaling pathway. Nat Immunol 2, 835-841.
    • (2001) Nat Immunol , vol.2 , pp. 835-841
    • Horng, T.1    Barton, G.M.2    Medzhitov, R.3
  • 20
    • 79961133270 scopus 로고    scopus 로고
    • MAVS forms functional prion-like aggregates to activate and propagate antiviral innate immune response
    • Hou, F. J., Sun, L. J., Zheng, H., Skaug, B., Jiang, Q. X., and Chen, Z. J. (2011). MAVS forms functional prion-like aggregates to activate and propagate antiviral innate immune response. Cell 146, 448-461.
    • (2011) Cell , vol.146 , pp. 448-461
    • Hou, F.J.1    Sun, L.J.2    Zheng, H.3    Skaug, B.4    Jiang, Q.X.5    Chen, Z.J.6
  • 21
    • 4944228934 scopus 로고    scopus 로고
    • Kit and FcepsilonRI mediate unique and convergent signals for release of inflammatory mediators from human mast cells
    • Hundley, T. R., Gilfillan, A. M., Tkaczyk, C., Andrade, M. V., Metcalfe, D. D., Beaven, M. A. (2004). Kit and FcepsilonRI mediate unique and convergent signals for release of inflammatory mediators from human mast cells. Blood 104, 2410-2417.
    • (2004) Blood , vol.104 , pp. 2410-2417
    • Hundley, T.R.1    Gilfillan, A.M.2    Tkaczyk, C.3    Andrade, M.V.4    Metcalfe, D.D.5    Beaven, M.A.6
  • 22
    • 70349943834 scopus 로고    scopus 로고
    • STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity
    • Ishikawa, H., Ma, Z., and Barber, G. N. (2009). STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity. Nature 461, 788-792.
    • (2009) Nature , vol.461 , pp. 788-792
    • Ishikawa, H.1    Ma, Z.2    Barber, G.N.3
  • 23
    • 84862994793 scopus 로고    scopus 로고
    • Ubiquitin-induced oligomerization of the RNA sensors RIG-I and Mda5 activates antiviral innate immune response
    • Jiang, X. M., Kinch, L. N., Brautigam, C. A., Chen, X., Du, F. H., Grishin, N. V., and Chen, Z. J. (2012). Ubiquitin-induced oligomerization of the RNA sensors RIG-I and Mda5 activates antiviral innate immune response. Immunity 36, 959-973.
    • (2012) Immunity , vol.36 , pp. 959-973
    • Jiang, X.M.1    Kinch, L.N.2    Brautigam, C.A.3    Chen, X.4    Du, F.H.5    Grishin, N.V.6    Chen, Z.J.7
  • 25
    • 0033166472 scopus 로고    scopus 로고
    • Unresponsiveness of MyD88-deficient mice to endotoxin
    • Kawai, T., Adachi, O., Ogawa, T., Takeda, K., and Akira, S. (1999). Unresponsiveness of MyD88-deficient mice to endotoxin. Immunity 11, 115-122.
    • (1999) Immunity , vol.11 , pp. 115-122
    • Kawai, T.1    Adachi, O.2    Ogawa, T.3    Takeda, K.4    Akira, S.5
  • 27
    • 80053379974 scopus 로고    scopus 로고
    • Innate immune recognition of bacterial ligands by NAIPs determines inflammasome specificity
    • Kofoed, E. M., and Vance, R. E. (2011). Innate immune recognition of bacterial ligands by NAIPs determines inflammasome specificity. Nature 477, 592-595.
    • (2011) Nature , vol.477 , pp. 592-595
    • Kofoed, E.M.1    Vance, R.E.2
  • 28
    • 78751560494 scopus 로고    scopus 로고
    • Pathogen recognition by the innate immune system
    • Kumar, H., Kawai, T., and Akira, S. (2011). Pathogen recognition by the innate immune system. Intl Rev Immunol 30, 16-34.
    • (2011) Intl Rev Immunol , vol.30 , pp. 16-34
    • Kumar, H.1    Kawai, T.2    Akira, S.3
  • 29
    • 34548656855 scopus 로고    scopus 로고
    • Signaling pathways downstream of pattern-recognition receptors and their cross talk
    • Lee, M. S., and Kim, Y. J. (2007). Signaling pathways downstream of pattern-recognition receptors and their cross talk. Annu Rev Biochem 76, 447-480.
    • (2007) Annu Rev Biochem , vol.76 , pp. 447-480
    • Lee, M.S.1    Kim, Y.J.2
  • 30
    • 0037300319 scopus 로고    scopus 로고
    • The role of MCP-1 (CCL2) and CCR2 in multiple sclerosis and experimental autoimmune encephalomyelitis (EAE)
    • Mahad, D. J., and Ransohoff, R. M. (2003). The role of MCP-1 (CCL2) and CCR2 in multiple sclerosis and experimental autoimmune encephalomyelitis (EAE). Semin Immunol 15, 23-32.
    • (2003) Semin Immunol , vol.15 , pp. 23-32
    • Mahad, D.J.1    Ransohoff, R.M.2
  • 31
    • 0030694108 scopus 로고    scopus 로고
    • IRAK (Pelle) Family Member IRAK-2 AND MyD88 as Proximal Mediators of IL-1 Signaling
    • Marta, M., Jian, N., Ping, F., and Vishva, M. D. (1997). IRAK (Pelle) Family Member IRAK-2 AND MyD88 as Proximal Mediators of IL-1 Signaling. Science 278, 1612-1615.
    • (1997) Science , vol.278 , pp. 1612-1615
    • Marta, M.1    Jian, N.2    Ping, F.3    Vishva, M.D.4
  • 32
    • 27144440476 scopus 로고    scopus 로고
    • Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus
    • Meylan, E., Curran, J., Hofmann, K., Moradpour, D., Binder, M., Bartenschlager, R., and Tschopp, J. (2005). Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus. Nature 437, 1167-1172.
    • (2005) Nature , vol.437 , pp. 1167-1172
    • Meylan, E.1    Curran, J.2    Hofmann, K.3    Moradpour, D.4    Binder, M.5    Bartenschlager, R.6    Tschopp, J.7
  • 35
    • 19644362276 scopus 로고    scopus 로고
    • Tissue-specific mRNA expression profiles of human toll-like receptors and related genes
    • Nishimura, M., and Naito, S. (2005). Tissue-specific mRNA expression profiles of human toll-like receptors and related genes. Biol Pharm Bull 28, 886-892.
    • (2005) Biol Pharm Bull , vol.28 , pp. 886-892
    • Nishimura, M.1    Naito, S.2
  • 36
    • 67749099300 scopus 로고    scopus 로고
    • Regulation of the innate immune response by threonine-phosphatase of Eyes absent
    • Okabe, Y., Sano, T., and Nagata, S. (2009). Regulation of the innate immune response by threonine-phosphatase of Eyes absent. Nature 460, 520-524.
    • (2009) Nature , vol.460 , pp. 520-524
    • Okabe, Y.1    Sano, T.2    Nagata, S.3
  • 37
    • 34548027736 scopus 로고    scopus 로고
    • Activation of the NALP3 inflammasome is triggered by low intracellular potassium concentration
    • Pétrilli, V., Papin, S., Dostert, C., Mayor, A., Martinon, F., and Tschopp, J. (2007). Activation of the NALP3 inflammasome is triggered by low intracellular potassium concentration. Cell Death Differ 14, 1583-1589.
    • (2007) Cell Death Differ , vol.14 , pp. 1583-1589
    • Pétrilli, V.1    Papin, S.2    Dostert, C.3    Mayor, A.4    Martinon, F.5    Tschopp, J.6
  • 41
    • 77950362382 scopus 로고    scopus 로고
    • The inflammasomes
    • Schroder, K., and Tschopp, J. (2010). The inflammasomes. Cell 140, 821-832.
    • (2010) Cell , vol.140 , pp. 821-832
    • Schroder, K.1    Tschopp, J.2
  • 42
    • 49149126701 scopus 로고    scopus 로고
    • IL-4 is a critical determinant in the generation of allergic inflammation initiated by a constitutively active Stat6
    • Sehra, S., Bruns, H. A., Ahyi, A.-N. N., Nguyen, E. T., Schmidt, N. W., Michels, E. G., von Bülow, G.-U., and Kaplan, M. H. (2008). IL-4 is a critical determinant in the generation of allergic inflammation initiated by a constitutively active Stat6. J Immunol 180, 3551-3559.
    • (2008) J Immunol , vol.180 , pp. 3551-3559
    • Sehra, S.1    Bruns, H.A.2    Ahyi, A.-N.N.3    Nguyen, E.T.4    Schmidt, N.W.5    Michels, E.G.6    von Bülow, G.-U.7    Kaplan, M.H.8
  • 44
    • 24144461689 scopus 로고    scopus 로고
    • Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-κB and IRF 3
    • Seth, R. B., Sun, L., Ea, C.-K., and Chen, Z. J. (2005). Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-κB and IRF 3. Cell 122, 669-682.
    • (2005) Cell , vol.122 , pp. 669-682
    • Seth, R.B.1    Sun, L.2    Ea, C.-K.3    Chen, Z.J.4
  • 45
    • 84856501373 scopus 로고    scopus 로고
    • Coronavirus papain-like proteases negatively regulate antiviral innate immune response through disruption of STING-mediated signaling
    • Sun, L., Xing, Y. L., Chen, X. J., Zheng, Y., Yang, Y. D., Nichols, D. B., Clementz, M. A., Banach, B. S., Li, K., Baker, S. C., et al. (2012). Coronavirus papain-like proteases negatively regulate antiviral innate immune response through disruption of STING-mediated signaling. PLoS ONE 7, e30802.
    • (2012) PLoS ONE , vol.7
    • Sun, L.1    Xing, Y.L.2    Chen, X.J.3    Zheng, Y.4    Yang, Y.D.5    Nichols, D.B.6    Clementz, M.A.7    Banach, B.S.8    Li, K.9    Baker, S.C.10
  • 47
    • 84857937262 scopus 로고    scopus 로고
    • STING specifies IRF3 phosphorylation by TBK1 in the cytosolic DNA signaling pathway
    • Tanaka, Y., and Chen. Z. J. (2012). STING specifies IRF3 phosphorylation by TBK1 in the cytosolic DNA signaling pathway. Sci Signal 5, ra20.
    • (2012) Sci Signal , vol.5
    • Tanaka, Y.1    Chen, Z.J.2
  • 48
    • 77950343791 scopus 로고    scopus 로고
    • Pattern recognition receptors and inflammation
    • Takeuchi, O., and Akira, S. (2010). Pattern recognition receptors and inflammation. Cell 140, 805-820.
    • (2010) Cell , vol.140 , pp. 805-820
    • Takeuchi, O.1    Akira, S.2
  • 49
    • 34548418935 scopus 로고    scopus 로고
    • Toll-like receptors, RIG-I-like RNA helicases and the antiviral innate immune response
    • Thompson, A. J. V., and Locarnini, S. A. (2007). Toll-like receptors, RIG-I-like RNA helicases and the antiviral innate immune response. Immunol Cell Biol 85, 435-445.
    • (2007) Immunol Cell Biol , vol.85 , pp. 435-445
    • Thompson, A.J.V.1    Locarnini, S.A.2
  • 50
    • 74049136127 scopus 로고    scopus 로고
    • Different modes of ubiquitination of the adaptor TRAF3 selectively activate the expression of type I interferons and proinflammatory cytokines
    • Tseng, P.-H., Matsuzawa, A., Zhang, W. Z., Mino, T., Vignali, D. A. A., and Karin, M. (2010). Different modes of ubiquitination of the adaptor TRAF3 selectively activate the expression of type I interferons and proinflammatory cytokines. Nat Immunol 11, 70-75.
    • (2010) Nat Immunol , vol.11 , pp. 70-75
    • Tseng, P.-H.1    Matsuzawa, A.2    Zhang, W.Z.3    Mino, T.4    Vignali, D.A.A.5    Karin, M.6
  • 51
    • 2142762520 scopus 로고    scopus 로고
    • TLRs: differential adapter utilization by toll-like receptors mediates TLR-specific patterns of gene expression
    • Vogel, S. N., Fitzgerald, K. A., and Fenton, M. J. (2003). TLRs: differential adapter utilization by toll-like receptors mediates TLR-specific patterns of gene expression. Mol Interv 3, 466-477.
    • (2003) Mol Interv , vol.3 , pp. 466-477
    • Vogel, S.N.1    Fitzgerald, K.A.2    Fenton, M.J.3
  • 52
  • 53
    • 34548459895 scopus 로고    scopus 로고
    • Structure, function and regulation of the Toll/IL-1 receptor adaptor proteins
    • Watters, T. M., Kenny, E. F., and O'Neill, L. A. J. (2007). Structure, function and regulation of the Toll/IL-1 receptor adaptor proteins. Immunol Cell Biol 85, 411-419.
    • (2007) Immunol Cell Biol , vol.85 , pp. 411-419
    • Watters, T.M.1    Kenny, E.F.2    O'Neill, L.A.J.3
  • 55
    • 33646941873 scopus 로고    scopus 로고
    • Organ-secific role of MyD88 for gene regulation during polymicrobial peritonitis
    • Weighardt, H., Mages, J., Jusek, G., Kaiser-Moore, S., Lang, R., and Holzmann, B. (2006). Organ-secific role of MyD88 for gene regulation during polymicrobial peritonitis. Infect Immun 74, 3618-3632.
    • (2006) Infect Immun , vol.74 , pp. 3618-3632
    • Weighardt, H.1    Mages, J.2    Jusek, G.3    Kaiser-Moore, S.4    Lang, R.5    Holzmann, B.6
  • 56
    • 34247588139 scopus 로고    scopus 로고
    • Lung-specific overexpression of CC chemokine ligand (CCL) 2 enhances the host defense to Streptococcus pneumoniae infection in mice: role of the CCL2-CCR2 axis
    • Winter, C., Taut, K., Srivastava, M., Länger, F., Mack, M., Briles, D. E., Paton, J. C., Maus, R., Welte, T., Gunn, M. D., et al. (2007). Lung-specific overexpression of CC chemokine ligand (CCL) 2 enhances the host defense to Streptococcus pneumoniae infection in mice: role of the CCL2-CCR2 axis. J Immunol 178, 5828-5838.
    • (2007) J Immunol , vol.178 , pp. 5828-5838
    • Winter, C.1    Taut, K.2    Srivastava, M.3    Länger, F.4    Mack, M.5    Briles, D.E.6    Paton, J.C.7    Maus, R.8    Welte, T.9    Gunn, M.D.10
  • 57
    • 24944538819 scopus 로고    scopus 로고
    • VISA is an adapter protein required for virus-triggered IFN-β signaling
    • Xu, L.-G., Wang, Y.-Y., Han, K.-J., Li, L.-Y., Zhai, Z. H., and Shu, H.-B. (2005). VISA is an adapter protein required for virus-triggered IFN-β signaling. Mol Cell 19, 727-740.
    • (2005) Mol Cell , vol.19 , pp. 727-740
    • Xu, L.-G.1    Wang, Y.-Y.2    Han, K.-J.3    Li, L.-Y.4    Zhai, Z.H.5    Shu, H.-B.6
  • 59
    • 77958114725 scopus 로고    scopus 로고
    • The cytosolic exonuclease TREX1 inhibits the innate immune response to human immunodeficiency virus type 1
    • Yan, N., Regalado-Magdos, A. D., Stiggelbout, B., Lee-kirsch, M. A., and Lieberman, J. (2011). The cytosolic exonuclease TREX1 inhibits the innate immune response to human immunodeficiency virus type 1. Nat Immunol 11, 1005-1013.
    • (2011) Nat Immunol , vol.11 , pp. 1005-1013
    • Yan, N.1    Regalado-Magdos, A.D.2    Stiggelbout, B.3    Lee-Kirsch, M.A.4    Lieberman, J.5
  • 60
    • 48949094095 scopus 로고    scopus 로고
    • Structural mechanism of RNA recognition by the RIG-I-like receptors
    • Yoneyama, M., and Fujita, T. (2008). Structural mechanism of RNA recognition by the RIG-I-like receptors. Immunity 29, 178-181.
    • (2008) Immunity , vol.29 , pp. 178-181
    • Yoneyama, M.1    Fujita, T.2
  • 61
    • 77951708374 scopus 로고    scopus 로고
    • Reconstitution of the RIG-I pathway reveals a signaling role of unanchored polyubiquitin chains in innate immunity
    • Zeng, W. W., Sun, L. J., Jiang, X. M., Chen, X., Hou, F. J., Adhikari, A., Xu, M., and Chen, Z. J. (2010). Reconstitution of the RIG-I pathway reveals a signaling role of unanchored polyubiquitin chains in innate immunity. Cell 141, 315-330.
    • (2010) Cell , vol.141 , pp. 315-330
    • Zeng, W.W.1    Sun, L.J.2    Jiang, X.M.3    Chen, X.4    Hou, F.J.5    Adhikari, A.6    Xu, M.7    Chen, Z.J.8
  • 62
    • 80053349020 scopus 로고    scopus 로고
    • The NLRC4 inflammasome receptors for bacterial flagellin and type III secretion apparatus
    • Zhao, Y., Yang, J. L., Shi, J. J., Gong, Y.-N., Lu, Q. H., Xu, H., Liu, L. P., and Shao, F. (2011). The NLRC4 inflammasome receptors for bacterial flagellin and type III secretion apparatus. Nature 477, 596-600.
    • (2011) Nature , vol.477 , pp. 596-600
    • Zhao, Y.1    Yang, J.L.2    Shi, J.J.3    Gong, Y.-N.4    Lu, Q.H.5    Xu, H.6    Liu, L.P.7    Shao, F.8
  • 63
    • 53349168904 scopus 로고    scopus 로고
    • The adaptor protein MITA links virus-sensing receptors to IRF3 transcription factor activation
    • Zhong, B., Yang, Y., Li, S., Wang, Y.-Y., Li, Y., Diao, F. C., Lei, C. Q., He, X., Zhang, L., Tien, P., et al. (2008). The adaptor protein MITA links virus-sensing receptors to IRF3 transcription factor activation. Immunity 29, 538-550.
    • (2008) Immunity , vol.29 , pp. 538-550
    • Zhong, B.1    Yang, Y.2    Li, S.3    Wang, Y.-Y.4    Li, Y.5    Diao, F.C.6    Lei, C.Q.7    He, X.8    Zhang, L.9    Tien, P.10


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.