Allopurinol improves cardiac dysfunction after ischemia-reperfusion via reduction of oxidative stress in isolated perfused rat hearts

Circulation Journal

Volumn 67, Issue 9, 2003, Pages 781-787

  Kinugasa, Yoshiharu ^a   Ogino, Kazuhide ^a   Furuse, Yoshiyuki ^a   Shiomi, Tetsuya ^b   Tsutsui, Hiroyuki ^b   Yamamoto, Tetsuya ^c   Igawa, Osamu ^a   Hisatome, Ichiro ^a   Shigemasa, Chiaki ^a  

^a TOTTORI UNIVERSITY   (Japan)

^b KYUSHU UNIVERSITY   (Japan)

^c HYOGO COLLEGE OF MEDICINE   (Japan)

Author keywords

Ischemia; Myocardial infarction; Oxygen; Reperfusion

Indexed keywords

ALLOPURINOL; HYDROXYL RADICAL; LACTATE DEHYDROGENASE; NITROXIDE; OXIPURINOL; TEMPOL; THIOBARBITURIC ACID REACTIVE SUBSTANCE; XANTHINE OXIDASE INHIBITOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL PROTECTION; CONTROLLED STUDY; ELECTRON SPIN RESONANCE; ENZYME ACTIVITY; HEART DISEASE; HEART MUSCLE ISCHEMIA; HEART MUSCLE PERFUSION; HEART PROTECTION; HEART VENTRICLE FUNCTION; ISOLATED HEART; LIPID PEROXIDATION; NONHUMAN; OXIDATIVE STRESS; RAT; REPERFUSION INJURY; RISK BENEFIT ANALYSIS;

EID: 0042320316     PISSN: 13469843     EISSN: None     Source Type: Journal    
DOI: 10.1253/circj.67.781     Document Type: Article

References (38)

1. Midorikawa J, Maehara K, Yaoita H, Watanabe T, Ohtani H, Ushiroda S, et al. Continuous observation of superoxide generation in an in-situ ischemia-reperfusion rat lung model. Jpn Circ J 2001; 65: 207-212.
2. Kaneda T, Ku K, Inoue T, Onoe M, Oku H. Postischemic reperfusion injury can be attenuated by oxygen tension control. Jpn Circ J 2001; 65: 213-218.
3. Chambers DE, Parks DA, Patterson G, Roy R, McCord JM, Yoshida S, et al. Xanthine oxidase as a source of free radical damage in myocardial ischemia. J Mol Cell Cardiol 1985; 17: 145-152.
4. Stewart JR, Crute SL, Loughlin V, Hess ML, Greenfield LJ. Prevention of free radical-induced myocardial reperfusion injury with allopurinol. J Thorac Cardiovasc Surg 1985; 90: 68-72.
5. Manning AS, Coltart DJ, Hearse DJ. Ischemia and reperfusion-induced arrhythmias in the rat: Effects of xanthine oxidase inhibition with allopurinol. Circ Res 1984; 55: 545-548.
6. Miwa-Nishimura N, Kanaide H, Abe S, Nakamura M. Does allopurinol prevent myocardial injury as a result of hypoxia-re-oxygenation in rats? Int J Exp Pathol 1990; 71: 727-739.
7. Terada LS, Rubinstein JD, Lesnefsky EJ, Horwitz LD, Leff JA, Repine JE. Existence and participation of xanthine oxidase in reperfusion injury of ischemic rabbit myocardium. Am J Physiol 1991; 260: H805-H810.
8. Godin DV, Bhimji S, McNeill JH. Effects of allopurinol pretreatment on myocardial ultrastructure and arrhythmias following coronary artery occlusion and reperfusion. Virchows Arch B Cell Pathol Incl Mol Pathol 1986; 52: 327-341.
9. Coghlan JG, Flitter WD, Clutton SM, Panda R, Daly R, Wright G, et al. Allopurinol pretreatment improves postoperative recovery and reduces lipid peroxidation in patients undergoing coronary artery bypass grafting. J Thorac Cardiovasc Surg 1994; 107: 248-256.
10. Adachi H, Motomatsu K, Yara I. Effect of allopurinol (zyloric) on patients undergoing open heart surgery. Jpn Circ J 1979; 43: 395-401.
11. McCord JM. Oxygen-derived free radicals in postischemic tissue injury. N Engl J Med 1985; 312: 159-163.
12. 2+-sensitizing effect is involved in the positive inotropic effect of troglitazone. Br J Pharmacol 2001; 133: 1307-1313.
13. Shimoyama M, Ogino K, Tanaka Y, Ikeda T, Hisatome I. Hemodynamic basis for the acute cardiac effects of troglitazone in isolated perfused rat hearts. Diabetes 1999; 48: 609-615.
14. Moriwaki Y, Yamamoto T, Suda M, Nasako Y, Takahashi S, Agbedana O, et al. Purification and immunohistochemical tissue localization of human xanthine oxidase. Biochim Biophys Acta 1993; 1164: 327-330.
15. Yamamoto T, Moriwaki Y, Takahashi S, Tsutsumi Z, Yamakita J, Nasako Y, et al. Determination of human plasma xanthine oxidase activity by high-performance liquid chromatography. J Chromatogr B Biomed Appl 1996; 681: 395-400.
16. Tekkanat KK, Fox IH. Isocratic separation of ATP and its degradation products from biological fluids by automated liquid chromatography. Clin Chem 1988: 34: 925-932.
17. Kikugawa K, Kojima T, Yamaki S, Kosugi H. Interpretation of the thiobarbituric acid reactivity of rat liver and brain homogenates in the presence of ferric ion and ethylenediaminetetraacetic acid. Anal Biochem 1992; 202: 249-255.
18. Ide T, Tsutsui H, Kinugawa S, Utsumi H, Kang D, Hattori N, et al. Mitochondrial electron transport complex I is a potential source of oxygen free radicals in the failing myocardium. Circ Res 1999; 85: 357-363.
19. Ide T, Tsutsui H, Kinugawa S, Suematsu N, Hayashidani S, Ichikawa K, et al. Direct evidence for increased hydroxyl radicals originating from superoxide in the failing myocardium. Circ Res 2000; 86: 152-157.
20. Kuppusamy P, Zweier JL. Characterization of free radical generation by xanthine oxidase: Evidence for hydroxyl radical generation. J Biol Chem 1989; 264: 9880-9884.
21. Xia Y, Zweier JL. Substrate control of free radical generation from xanthine oxidase in the postischemic heart. J Biol Chem 1995; 270: 18797-18803.
22. Thompson-Gorman SL, Zweier JL. Evaluation of the role of xanthine oxidase in myocardial reperfusion injury. J Biol Chem 1990; 265: 6656-6663.
23. Pisarenko OI, Lakomkin VL, Studneva IM, Timoshin AA, Kuzmin AI, Ruuge EK, et al. Allopurinol-enhanced postischemic recovery in the isolated rat heart involves repletion of high-energy phosphates. Biochem Med Metab Biol 1994; 51: 16-26.
24. Harrison GJ, Willis RJ, Headrick JP. Extracellular adenosine levels and cellular energy metabolism in ischemically preconditioned rat heart. Cardiovasc Res 1998; 40: 74-87.
25. Angelos MG, Murray HN, Gorsline RT, Klawitter PF. Glucose, insulin and potassium (GIK) during reperfusion mediates improved myocardial bioenergetics. Resuscitation 2002; 55: 329-336.
26. Lasley RD, Ely SW, Berne RM, Mentzer RM Jr. Allopurinol enhanced adenine nucleotide repletion after myocardial ischemia in the isolated rat heart. J Clin Invest 1988; 81: 16-20.
27. Khatib SY, Farah H, El-Migdadi F. Allopurinol enhances adenine nucleotide levels and improves myocardial function in isolated hypoxic rat heart. Biochemistry (Mosc) 2001; 66: 328-333.
28. Hearse DJ, Manning AS, Downey JM, Yellon DM. Xanthine oxidase: A critical mediator of myocardial injury during ischemia and reperfusion? Acta Physiol Scand Suppl 1986; 548: 65-78.
29. McCord JM, Roy RS. The pathophysiology of superoxide: Roles in inflammation and ischemia. Can J Physiol Pharmacol 1982; 60: 1346-1352.
30. Kehrer JP, Piper HM, Sies H. Xanthine oxidase is not responsible for reoxygenation injury in isolated-perfused rat heart. Free Radic Res Commun 1987; 3: 69-78.
31. Chambers DJ, Takahashi A, Humphrey SM, Harvey DM, Hearse DJ. Allopurinol-enhanced myocardial protection does not involve xanthine oxidase inhibition or purine salvage. Basic Res Cardiol 1992; 87: 227-238.
32. McCord JM. Free radicals and myocardial ischemia: Overview and outlook. Free Radic Biol Med 1988; 4: 9-14.
33. Saugstad OD. Role of xanthine oxidase and its inhibitor in hypoxia: Reoxygenation injury. Pediatrics 1996; 98: 103-107.
34. Downey JM, Miura T, Eddy LJ, Chambers DE, Mellert T, Hearse DJ, et al. Xanthine oxidase is not a source of free radicals in the ischemic rabbit heart. J Mol Cell Cardiol 1987; 19: 1053-1060.
35. Myers CL, Weiss SJ, Kirsh MM, Shepard BM, Shlafer M. Effects of supplementing hypothermic crystalloid cardioplegic solution with catalase, superoxide dismutase, allopurinol, or deferoxamine on functional recovery of globally ischemic and reperfused isolated hearts. J Thorac Cardiovasc Surg 1986; 91: 281-289.
36. de Jong JW, Schoemaker RG, de Jonge R, Bernocchi P, Keijzer E, Harrison R, et al. Enhanced expression and activity of xanthine oxidoreductase in the failing heart. J Mol Cell Cardiol 2000; 32: 2083-2089.
37. Saavedra W, Paolocci N, St John M, Skaf M, Stewart G, Xie J, et al. Imbalance between xanthine oxidase and nitric oxide synthase signaling pathways underlies mechanoenergetic uncoupling in the failing heart. Circ Res 2002; 90: 297-304.
38. White CR, Darley-Usmar V, Berrington WR, McAdams M, Gore JZ, Thompson JA, et al. Circulating plasma xanthine oxidase contributes to vascular dysfunction in hypercholesterolemic rabbits. Proc Natl Acad Sci USA 1996; 93: 8745-8749.