Antiglioma activity of curcumin-loaded lipid nanoparticles and its enhanced bioavailability in brain tissue for effective glioblastoma therapy

Acta Biomaterialia

Volumn 8, Issue 7, 2012, Pages 2670-2687

  Kundu, Paromita ^a   Mohanty, Chandana ^a   Sahoo, Sanjeeb K ^a  

^a INSTITUTE OF LIFE SCIENCES   (India)

Author keywords

Blood brain barrier; Curcumin; Glioblastoma; Multi drug resistance proteins; Telomerase

Indexed keywords

BIOCHEMISTRY; BLOOD; CELL DEATH; CELL PROLIFERATION; CONTROLLED DRUG DELIVERY; NANOPARTICLES; PROTEINS; TARGETED DRUG DELIVERY; TUMORS;

BLOOD-BRAIN BARRIER; BRAIN TISSUE; CELLULAR PROLIFERATIONS; CURCUMIN; GLIOBLASTOMAS; GLIOMA CELLS; GLYCERYL MONOOLEATE; HIGH RATE; MULTI DRUG RESISTANCE PROTEINS; TELOMERASE;

BRAIN;

ALPHA TOCOPHEROL; BETA ACTIN; CASPASE 8; CASPASE 9; CURCUMIN; CYTOCHROME C; DEXTRO ALPHA TOCOPHERYL POLYETHYLENE GLYCOL 1000 SUCCINATE; GLYCEROL OLEATE; LIPID NANOPARTICLE; MESSENGER RNA; MULTIDRUG RESISTANCE PROTEIN; MULTIDRUG RESISTANCE PROTEIN 1; NANOPARTICLE; POLOXAMER; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BID; STAT3 PROTEIN; TELOMERASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; BLOOD BRAIN BARRIER; BRAIN TISSUE; CANCER CELL CULTURE; CANCER INHIBITION; CANCER THERAPY; CELL CYCLE ARREST; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL INVASION; CELL MIGRATION; CELL PROLIFERATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG CYTOTOXICITY; DRUG DELIVERY SYSTEM; DRUG EFFICACY; DRUG FORMULATION; DRUG MECHANISM; DRUG METABOLISM; DRUG PENETRATION; ENZYME INHIBITION; GLIOBLASTOMA; GLIOMA CELL; IN VIVO STUDY; MALE; NONHUMAN; PARTICLE SIZE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT;

RATTUS;

EID: 84861646477     PISSN: 17427061     EISSN: 18787568     Source Type: Journal    
DOI: 10.1016/j.actbio.2012.03.048     Document Type: Article

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