Cisplatin ototoxicity: Involvement of iron and enhanced formation of superoxide anion radicals

Toxicology and Applied Pharmacology

Volumn 174, Issue 1, 2001, Pages 27-34

  Dehne, N ^a   Lautermann, J ^a   Petrat, F ^a   Rauen, U ^a   De Groot, H ^a  

^a UNIVERSITY OF DUISBURG ESSEN   (Germany)

Author keywords

Chelatable iron pool; Inner ear; Superoxide anion

Indexed keywords

2,2' BIPYRIDINE; CISPLATIN; DEFEROXAMINE; DEFEROXAMINE MESYLATE; FLUORESCENT DYE; HOE 33342; IRON; PHEN GREEN SK; QUIN 2 AM; SUPEROXIDE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; FEMALE; GUINEA PIG; IRON CHELATION; MALE; NERVE CELL CULTURE; NEUROPROTECTION; NONHUMAN; OTOTOXICITY; OXIDATIVE STRESS; PATHOPHYSIOLOGY;

CAVIA PORCELLUS; SUS SCROFA;

EID: 0035397409     PISSN: 0041008X     EISSN: None     Source Type: Journal    
DOI: 10.1006/taap.2001.9171     Document Type: Article

References (50)

1. Iron metabolism
2. Increase in bleomycin-detectable iron in ischaemia/reperfusion injury to rat kidneys
3. In vitro and in vivo evidence suggesting a role for iron in cisplatin-induced nephrotoxicity
4. Role of cytochrome P-450 as a source of catalytic iron in cisplatin-induced nephrotoxicity
5. Iron acquired from transferrin by K562 cells is delivered into a cytoplasmic pool of chelatable iron(II)
6. Induction of ferritin synthesis by oxidative stress. Transcriptional and post-transcriptional regulation by expansion of the "free" iron pool
7. Direct detection of ototoxicant-induced reactive oxygen species generation in cochlear explants
8. Early morphological and chemical changes induced by cisplatin in the guinea pig organ of Corti
9. Reactive oxygen species in tissue injury
10. In vitro effects of hydrogen peroxide on the cochlear neurosensory epithelium of the guinea pig
11. Fluorescence analysis of the labile iron pool of mammalian cells
12. Cisdiamminedichloroplatinum (II) ototoxicity in the guinea pig
13. Superoxide-dependent formation of hydroxyl radicals in the presence of iron salts. Detection of 'free' iron in biological systems by using bleomycin-dependent degradation of DNA
14. Biologically relevant metal ion-dependent hydroxyl radical generation. An update
15. cis-Platinum ototoxicity
16. Most free-radical injury is iron-related: It is promoted by iron, hemin, holoferritin and vitamin C, and inhibited by desferoxamine and apoferritin
17. Iron chelators in medicine
18. Iron chelation therapy
19. Effects of zinc gluconate on nephrotoxicity and glutathione metabolism disorder induced by cis-platin in mice
20. Protection by ebselen against cisplatin-induced nephrotoxicity: Antioxidant system
21. Effect of 4-methylthiobenzoic acid on cisplatin-induced ototoxicity in the rat
22. Elevated serum iron levels following administration of cisplatinum
23. Use of organotypic cultures of Corti's organ to study the protective effects of antioxidant molecules on cisplatin-induced damage of auditory hair cells
24. Cisplatin-induced nephrotoxicity in porcine proximal tubular cells: Mitochondrial dysfunction by inhibition of complexes I to IV of the respiratory chain
25. Immunohistochemical localization of manganese superoxide dismutase in the rat cochlea
26. Diet is a risk factor in cisplatin ototoxicity
27. 2
28. Cisplatin generates superoxide anion by interaction with DNA in a cell-free system
29. The role of oxygen free radicals in cisplatin-induced acute renal failure in rats
30. Non-transferrin-bound-iron in serum and low-molecular-weight-iron in the liver of dietary iron-loaded rats
31. Visual and auditory neurotoxicity in patients receiving subcutanous deferoxamine infusions
32. Determination of the chelatable iron pool of isolated rat hepatocytes by digital fluorescence microscopy using the fluorescent probe, phen green SK
33. Determination of the chelatable iron pool of single intact cells by laser scanning microscopy
34. Microassay for superoxide and hydrogen peroxide production and nitroblue tetrazolium reduction using an enzyme immunoassay microplate reader
35. Receptor-mediated iron uptake and intracellular iron transport
36. Assessment of auditory dysfunction
37. Localization of Cu/Zn-SOD and Mn-SOD in the rat cochlea
38. Involvement of reactive oxygen species in the preservation injury to cultured liver endothelial cells
39. Cold-induced apoptosis in cultured hepatocytes and liver endothelial cells: Mediation by reactive oxygen species
40. 2 formation
41. Mechanism of cisplatin ototoxicity: Antioxidant system
42. Metal ion transporters in mammals: Structure, function and pathological implications
43. A simple method to identify NBT-positive cells in isolated glomeruli
44. Mechanism of protection by diethyldithiocarbamate against cisplatin ototoxicity: Antioxidant system
45. An XRF study of trace elements accumulation in kidneys of tumor-bearing mice after treatment with cis-DDP with and without selenite and selenocistamine
46. Therapeutic iron chelators and their potential side-effects
47. Diethyldithiocarbamate protection against cisplatin nephrotoxicity: Antioxidant system
48. Modification of cisplatin toxicity by antioxidants
49. 2 production in cisplatin-induced nephrotoxicity