메뉴 건너뛰기




Volumn 9, Issue 11, 2012, Pages 1347-1364

Emerging role of nanocarriers to increase the solubility and bioavailability of curcumin

Author keywords

Absorption; Bioavailability; Curcumin; Metabolism; Nanocarrirer; Poor solubility

Indexed keywords

CURCUMIN; DEMETHOXYCURCUMIN; DENDRIMER; DRUG ANALOG; GENUC DERUM CURCIMIN; LIPOSOME; N CURCUMIN; NANOCARRIER; NANOCURCUMINOIDS; NANOSUSPENSION; PHOSPHOLIPID; SOLID LIPID NANOPARTICLE; THERACURCUMIN; UNCLASSIFIED DRUG;

EID: 84867782202     PISSN: 17425247     EISSN: 17447593     Source Type: Journal    
DOI: 10.1517/17425247.2012.724676     Document Type: Article
Times cited : (151)

References (132)
  • 1
    • 79959605403 scopus 로고    scopus 로고
    • Curcumin: An anti-inflammatory molecule from a curry spice on the path to cancer treatment
    • Basnet P, Skalko-Basnet N. Curcumin: An anti-inflammatory molecule from a curry spice on the path to cancer treatment. Molecules 2011;16:4567-98
    • (2011) Molecules , Issue.16 , pp. 4567-4598
    • Basnet, P.1    Skalko-Basnet, N.2
  • 3
    • 34548058841 scopus 로고    scopus 로고
    • Curcumin, demethoxycurcumin, bisdemethoxycurcumin, tetrahydrocurcumin and turmerones differentially regulate anti-inflammatory and anti-proliferative responses through a ROS-independent mechanism
    • DOI 10.1093/carcin/bgm123
    • Sandur SK, Pandey MK, Sung B, et al. Curcumin, demethoxycurcumin, bisdemethoxycurcumin, tetrahydrocurcumin and turmerones differentially regulate anti-inflammatory and anti-proliferative responses through a ROS-independent mechanism. Carcinogenesis 2007;28:1765-73 (Pubitemid 47289040)
    • (2007) Carcinogenesis , vol.28 , Issue.8 , pp. 1765-1773
    • Sandur, S.K.1    Pandey, M.K.2    Sung, B.3    Ahn, K.S.4    Murakami, A.5    Sethi, G.6    Limtrakul, P.7    Badmaev, V.8    Aggarwal, B.B.9
  • 5
    • 55949117806 scopus 로고    scopus 로고
    • Potential therapeutic effects of curcumin, the anti-inflammatory agent, against neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic diseases
    • Aggarwal BB, Harikumar KB. Potential therapeutic effects of curcumin, the anti-inflammatory agent, against neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic diseases. Int J Biochem Cell Biol 2009;41:40-59
    • (2009) Int J Biochem Cell Biol , vol.41 , pp. 40-59
    • Aggarwal, B.B.1    Harikumar, K.B.2
  • 6
    • 33644901007 scopus 로고    scopus 로고
    • Multiple biological activities of curcumin: A short review
    • Maheshwari RK, Singh AK, Gaddipati J, et al. Multiple biological activities of curcumin: A short review. Life Sci 2006;78:2081-7
    • (2006) Life Sci , vol.78 , pp. 2081-2087
    • Maheshwari, R.K.1    Singh, A.K.2    Gaddipati, J.3
  • 7
    • 81355142057 scopus 로고    scopus 로고
    • Multitargeting by curcumin as revealed by molecular interaction studies
    • Gupta SC, Prasad S, Kim JH, et al. Multitargeting by curcumin as revealed by molecular interaction studies. Nat Prod Rep 2011;28:1937-55
    • (2011) Nat Prod Rep , vol.28 , pp. 1937-1955
    • Gupta, S.C.1    Prasad, S.2    Kim, J.H.3
  • 9
    • 84934443974 scopus 로고    scopus 로고
    • Curcumin as chemosensitizer
    • Limtrakul P. Curcumin as chemosensitizer. Adv Exp Med Biol 2007;595:269-300
    • (2007) Adv Exp Med Biol , vol.595 , pp. 269-300
    • Limtrakul, P.1
  • 11
    • 37549051274 scopus 로고    scopus 로고
    • Bioavailability of curcumin: Problems and promises
    • Anand P, Kunnumakkara AB, Newman RA, et al. Bioavailability of curcumin: Problems and promises. Mol Pharm 2007;4:807-18
    • (2007) Mol Pharm , vol.4 , pp. 807-818
    • Anand, P.1    Kunnumakkara, A.B.2    Newman, R.A.3
  • 12
    • 77953958625 scopus 로고    scopus 로고
    • The in vitro stability and in vivo pharmacokinetics of curcumin prepared as an aqueous nanoparticulate formulation
    • Mohanty C, Sahoo SK. The in vitro stability and in vivo pharmacokinetics of curcumin prepared as an aqueous nanoparticulate formulation. Biomaterials 2010;31:6597-611
    • (2010) Biomaterials , vol.31 , pp. 6597-6611
    • Mohanty, C.1    Sahoo, S.K.2
  • 13
    • 51649118928 scopus 로고    scopus 로고
    • Phase II trial of curcumin in patients with advanced pancreatic cancer
    • Dhillon N, Aggarwal BB, Newman RA, et al. Phase II trial of curcumin in patients with advanced pancreatic cancer. Clin Cancer Res 2008;14:4491-9
    • (2008) Clin Cancer Res , vol.14 , pp. 4491-4499
    • Dhillon, N.1    Aggarwal, B.B.2    Newman, R.A.3
  • 15
    • 0031860081 scopus 로고    scopus 로고
    • Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers
    • DOI 10.1055/s-2006-957450
    • Shoba G, Joy D, Joseph T, et al. Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers. Planta Med 1998;64:353-6 (Pubitemid 28234275)
    • (1998) Planta Medica , vol.64 , Issue.4 , pp. 353-356
    • Shoba, G.1    Joy, D.2    Joseph, T.3    Majeed, M.4    Rajendran, R.5    Srinivas, P.S.S.R.6
  • 16
    • 55949084512 scopus 로고    scopus 로고
    • Biological activities of curcumin and its analogues (Congeners) made by man and Mother Nature
    • Anand P, Thomas SG, Kunnumakkara AB, et al. Biological activities of curcumin and its analogues (Congeners) made by man and Mother Nature. Biochem Pharmacol 2008;76:1590-611
    • (2008) Biochem Pharmacol , vol.76 , pp. 1590-1611
    • Anand, P.1    Thomas, S.G.2    Kunnumakkara, A.B.3
  • 17
    • 84861646477 scopus 로고    scopus 로고
    • Antiglioma activity of curcumin-loaded lipid nanoparticles and its enhanced bioavailability in brain tissue for effective glioblastoma therapy
    • Kundu P, Mohanty C, Sahoo SK. Antiglioma activity of curcumin-loaded lipid nanoparticles and its enhanced bioavailability in brain tissue for effective glioblastoma therapy. Acta Biomater 2012;8:2670-87
    • (2012) Acta Biomater , vol.8 , pp. 2670-2687
    • Kundu, P.1    Mohanty, C.2    Sahoo, S.K.3
  • 18
    • 47049093012 scopus 로고    scopus 로고
    • Micelles of poly(ethylene oxide)-b-poly(ε-caprolactone) as vehicles for the solubilization, stabilization, and controlled delivery of curcumin
    • DOI 10.1002/jbm.a.31584
    • Ma Z, Haddadi A, Molavi O, et al. Micelles of poly(ethylene oxide)-b-poly (epsilon-caprolactone) as vehicles for the solubilization, stabilization, and controlled delivery of curcumin. J Biomed Mater Res A 2008; 86:300-10 (Pubitemid 351969628)
    • (2008) Journal of Biomedical Materials Research - Part A , vol.86 , Issue.2 , pp. 300-310
    • Ma, Z.1    Haddadi, A.2    Molavi, O.3    Lavasanifar, A.4    Lai, R.5    Samuel, J.6
  • 19
    • 84857694629 scopus 로고    scopus 로고
    • Curcumin loaded-PLGA nanoparticles conjugated with Tet-1 peptide for potential use in Alzheimer's disease
    • Mathew A, Fukuda T, Nagaoka Y, et al. Curcumin loaded-PLGA nanoparticles conjugated with Tet-1 peptide for potential use in Alzheimer's disease. PLoS ONE 2012;7:e32616
    • (2012) PLoS ONE , Issue.7
    • Mathew, A.1    Fukuda, T.2    Nagaoka, Y.3
  • 20
    • 77951218485 scopus 로고    scopus 로고
    • Curcumin-encapsulated MePEG/PCL diblock copolymeric micelles: A novel controlled delivery vehicle for cancer therapy
    • Mohanty C, Acharya S, Mohanty AK, et al. Curcumin-encapsulated MePEG/PCL diblock copolymeric micelles: A novel controlled delivery vehicle for cancer therapy. Nanomedicine (Lond) 2010;5:433-49
    • (2010) Nanomedicine (Lond) , Issue.5 , pp. 433-449
    • Mohanty, C.1    Acharya, S.2    Mohanty, A.K.3
  • 22
    • 0346848865 scopus 로고    scopus 로고
    • Nanotech approaches to drug delivery and imaging
    • DOI 10.1016/S1359-6446(03)02903-9, PII S1359644603029039
    • Sahoo SK, Labhasetwar V. Nanotech approaches to drug delivery and imaging. Drug Discov Today 2003;8:1112-20 (Pubitemid 37547917)
    • (2003) Drug Discovery Today , vol.8 , Issue.24 , pp. 1112-1120
    • Sahoo, S.K.1    Labhasetwar, V.2
  • 23
    • 78650875977 scopus 로고    scopus 로고
    • Receptor mediated tumor targeting: An emerging approach for cancer therapy
    • Mohanty C, Das M, Kanwar JR, et al. Receptor mediated tumor targeting: An emerging approach for cancer therapy. Curr Drug Deliv 2011;8:45-58
    • (2011) Curr Drug Deliv , vol.8 , pp. 45-58
    • Mohanty, C.1    Das, M.2    Kanwar, J.R.3
  • 24
  • 25
    • 84855837427 scopus 로고    scopus 로고
    • Curcumin nanoformulations: A future nanomedicine for cancer
    • Yallapu MM, Jaggi M, Chauhan SC. Curcumin nanoformulations: A future nanomedicine for cancer. Drug Discov Today 2012;17:71-80
    • (2012) Drug Discov Today , vol.17 , pp. 71-80
    • Yallapu, M.M.1    Jaggi, M.2    Chauhan, S.C.3
  • 26
    • 34548279788 scopus 로고    scopus 로고
    • Molecular understanding and modern application of traditional medicines: Triumphs and trials
    • DOI 10.1016/j.cell.2007.08.021, PII S0092867407010847
    • Corson TW, Crews CM. Molecular understanding and modern application of traditional medicines: Triumphs and trials. Cell 2007;130:769-74 (Pubitemid 47332575)
    • (2007) Cell , vol.130 , Issue.5 , pp. 769-774
    • Corson, T.W.1    Crews, C.M.2
  • 28
    • 76249093127 scopus 로고    scopus 로고
    • Partial correction of cystic fibrosis defects with PLGA nanoparticles encapsulating curcumin
    • Cartiera MS, Ferreira EC, Caputo C, et al. Partial correction of cystic fibrosis defects with PLGA nanoparticles encapsulating curcumin. Mol Pharm 2010;7:86-93
    • (2010) Mol Pharm , vol.7 , pp. 86-93
    • Cartiera, M.S.1    Ferreira, E.C.2    Caputo, C.3
  • 29
    • 68449085126 scopus 로고    scopus 로고
    • Curcumin has bright prospects for the treatment of inflammatory bowel disease
    • Hanai H, Sugimoto K. Curcumin has bright prospects for the treatment of inflammatory bowel disease. Curr Pharm Des 2009;15:2087-94
    • (2009) Curr Pharm Des , vol.15 , pp. 2087-2094
    • Hanai, H.1    Sugimoto, K.2
  • 30
    • 80052168264 scopus 로고    scopus 로고
    • Curcumin for inflammatory bowel disease: A review of human studies
    • Taylor RA, Leonard MC. Curcumin for inflammatory bowel disease: A review of human studies. Altern Med Rev 2011;16:152-6
    • (2011) Altern Med Rev , vol.16 , pp. 152-156
    • Taylor, R.A.1    Leonard, M.C.2
  • 31
    • 27144456477 scopus 로고    scopus 로고
    • Curcumin therapy in inflammatory bowel disease: A pilot study
    • DOI 10.1007/s10620-005-3032-8
    • Holt PR, Katz S, Kirshoff R. Curcumin therapy in inflammatory bowel disease: A pilot study. Dig Dis Sci 2005;50:2191-3 (Pubitemid 41504112)
    • (2005) Digestive Diseases and Sciences , vol.50 , Issue.11 , pp. 2191-2193
    • Holt, P.R.1    Katz, S.2    Kirshoff, R.3
  • 32
    • 0028887709 scopus 로고
    • Prevention of ischaemia-induced biochemical changes by curcumin & quinidine in the cat heart
    • Dikshit M, Rastogi L, Shukla R, et al. Prevention of ischaemia-induced biochemical changes by curcumin & quinidine in the cat heart. Indian J Med Res 1995;101:31-5
    • (1995) Indian J Med Res , vol.101 , pp. 31-35
    • Dikshit, M.1    Rastogi, L.2    Shukla, R.3
  • 33
    • 0026657246 scopus 로고
    • Inhibitory effect of curcumin, an anti-inflammatory agent, on vascular smooth muscle cell proliferation
    • Huang HC, Jan TR, Yeh SF. Inhibitory effect of curcumin, an anti-inflammatory agent, on vascular smooth muscle cell proliferation. Eur J Pharmacol 1992;221:381-4
    • (1992) Eur J Pharmacol , vol.221 , pp. 381-384
    • Huang, H.C.1    Jan, T.R.2    Yeh, S.F.3
  • 34
    • 2942596263 scopus 로고    scopus 로고
    • Curcumin modulates free radical quenching in myocardial ischaemia in rats
    • Manikandan P, Sumitra M, Aishwarya S, et al. Curcumin modulates free radical quenching in myocardial ischaemia in rats. Int J Biochem Cell Biol 2004;36:1967-80
    • (2004) Int J Biochem Cell Biol , vol.36 , pp. 1967-1980
    • Manikandan, P.1    Sumitra, M.2    Aishwarya, S.3
  • 35
    • 31344440514 scopus 로고    scopus 로고
    • Curcumin and its analogues as potent inhibitors of low density lipoprotein oxidation: H-atom abstraction from the phenolic groups and possible involvement of the 4-hydroxy-3-methoxyphenyl groups
    • DOI 10.1016/j.freeradbiomed.2005.09.008, PII S0891584905005265
    • Chen WF, Deng SL, Zhou B, et al. Curcumin and its analogues as potent inhibitors of low density lipoprotein oxidation: H-atom abstraction from the phenolic groups and possible involvement of the 4-hydroxy-3-methoxyphenyl groups. Free Radic Biol Med 2006;40:526-35 (Pubitemid 43139688)
    • (2006) Free Radical Biology and Medicine , vol.40 , Issue.3 , pp. 526-535
    • Chen, W.-F.1    Deng, S.-L.2    Zhou, B.3    Yang, L.4    Liu, Z.-L.5
  • 37
    • 84855849474 scopus 로고    scopus 로고
    • Curcumin-glucoside, a novel synthetic derivative of curcumin, inhibits alpha-synuclein oligomer formation: Relevance to Parkinson's disease
    • Gadad BS, Subramanya PK, Pullabhatla S, et al. Curcumin-glucoside, a novel synthetic derivative of curcumin, inhibits alpha-synuclein oligomer formation: relevance to Parkinson's disease. Curr Pharm Des 2012;18:76-84
    • (2012) Curr Pharm Des , vol.18 , pp. 76-84
    • Gadad, B.S.1    Subramanya, P.K.2    Pullabhatla, S.3
  • 38
    • 3042857903 scopus 로고    scopus 로고
    • Alzheimer's disease
    • Cummings JL. Alzheimer's disease. N Engl J Med 2004;351:56-67
    • (2004) N Engl J Med , vol.351 , pp. 56-67
    • Cummings, J.L.1
  • 39
    • 0035503597 scopus 로고    scopus 로고
    • The curry spice curcumin reduces oxidative damage and amyloid pathology in an Alzheimer transgenic mouse
    • Lim GP, Chu T, Yang F, et al. The curry spice curcumin reduces oxidative damage and amyloid pathology in an Alzheimer transgenic mouse. J Neurosci 2001;21:8370-7 (Pubitemid 33051435)
    • (2001) Journal of Neuroscience , vol.21 , Issue.21 , pp. 8370-8377
    • Lim, G.P.1    Chu, T.2    Yang, F.3    Beech, W.4    Frautschy, S.A.5    Cole, G.M.6
  • 41
    • 0028807262 scopus 로고
    • Influence of dietary curcumin and cholesterol on the progression of experimentally induced diabetes in albino rat
    • Babu PS, Srinivasan K. Influence of dietary curcumin and cholesterol on the progression of experimentally induced diabetes in albino rat. Mol Cell Biochem 1995;152:13-21
    • (1995) Mol Cell Biochem , vol.152 , pp. 13-21
    • Babu, P.S.1    Srinivasan, K.2
  • 42
    • 0036007614 scopus 로고    scopus 로고
    • Efficacy of turmeric on blood sugar and polyol pathway in diabetic albino rats
    • DOI 10.1023/A:1013106527829
    • Arun N, Nalini N. Efficacy of turmeric on blood sugar and polyol pathway in diabetic albino rats. Plant Foods Hum Nutr 2002;57:41-52 (Pubitemid 34128408)
    • (2002) Plant Foods for Human Nutrition , vol.57 , Issue.1 , pp. 41-52
    • Arun, N.1    Nalini, N.2
  • 43
    • 22144432295 scopus 로고    scopus 로고
    • Curcumin and turmeric delay streptozotocin-induced diabetic cataract in rats
    • Suryanarayana P, Saraswat M, Mrudula T, et al. Curcumin and turmeric delay streptozotocin-induced diabetic cataract in rats. Invest Ophthalmol Vis Sci 2005;46:2092-9
    • (2005) Invest Ophthalmol Vis Sci , vol.46 , pp. 2092-2099
    • Suryanarayana, P.1    Saraswat, M.2    Mrudula, T.3
  • 45
    • 30044446136 scopus 로고    scopus 로고
    • Curcumin (diferuloylmethane) down-regulates expression of cell proliferation and antiapoptotic and metastatic gene products through suppression of IκBα kinase and Akt activation
    • DOI 10.1124/mol.105.017400
    • Aggarwal S, Ichikawa H, Takada Y, et al. Curcumin (diferuloylmethane) down-regulates expression of cell proliferation and antiapoptotic and metastatic gene products through suppression of IkappaBalpha kinase and Akt activation. Mol Pharmacol 2006;69:195-206 (Pubitemid 43048906)
    • (2006) Molecular Pharmacology , vol.69 , Issue.1 , pp. 195-206
    • Aggarwal, S.1    Ichikawa, H.2    Takada, Y.3    Sandur, S.K.4    Shishodia, S.5    Aggarwal, B.B.6
  • 46
    • 84858696604 scopus 로고    scopus 로고
    • Folate decorated dual drug loaded nanoparticle: Role of curcumin in enhancing therapeutic potential of nutlin-3a by reversing multidrug resistance
    • Das M, Sahoo SK. Folate decorated dual drug loaded nanoparticle: role of curcumin in enhancing therapeutic potential of nutlin-3a by reversing multidrug resistance. PLoS ONE 2012;7:e32920
    • (2012) PLoS ONE , Issue.7
    • Das, M.1    Sahoo, S.K.2
  • 47
    • 0037236792 scopus 로고    scopus 로고
    • Anticancer potential of curcumin: Preclinical and clinical studies
    • Aggarwal BB, Kumar A, Bharti AC. Anticancer potential of curcumin: Preclinical and clinical studies. Anticancer Res 2003;23:363-98 (Pubitemid 36361976)
    • (2003) Anticancer Research , vol.23 , Issue.1 A , pp. 363-398
    • Aggarwal, B.B.1    Kumar, A.2    Bharti, A.C.3
  • 48
    • 79955612431 scopus 로고    scopus 로고
    • Targeted nutlin-3a loaded nanoparticles inhibiting p53-MDM2 interaction: Novel strategy for breast cancer therapy
    • Das M, Dilnawaz F, Sahoo SK. Targeted nutlin-3a loaded nanoparticles inhibiting p53-MDM2 interaction: novel strategy for breast cancer therapy. Nanomedicine (Lond) 2011;6:489-507
    • (2011) Nanomedicine (Lond) , Issue.6 , pp. 489-507
    • Das, M.1    Dilnawaz, F.2    Sahoo, S.K.3
  • 49
    • 78049435057 scopus 로고    scopus 로고
    • Epithelial cell adhesion molecule targeted nutlin-3a loaded immunonanoparticles for cancer therapy
    • Das M, Sahoo SK. Epithelial cell adhesion molecule targeted nutlin-3a loaded immunonanoparticles for cancer therapy. Acta Biomater 2011;7:355-69
    • (2011) Acta Biomater , vol.7 , pp. 355-369
    • Das, M.1    Sahoo, S.K.2
  • 50
    • 79958271282 scopus 로고    scopus 로고
    • Coformulation of doxorubicin and curcumin in poly(D,Llactide-co- glycolide) nanoparticles suppresses the development of multidrug resistance in K562 cells
    • Misra R, Sahoo SK. Coformulation of doxorubicin and curcumin in poly(D,Llactide-co-glycolide) nanoparticles suppresses the development of multidrug resistance in K562 cells. Mol Pharm 2011;8:852-66
    • (2011) Mol Pharm , Issue.8 , pp. 852-866
    • Misra, R.1    Sahoo, S.K.2
  • 51
    • 59349120231 scopus 로고    scopus 로고
    • Pharmacological basis for the role of curcumin in chronic diseases: An age-old spice with modern targets
    • Aggarwal BB, Sung B. Pharmacological basis for the role of curcumin in chronic diseases: An age-old spice with modern targets. Trends Pharmacol Sci 2009;30:85-94
    • (2009) Trends Pharmacol Sci , vol.30 , pp. 85-94
    • Aggarwal, B.B.1    Sung, B.2
  • 52
    • 0037026270 scopus 로고    scopus 로고
    • Studies of curcumin and curcuminoids. XXVII. Cyclodextrin complexation: Solubility, chemical and photochemical stability
    • DOI 10.1016/S0378-5173(02)00323-X, PII S037851730200323X
    • Tonnesen HH, Masson M, Loftsson T. Studies of curcumin and curcuminoids. XXVII. Cyclodextrin complexation: solubility, chemical and photochemical stability. Int J Pharm 2002;244:127-35 (Pubitemid 35245453)
    • (2002) International Journal of Pharmaceutics , vol.244 , Issue.1-2 , pp. 127-135
    • Tonnesen, H.H.1    Masson, M.2    Loftsson, T.3
  • 54
    • 0034492793 scopus 로고    scopus 로고
    • Recent studies on the biofunctions and biotransformations of curcumin
    • Lin JK, Pan MH, Lin-Shiau SY. Recent studies on the biofunctions and biotransformations of curcumin. Biofactors 2000;13:153-8
    • (2000) Biofactors , vol.13 , pp. 153-158
    • Lin, J.K.1    Pan, M.H.2    Lin-Shiau, S.Y.3
  • 55
    • 0030839940 scopus 로고    scopus 로고
    • Stability of curcumin in buffer solutions and characterization of its degradation products
    • Wang YJ, Pan MH, Cheng AL, et al. Stability of curcumin in buffer solutions and characterization of its degradation products. J Pharm Biomed Anal 1997;15:1867-76
    • (1997) J Pharm Biomed Anal , vol.15 , pp. 1867-1876
    • Wang, Y.J.1    Pan, M.H.2    Cheng, A.L.3
  • 58
    • 0019421988 scopus 로고
    • In vitro studies on the intestinal absorption of curcumin in rats
    • DOI 10.1016/0300-483X(81)90056-1
    • Ravindranath V, Chandrasekhara N. In vitro studies on the intestinal absorption of curcumin in rats. Toxicology 1981;20:251-7 (Pubitemid 11117911)
    • (1981) Toxicology , vol.20 , Issue.2-3 , pp. 251-257
    • Ravindranath, V.1    Chandrasekhara, N.2
  • 59
    • 0018222291 scopus 로고
    • The metabolism and excretion of curcumin (1,7-bis-(4-hydroxy-3- methoxyphenyl)-1,6-heptadiene-3,5-dione) in the rat
    • Holder GM, Plummer JL, Ryan AJ. The metabolism and excretion of curcumin (1,7-bis-(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione) in the rat. Xenobiotica 1978;8:761-8 (Pubitemid 9119050)
    • (1978) Xenobiotica , vol.8 , Issue.12 , pp. 761-768
    • Holder, G.M.1    Plummer, J.L.2    Ryan, A.J.3
  • 61
    • 70449637229 scopus 로고    scopus 로고
    • Design of curcumin-loaded PLGA nanoparticles formulation with enhanced cellular uptake, and increased bioactivity in vitro and superior bioavailability in vivo
    • Anand P, Nair HB, Sung B, et al. Design of curcumin-loaded PLGA nanoparticles formulation with enhanced cellular uptake, and increased bioactivity in vitro and superior bioavailability in vivo. Biochem Pharmacol 2010;79:330-8
    • (2010) Biochem Pharmacol , vol.79 , pp. 330-338
    • Anand, P.1    Nair, H.B.2    Sung, B.3
  • 62
    • 0032926620 scopus 로고    scopus 로고
    • Biotransformation of curcumin through reduction and glucuronidation in mice
    • Pan MH, Huang TM, Lin JK. Biotransformation of curcumin through reduction and glucuronidation in mice. Drug Metab Dispos 1999;27:486-94
    • (1999) Drug Metab Dispos , vol.27 , pp. 486-494
    • Pan, M.H.1    Huang, T.M.2    Lin, J.K.3
  • 64
    • 58149084882 scopus 로고    scopus 로고
    • A Pilot Cross-Over Study to Evaluate Human Oral Bioavailability of BCM-95-CG (Biocurcumax-), A Novel Bioenhanced Preparation of Curcumin
    • Antony B, Merina B, Iyer V, et al. A Pilot Cross-Over Study to Evaluate Human Oral Bioavailability of BCM-95-CG (Biocurcumax-), A Novel Bioenhanced Preparation of Curcumin. Indian J Pharm Sci 2008;70:445-9
    • (2008) Indian J Pharm Sci , Issue.70 , pp. 445-449
    • Antony, B.1    Merina, B.2    Iyer, V.3
  • 66
    • 0031976901 scopus 로고    scopus 로고
    • Curcumin and curcumin derivatives inhibit Tat-mediated transactivation of type 1 human immunodeficiency virus long terminal repeat
    • DOI 10.1016/S0923-2516(97)86899-9
    • Barthelemy S, Vergnes L, Moynier M, et al. Curcumin and curcumin derivatives inhibit Tat-mediated transactivation of type 1 human immunodeficiency virus long terminal repeat. Res Virol 1998;149:43-52 (Pubitemid 28162429)
    • (1998) Research in Virology , vol.149 , Issue.1 , pp. 43-52
    • Barthelemy, S.1    Vergnes, L.2    Moynier, M.3    Guyot, D.4    Labidalle, S.5    Bahraoui, E.6
  • 67
    • 0141558921 scopus 로고    scopus 로고
    • Design and synthesis of curcumin-bioconjugates to improve systemic delivery
    • Kumar S, Dubey KK, Tripathi S, et al. Design and synthesis of curcumin-bioconjugates to improve systemic delivery. Nucleic Acids Symp Ser 2000;(44):75-6
    • (2000) Nucleic Acids Symp Ser , vol.44 , pp. 75-76
    • Kumar, S.1    Dubey, K.K.2    Tripathi, S.3
  • 69
    • 40949164269 scopus 로고    scopus 로고
    • Synthesis and exploration of novel curcumin analogues as anti-malarial agents
    • DOI 10.1016/j.bmc.2007.12.054, PII S0968089607011248
    • Mishra S, Karmodiya K, Surolia N, et al. Synthesis and exploration of novel curcumin analogues as anti-malarial agents. Bioorg Med Chem 2008;16:2894-902 (Pubitemid 351418213)
    • (2008) Bioorganic and Medicinal Chemistry , vol.16 , Issue.6 , pp. 2894-2902
    • Mishra, S.1    Karmodiya, K.2    Surolia, N.3    Surolia, A.4
  • 70
    • 33646082493 scopus 로고    scopus 로고
    • Apoptosis-inducing effects of curcumin derivatives in human bladder cancer cells
    • Tong QS, Zheng LD, Lu P, et al. Apoptosis-inducing effects of curcumin derivatives in human bladder cancer cells. Anticancer Drugs 2006;17:279-87
    • (2006) Anticancer Drugs , vol.17 , pp. 279-287
    • Tong, Q.S.1    Zheng, L.D.2    Lu, P.3
  • 71
    • 84877578131 scopus 로고    scopus 로고
    • Attenuation of high-glucose-induced inflammatory response by a novel curcumin derivative B06 contributes to its protection from diabetic pathogenic changes in rat kidney and heart
    • Epub ahead of print
    • Pana Y, Zhub G, Wanga Y, et al. Attenuation of high-glucose-induced inflammatory response by a novel curcumin derivative B06 contributes to its protection from diabetic pathogenic changes in rat kidney and heart. J Nutr Biochem 2012; Epub ahead of print
    • (2012) J Nutr Biochem
    • Pana, Y.1    Zhub, G.2    Wanga, Y.3
  • 72
    • 79954580263 scopus 로고    scopus 로고
    • Brain and spinal cord interaction: A dietary curcumin derivative counteracts locomotor and cognitive deficits after brain trauma
    • Wu A, Ying Z, Schubert D, et al. Brain and spinal cord interaction: A dietary curcumin derivative counteracts locomotor and cognitive deficits after brain trauma. Neurorehabil Neural Repair 2011;25:332-42
    • (2011) Neurorehabil Neural Repair , Issue.25 , pp. 332-342
    • Wu, A.1    Ying, Z.2    Schubert, D.3
  • 73
    • 84863113557 scopus 로고    scopus 로고
    • Barrier protective activities of curcumin and its derivative
    • Kim DC, Ku SK, Lee W, et al. Barrier protective activities of curcumin and its derivative. Inflamm Res 2012;61:437-44
    • (2012) Inflamm Res , vol.61 , pp. 437-444
    • Kim, D.C.1    Ku, S.K.2    Lee, W.3
  • 75
    • 34247880427 scopus 로고    scopus 로고
    • Curcuminoids, curcumin, and demethoxycurcumin reduce lead-induced memory deficits in male Wistar rats
    • Dairam A, Limson JL, Watkins GM, et al. Curcuminoids, curcumin, and demethoxycurcumin reduce lead-induced memory deficits in male Wistar rats. J Agric Food Chem 2007;55:1039-44
    • (2007) J Agric Food Chem , vol.55 , pp. 1039-1044
    • Dairam, A.1    Limson, J.L.2    Watkins, G.M.3
  • 77
    • 0032479574 scopus 로고    scopus 로고
    • Inhibitory effect of curcuminoids on MCF-7 cell proliferation and structure-activity relationships
    • DOI 10.1016/S0304-3835(98)00092-5, PII S0304383598000925
    • Simon A, Allais DP, Duroux JL, et al. Inhibitory effect of curcuminoids on MCF-7 cell proliferation and structure-activity relationships. Cancer Lett 1998;129:111-16 (Pubitemid 28375245)
    • (1998) Cancer Letters , vol.129 , Issue.1 , pp. 111-116
    • Simon, A.1    Allais, D.P.2    Duroux, J.L.3    Basly, J.P.4    Durand-Fontanier, S.5    Delage, C.6
  • 78
    • 64049090200 scopus 로고    scopus 로고
    • Synthesis, cytotoxic and combined cDDP activity of new stable curcumin derivatives
    • Ferrari E, Lazzari S, Marverti G, et al. Synthesis, cytotoxic and combined cDDP activity of new stable curcumin derivatives. Bioorg Med Chem 2009;17:3043-52
    • (2009) Bioorg Med Chem , vol.17 , pp. 3043-3052
    • Ferrari, E.1    Lazzari, S.2    Marverti, G.3
  • 79
    • 62149086696 scopus 로고    scopus 로고
    • Exploration and synthesis of curcumin analogues with improved structural stability both in vitro and in vivo as cytotoxic agents
    • Liang G, Shao L, Wang Y, et al. Exploration and synthesis of curcumin analogues with improved structural stability both in vitro and in vivo as cytotoxic agents. Bioorg Med Chem 2009;17:2623-31
    • (2009) Bioorg Med Chem , vol.17 , pp. 2623-2631
    • Liang, G.1    Shao, L.2    Wang, Y.3
  • 80
    • 65349175650 scopus 로고    scopus 로고
    • Newly synthesized curcumin analog has improved potential to prevent colorectal carcinogenesis in vivo
    • Shibata H, Yamakoshi H, Sato A, et al. Newly synthesized curcumin analog has improved potential to prevent colorectal carcinogenesis in vivo. Cancer Sci 2009;100:956-60
    • (2009) Cancer Sci , vol.100 , pp. 956-960
    • Shibata, H.1    Yamakoshi, H.2    Sato, A.3
  • 82
    • 79959202798 scopus 로고    scopus 로고
    • PAC, a novel curcumin analogue, has anti-breast cancer properties with higher efficiency on ER-negative cells
    • Al-Hujaily EM, Mohamed AG, Al-Sharif I, et al. PAC, a novel curcumin analogue, has anti-breast cancer properties with higher efficiency on ER-negative cells. Breast Cancer Res Treat 2011;128:97-107
    • (2011) Breast Cancer Res Treat , vol.128 , pp. 97-107
    • Al-Hujaily, E.M.1    Mohamed, A.G.2    Al-Sharif, I.3
  • 83
    • 77957677097 scopus 로고    scopus 로고
    • Cancer nanotechnology: Application of nanotechnology in cancer therapy
    • Misra R, Acharya S, Sahoo SK. Cancer nanotechnology: Application of nanotechnology in cancer therapy. Drug Discov Today 2010;15:842-50
    • (2010) Drug Discov Today , vol.15 , pp. 842-850
    • Misra, R.1    Acharya, S.2    Sahoo, S.K.3
  • 84
    • 41849105252 scopus 로고    scopus 로고
    • Lipid-based colloidal carriers for peptide and protein delivery-liposomes versus lipid nanoparticles
    • Martins S, Sarmento B, Ferreira DC, et al. Lipid-based colloidal carriers for peptide and protein delivery-liposomes versus lipid nanoparticles. Int J Nanomedicine 2007;2:595-607
    • (2007) Int J Nanomedicine , vol.2 , pp. 595-607
    • Martins, S.1    Sarmento, B.2    Ferreira, D.C.3
  • 85
    • 77953283407 scopus 로고    scopus 로고
    • Lipid nanoparticles: Effect on bioavailability and pharmacokinetic changes
    • Souto EB, Muller RH. Lipid nanoparticles: effect on bioavailability and pharmacokinetic changes. Handb Exp Pharmacol 2010(197):115-41
    • (2010) Handb Exp Pharmacol , Issue.197 , pp. 115-141
    • Souto, E.B.1    Muller, R.H.2
  • 86
    • 70450172133 scopus 로고    scopus 로고
    • A special issue on Lipid-based delivery systems (liposomes, lipid nanoparticles, lipid matrices and medicines)
    • Souto EB. A special issue on Lipid-based delivery systems (liposomes, lipid nanoparticles, lipid matrices and medicines). J Biomed Nanotechnol 2009;5:315-16
    • (2009) J Biomed Nanotechnol , vol.5 , pp. 315-316
    • Souto, E.B.1
  • 87
    • 78649812260 scopus 로고    scopus 로고
    • Pharmacokinetic applicability of a validated liquid chromatography tandem mass spectroscopy method for orally administered curcumin loaded solid lipid nanoparticles to rats
    • Kakkar V, Singh S, Singla D, et al. Pharmacokinetic applicability of a validated liquid chromatography tandem mass spectroscopy method for orally administered curcumin loaded solid lipid nanoparticles to rats. J Chromatogr B Analyt Technol Biomed Life Sci 2010;878:3427-31
    • (2010) J Chromatogr B Analyt Technol Biomed Life Sci , vol.878 , pp. 3427-3431
    • Kakkar, V.1    Singh, S.2    Singla, D.3
  • 89
    • 61849105340 scopus 로고    scopus 로고
    • Anti-malarial activities of Andrographis paniculata and Hedyotis corymbosa extracts and their combination with curcumin
    • Mishra K, Dash AP, Swain BK, et al. Anti-malarial activities of Andrographis paniculata and Hedyotis corymbosa extracts and their combination with curcumin. Malar J 2009;8:26
    • (2009) Malar J , vol.8 , pp. 26
    • Mishra, K.1    Dash, A.P.2    Swain, B.K.3
  • 90
    • 77956009968 scopus 로고    scopus 로고
    • Curcuminoids-loaded lipid nanoparticles: Novel approach towards malaria treatment
    • Nayak AP, Tiyaboonchai W, Patankar S, et al. Curcuminoids-loaded lipid nanoparticles: novel approach towards malaria treatment. Colloids Surf B Biointerfaces 2010;81:263-73
    • (2010) Colloids Surf B Biointerfaces , vol.81 , pp. 263-273
    • Nayak, A.P.1    Tiyaboonchai, W.2    Patankar, S.3
  • 91
    • 80755172277 scopus 로고    scopus 로고
    • Nanosuspensions in drug delivery: Recent advances, patent scenarios, and commercialization aspects
    • Chavhan SS, Petkar KC, Sawant KK. Nanosuspensions in drug delivery: recent advances, patent scenarios, and commercialization aspects. Crit Rev Ther Drug Carrier Syst 2011;28:447-88
    • (2011) Crit Rev Ther Drug Carrier Syst , vol.28 , pp. 447-488
    • Chavhan, S.S.1    Petkar, K.C.2    Sawant, K.K.3
  • 92
  • 93
    • 0029080002 scopus 로고
    • Particle size reduction for improvement of oral bioavailability of hydrophobic drugs: I. Absolute oral bioavailability of nanocrystalline danazol in beagle dogs
    • Liversidge G, Cundy K. Particle size reduction for improvement of oral bioavailability of hydrophobic drugs: I. Absolute oral bioavailability of nanocrystalline danazol in beagle dogs. Int J Pharm 1995;125:91-7
    • (1995) Int J Pharm , vol.125 , pp. 91-97
    • Liversidge, G.1    Cundy, K.2
  • 94
    • 78650778104 scopus 로고    scopus 로고
    • Preparation and characterization of intravenously injectable curcumin nanosuspension
    • Gao Y, Li Z, Sun M, et al. Preparation and characterization of intravenously injectable curcumin nanosuspension. Drug Deliv 2011;18:131-42
    • (2011) Drug Deliv , Issue.18 , pp. 131-142
    • Gao, Y.1    Li, Z.2    Sun, M.3
  • 96
    • 74249109604 scopus 로고    scopus 로고
    • Bioavailability and delivery of nutraceuticals using nanotechnology
    • Huang Q, Yu H, Ru Q. Bioavailability and delivery of nutraceuticals using nanotechnology. J Food Sci 2011;75:R50-7
    • (2011) J Food Sci , vol.75
    • Huang, Q.1    Yu, H.2    Ru, Q.3
  • 97
    • 77949844000 scopus 로고    scopus 로고
    • Formulation design and photochemical studies on nanocrystal solid dispersion of curcumin with improved oral bioavailability
    • Onoue S, Takahashi H, Kawabata Y, et al. Formulation design and photochemical studies on nanocrystal solid dispersion of curcumin with improved oral bioavailability. J Pharm Sci 2010;99:1871-81
    • (2010) J Pharm Sci , vol.99 , pp. 1871-81
    • Onoue, S.1    Takahashi, H.2    Kawabata, Y.3
  • 98
    • 79952024052 scopus 로고    scopus 로고
    • Pharmacokinetics of dietary cancer chemopreventive compound dibenzoylmethane in rats and the impact of nanoemulsion and genetic knockout of Nrf2 on its disposition
    • Lin W, Hong JL, Shen G, et al. Pharmacokinetics of dietary cancer chemopreventive compound dibenzoylmethane in rats and the impact of nanoemulsion and genetic knockout of Nrf2 on its disposition. Biopharm Drug Dispos 2010;32:65-75
    • (2010) Biopharm Drug Dispos , vol.32 , pp. 65-75
    • Lin, W.1    Hong, J.L.2    Shen, G.3
  • 99
    • 84861632327 scopus 로고    scopus 로고
    • Improving the oral bioavailability of curcumin using novel organogel-based nanoemulsions
    • Yu H, Huang Q. Improving the oral bioavailability of curcumin using novel organogel-based nanoemulsions. J Agric Food Chem 2012;60:5373-9
    • (2012) J Agric Food Chem , vol.60 , pp. 5373-5379
    • Yu, H.1    Huang, Q.2
  • 101
    • 78049522183 scopus 로고    scopus 로고
    • Curcumin-loaded hydrogel nanoparticles: Application in anti-malarial therapy and toxicological evaluation
    • Dandekar PP, Jain R, Patil S, et al. Curcumin-loaded hydrogel nanoparticles: Application in anti-malarial therapy and toxicological evaluation. J Pharm Sci 2010;99:4992-5010
    • (2010) J Pharm Sci , vol.99 , pp. 4992-5010
    • Dandekar, P.P.1    Jain, R.2    Patil, S.3
  • 102
    • 28844433357 scopus 로고    scopus 로고
    • The preparation of silybin-phospholipid complex and the study on its pharmacokinetics in rats
    • DOI 10.1016/j.ijpharm.2005.10.001, PII S0378517305006472
    • Yanyu X, Yunmei S, Zhipeng C, et al. The preparation of silybin-phospholipid complex and the study on its pharmacokinetics in rats. Int J Pharm 2006;307:77-82 (Pubitemid 41773254)
    • (2006) International Journal of Pharmaceutics , vol.307 , Issue.1 , pp. 77-82
    • Yanyu, X.1    Yunmei, S.2    Zhipeng, C.3    Qineng, P.4
  • 103
    • 77957725143 scopus 로고    scopus 로고
    • Complexation with phosphatidyl choline as a strategy for absorption enhancement of boswellic acid
    • Sharma A, Gupta NK, Dixit VK. Complexation with phosphatidyl choline as a strategy for absorption enhancement of boswellic acid. Drug Deliv 2010;17:587-95
    • (2010) Drug Deliv , vol.17 , pp. 587-595
    • Sharma, A.1    Gupta, N.K.2    Dixit, V.K.3
  • 104
    • 79952238275 scopus 로고    scopus 로고
    • Bioavailability enhancement of curcumin by complexation with phosphatidyl choline
    • Gupta NK, Dixit VK. Bioavailability enhancement of curcumin by complexation with phosphatidyl choline. J Pharm Sci 2011;100:1987-95
    • (2011) J Pharm Sci , vol.100 , pp. 1987-1995
    • Gupta, N.K.1    Dixit, V.K.2
  • 105
    • 79955411920 scopus 로고    scopus 로고
    • Comparative absorption of a standardized curcuminoid mixture and its lecithin formulation
    • Cuomo J, Appendino G, Dern AS, et al. Comparative absorption of a standardized curcuminoid mixture and its lecithin formulation. J Nat Prod 2011;74:664-9
    • (2011) J Nat Prod , vol.74 , pp. 664-669
    • Cuomo, J.1    Appendino, G.2    Dern, A.S.3
  • 106
    • 84856452267 scopus 로고    scopus 로고
    • Liposomal drug formulations in cancer therapy: 15 years along the road
    • Slingerland M, Guchelaar HJ, Gelderblom H. Liposomal drug formulations in cancer therapy: 15 years along the road. Drug Discov Today 2011;17:160-6
    • (2011) Drug Discov Today , vol.17 , pp. 160-166
    • Slingerland, M.1    Guchelaar, H.J.2    Gelderblom, H.3
  • 107
    • 80052385786 scopus 로고    scopus 로고
    • Metabolic and pharmacokinetic studies of curcumin, demethoxycurcumin and bisdemethoxycurcumin in mice tumor after intragastric administration of nanoparticle formulations by liquid chromatography coupled with tandem mass spectrometry
    • Li R, Qiao X, Li Q, et al. Metabolic and pharmacokinetic studies of curcumin, demethoxycurcumin and bisdemethoxycurcumin in mice tumor after intragastric administration of nanoparticle formulations by liquid chromatography coupled with tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci 2011;879:2751-8
    • (2011) J Chromatogr B Analyt Technol Biomed Life Sci , Issue.879 , pp. 2751-2758
    • Li, R.1    Qiao, X.2    Li, Q.3
  • 108
    • 0028180311 scopus 로고
    • Liposomal doxorubicin in the treatment of advanced AIDS-related Kaposi sarcoma
    • Bogner JR, Kronawitter U, Rolinski B, et al. Liposomal doxorubicin in the treatment of advanced AIDS-related Kaposi sarcoma. J Acquir Immune Defic Syndr 1994;7:463-8
    • (1994) J Acquir Immune Defic Syndr , vol.7 , pp. 463-468
    • Bogner, J.R.1    Kronawitter, U.2    Rolinski, B.3
  • 109
    • 79952814944 scopus 로고    scopus 로고
    • Cyclodextrin-mediated entrapment of curcuminoid 4-[3,5-bis(2- chlorobenzylidene-4-oxo-piperidine-1-yl)-4-oxo-2-butenoic acid] or CLEFMA in liposomes for treatment of xenograft lung tumor in rats
    • Agashe H, Sahoo K, Lagisetty P, et al. Cyclodextrin-mediated entrapment of curcuminoid 4-[3,5-bis(2-chlorobenzylidene-4-oxo-piperidine-1-yl)-4-oxo-2- butenoic acid] or CLEFMA in liposomes for treatment of xenograft lung tumor in rats. Colloids Surf B Biointerfaces 2011;84:329-37
    • (2011) Colloids Surf B Biointerfaces , Issue.84 , pp. 329-337
    • Agashe, H.1    Sahoo, K.2    Lagisetty, P.3
  • 111
    • 58149165086 scopus 로고    scopus 로고
    • Liposome-encapsulated curcumin suppresses growth of head and neck squamous cell carcinoma in vitro and in xenografts through the inhibition of nuclear factor kappaB by an AKT-independent pathway
    • Wang D, Veena MS, Stevenson K, et al. Liposome-encapsulated curcumin suppresses growth of head and neck squamous cell carcinoma in vitro and in xenografts through the inhibition of nuclear factor kappaB by an AKT-independent pathway. Clin Cancer Res 2008;14:6228-36
    • (2008) Clin Cancer Res , vol.14 , pp. 6228-6236
    • Wang, D.1    Veena, M.S.2    Stevenson, K.3
  • 112
    • 34248205135 scopus 로고    scopus 로고
    • Polymeric nanoparticle-encapsulated curcumin ("nanocurcumin"): A novel strategy for human cancer therapy
    • Bisht S, Feldmann G, Soni S, et al. Polymeric nanoparticle-encapsulated curcumin ("nanocurcumin"): A novel strategy for human cancer therapy. J Nanobiotechnol 2007;5:3
    • (2007) J Nanobiotechnol , vol.5 , pp. 3
    • Bisht, S.1    Feldmann, G.2    Soni, S.3
  • 113
    • 77955485060 scopus 로고    scopus 로고
    • Systemic administration of polymeric nanoparticle-encapsulated curcumin (NanoCurc) blocks tumor growth and metastases in preclinical models of pancreatic cancer
    • Bisht S, Mizuma M, Feldmann G, et al. Systemic administration of polymeric nanoparticle-encapsulated curcumin (NanoCurc) blocks tumor growth and metastases in preclinical models of pancreatic cancer. Mol Cancer Ther 2010;9:2255-64
    • (2010) Mol Cancer Ther , vol.9 , pp. 2255-2264
    • Bisht, S.1    Mizuma, M.2    Feldmann, G.3
  • 114
    • 34248403310 scopus 로고    scopus 로고
    • High-performance liquid chromatography analysis of curcumin in rat plasma: Application to pharmacokinetics of polymeric micellar formulation of curcumin
    • DOI 10.1002/bmc.795
    • Ma Z, Shayeganpour A, Brocks DR, et al. High-performance liquid chromatography analysis of curcumin in rat plasma: Application to pharmacokinetics of polymeric micellar formulation of curcumin. Biomed Chromatogr 2007;21:546-52 (Pubitemid 46736190)
    • (2007) Biomedical Chromatography , vol.21 , Issue.5 , pp. 546-552
    • Ma, Z.1    Shayeganpour, A.2    Brocks, D.R.3    Lavasanifar, A.4    Samuel, J.5
  • 115
    • 78650179595 scopus 로고    scopus 로고
    • Curcumin-loaded PLGA-PEG-PLGA triblock copolymeric micelles: Preparation, pharmacokinetics and distribution in vivo
    • Song Z, Feng R, Sun M, et al. Curcumin-loaded PLGA-PEG-PLGA triblock copolymeric micelles: Preparation, pharmacokinetics and distribution in vivo. J Colloid Interface Sci 2011;354:116-23
    • (2011) J Colloid Interface Sci , vol.354 , pp. 116-123
    • Song, Z.1    Feng, R.2    Sun, M.3
  • 116
    • 84858119036 scopus 로고    scopus 로고
    • Dendrimers bind antioxidant polyphenols and cisplatin drug
    • Abderrezak A, Bourassa P, Mandeville JS, et al. Dendrimers bind antioxidant polyphenols and cisplatin drug. PLoS One 2012;7:e33102
    • (2012) PLoS One , Issue.7
    • Abderrezak, A.1    Bourassa, P.2    Mandeville, J.S.3
  • 117
    • 38349130550 scopus 로고    scopus 로고
    • Synthesis of monofunctional curcumin derivatives, clicked curcumin dimer, and a PAMAM dendrimer curcumin conjugate for therapeutic applications
    • Shi W, Dolai S, Rizk S, et al. Synthesis of monofunctional curcumin derivatives, clicked curcumin dimer, and a PAMAM dendrimer curcumin conjugate for therapeutic applications. Org Lett 2007;9:5461-4
    • (2007) Org Lett , vol.9 , pp. 5461-5464
    • Shi, W.1    Dolai, S.2    Rizk, S.3
  • 118
    • 79956154340 scopus 로고    scopus 로고
    • Mucoadhesive curcumin nanospheres: Biological activity, adhesion to stomach mucosa and release of curcumin into the circulation
    • Suwannateep N, Banlunara W, Wanichwecharungruang SP, et al. Mucoadhesive curcumin nanospheres: biological activity, adhesion to stomach mucosa and release of curcumin into the circulation. J Control Release 2011;151:176-82
    • (2011) J Control Release , vol.151 , pp. 176-182
    • Suwannateep, N.1    Banlunara, W.2    Wanichwecharungruang, S.P.3
  • 119
    • 80052312305 scopus 로고    scopus 로고
    • Curcumin-loaded lipid and polymeric nanocapsules stabilized by nonionic surfactants: An in vitro and In vivo antitumor activity on B16-F10 melanoma and macrophage uptake comparative study
    • Mazzarino L, Silva LF, Curta JC, et al. Curcumin-loaded lipid and polymeric nanocapsules stabilized by nonionic surfactants: An in vitro and In vivo antitumor activity on B16-F10 melanoma and macrophage uptake comparative study. J Biomed Nanotechnol 2011;7:406-14
    • (2011) J Biomed Nanotechnol , Issue.7 , pp. 406-414
    • Mazzarino, L.1    Silva, L.F.2    Curta, J.C.3
  • 120
    • 84855446953 scopus 로고    scopus 로고
    • Transferrin-conjugated curcumin-loaded superparamagnetic iron oxide nanoparticles induce augmented cellular uptake and apoptosis in K562 cells
    • Dilnawaz F, Singh A, Sahoo SK. Transferrin-conjugated curcumin-loaded superparamagnetic iron oxide nanoparticles induce augmented cellular uptake and apoptosis in K562 cells. Acta Biomater 2012;8:704-19
    • (2012) Acta Biomater , vol.8 , pp. 704-719
    • Dilnawaz, F.1    Singh, A.2    Sahoo, S.K.3
  • 121
    • 84866772589 scopus 로고    scopus 로고
    • Curcumin-loaded magnetic nanoparticles for breast cancer therapeutics and imaging applications
    • Yallapu MM, Othman SF, Curtis ET, et al. Curcumin-loaded magnetic nanoparticles for breast cancer therapeutics and imaging applications. Int J Nanomedicine 2012;7:1761-79
    • (2012) Int J Nanomedicine , vol.7 , pp. 1761-1779
    • Yallapu, M.M.1    Othman, S.F.2    Curtis, E.T.3
  • 122
    • 78049295075 scopus 로고    scopus 로고
    • Development and evaluation of self-microemulsifying liquid and pellet formulations of curcumin, and absorption studies in rats
    • Setthacheewakul S, Mahattanadul S, Phadoongsombut N, et al. Development and evaluation of self-microemulsifying liquid and pellet formulations of curcumin, and absorption studies in rats. Eur J Pharm Biopharm 2010;76:475-85
    • (2010) Eur J Pharm Biopharm , Issue.76 , pp. 475-485
    • Setthacheewakul, S.1    Mahattanadul, S.2    Phadoongsombut, N.3
  • 123
    • 77955665447 scopus 로고    scopus 로고
    • Cyclodextrin-complexed curcumin exhibits anti-inflammatory and antiproliferative activities superior to those of curcumin through higher cellular uptake
    • Yadav VR, Prasad S, Kannappan R, et al. Cyclodextrin-complexed curcumin exhibits anti-inflammatory and antiproliferative activities superior to those of curcumin through higher cellular uptake. Biochem Pharmacol 2010;80:1021-32
    • (2010) Biochem Pharmacol , vol.80 , pp. 1021-1032
    • Yadav, V.R.1    Prasad, S.2    Kannappan, R.3
  • 124
    • 84856974148 scopus 로고    scopus 로고
    • Preparation and pharmacokinetic evaluation of curcumin solid dispersion using Solutol(R) HS15 as a carrier
    • Seo SW, Han HK, Chun MK, et al. Preparation and pharmacokinetic evaluation of curcumin solid dispersion using Solutol(R) HS15 as a carrier. Int J Pharm 2012;424:18-25
    • (2012) Int J Pharm , Issue.424 , pp. 18-25
    • Seo, S.W.1    Han, H.K.2    Chun, M.K.3
  • 125
    • 67049117980 scopus 로고    scopus 로고
    • Encapsulation and sustained release of curcumin using superparamagnetic silica reservoirs
    • Chin SF, Iyer KS, Saunders M, et al. Encapsulation and sustained release of curcumin using superparamagnetic silica reservoirs. Chemistry (Easton) 2009;15:5661-5
    • (2009) Chemistry (Easton) , Issue.15 , pp. 5661-5665
    • Chin, S.F.1    Iyer, K.S.2    Saunders, M.3
  • 126
    • 84856725493 scopus 로고    scopus 로고
    • Dose-escalation and pharmacokinetic study of nanoparticle curcumin, a potential anticancer agent with improved bioavailability, in healthy human volunteers
    • Kanai M, Imaizumi A, Otsuka Y, et al. Dose-escalation and pharmacokinetic study of nanoparticle curcumin, a potential anticancer agent with improved bioavailability, in healthy human volunteers. Cancer Chemother Pharmacol 2012;69:65-70
    • (2012) Cancer Chemother Pharmacol , vol.69 , pp. 65-70
    • Kanai, M.1    Imaizumi, A.2    Otsuka, Y.3
  • 127
    • 46949106134 scopus 로고    scopus 로고
    • The long and short of carbon nanotube toxicity
    • DOI 10.1038/nbt0708-774, PII NBT0708774
    • Kostarelos K. The long and short of carbon nanotube toxicity. Nat Biotechnol 2008;26:774-6 (Pubitemid 351961446)
    • (2008) Nature Biotechnology , vol.26 , Issue.7 , pp. 774-776
    • Kostarelos, K.1
  • 128
    • 33645744010 scopus 로고    scopus 로고
    • A review of carbon nanotube toxicity and assessment of potential occupational and environmental health risks
    • Lam CW, James JT, McCluskey R, et al. A review of carbon nanotube toxicity and assessment of potential occupational and environmental health risks. Crit Rev Toxicol 2006;36:189-217
    • (2006) Crit Rev Toxicol , vol.36 , pp. 189-217
    • Lam, C.W.1    James, J.T.2    McCluskey, R.3
  • 129
    • 79955701862 scopus 로고    scopus 로고
    • Design, synthesis and evaluation of novel PEGylated curcumin analogs as potent Nrf2 activators in human bronchial epithelial cells
    • Pandey MK, Kumar S, Thimmulappa RK, et al. Design, synthesis and evaluation of novel PEGylated curcumin analogs as potent Nrf2 activators in human bronchial epithelial cells. Eur J Pharm Sci 2011;43:16-24
    • (2011) Eur J Pharm Sci , vol.43 , pp. 16-24
    • Pandey, M.K.1    Kumar, S.2    Thimmulappa, R.K.3
  • 130
    • 79952341098 scopus 로고    scopus 로고
    • A polymeric nanoparticle formulation of curcumin inhibits growth, clonogenicity and stem-like fraction in malignant brain tumors
    • Lim KJ, Bisht S, Bar EE, et al. A polymeric nanoparticle formulation of curcumin inhibits growth, clonogenicity and stem-like fraction in malignant brain tumors. Cancer Biol Ther 2011;11:464-73
    • (2011) Cancer Biol Ther , Issue.11 , pp. 464-473
    • Lim, K.J.1    Bisht, S.2    Bar, E.E.3
  • 131
    • 84861507321 scopus 로고    scopus 로고
    • Neuronal uptake and neuroprotective effect of curcumin-loaded PLGA nanoparticles on the human SK-N-SH cell line
    • Doggui S, Sahni JK, Arseneault M, et al. Neuronal uptake and neuroprotective effect of curcumin-loaded PLGA nanoparticles on the human SK-N-SH cell line. J Alzheimers Dis 2012;30:377-92
    • (2012) J Alzheimers Dis , Issue.30 , pp. 377-392
    • Doggui, S.1    Sahni, J.K.2    Arseneault, M.3
  • 132
    • 79957890122 scopus 로고    scopus 로고
    • Sustained targeting of Bcr-Abl + leukemia cells by synergistic action of dual drug loaded nanoparticles and its implication for leukemia therapy
    • Acharya S, Sahoo SK. Sustained targeting of Bcr-Abl + leukemia cells by synergistic action of dual drug loaded nanoparticles and its implication for leukemia therapy. Biomaterials 2012;32:5643-62
    • (2012) Biomaterials , vol.32 , pp. 5643-5662
    • Acharya, S.1    Sahoo, S.K.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.