Pharmacokinetic applicability of a validated liquid chromatography tandem mass spectroscopy method for orally administered curcumin loaded solid lipid nanoparticles to rats

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 878, Issue 32, 2010, Pages 3427-3431

  Kakkar, Vandita ^a   Singh, Sukhjeet ^b   Singla, Dinesh ^b   Sahwney, Sudhir ^b   Chauhan, Anurag Singh ^b   Singh, Gangandeep ^b   Kaur, Indu Pal ^a  

^a PANJAB UNIVERSITY   (India)

^b Panacea Biotec Ltd   (India)

Author keywords

Curcumin; LC MS MS; Liquid liquid extraction (LLE); Plasma; Solid lipid nanoparticles (SLNs)

Indexed keywords

AGILENT; AMMONIUM ACETATE; ANALYTICAL METHOD; CALIBRATION CURVES; CHROMOLITH; CONCENTRATION RANGES; CURCUMIN; DETERMINATION COEFFICIENTS; ELECTROSPRAY IONIZATION INTERFACE; INTERNAL STANDARDS; ISOCRATIC ELUTION; LC-MS/MS; LIQUID LIQUID EXTRACTION (LLE); LOWER LIMIT OF QUANTIFICATIONS; MULTIPLE REACTION MONITORING; NIMESULIDE; PHARMACOKINETIC STUDIES; RAT PLASMA; RUNTIMES; SOLID LIPID NANOPARTICLES; SOLID LIPID NANOPARTICLES (SLNS); TANDEM MASS SPECTROSCOPY; TRIPLE-QUADRUPOLE MASS SPECTROMETER;

ACETONITRILE; AMMONIUM COMPOUNDS; ELECTROSPRAY IONIZATION; LIQUID CHROMATOGRAPHY; MASS SPECTROMETERS; MASS SPECTROMETRY; NANOPARTICLES; PHARMACOKINETICS; PLASMAS; RATS; SOLVENT EXTRACTION; SPECTROSCOPIC ANALYSIS;

LIQUIDS;

ACETONITRILE; AMMONIUM ACETATE; CURCUMIN; NIMESULIDE; SOLID LIPID NANOPARTICLE;

ACCURACY; ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; BLOOD SAMPLING; CALIBRATION; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DELIVERY SYSTEM; DRUG DETERMINATION; DRUG DISTRIBUTION; DRUG METABOLISM; ELECTROSPRAY MASS SPECTROMETRY; ELUTION; FLOW RATE; IN VIVO STUDY; LIQUID CHROMATOGRAPHY; MALE; MASS SPECTROMETER; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; PH; PHARMACOLOGICAL PARAMETERS; PHASE TRANSITION; PRIORITY JOURNAL; QUADRUPOLE MASS SPECTROMETRY; RAT; REACTOR MONITORING; SENSITIVITY AND SPECIFICITY; SINGLE DRUG DOSE; TANDEM MASS SPECTROMETRY; TIME TO MAXIMUM PLASMA CONCENTRATION;

ADMINISTRATION, ORAL; ANIMALS; CHROMATOGRAPHY, LIQUID; CURCUMIN; DRUG DELIVERY SYSTEMS; LEAST-SQUARES ANALYSIS; MALE; NANOPARTICLES; RATS; RATS, WISTAR; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SULFONAMIDES; TANDEM MASS SPECTROMETRY;

RATTUS;

EID: 78649812260     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2010.10.017     Document Type: Article

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