Role of protein kinase C and mitochondrial permeability transition pore in the neuroprotective effect of ceramide in ischemia-induced cell death

FEBS Letters

Volumn 585, Issue 1, 2011, Pages 99-103

  Agudo López, Alba ^a   Miguel, Begoña G ^a   Fernández, Inmaculada ^a   Martínez, Ana M ^a  

^a UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

Author keywords

Ceramide; Ischemia; Mitochondria; Neuroprotection

Indexed keywords

CERAMIDE; PROTEIN KINASE C; PROTEIN KINASE C EPSILON; PROTEIN KINASE C ZETA; REACTIVE OXYGEN METABOLITE;

ARTICLE; CALCIUM CELL LEVEL; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; HUMAN; HUMAN CELL; ISCHEMIA; MITOCHONDRIAL PERMEABILITY; NERVE CELL NECROSIS; NEUROBLASTOMA CELL; NEUROPROTECTION; PRIORITY JOURNAL;

APOPTOSIS; BLOTTING, WESTERN; CALCIUM; CELL HYPOXIA; CELL LINE, TUMOR; CELL SURVIVAL; CERAMIDES; GLUCOSE; HUMANS; MICROSCOPY, CONFOCAL; MITOCHONDRIA; MITOCHONDRIAL MEMBRANE TRANSPORT PROTEINS; NEUROBLASTOMA; PROTEIN KINASE C; PROTEIN KINASE C-EPSILON; REACTIVE OXYGEN SPECIES;

EID: 78650873412     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.febslet.2010.11.015     Document Type: Article

References (25)

1. N. Bartke, and Y.A. Hannun Bioactive sphingolipids: metabolism and function J. Lipid Res. 50 2009 S91 S96
2. Y.A. Hannun Functions of ceramide in coordinating cellular response to stress Science 274 1996 1855 1859
3. M. Kubota, K. Narita, T. Nakkagomi, A. Tamura, H. Shimasaki, N. Ueta, and S. Yoshida Sphingomyelin changes in rat cerebral cortex during focal ischemia Neurol. Res. 18 1996 337 341
4. A. Beresewicz, A. Dobrzyn, and J. Gorski Accumulation of specific ceramides in ischemic/repefused rat heart; effect of ischemic preconditioning J. Physiol. Pharmacol. 53 2002 371 382
5. S. Lecour, E. Van der Merne, L.H. Opie, and M.N. Sack Ceramide attenuates hypoxic cell death via reactive oxygen species signaling J. Cardiovasc. Pharmacol. 47 2006 158 163
6. J. Cui, R.M. Engelman, N. Maulik, and D.K. Das Role of ceramide in ischemic preconditioning J. Am. Coll. Surg. 198 2004 770 777
7. C.A. Piot, D.D. Padmaneban, P.C. Ursell, R.E. Sievers, and C.L. Wolfe Ischemia preconditioning decreases apoptosis in rat heart in vivo Circulation 96 1997 1598 1604
8. A. Rasola, M. Sciacoelli, B. Pantic, and P. Bernardi Signal transduction to the permeability transition pore FEBS Lett. 584 2010 1989 1996
9. A.P. Halestrap What is the mitochondrial permeability transition pore? J. Mol. Cardiol. 46 2009 821 831
10. M.E. Barnett, D.K. Madgwick, and D.J. Takemoto Protein kinase C as a stress sensor Cell. Signal. 19 2007 2007 1820 1829
11. + channel copurify and coreconstitute to form a functioning signaling module in proteoliposomes Circ. Res. 99 2006 878 883
12. 2 inhibit the mitochondrial permeability transition J. Biol. Chem. 281 2006 20801 20808
13. M.C. Alley, D.A. Scudiero, A. Monks, M.L. Hursey, M.J. Czerwinski, D.L. Fine, B.J. Abbott, J.G. Mayo, R.H. Shoemaker, and M.R. Boyd Feasibility of drug screening with panels of human tumor cell lines using a microculture tetrazolium assay Cancer Res. 48 1988 589 601
14. A. Agudo-López, B.G. Miguel, I. Fernández, and A.M. Martínez Involvement of mitochondria on neuroprotective effect of sphingosine-1-phosphate in cell death in an in vitro model of brain ischemia Neurosci. Lett. 470 2010 130 133
15. V. Petronilli, G. Miotto, M. Canton, M. Brini, R. Colonna, P. Bernardi, and F. Di Lisa Transient and long-lasting openings of the mitochondrial permeability transition pore can be monitored directly in intact cells by changes in mitochondrial calcein fluorescence Biophys. J. 76 1999 725 734
16. Y. Qin, M. Lu, and X. Gong Dihydrorhodamine 123 is superior to 2,7-dichlorodihydrofluorescein diacetate and dihydrorhodamine 6G in detecting intracellular hydrogen peroxide in tumor cells Cell Biol. Int. 32 2008 224 228
17. M.C. Calcerrada, B.G. Miguel, L. Martín, R.E. Catalán, and A.M. Martínez Involvement of phosphatidylinositol 3-kinase in nuclear translocation of protein kinase C ζ induced by C2-ceramide in rat hepatocytes FEBS Lett. 514 2002 361 365
18. I. Khaliulin, H. Schwalb, P. Wang, E. Houminer, L. Grinberg, H. Katzeff, J.B. Borman, and S.R. Powell Preconditioning improves postischemic mitochondrial function and diminishes oxidation of mitochondrial proteins Free Radic. Biol. Med. 37 2004 1 9
19. P.A. Hill, and A. Tumber Ceramide-induced death/survival in murine osteoblasts J. Endocrinol. 206 2010 225 233
20. Y. Wang, M.L. Seibenhener, M.L. Vandenplas, and M. Wooten Atypical PKC ζ is activated by ceramide, resulting in coactivation of NF-κb/JNK kinase and cell survival J. Neurosci. Res. 55 1999 293 302
21. S. Javadov, and M. Karmazyn Mitochondrial permeability transition pore opening as an endpoint to initiate cell death and as a putative target for cardioprotection Cell. Physiol. Biochem. 20 2007 1 22
22. T. Iijima Mitochondrial membrane potential and ischemic neuronal death Neurosci. Res. 55 2006 234 243
23. G.R. Budas, and D. Mochly-Rosen Mitochondrial protein kinase C (PKC ): emerging role in cardiac protection from ischaemic damage Biochem. Soc. Trans. 35 2007 1052 1054
24. P.S. Brookes, Y. Yoon, J.L. Robotham, M.W. Anders, and S.S. Sheu Calcium, ATP and ROS: a mitochondrial love-hate triangle Am. J. Physiol. Cell Physiol. 287 2004 C817 C833
25. D. Hausenloy, A. Wynne, M. Duchen, and D. Yellon Transient mitochondrial permeability transition pore opening mediates preconditioning-induced protection Circulation 109 2004 1714 1717