The role of ceramides in selected brain pathologies: Ischemia/hypoxia, Alzheimer disease;Rola ceramidów w wybranych patologiach mózgu: Ischemia/hipoksja, choroba Alzheimera

Postepy Higieny i Medycyny Doswiadczalnej

Volumn 66, Issue , 2012, Pages 295-303

  Car, Halina ^a   Zendzian Piotrowska, Małgorzata ^b   Fiedorowicz, Anna ^a   Prokopiuk, Sławomir ^a   Sadowska, Anna ^a   Kurek, Krzysztof ^b  

^a Zak ad Farmakologii Do wiadczalnej   (Poland)

^b Zak ad Fizjologii   (Poland)

Author keywords

Alzheimer disease; Brain; Ceramides; Ischemia hypoxia

Indexed keywords

EID: 84867944937     PISSN: 00325449     EISSN: 17322693     Source Type: Journal    
DOI: 10.5604/17322693.999024     Document Type: Review

References (95)

1. Adibhatla R. M., Hatcher J. F.: Phospholipase A2, reactive oxygen species, and lipid peroxidation in cerebral ischemia. Free Radic. Biol. Med. 2006;40:376-387
2. Adibhatla R. M., Hatcher J. F.: Protection by D609 through cell-cycle regulation after stroke. Mol. Neurobiol., 2010;41:206-217
3. Adibhatla R. M., Hatcher J. F., Dempsey R. J.: Lipids and lipidomics in brain injury and diseases. AAPSJ, 2006;8:E314-E321
4. Agudo-López A., Miguel B. G., Fernández I, Martínez A. M.: Role of protein kinase C and mitochondrial permeability transition pore in the neuroprotective effect of ceramide in ischemia-induced cell death. FEBS Lett., 2011;585:99-103
5. Ayasolla K., Khan M., Singh A. K., Singh I.: Infammatory mediator and beta-amyloid (25-35)-induced ceramide generation and iNOS expression are inhibited by vitamin E. Free Radic. Biol. Med., 2004;37:325-338
6. Barrier L., Ingrand S., Fauconneau B., Page G.: Gender-dependent accumulation of ceramides in the cerebral cortex of the APP (SL)/PS1Ki mouse model of Alzheimer's disease. Neurobiol. Aging, 2010;31:1843-1853
7. Bernardo K., Krut O., Wiegmann K., Kreder D., Micheli M., Schäfer R., Sickman A., Schmidt W. E., Schroder J. M., Meyer H. E., Sandhoff K., Kronke M.: Purification and characterization of a magnesium-dependent neutral sphingomyelinase from bovine brain. J. Biol. Chem., 2000;275:7641-7647
8. Bhuiyan M. I., Islam M. N., Jung S. Y., Yoo H. H., Lee Y. S., Jin C.: Involvement of ceramide in ischemic tolerance induced by preconditioning with sublethal oxygen-glucose deprivation in primary cultured cortical neurons of rats. Biol. Pharm. Bull. 2010;33:11-17
9. Bligh E. G, Dyer W. J.: A rapid method of total lipid extraction and purification. Can. J. Biochem. Physiol., 1988;37:911-917
10. Bose R., Verheij M., Haimovitz-Friedman A., Scotto K., Fuks Z., Kolesnick R.: Ceramide synthase mediates daunorubicin-induced apoptosis: an alternative mechanism for generating death signals. Cell, 1995;82:405-414
11. Chen Y., Ginis I., Hallenbeck J. M.: The protective effect of ceramide in immature rat brain hypoxia-ischemia involves up-regulation of bcl-2 and reduction of TUNEL-positive cells. J. Cereb. Blood Flow Metab., 2001;21:34-40
12. Cordy J. M., Hussain I., Dingwall C., Hooper N. M., Turner A. J.: Exclusively targeting beta-secretase to lipid rafts by GPI-anchor addition up-regulates β-site processing of the amyloid precursor protein. Proc. Natl. Acad. Sci. USA, 2003;100:11735-11740
13. Cutler R. G., Kelly J., Storie K., Pedersen W. A., Tammara A., Hatanpaa K., Troncoso J. C., Mattson M. P.: Involvement of oxidative stress-induced abnormalities in ceramide and cholesterol metabolism in brain aging and Alzheimer's disease. Proc. Natl. Acad. Sci. USA, 2004;101:2070-2075
14. Dawson D. A., Furuya K., Gotoh J., Nakao Y., Hallenbeck J. M.: Cerebrovascular hemodynamics and ischemic tolerance: lipopolysaccharide-induced resistance to focal cerebral ischemia is not due to changes in severity of the initial ischemic insult, but is associated with preservation of microvascular perfusion. J. Cereb. Blood Flow Metab., 1999;19:616-623
15. Degli Esposti M., McLennan H.: Mitochondria and cells produce reactive oxygen species in virtual anaerobiosis: relevance to ceramide induced apoptosis. FEBS Lett., 1998;430:338-342
16. Dobrzyń A., Chocian G.: Sfingomielinowy szlak transmisji sygnałów. Med. Met., 2003;7:75-80
17. Garcia-Ruiz C., Colell A., Mari M., Morales A., Fernandez-Checa J. C.: Direct effect of ceramide on the mitochondrial electron transport chain leads to generation of reactive oxygen species - role of mitochondrial glutathione. J. Biol. Chem., 1997;272:11369-11377
18. Ghafourifar P., Klein S. D., Schucht O., Schenk U., Pruschy M., Rocha S., Richter C.: Ceramide induces cytochrome c release from isolated mitochondria. Importance of mitochondrial redox state. J. Biol. Chem., 1999;274:6080-6084
19. Ginis U., Schweizer M., Brenner J., Liu N., Azzam M., Spatz J. M.: TNF-α pretreatment prevents subsequent activation of cultured brain cells with TNF-α and hypoxia via ceramide. Am. J. Physiol., 1999;276:C1171-C1183
20. Goodman Y., Mattson M. P.: Ceramide protects hippocampal neurons against excitotoxic and oxidative insults, and amyloid β peptide toxicity. J. Neurochem., 1996;66:869-872
21. Goswami R., Dawson G.: Does ceramide play a role in neural cell apoptosis? J Neurosci. Res., 2000;60:141-149
22. Gottlieb M., Leal-Campanario R., Campos-Esparza M. R., Sánchez-Gómez M. V., Alberdi E., Arranz A., Delgado-García J. M., Gruart A., Matute C.: Neuroprotection by two polyphenols following excitotoxicity and experimental ischemia. Neurobiol. Dis., 2006;23:374-386
23. Gottschalk A. R., McShan C., Kilkus J., Dawson G., Quintans J.: Resistance to anti-IgM-induced apoptosis in a WEHI-231 subline is due to insufficient production of ceramide. Eur. J. Immunol., 1995;25:1032-1038
24. Guan X. L., He X., Ong W.-Y., Yeo W. K., Shui G., Wenk M. R.: Nontargeted profiling of lipids during kainite-induced neuronal injury. FASEB J., 2006;20:1152-1161
25. Haimovitz-Friedman A., Kan C. C., Ehleiter D., Persaud R. S., McLoughlin M., Fuks Z., Kolesnick R. N.: Ionizing radiation acts on cellular membranes to generate ceramide and initiate apoptosis. J. Exp. Med., 1994;180:525-535
26. Han X. M., Holtzman D., McKeel D. W. Jr, Kelley J., Morris J. C.: Substantial sulfatide deficiency and ceramide elevation in very early Alzheimer's disease: potential role in disease pathogenesis. J. Neurochem., 2002;82:809-818
27. Hanna A. N., Chan E. Y., Xu J., Stone J. C., Brindley D. N.: A novel pathway for tumor necrosis factor-α and ceramide signaling involving sequential activation of tyrosine kinase, p21ras, and phosphatidylinositol 3-kinase. J. Biol. Chem., 1999;274:12722-12729
28. Hannun Y. A.: Functions of ceramide in coordinating cellular responses to stress. Science, 1996;274:1855-1859
29. Hannun Y. A., Obeid L. M.: Ceramide: an intracellular signal for apoptosis. Trends Biochem. Sci., 1995;20:73-77
30. Hannun Y. A., Obeid L. M.: Principles of bioactive lipid signaling: lessons from sphingolipids. Nat. Rev. Mol. Cell Biol., 2008;9:139-150
31. Harris B., Pereira I., Parkin E.: Targeting ADAM10 to lipid rafts in neuroblastoma SH-SY5Y cells impairs amyloidogenic processing of the amyloid precursor protein. Brain Res., 2009;1296:203-215
32. He X., Huang Y., Li B., Gong C. X., Schuchman E. H.: Deregulation of sphingolipid metabolism in Alzheimer's disease. Neurobiol. Aging, 2010;31:398-408
33. Hearps A. C., Burrows J., Connor C. E., Woods G. M., Lowenthal R. M., Ragg S. J.: Mitochondrial cytochrome c release precedes transmembrane depolarisation and caspase-3 activation during ceramide-induced apoptosis of Jurkat T cells. Apoptosis, 2002;7:387-394
34. Herr I., Martin-Villalba A., Kurz E., Roncaioli P., Schenkel J., Cifone M. G., Debatin K. M.: FK 506 prevents stroke-induced generation of ceramide and apoptosis signaling. Brain Res., 1999;826:210-219
35. Hida H., Takeda M., Soliven B.: Ceramide inhibits inwardly rectifying K+ currents via a Rasand Raf-1-dependent pathway in cultured oligodendrocytes. J. Neurosci., 1998;18:8712-8719
36. Holland W. L., Summers S. A.: Sphingolipids, insulin resistance, and metabolic disease: new insights from in vivo manipulation of sphingolipid metabolism. Endocr. Rev., 2008;29:381-402
37. Huitema K., van den Dikkenberg J., Brouwers J. F., Holthuis J. C.: Identification of a family of animal sphingomyelin synthases. EMBO J., 2004;23:33-44
38. Irie F., Hirabayashi Y.: Application of exogenous ceramide to cultured rat spinal motoneurons promotes survival or death by regulation of apoptosis depending on its concentrations. J. Neurosci. Res., 1998;54:475-485
39. Ito A., Horigome K.: Ceramide prevents neuronal programmed cell death induced by nerve growth factor deprivation. J. Neurochem., 1995;65:463-466
40. Jaffrezou J. P., Maestre N., de Mas-Mansat V., Bezombes C., Levade T., Laurent G.: Positive feedback control of neutral sphingomyelinase activity by ceramide. FASEB J., 1998;12, 999-1006
41. Jana A., Pahan K.: Fibrillar amyloid-β peptides kill human primary neurons via NADPH oxidase-mediated activation of neutral sphingomyelinase. Implications for Alzheimer's disease. J. Biol. Chem., 2004;279:51451-51459
42. Kalinowski S.: Elektrochemia membran lipidowych. Wydawnictwo Uniwersytetu Warmińsko-Mazurskiego, Olsztyn 2004:20-25
43. Kitagawa K, Matsumoto M., Matsushita K., Mandai K., Mabuchi T., Yanagihara T., Kamada T.: Ischemic tolerance in moderately symptomatic gerbils after unilateral carotid occlusion. Brain Res., 1996;716:39-46
44. Kitatani K., Idkowiak-Baldys J., Hannun Y. A.: The sphingolipid salvage pathway in ceramide metabolism and signaling. Cell Signal., 2008;30:1010-1018
45. Kobrinsky E., Spielman A. I., Rosenzweig S., Marks A. R.: Ceramide triggers intracellular calcium release via the IP3 receptor in Xenopus laevis oocytes. Am. J. Physiol., 1999;277:C665-C672
46. Kubota M., Nakane M., Nakagomi T., Tamura A., Hisaki H., Ueta N., Inokuchi J., Hirayama A.: Sphingolipid biosynthesis by l-PDMP after rat MCA occlusion. Acta Neurochir., 2000; Suppl. 76:339-341
47. Kubota M., Narita K., Nakagomi T., Tamura A., Shimasaki H., Ueta N., Yoshida S.: Sphingomyelin changes in rat cerebral cortex during focal ischemia. Neurol. Res., 1996;18:337-341
48. Lecour S., Van der Merwe E., Opie L. H., Sack M. N.: Ceramide attenuates hypoxic cell death via reactive oxygen species signaling. J. Cardiovasc. Pharmacol., 2006;47:158-163
49. Lee J. T., Xu J., Lee J. M., Ku G., Han X., Yang D. I., Chen S., Hsu C. Y.: Amyloid-β peptide induces oligodendrocyte death by activating the neutral sphingomyelinase-ceramide pathway. J. Cell Biol., 2004;164:123-131
50. Lees G. J.: The possible contribution of microglia and macrophages to delayed neuronal death after ischemia. J. Neurol. Sci., 1993;114:119-122
51. Lipton P.: Ischemic cell death in brain neurons. Physiol. Rev., 1999;79:1431-1568
52. Liu B., Hassler D. F., Smith G. K., Weaver K., Hannun Y. A.: Purification and characterization of a membrane bound neutral pH optimum magnesium-dependent and phosphatidylserine-stimulated sphingomyelinase from rat brain. J. Biol. Chem., 1998;273:34472-34479
53. Luberto C., Hannun Y. A.: Sphingomyelin synthase, a potential regulator of intracellular levels of ceramide and diacylglycerol during SV40 transformation. Does sphingomyelin synthase account for the putative phosphatidylcholine-specific phospholipase C? J. Biol. Chem., 1998;273:14550-14559
54. MacPhee I., Barker P. A.: Extended ceramide exposure activates the trkA receptor by increasing receptor homodimer formation. J. Neurochem., 1999;72:1423-1430
55. Mandon E. C., Ehses I., Rother J., van Echten G., Sandhoff K.: Subcellular localization and membrane topology of serine palmitoyltransferase, 3-dehydrosphinganine reductase, and sphinganine N-acyltransferase in mouse liver. J. Biol. Chem., 1992;267:11144-11148
56. Masumura M., Hata R., Nagai Y., Sawada T.: Oligodendroglial cell death with DNA fragmentation in the white matter under chronic cerebral hypoperfusion: comparison between normotensive and spontaneously hypertensive rats. Neurosci. Res., 2001;39:401-412
57. Mathias S., Pen̂a L. A., Kolesnick R. N.: Signal transduction of stress via ceramide. Biochem. J., 1998;335:465-480
58. Merrill A. H. Jr., van Echten G., Wang E., Sandhoff K.: Fumonisin B1 inhibits sphingosine (sphinganine) N-acyltransferase and de novo sphingolipid biosynthesis in cultured neurons in situ. J. Biol. Chem., 1993;268:27299-27306
59. Michel C., van Echten-Deckert G.: Conversion of dihydroceramide to ceramide occurs at the cytosolic face of the endoplasmic reticulum. FEBS Lett., 1997;416:153-155
60. Mielke M. M., Bandaru V. V., Haughey N. J., Rabins P. V., Lyketsos C. G., Carlson M. C.: Serum sphingomyelins and ceramides are early predictors of memory impairment. Neurobiol. Aging, 2010;31:17-24
61. 2+ in cultured cortical neurons. Biochem. Biophys. Res. Commun., 1996;222:494-498
62. Monick M. M., Mallampalli R. K., Carter A. B., Flaherty D. M., McCoy D., Robeff P. K., Peterson M. W., Hunninghake G. W.: Ceramide regulates lipopolysaccharide-induced phosphatidylinositol 3-kinase and Akt activity in human alveolar macrophages. J immunol., 2001;167:5977-5985
63. Morales A., Lee H., Gon̂i F. M., Kolesnick R., Fernandez-Checa J. C.: Sphingolipids and cell death. Apoptosis, 2007;12:923-939
64. Muller G., Ayoub M., Storz P., Rennecke J., Fabbro D., Pfizenmaier K.: PKC ξ is a molecular switch in signal transduction of TNF-α, bifunctionally regulated by ceramide and arachidonic acid. EMBO J., 1995;14:1961-1969
65. Nakane M., Kubota M., Nakagomi T., Tamura A., Hisaki H., Shimasaki H., Ueda N.: Lethal forebrain ischemia stimulates sphingomyelin hydrolysis and ceramide generation in the gerbil hippocampus. Neurosci. Lett., 2000;296:89-92
66. Ohtani R., Tomimoto H., Kondo T., Wakita H., Akiguchi I., Shibasaki H., Okazaki T.: Upregulation of ceramide and its regulating mechanism in a rat model of chronic cerebral ischemia. Brain Res., 2004;1023:31-40
67. Patil S., Melrose J., Chan C.: Involvement of astroglial ceramide in palmitic acid-induced Alzheimer-like changes in primary neurons. Eur. J. Neurosci., 2007;26:2131-2141
68. Perl D. P.: Neuropathology of Alzheimer's disease. Mt Sinai J. Med., 2010;77:32-42
69. Perry D. K., Hannun Y. A.: The role of ceramide in cell signaling. Biochim. Biophys. Acta, 1998;1436:233-243
70. Pettus B. J., Chalfant C. E., Hannun Y. A.: Ceramide in apoptosis: an overview and current perspectives. Biochim. Biophys. Acta, 2002;1585:114-125
71. Pettus B. J., Chalfant C. E., Hannun Y. A.: Sphingolipids in infiammation: roles and implications. Curr. Mol. Med., 2004;4:405-418
72. Phillis J. W., O'Regan M. H.: The role of phospholipases, cyclooxygenases, and lipoxygenases in cerebral ischemic/traumatic injuries. Crit. Rev. Neurobiol., 2003;15:61-90
73. Rao A. M., Hatcher J. F., Dempsey R. J.: Lipid metabolism in ischemic neuronal death. Recent Res. Develop. Neurochem., 1999;2:533-549
74. Riboni L., Viani P., Bassi R., Giussani P., Tettamanti G.: Basic fibroblast growth factor-induced proliferation of primary astrocytes. Evidence for the involvement of sphingomyelin biosynthesis. J. Biol. Chem., 2001;276:12797-12804
75. Satoi H., Tomimoto H., Ohtani R., Kitano T., Kondo T., Watanabe M., Oka N., Akiguchi I., Furuya S., Hirabayashi Y., Okazaki T.: Astroglial expression of ceramide in Alzheimer's disease brains: a role during neuronal apoptosis. Neuroscience, 2005;130:657-666
76. Schwandner R., Wiegmann K., Bernardo K., Kreder D., Kronke M.: TNF receptor death domain-associated proteins TRADD and FADD signal activation of acid sphingomyelinase. J. Biol. Chem., 1998;273:5916-5922
77. Shinpo K., Kikuchi S., Moriwaka F., Tashiro K.: Protective effects of the TNF-ceramide pathway against glutamate neurotoxicity on cultured mesencephalic neurons. Brain Res., 1999;819:170-173
78. Siskind L. J., Kolesnick R. N., Colombini M.: Ceramide channels increase the permeability of the mitochondrial outer membrane to small proteins. J. Biol. Chem., 2002;277:26796-26803
79. Siskind L. J., Kolesnick R. N., Colombini M.: Ceramide forms channels in mitochondrial outer membranes at physiologically relevant concentrations. Mitochondrion, 2006;6:118-125
80. Soeda S., Tsuji Y., Ochiai T., Mishima K., Iwasaki K., Fujiwara M., Yokomatsu T., Murano T., Shibuya S., Shimeno H.: Inhibition of sphingomyelinase activity helps to prevent neuron death caused by ischemic stress. Neurochem. Int., 2004;45:619-626
81. Song M. S., Posse de Chaves E. I.: Inhibition of rat sympathetic neuron apoptosis by ceramide. Role of p75NTR in ceramide generation. Neuropharmacology, 2003;45:1130-1150
82. Spiegel S., Merrill A. H. Jr.: Sphingolipid metabolism and cell growth regulation. FASEB J., 1996;10:1388-1397
83. Steinbrecher U. P., Gomez-Munoz A., Duronio V.: Acid sphingomyelinase in macrophage apoptosis. Curr. Opin. Lipidol., 2004;15:531-537
84. Stiban J., Fistere D., Colombini M.: Dihydroceramide hinders ceramide channel formation: Implications on apoptosis. Apoptosis, 2006;11:773-780
85. Summers S. A.: Ceramides in insulin resistance and lipotoxicity. Prog. Lipid Res., 2006;45:42-72
86. Tafesse F. G., Ternes P., Holthuis J. C.: The multigenic sphingomyelin synthase family. J. Biol. Chem., 2006;281:29421-29425
87. Takahashi K., Ginis I., Nishioka R., Klimanis D., Barone F. C., White R. F., Chen Y., Hallenbeck J. M.: Glucosylceramide synthase activity and ceramide levels are modulated during cerebral ischemia after ischemic preconditioning. J. Cereb. Blood Flow Metab., 2004;24:623-627
88. Tomimoto H., Ihara M., Wakita H., Ohtani R., Lin J. X., Akiguchi I., Kinoshita M., Shibasaki M.: Chronic cerebral hypoperfusion induces white matter lesions and loss of oligodendroglia with DNA fragmentations in the rat. Acta Neuropathol., 2003;106:527-534
89. Vivekananda J., Smith D., King R. J.: Sphingomyelin metabolites inhibit sphingomyelin synthase and CTP: phosphocholine cytidylyltransferase. Am. J. Physiol. Lung Cell. Mol. Physiol., 2001;281:L98-L107
90. Wang G., Silva J., Dasgupta S., Bieberich E.: Long-chain ceramide is elevated in presenilin 1 (PS1M146V) mouse brain and induces apoptosis in PS1 astrocytes. Glia, 2008;56:449-456
91. Wiegmann K., Schutze S., Machleidt T., Witte D., Kronke M.: Functional dichotomy of neutral and acidic sphingomyelinases in tumor necrosis factor signaling. Cell, 1994;78:1005-1015
92. Willaime-Morawek S., Brami-Cherrier K., Mariani J., Caboche J., Brugg B.: c-Jun. N-terminal kinases/c-Jun. and p38 pathways cooperate in ceramide-induced neuronal apoptosis. Neuroscience, 2003;119:387-397
93. Yoshimura S., Banno Y., Nakashima S., Takenaka K., Sakai H., Nishimura Y., Sakai N., Shimizu S., Eguchi Y., Tsujimoto Y., Nozawa Y.: Ceramide formation leads to caspase-3 activation during hypoxic PC12 cell-death. J. Biol. Chem., 1998;273:6921-6927
94. Yu Z. F., Nikolova-Karakashian M., Zhou D. H., Cheng G. J., Schuchman E. H., Mattson M. P.: Pivotal role for acidic sphingomyelinase in cerebral ischemia-induced ceramide and cytokine production, and neuronal apoptosis. J. Mol. Neurosci., 2000;15:85-97
95. Zhang Y., Li X., Becker K. A., Gulbins E.: Ceramide-enriched membrane domains-structure and function. Biochim. Biophys. Acta, 2009;1788:178-183