메뉴 건너뛰기




Volumn 31, Issue 11, 2010, Pages 1843-1853

Gender-dependent accumulation of ceramides in the cerebral cortex of the APPSL/PS1Ki mouse model of Alzheimer's disease

Author keywords

Alzheimer disease; Brain; Ceramides; Galactosylceramides; Gender; Sphingomyelin; Sulfatides; Transgenic mice

Indexed keywords

CERAMIDE; GALACTOSYLCERAMIDE; HYDROXY FATTY ACID; SPHINGOMYELIN; SULFATIDE;

EID: 77956928859     PISSN: 01974580     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neurobiolaging.2008.10.011     Document Type: Article
Times cited : (28)

References (54)
  • 2
    • 61649120841 scopus 로고    scopus 로고
    • ApoE4 disrupts sterol and sphingolipid metabolism in Alzheimer's but not normal brain
    • doi:10.1016/j.neurobiolaging.2007.07.024
    • Bandaru V.V.R., Troncoso J., Wheeler D., Pletnikova O., Wang J., Conan K., Haughey N.J. ApoE4 disrupts sterol and sphingolipid metabolism in Alzheimer's but not normal brain. Neurobiol. Aging 2007, doi:10.1016/j.neurobiolaging.2007.07.024.
    • (2007) Neurobiol. Aging
    • Bandaru, V.V.R.1    Troncoso, J.2    Wheeler, D.3    Pletnikova, O.4    Wang, J.5    Conan, K.6    Haughey, N.J.7
  • 3
    • 22144439022 scopus 로고    scopus 로고
    • Lactic acidosis stimulates ganglioside and ceramide generation without sphingomyelin hydrolysis in rat cortical astrocytes
    • Barrier L., Ingrand S., Piriou A., Touzalin A., Fauconneau B. Lactic acidosis stimulates ganglioside and ceramide generation without sphingomyelin hydrolysis in rat cortical astrocytes. Neurosci. Lett. 2005, 385:224-229.
    • (2005) Neurosci. Lett. , vol.385 , pp. 224-229
    • Barrier, L.1    Ingrand, S.2    Piriou, A.3    Touzalin, A.4    Fauconneau, B.5
  • 4
    • 35148814075 scopus 로고    scopus 로고
    • Genotype-related changes of ganglioside composition in brain regions of transgenic mouse models of Alzheimer's disease
    • Barrier L., Ingrand S., Damjanac M., Rioux Bilan A., Hugon J., Page G. Genotype-related changes of ganglioside composition in brain regions of transgenic mouse models of Alzheimer's disease. Neurobiol. Aging 2007, 28:1863-1872.
    • (2007) Neurobiol. Aging , vol.28 , pp. 1863-1872
    • Barrier, L.1    Ingrand, S.2    Damjanac, M.3    Rioux Bilan, A.4    Hugon, J.5    Page, G.6
  • 6
    • 0033801428 scopus 로고    scopus 로고
    • A procedure for extraction of sphingolipid classes by solid-phase extraction on aminopropyl cartridges
    • Bodennec J., Koul O., Aguado I., Brichon G., Zwingelstein G., Portoukalian J. A procedure for extraction of sphingolipid classes by solid-phase extraction on aminopropyl cartridges. J. Lipid Res. 2000, 41:1524-1531.
    • (2000) J. Lipid Res. , vol.41 , pp. 1524-1531
    • Bodennec, J.1    Koul, O.2    Aguado, I.3    Brichon, G.4    Zwingelstein, G.5    Portoukalian, J.6
  • 7
    • 0024276668 scopus 로고
    • Influence of structural modifications on the phase behavior of semi-synthetic cerebroside sulfate
    • Boggs J.M., Koshy K.M., Rangaraj G. Influence of structural modifications on the phase behavior of semi-synthetic cerebroside sulfate. Biochim. Biophys. Acta 1988, 938:361-372.
    • (1988) Biochim. Biophys. Acta , vol.938 , pp. 361-372
    • Boggs, J.M.1    Koshy, K.M.2    Rangaraj, G.3
  • 9
    • 33645858245 scopus 로고    scopus 로고
    • Amyloid beta peptide increases DP5 expression via activation of neutral sphingomyelinase and JNK in oligodendrocytes
    • Chen S., Lee J.M., Zeng C., Chen H., Hsu C.Y., Xu J. Amyloid beta peptide increases DP5 expression via activation of neutral sphingomyelinase and JNK in oligodendrocytes. J. Neurochem. 2006, 97:631-640.
    • (2006) J. Neurochem. , vol.97 , pp. 631-640
    • Chen, S.1    Lee, J.M.2    Zeng, C.3    Chen, H.4    Hsu, C.Y.5    Xu, J.6
  • 11
    • 0014750491 scopus 로고
    • Factors affecting the glycosphingolipid composition of murine tissues
    • Coles L., Hay J.B., Gray G.M. Factors affecting the glycosphingolipid composition of murine tissues. J. Lipid Res. 1970, 11:158-163.
    • (1970) J. Lipid Res. , vol.11 , pp. 158-163
    • Coles, L.1    Hay, J.B.2    Gray, G.M.3
  • 13
    • 38149055561 scopus 로고    scopus 로고
    • Dissociation of Akt/PKB and ribosomal S6 kinase signaling markers in a transgenic mouse model of Alzheimer's disease
    • Damjanac M., Rioux Bilan A., Paccalin M., Pontcharraud R., Fauconneau B., Hugon J., Page G. Dissociation of Akt/PKB and ribosomal S6 kinase signaling markers in a transgenic mouse model of Alzheimer's disease. Neurobiol. Dis. 2008, 29:354-367.
    • (2008) Neurobiol. Dis. , vol.29 , pp. 354-367
    • Damjanac, M.1    Rioux Bilan, A.2    Paccalin, M.3    Pontcharraud, R.4    Fauconneau, B.5    Hugon, J.6    Page, G.7
  • 17
    • 22244450011 scopus 로고    scopus 로고
    • Reversal of non-hydroxy: α-hydroxy galactosylceramide ratio and unstable myelin in transgenic mice overexpressing UDP-galactose: ceramide galactosyltransferase
    • Fewou S.N., Büssow H., Schaeren-Wiermers N., Vanier M.T., Macklin W.B., Gieselmann V., Eckhardt M. Reversal of non-hydroxy: α-hydroxy galactosylceramide ratio and unstable myelin in transgenic mice overexpressing UDP-galactose: ceramide galactosyltransferase. J. Neurochem. 2005, 94:469-481.
    • (2005) J. Neurochem. , vol.94 , pp. 469-481
    • Fewou, S.N.1    Büssow, H.2    Schaeren-Wiermers, N.3    Vanier, M.T.4    Macklin, W.B.5    Gieselmann, V.6    Eckhardt, M.7
  • 18
    • 0036677303 scopus 로고    scopus 로고
    • Substantial sulfatide deficiency and ceramide elevation in very early Alzheimer's disease: potential role in disease pathogenesis
    • Han X., Holtzman D.M., McKeel D.W., Kelley J., Morris J.C. Substantial sulfatide deficiency and ceramide elevation in very early Alzheimer's disease: potential role in disease pathogenesis. J. Neurochem. 2002, 82:809-818.
    • (2002) J. Neurochem. , vol.82 , pp. 809-818
    • Han, X.1    Holtzman, D.M.2    McKeel, D.W.3    Kelley, J.4    Morris, J.C.5
  • 19
    • 0037135626 scopus 로고    scopus 로고
    • The ceramide-centric universe of lipid-mediated cell regulation: stress encounters of the lipid kind
    • Hannun Y.A., Obeid L.M. The ceramide-centric universe of lipid-mediated cell regulation: stress encounters of the lipid kind. J. Biol. Chem. 2002, 277:25847-25850.
    • (2002) J. Biol. Chem. , vol.277 , pp. 25847-25850
    • Hannun, Y.A.1    Obeid, L.M.2
  • 21
    • 0141596079 scopus 로고    scopus 로고
    • Transgenic mouse models of Alzheimer's disease: phenotype and application
    • Higgins G.A., Jacobsen H. Transgenic mouse models of Alzheimer's disease: phenotype and application. Behav. Pharmacol. 2003, 14:419-438.
    • (2003) Behav. Pharmacol. , vol.14 , pp. 419-438
    • Higgins, G.A.1    Jacobsen, H.2
  • 22
    • 10944272619 scopus 로고    scopus 로고
    • Fibrillar amyloid-beta peptides kill human primary neurons via NADPH oxidase-mediated activation of neutral sphingomyelinase. Implications for Alzheimer's disease
    • Jana A., Pahan K. Fibrillar amyloid-beta peptides kill human primary neurons via NADPH oxidase-mediated activation of neutral sphingomyelinase. Implications for Alzheimer's disease. J. Biol. Chem. 2004, 279:51451-51459.
    • (2004) J. Biol. Chem. , vol.279 , pp. 51451-51459
    • Jana, A.1    Pahan, K.2
  • 23
    • 0031720801 scopus 로고    scopus 로고
    • The incidence of dementia: a meta-analysis
    • Jorm A.F., Jolley D. The incidence of dementia: a meta-analysis. Neurology 1998, 51:728-733.
    • (1998) Neurology , vol.51 , pp. 728-733
    • Jorm, A.F.1    Jolley, D.2
  • 24
    • 33947577504 scopus 로고    scopus 로고
    • Gene expression alterations in the sphingolipid metabolism pathways during progression of dementia and Alzheimer's disease: a shift toward ceramide accumulation at the earliest recognizable stages of Alzheimer's disease?
    • Katsel P., Li C., Haroutunian V. Gene expression alterations in the sphingolipid metabolism pathways during progression of dementia and Alzheimer's disease: a shift toward ceramide accumulation at the earliest recognizable stages of Alzheimer's disease?. Neurochem. Res. 2007, 32:845-856.
    • (2007) Neurochem. Res. , vol.32 , pp. 845-856
    • Katsel, P.1    Li, C.2    Haroutunian, V.3
  • 26
    • 0023876552 scopus 로고
    • Synthesis and transport of cerebrosides and sulfatides in rat brain during development
    • Koul O., Singh I., Jungalwala F.B. Synthesis and transport of cerebrosides and sulfatides in rat brain during development. J. Neurochem. 1988, 50:580-588.
    • (1988) J. Neurochem. , vol.50 , pp. 580-588
    • Koul, O.1    Singh, I.2    Jungalwala, F.B.3
  • 28
    • 0021954882 scopus 로고
    • A solvent partition method for microscale ganglioside purification
    • Ladisch S., Gillard B. A solvent partition method for microscale ganglioside purification. Anal. Biochem. 1985, 146:220-231.
    • (1985) Anal. Biochem. , vol.146 , pp. 220-231
    • Ladisch, S.1    Gillard, B.2
  • 29
    • 0017636970 scopus 로고
    • Molecular arrangements of sphingolipids. The monolayer behaviour of ceramides
    • Lofgren H., Pascher I. Molecular arrangements of sphingolipids. The monolayer behaviour of ceramides. Chem. Phys. Lipids 1977, 20:273-284.
    • (1977) Chem. Phys. Lipids , vol.20 , pp. 273-284
    • Lofgren, H.1    Pascher, I.2
  • 31
    • 33644502874 scopus 로고    scopus 로고
    • Sulfatide is essential for the maintenance of CNS myelin and axone structure
    • Marcus J., Honigbaum S., Shroff S., Honke K., Rosenbluth J., Dupree J.L. Sulfatide is essential for the maintenance of CNS myelin and axone structure. Glia 2006, 53:372-381.
    • (2006) Glia , vol.53 , pp. 372-381
    • Marcus, J.1    Honigbaum, S.2    Shroff, S.3    Honke, K.4    Rosenbluth, J.5    Dupree, J.L.6
  • 32
    • 38349051098 scopus 로고    scopus 로고
    • Glucosylceramide synthase decrease in frontal cortex of Alzheimer brain correlates with abnormal increase in endogenous ceramides: consequences to morphology and viability on enzyme suppression in cultured primary neurons
    • Marks N., Berg M.J., Saito M., Saito M. Glucosylceramide synthase decrease in frontal cortex of Alzheimer brain correlates with abnormal increase in endogenous ceramides: consequences to morphology and viability on enzyme suppression in cultured primary neurons. Brain Res. 2008, 1191:136-147.
    • (2008) Brain Res. , vol.1191 , pp. 136-147
    • Marks, N.1    Berg, M.J.2    Saito, M.3    Saito, M.4
  • 33
    • 8444224225 scopus 로고    scopus 로고
    • Mutation in saposin D domain of sphingolipid activator protein gene causes urinary system defects and cerebellar Purkinje cell degeneration with accumulation of hydroxy fatty acid-containing ceramide in mouse
    • Matsuda J., Kido M., Tadano-Aritomi K., Ishizuka I., Tominaga K., Toida K., Takeda E., Suzuki K., Kuroda Y. Mutation in saposin D domain of sphingolipid activator protein gene causes urinary system defects and cerebellar Purkinje cell degeneration with accumulation of hydroxy fatty acid-containing ceramide in mouse. Hum. Mol. Genet. 2004, 13:2709-2723.
    • (2004) Hum. Mol. Genet. , vol.13 , pp. 2709-2723
    • Matsuda, J.1    Kido, M.2    Tadano-Aritomi, K.3    Ishizuka, I.4    Tominaga, K.5    Toida, K.6    Takeda, E.7    Suzuki, K.8    Kuroda, Y.9
  • 34
    • 33646145729 scopus 로고    scopus 로고
    • Gender and genetic background effects on brain metal levels in APP transgenic and normal mice: implications for Alzheimer β-amyloid pathology
    • Maynard C.J., Cappai R., Volitakis I., Cherny R.A., Masters C.L., Li Q., Bush A.I. Gender and genetic background effects on brain metal levels in APP transgenic and normal mice: implications for Alzheimer β-amyloid pathology. J. Inorg. Biochem. 2006, 100:952-962.
    • (2006) J. Inorg. Biochem. , vol.100 , pp. 952-962
    • Maynard, C.J.1    Cappai, R.2    Volitakis, I.3    Cherny, R.A.4    Masters, C.L.5    Li, Q.6    Bush, A.I.7
  • 35
    • 58149462858 scopus 로고    scopus 로고
    • Synthesis of 2-hydroxy-ceramide by ceramide synthase family members: enzymatic basis for the preference of fatty acid chain length in cultured cell models. J. Lipid Res., doi:10.1194/jlr.M800158-JLR200
    • Mizutani, Y., Kihara, A., Chiba, H., Tojo, H., Igarashi, Y., 2008. Synthesis of 2-hydroxy-ceramide by ceramide synthase family members: enzymatic basis for the preference of fatty acid chain length in cultured cell models. J. Lipid Res., doi:10.1194/jlr.M800158-JLR200.
    • (2008)
    • Mizutani, Y.1    Kihara, A.2    Chiba, H.3    Tojo, H.4    Igarashi, Y.5
  • 38
    • 36448995805 scopus 로고    scopus 로고
    • Developmental changes of glycosphingolipids and expression of glycogenes in mouse brains
    • Ngamukote S., Yanagisawa M., Ariga T., Ando S., Yu R.K. Developmental changes of glycosphingolipids and expression of glycogenes in mouse brains. J. Neurochem. 2007, 103:2327-2341.
    • (2007) J. Neurochem. , vol.103 , pp. 2327-2341
    • Ngamukote, S.1    Yanagisawa, M.2    Ariga, T.3    Ando, S.4    Yu, R.K.5
  • 40
    • 0037203342 scopus 로고    scopus 로고
    • Ceramide in apoptosis: an overview and current perspectives
    • Pettus B.J., Chalfant C.E., Hannun Y.A. Ceramide in apoptosis: an overview and current perspectives. Biochim. Biophys. Acta 2002, 1585:114-125.
    • (2002) Biochim. Biophys. Acta , vol.1585 , pp. 114-125
    • Pettus, B.J.1    Chalfant, C.E.2    Hannun, Y.A.3
  • 41
    • 0037490159 scopus 로고    scopus 로고
    • Ceramide stabilizes beta-site amyloid precursor protein-cleaving enzyme 1 and promotes amyloid beta-peptide biogenesis
    • Puglielli L., Ellis B.C., Saundersn A.J., Kovacs D.M. Ceramide stabilizes beta-site amyloid precursor protein-cleaving enzyme 1 and promotes amyloid beta-peptide biogenesis. J. Biol. Chem. 2003, 278:19777-19783.
    • (2003) J. Biol. Chem. , vol.278 , pp. 19777-19783
    • Puglielli, L.1    Ellis, B.C.2    Saundersn, A.J.3    Kovacs, D.M.4
  • 44
    • 0028882458 scopus 로고
    • The UDP-galactose: ceramide galactosyltransferase: expression pattern in oligodendrocytes and Schwann cells during myelination and substrate preference for hydroxyceramide
    • Schaeren-Wiemers N., van der Bijl P., Schwab M.E. The UDP-galactose: ceramide galactosyltransferase: expression pattern in oligodendrocytes and Schwann cells during myelination and substrate preference for hydroxyceramide. J. Neurochem. 1995, 65:2267-2278.
    • (1995) J. Neurochem. , vol.65 , pp. 2267-2278
    • Schaeren-Wiemers, N.1    van der Bijl, P.2    Schwab, M.E.3
  • 45
    • 33847310829 scopus 로고    scopus 로고
    • Gender-dependent APP processing in a transgenic mouse model of Alzheimer's disease
    • Schäfer S., Wirths O., Multhaup G., Bayer T.A. Gender-dependent APP processing in a transgenic mouse model of Alzheimer's disease. J. Neural. Transm. 2007, 114:387-394.
    • (2007) J. Neural. Transm. , vol.114 , pp. 387-394
    • Schäfer, S.1    Wirths, O.2    Multhaup, G.3    Bayer, T.A.4
  • 47
    • 0028157335 scopus 로고
    • Membrane lipids, selectively diminished in Alzheimer brains, suggest synapse loss as a primary event in early-onset form (type I) and demyelination in late-onset form (type II)
    • Svennerholm L., Gottfries C.G. Membrane lipids, selectively diminished in Alzheimer brains, suggest synapse loss as a primary event in early-onset form (type I) and demyelination in late-onset form (type II). J. Neurochem. 1994, 62:1039-1047.
    • (1994) J. Neurochem. , vol.62 , pp. 1039-1047
    • Svennerholm, L.1    Gottfries, C.G.2
  • 48
    • 0033842398 scopus 로고    scopus 로고
    • Kidney lipids in galactosylceramide synthase-deficient mice: absence of galactosylsulfatide and compensatory increase in more polar sulfoglycolipids
    • Tadano-Aritomi K., Hikita T., Fujimoto H., Suzuki K., Motegi K., Ishizuka I. Kidney lipids in galactosylceramide synthase-deficient mice: absence of galactosylsulfatide and compensatory increase in more polar sulfoglycolipids. J. Lipid Res. 2000, 41:1237-1243.
    • (2000) J. Lipid Res. , vol.41 , pp. 1237-1243
    • Tadano-Aritomi, K.1    Hikita, T.2    Fujimoto, H.3    Suzuki, K.4    Motegi, K.5    Ishizuka, I.6
  • 49
    • 23044510465 scopus 로고    scopus 로고
    • Inhibition of glycosphingolipid biosynthesis reduces secretion of the β-amyloid precursor protein and amyloid β-peptide
    • Tamboli I.Y., Prager K., Barth E., Heneka M., Sandhoff K., Walter J. Inhibition of glycosphingolipid biosynthesis reduces secretion of the β-amyloid precursor protein and amyloid β-peptide. J. Biol. Chem. 2005, 280:28110-28117.
    • (2005) J. Biol. Chem. , vol.280 , pp. 28110-28117
    • Tamboli, I.Y.1    Prager, K.2    Barth, E.3    Heneka, M.4    Sandhoff, K.5    Walter, J.6
  • 52
    • 38949163057 scopus 로고    scopus 로고
    • Long-chain ceramide is elevated in presenilin1 (PS1M146V) mouse brain and induces apoptosis in PS1 astrocytes
    • Wang G., Silva J., Dasgupta S., Bieberich E. Long-chain ceramide is elevated in presenilin1 (PS1M146V) mouse brain and induces apoptosis in PS1 astrocytes. Glia 2008, 56:449-456.
    • (2008) Glia , vol.56 , pp. 449-456
    • Wang, G.1    Silva, J.2    Dasgupta, S.3    Bieberich, E.4
  • 53
    • 42649134163 scopus 로고    scopus 로고
    • Deficits in working memory and motor performance in the APP/PS1ki mouse model for Alzheimer's disease
    • Wirths O., Breyhan H., Schäfer S., Roth C., Bayer T.A. Deficits in working memory and motor performance in the APP/PS1ki mouse model for Alzheimer's disease. Neurobiol. Aging 2008, 29:891-901.
    • (2008) Neurobiol. Aging , vol.29 , pp. 891-901
    • Wirths, O.1    Breyhan, H.2    Schäfer, S.3    Roth, C.4    Bayer, T.A.5
  • 54
    • 0037017399 scopus 로고    scopus 로고
    • Selective cytotoxicity of intracellular amyloid beta peptide 1-42 through p53 and Bax in cultured primary human neurons
    • Zhang Y., McLaughlin R., Goodyer C., LeBlanc A. Selective cytotoxicity of intracellular amyloid beta peptide 1-42 through p53 and Bax in cultured primary human neurons. J. Cell Biol. 2002, 156:519-529.
    • (2002) J. Cell Biol. , vol.156 , pp. 519-529
    • Zhang, Y.1    McLaughlin, R.2    Goodyer, C.3    LeBlanc, A.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.