Curcumin, a Major Constituent of Turmeric, Corrects Cystic Fibrosis Defects

Science

Volumn 304, Issue 5670, 2004, Pages 600-602

  Egan, Marie E ^a   Pearson, Marilyn ^a   Weiner, Scott A ^a   Rajendran, Vanathy ^a   Rubin, Daniel ^a   Glöckner Pagel, Judith ^a   Canny, Susan ^a   Du, Kai ^b   Lukacs, Gergely L ^b   Caplan, Michael J ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b HOSPITAL FOR SICK CHILDREN   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CELL MEMBRANES; GENES; MUTAGENESIS; PROTEINS;

CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR (CFTR); ENDOPLASMIC RETICULUM;

GENETIC ENGINEERING;

ADENOSINE TRIPHOSPHATASE (CALCIUM); CURCUMIN; TRANSMEMBRANE CONDUCTANCE REGULATOR;

MEDICINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL MEMBRANE; CELL STRAIN BHK; CONTROLLED STUDY; CURCUMA LONGA; CYSTIC FIBROSIS; ENDOPLASMIC RETICULUM; GENE EXPRESSION; GENE MUTATION; GENETIC TRANSFECTION; HOMOZYGOSITY; KNOCKOUT GENE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FOLDING;

ANIMALS; CALCIUM; CALNEXIN; CELL LINE; CELL MEMBRANE; CRICETINAE; CURCUMIN; CYSTIC FIBROSIS; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; ELECTROLYTES; ENDOPLASMIC RETICULUM; GENE TARGETING; GLYCOSYLATION; HUMANS; INTESTINAL MUCOSA; INTESTINAL OBSTRUCTION; ISOPROTERENOL; MEMBRANE POTENTIALS; MICE; MICE, KNOCKOUT; MUTATION; NASAL MUCOSA; POLYETHYLENE GLYCOLS; PROTEIN FOLDING; RECTUM; TRANSFECTION;

ANIMALIA; CRICETINAE; CURCUMA; CURCUMA LONGA;

EID: 11144355340     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1093941     Document Type: Article

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28. The authors are grateful to M. Drumm for the gift of the ΔF508 CFTR mice, B. Grubb for the gift of the CFTR knockout mice, J. Riordan for the gift of the CHO cells expressing ΔF508 CFTR, and to M. Nantz, H. K. Bottomly, J. Burger, and members of the Egan and Caplan lab groups for helpful suggestions and careful readings of the manuscript. This work was supported by the Alyward Family/Pitney Bowes Gift Fund, Cystic Fibrosis Foundation Research grants EGAN03G0 and CAPLAN03G0, NIH grants DK53428 (M.E.E.), GM42136 (M.J.C.), and DK17433 (M.J.C.), Canadian Institutes of Health Research and Canadian Cystic Fibrosis Foundation grants (G.L.L.), and a sponsored research grant from Seer Pharmaceuticals. The technology described in this paper has been licensed by Yale University to Seer Pharmaceuticals.