Ginkgo biloba extract in the treatment of tinnitus: A systematic review

Neuropsychiatric Disease and Treatment

Volumn 7, Issue 1, 2011, Pages 441-447

  von Boetticher, Alexander ^a  

^a Ear Nose and Throat Surgery   (Germany)

Author keywords

Ginkgo biloba; Systematic review; Tinnitus

Indexed keywords

GINKGO BILOBA EXTRACT; PLACEBO;

ANGER; ANXIETY DISORDER; AUDITORY NERVOUS SYSTEM; CAUSAL ATTRIBUTION; CHRONIC DISEASE; COGNITIVE DEFECT; COMORBIDITY; DEMENTIA; DEPRESSION; DISEASE ASSOCIATION; DISEASE CLASSIFICATION; DRUG EFFICACY; EVIDENCE BASED MEDICINE; HAIR CELL; HUMAN; META ANALYSIS; OUTCOMES RESEARCH; PATHOGENESIS; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW; SIGNAL PROCESSING; SYSTEMATIC REVIEW; TINNITUS; TREATMENT DURATION;

EID: 80955136983     PISSN: 11766328     EISSN: 11782021     Source Type: Journal    
DOI: 10.2147/ndt.s22793     Document Type: Review

References (36)

1. Shargorodsky J, Curhan GC, Farwell WR. Prevalence and characteristics of tinnitus among U S adults. Am J Med. 2010;123(8):711-718.
2. Davis A, Rafaie EA. Epidemiology of tinnitus. In: Tyler RS, editor. Tinnitus Handbook. San Diego, CA: Singular; 2000.
3. Ahmad N, Seidman M. Tinnitus in the older adult: epidemiology, pathophysiology and treatment options. Drugs Aging. 2004;21(5): 297-305.
4. Lockwood AH, Salvi RJ, Burkard RF. Tinnitus. N Engl J Med. 2002; 347(12):904-910.
5. Stouffer JL, Tyler RS. Characterization of tinnitus by tinnitus patients. J Speech Hear Disord. 1990;55(3):439-453.
6. Gopinath B, McMahon CM, Rochtchina E, Karpa MJ, Mitchell P. Incidence, persistence, and progression of tinnitus symptoms in older adults: the blue mountains hearing study. Ear Hear. 2010;31(3): 407-412.
7. Eggermont JJ, Roberts LE. The neuroscience of tinnitus. Trends Neurosci. 2004;27(11):676-682.
8. Hallam RS, Jakes SC, Hinchcliffe R. Cognitive variables in tinnitus annoyance. Br J Clin Psychol. 1988;27(Pt 3):213-222.
9. Mazurek B, Olze H, Haupt H, Szczepek AJ. The more the worse: the grade of noise-induced hearing loss associates with the severity of tinnitus. Int J Environ Res Public Health. 2010;7(8):3071-3079.
10. Jastreboff PJ, Hazell JW. A neurophysiological approach to tinnitus: clinical implications. Br J Audiol. 1993;27(1):7-17.
11. Goebel G, Buettner U. Basics of tinnitus: diagnostics and therapy. Psychoneuro. 2004;30(6):322-329. [German].
12. Yamasoba T, Someya S, Yamada C, Weindruch R, Prolla TA, Tanokura M. Role of mitochondrial dysfunction and mitochondrial DNA mutations in age-related hearing loss. Hear Res. 2007;226(1-2):185-193.
13. Neri S, Signorelli S, Pulvirenti D, et al. Oxidative stress, nitric oxide, endothelial dysfunction and tinnitus. Free Radic Res. 2006;40(6): 615-618.
14. Schacht J. Amino glycoside ototoxicity: prevention in sight? Otolaryngol Head Neck Surg. 1998;118(5):674-677.
15. Yamashita D, Jiang HY, Schacht J, Miller JM. Delayed production of free radicals following noise exposure. Brain Res. 2004;1019(1-2): 201-209.
16. ®. Clin Hemorheol. 1995;15(4):649-656.
17. Erdinçler DS, Karakoç Y, Toplan S, et al. The effect of Ginkgo biloba glycoside on the blood viscosity and erythrocyte deformability. Clin Hemorheol. 1996;16(3):271-276.
18. Maass B, Silberzahn J, Simon R. On the effect of Ginkgo biloba extract (Tebonin) on the hydrogen clearance at the cochlea basis under hypotensive ischemia Extracta Otorhinolanryngol. 1987;9(5):169-172. [German].
19. ®) prevents mitochondrial aging by protecting against oxidative stress. Free Radic Biol Med. 1998;24(2):298-304.
20. ®. Ann N Y Acad Sci. 2005;1056:474-485.
21. Jastreboff PJ, Zhou S, Jastreboff MM, Kwapisz U, Gryczynska U. Attenutation of salicylate-induced tinnitus by Ginkgo biloba extract in rats. Audiol Neurootol. 1997;2(4):197-212.
22. Huang X, Whitworth CA, Rybak LP. Ginkgo biloba extract (EGb 761) protects against cisplatin-induced ototoxicity in rats. Otol Neurotol. 2007;28(6):828-833.
23. ® in patients with tinnitus. Int J Clin Pharmacol Ther. 2002;40(5):188-197.
24. ®. Fortschr Med Orig. 1997;115(4):57-58. German.
25. Meyer B. A multicentre, randomized, double-blind drug versus placebo study of Ginkgo biloba extract in the tratment of tinnitus. Presse Med. 1986;15(31):1562-1564. French.
26. ® in dementia with neuropsychiatric features. A randomized controlled trial. Int J Geriatr Psychiatry. 2010 Dec 7.
27. Napryeyenko O, Borzenko I; for the GINDEM-NP Study Group. Ginkgo biloba special extract in dementia with neuropsychiatric features. A randomized, placebo-controlled, double-blind clinical trial. Arzneimittelforschung. 2007;57(1):4-11.
28. Halama P, Bartsch G, Meng G. Cerebrovascular insufficiency. A placebo- controlled randomized double-blind trial on the effect of Ginkgo biloba extract. Fortschr Med. 1988;106(19):408-412. German.
29. ® forte in patients with cerebrovascular insufficiency. Fortschr Med. 1982;100(31/32):1474-1478. German.
30. Holgers KM, Axelsson A, Pringle I. Ginkgo biloba extract for the treatment of tinnitus. Audiology. 1994;33(2):85-92.
31. Drew S, Davies E. Effectiveness of Ginkgo biloba in treating tinnitus: double blind, placebo controlled trial. BMJ. 2001;322(7278):1-6.
32. Rejali D, Sivakumar A, Balaji N. Ginkgo biloba does not benefit patients with tinnitus: a randomized placebo-controlled double-blind trial and meta-analysis of randomized trials. Clin Otolaryngol Allied Sci. 2004;39(3):226-231.
33. Smith PF, Zheng Y, Darlington CL. Ginkgo biloba extracts for tinnitus: more hype than hope? J Ethnopharmacol. 2005;100(1-2):95-99.
34. Hilton MP, Stuart EL. Ginkgo biloba for tinnitus. Cochrane Database Syst Rev. 2004;2:CD003852.
35. ® in the treatment of tinnitus. An overview of the results of clinical trials. Fortschr Med Orig. 2000;118(4):157-164. German.
36. Sackett DL, Rosenberg WM, Gray JA, Haynes RB, Richardson WS. Evidence based medicine: what it is and what it isn't. BMJ. 1996; 312(7023):71-72.