Scaffold protein Homer 1: Implications for neurological diseases

Neurochemistry International

Volumn 61, Issue 5, 2012, Pages 731-738

  Luo, Peng ^a   Li, Xia ^a   Fei, Zhou ^a   Poon, Waisang ^b  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^b CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

Addiction; Fragile X syndrome; Homer protein; Metabotropic glutamate receptor; Neuropathic pain; Postsynaptic density; Schizophrenia; Transient receptor potential channel; Traumatic brain injury; X linked mental retardation

Indexed keywords

GLUTAMATE RECEPTOR 1; GLUTAMATE RECEPTOR 5; NEUROLEPTIC AGENT; PROTEIN HOMER 1; TRANSIENT RECEPTOR POTENTIAL CHANNEL C;

ALZHEIMER DISEASE; AMINO TERMINAL SEQUENCE; CALCIUM CELL LEVEL; CALCIUM HOMEOSTASIS; CARBOXY TERMINAL SEQUENCE; CELL MIGRATION; CLUSTER ANALYSIS; DRUG DEPENDENCE; GENETIC CODE; GENETIC VARIABILITY; HUMAN; LONG TERM DEPRESSION; MENTAL DEFICIENCY; NEUROLOGIC DISEASE; NONHUMAN; PAIN; POSTSYNAPTIC DENSITY; PRIORITY JOURNAL; PROTEIN STRUCTURE; REVIEW; SCHIZOPHRENIA; SIGNAL TRANSDUCTION; SYNAPSE; TRAUMATIC BRAIN INJURY;

EID: 84867494020     PISSN: 01970186     EISSN: 18729754     Source Type: Journal    
DOI: 10.1016/j.neuint.2012.06.014     Document Type: Short Survey

References (81)

1. H. Abe, T. Misaka, M. Tateyama, and Y. Kubo Effects of coexpression with Homer isoforms on the function of metabotropic glutamate receptor 1alpha Mol. Cell. Neurosci. 23 2003 157 168
2. F. Ango, D. Robbe, J.C. Tu, B. Xiao, P.F. Worley, J.P. Pin, J. Bockaert, and L. Fagni Homer-dependent cell surface expression of metabotropic glutamate receptor type 5 in neurons Mol. Cell. Neurosci. 20 2002 323 329
3. O. Ben-Shahar, I. Obara, A.W. Ary, N. Ma, M.A. Mangiardi, R.L. Medina, and K.K. Szumlinski Extended daily access to cocaine results in distinct alterations in Homer 1b/c and NMDA receptor subunit expression within the medial prefrontal cortex Synapse 63 2009 598 609
4. J. Beneken, J.C. Tu, B. Xiao, M. Nuriya, J.P. Yuan, P.F. Worley, and D.J. Leahy Structure of the Homer EVH1 domain-peptide complex reveals a new twist in polyproline recognition Neuron 26 2000 143 154
5. F. Bertaso, G. Roussignol, P. Worley, J. Bockaert, L. Fagni, and F. Ango Homer1a-dependent crosstalk between NMDA and metabotropic glutamate receptors in mouse neurons PLoS One 5 2010 e9755
6. P.R. Brakeman, A.A. Lanahan, R. O'Brien, K. Roche, C.A. Barnes, R.L. Huganir, and P.F. Worley Homer: a protein that selectively binds metabotropic glutamate receptors Nature 386 1997 284 288
7. T.B. Cole Global road safety crisis remedy sought: 1.2 million killed, 50 million injured annually JAMA 291 2004 2531 2532
8. A. de Bartolomeis, L. Aloj, A. Ambesi-Impiombato, D. Bravi, C. Caraco, G. Muscettola, and P. Barone Acute administration of antipsychotics modulates Homer striatal gene expression differentially Brain Res. Mol. Brain Res. 98 2002 124 129
9. C. Dell'aversano, C. Tomasetti, F. Iasevoli, and A. de Bartolomeis Antipsychotic and antidepressant co-treatment: effects on transcripts of inducible postsynaptic density genes possibly implicated in behavioural disorders Brain Res. Bull. 79 2009 123 129
10. C.A. Dickey, J.F. Loring, J. Montgomery, M.N. Gordon, P.S. Eastman, and D. Morgan Selectively reduced expression of synaptic plasticity-related genes in amyloid precursor protein + presenilin-1 transgenic mice J. Neurosci. 23 2003 5219 5226
11. J.B. Dietrich, M.P. Arpin-Bott, D. Kao, S. Dirrig-Grosch, D. Aunis, and J. Zwiller Cocaine induces the expression of homer 1b/c, homer 3a/b, and hsp 27 proteins in rat cerebellum Synapse 61 2007 587 594
12. S.H. Fatemi, T.J. Reutiman, T.D. Folsom, C. Bell, L. Nos, P. Fried, D.A. Pearce, S. Singh, D.P. Siderovski, F.S. Willard, and M. Fukuda Chronic olanzapine treatment causes differential expression of genes in frontal cortex of rats as revealed by DNA microarray technique Neuropsychopharmacology 31 2006 1888 1899
13. K. Fujiyama, Y. Kajii, S. Hiraoka, and T. Nishikawa Differential regulation by stimulants of neocortical expression of mrt1, arc, and homer1a mRNA in the rats treated with repeated methamphetamine Synapse 49 2003 143 149
14. J. Ghajar Traumatic brain injury Lancet 356 2000 923 929
15. R. Giuffrida, S. Musumeci, S. D'Antoni, C.M. Bonaccorso, A.M. Giuffrida-Stella, B.A. Oostra, and M.V. Catania A reduced number of metabotropic glutamate subtype 5 receptors are associated with constitutive homer proteins in a mouse model of fragile X syndrome J. Neurosci. 25 2005 8908 8916
16. E.E. Govek, S.E. Newey, C.J. Akerman, J.R. Cross, L. Van der Veken, and L. Van Aelst The X-linked mental retardation protein oligophrenin-1 is required for dendritic spine morphogenesis Nat. Neurosci. 7 2004 364 372
17. W. Guo, F. Wei, S. Zou, M.T. Robbins, S. Sugiyo, T. Ikeda, J.C. Tu, P.F. Worley, R. Dubner, and K. Ren Group I metabotropic glutamate receptor NMDA receptor coupling and signaling cascade mediate spinal dorsal horn NMDA receptor 2B tyrosine phosphorylation associated with inflammatory hyperalgesia J. Neurosci. 24 2004 9161 9173
18. K. Hashimoto, T. Nakahara, H. Yamada, M. Hirano, T. Kuroki, and S. Kanba A neurotoxic dose of methamphetamine induces gene expression of Homer 1a, but not Homer 1b or 1c, in the striatum and nucleus accumbens Neurochem. Int. 51 2007 227 232
19. M.K. Hayashi, H.M. Ames, and Y. Hayashi Tetrameric hub structure of postsynaptic scaffolding protein homer J. Neurosci. 26 2006 8492 8501
20. M.K. Hayashi, C. Tang, C. Verpelli, R. Narayanan, M.H. Stearns, R.M. Xu, H. Li, C. Sala, and Y. Hayashi The postsynaptic density proteins Homer and Shank form a polymeric network structure Cell 137 2009 159 171
21. P.J. Hernandez, C.A. Schiltz, and A.E. Kelley Dynamic shifts in corticostriatal expression patterns of the immediate early genes Homer 1a and Zif268 during early and late phases of instrumental training Learn. Mem. 13 2006 599 608
22. + channels in glutamatergic hippocampal terminals and their role in spike repolarization and regulation of transmitter release J. Neurosci. 21 2001 9585 9597
23. J.H. Hu, J.M. Park, S. Park, B. Xiao, M.H. Dehoff, S. Kim, T. Hayashi, M.K. Schwarz, R.L. Huganir, P.H. Seeburg, D.J. Linden, and P.F. Worley Homeostatic scaling requires group I mGluR activation mediated by Homer1a Neuron 68 2010 1128 1142
24. W.D. Huang, Z. Fei, and X. Zhang Traumatic injury induced homer-1a gene expression in cultured cortical neurons of rat Neurosci. Lett. 389 2005 46 50
25. K.M. Huber, S.M. Gallagher, S.T. Warren, and M.F. Bear Altered synaptic plasticity in a mouse model of fragile X mental retardation Proc. Natl. Acad. Sci. USA 99 2002 7746 7750
26. K.M. Huber, M.S. Kayser, and M.F. Bear Role for rapid dendritic protein synthesis in hippocampal mGluR-dependent long-term depression Science 288 2000 1254 1257
27. F. Iasevoli, G. Fiore, M. Cicale, G. Muscettola, and A. de Bartolomeis Haloperidol induces higher Homer1a expression than risperidone, olanzapine and sulpiride in striatal sub-regions Psychiatry Res. 177 2010 255 260
28. F. Iasevoli, C. Tomasetti, A. Ambesi-Impiombato, G. Muscettola, and A. de Bartolomeis Dopamine receptor subtypes contribution to Homer1a induction: insights into antipsychotic molecular action Prog. Neuropsychopharmacol. Biol. Psychiatry 33 2009 813 821
29. P.J. Kammermeier Surface clustering of metabotropic glutamate receptor 1 induced by long Homer proteins BMC Neurosci. 7 2006 1
30. P.J. Kammermeier, and P.F. Worley Homer 1a uncouples metabotropic glutamate receptor 5 from postsynaptic effectors Proc. Natl. Acad. Sci. USA 104 2007 6055 6060
31. J.K. Kane, Y. Hwang, O. Konu, S.E. Loughlin, F.M. Leslie, and M.D. Li Regulation of Homer and group I metabotropic glutamate receptors by nicotine Eur. J. Neurosci. 21 2005 1145 1154
32. A. Kato, F. Ozawa, Y. Saitoh, Y. Fukazawa, H. Sugiyama, and K. Inokuchi Novel members of the Vesl/Homer family of PDZ proteins that bind metabotropic glutamate receptors J. Biol. Chem. 273 1998 23969 23975
33. A. Kato, F. Ozawa, Y. Saitoh, K. Hirai, and K. Inokuchi Vesl, a gene encoding VASP/Ena family related protein, is upregulated during seizure, long-term potentiation and synaptogenesis FEBS Lett. 412 1997 183 189
34. L. Kelly, M. Farrant, and S.G. Cull-Candy Synaptic mGluR activation drives plasticity of calcium-permeable AMPA receptors Nat. Neurosci. 12 2009 593 601
35. J.Y. Kim, W. Zeng, K. Kiselyov, J.P. Yuan, M.H. Dehoff, K. Mikoshiba, P.F. Worley, and S. Muallem Homer 1 mediates store- and inositol 1,4,5-trisphosphate receptor-dependent translocation and retrieval of TRPC3 to the plasma membrane J. Biol. Chem. 281 2006 32540 32549
36. L.A. Knackstedt, K. Moussawi, R. Lalumiere, M. Schwendt, M. Klugmann, and P.W. Kalivas Extinction training after cocaine self-administration induces glutamatergic plasticity to inhibit cocaine seeking J. Neurosci. 30 2010 7984 7992
37. S. Lim, S. Naisbitt, J. Yoon, J.I. Hwang, P.G. Suh, M. Sheng, and E. Kim Characterization of the Shank family of synaptic proteins. Multiple genes, alternative splicing, and differential expression in brain and development J. Biol. Chem. 274 1999 29510 29518
38. H. Liu, E. Moczydlowski, and G.G. Haddad O(2) deprivation inhibits Ca(2+)-activated K(+) channels via cytosolic factors in mice neocortical neurons J. Clin. Invest. 104 1999 577 588
39. K.D. Lominac, E.B. Oleson, M. Pava, M. Klugmann, M.K. Schwarz, P.H. Seeburg, M.J. During, P.F. Worley, P.W. Kalivas, and K.K. Szumlinski Distinct roles for different Homer1 isoforms in behaviors and associated prefrontal cortex function J. Neurosci. 25 2005 11586 11594
40. C. Luscher, and R.C. Malenka Drug-evoked synaptic plasticity in addiction: from molecular changes to circuit remodeling Neuron 69 2011 650 663
41. L. Mao, L. Yang, Q. Tang, S. Samdani, G. Zhang, and J.Q. Wang The scaffold protein Homer1b/c links metabotropic glutamate receptor 5 to extracellular signal-regulated protein kinase cascades in neurons J. Neurosci. 25 2005 2741 2752
42. T.G. Mast, J.H. Brann, and D.A. Fadool The TRPC2 channel forms protein-protein interactions with Homer and RTP in the rat vomeronasal organ BMC Neurosci 11 2010 61
43. R. Minakami, A. Kato, and H. Sugiyama Interaction of Vesl-1L/Homer 1c with syntaxin 13 Biochem. Biophys. Res. Commun. 272 2000 466 471
44. T. Miyabe, G. Miletic, and V. Miletic Loose ligation of the sciatic nerve in rats elicits transient up-regulation of Homer1a gene expression in the spinal dorsal horn Neurosci. Lett. 398 2006 296 299
45. N. Nadif Kasri, A. Nakano-Kobayashi, R. Malinow, B. Li, and L. Van Aelst The Rho-linked mental retardation protein oligophrenin-1 controls synapse maturation and plasticity by stabilizing AMPA receptors Gene Dev. 23 2009 1289 1302
46. N. Nadif Kasri, A. Nakano-Kobayashi, and L. Van Aelst Rapid synthesis of the X-linked mental retardation protein OPHN1 mediates mGluR-dependent LTD through interaction with the endocytic machinery Neuron 72 2011 300 315
47. M. Nakamura, K. Sato, M. Fukaya, K. Araishi, A. Aiba, M. Kano, and M. Watanabe Signaling complex formation of phospholipase Cbeta4 with metabotropic glutamate receptor type 1alpha and 1,4,5-trisphosphate receptor at the perisynapse and endoplasmic reticulum in the mouse brain Eur. J. Neurosci. 20 2004 2929 2944
48. E.A. Nimchinsky, A.M. Oberlander, and K. Svoboda Abnormal development of dendritic spines in FMR1 knock-out mice J. Neurosci. 21 2001 5139 5146
49. N. Norton, H.J. Williams, N.M. Williams, G. Spurlock, S. Zammit, G. Jones, S. Jones, R. Owen, M.C. O'Donovan, and M.J. Owen Mutation screening of the Homer gene family and association analysis in schizophrenia Am. J. Med. Genet. B Neuropsychiatr. Genet. 120B 2003 18 21
50. S. Okabe, T. Urushido, D. Konno, H. Okado, and K. Sobue Rapid redistribution of the postsynaptic density protein PSD-Zip45 (Homer 1c) and its differential regulation by NMDA receptors and calcium channels J. Neurosci. 21 2001 9561 9571
51. H.T. Park, E.K. Kang, and K.W. Bae Light regulates Homer mRNA expression in the rat suprachiasmatic nucleus Brain Res. Mol. Brain Res. 52 1997 318 322
52. O. Penagarikano, J.G. Mulle, and S.T. Warren The pathophysiology of fragile x syndrome Annu. Rev. Genomics Hum. Genet. 8 2007 109 129
53. D. Polese, A.A. de Serpis, A. Ambesi-Impiombato, G. Muscettola, and A. de Bartolomeis Homer 1a gene expression modulation by antipsychotic drugs: involvement of the glutamate metabotropic system and effects of d-cycloserine Neuropsychopharmacology 27 2002 906 913
54. K. Rezvani, Y. Teng, D. Shim, and M. De Biasi Nicotine regulates multiple synaptic proteins by inhibiting proteasomal activity J. Neurosci. 27 2007 10508 10519
55. K.W. Roche, J.C. Tu, R.S. Petralia, B. Xiao, R.J. Wenthold, and P.F. Worley Homer 1b regulates the trafficking of group I metabotropic glutamate receptors J. Biol. Chem. 274 1999 25953 25957
56. J.A. Ronesi, K.A. Collins, S.A. Hays, N.P. Tsai, W. Guo, S.G. Birnbaum, J.H. Hu, P.F. Worley, J.R. Gibson, and K.M. Huber Disrupted Homer scaffolds mediate abnormal mGluR5 function in a mouse model of fragile X syndrome Nat. Neurosci. 15 431-440 2012 S431
57. J.A. Ronesi, and K.M. Huber Homer interactions are necessary for metabotropic glutamate receptor-induced long-term depression and translational activation J. Neurosci. 28 2008 543 547
58. R. Rong, J.Y. Ahn, H. Huang, E. Nagata, D. Kalman, J.A. Kapp, J. Tu, P.F. Worley, S.H. Snyder, and K. Ye PI3 kinase enhancer-Homer complex couples mGluRI to PI3 kinase, preventing neuronal apoptosis Nat. Neurosci. 6 2003 1153 1161
59. F. Roselli, P. Hutzler, Y. Wegerich, P. Livrea, and O.F. Almeida Disassembly of shank and homer synaptic clusters is driven by soluble beta-amyloid(1-40) through divergent NMDAR-dependent signalling pathways PLoS One 4 2009 e6011
60. F. Roselli, M. Tirard, J. Lu, P. Hutzler, P. Lamberti, P. Livrea, M. Morabito, and O.F. Almeida Soluble beta-amyloid1-40 induces NMDA-dependent degradation of postsynaptic density-95 at glutamatergic synapses J. Neurosci. 25 2005 11061 11070
61. Y. Sakagami, K. Yamamoto, S. Sugiura, K. Inokuchi, T. Hayashi, and N. Kato Essential roles of Homer-1a in homeostatic regulation of pyramidal cell excitability: a possible link to clinical benefits of electroconvulsive shock Eur. J. Neurosci. 21 2005 3229 3239
62. C. Sala, K. Futai, K. Yamamoto, P.F. Worley, Y. Hayashi, and M. Sheng Inhibition of dendritic spine morphogenesis and synaptic transmission by activity-inducible protein Homer1a J. Neurosci. 23 2003 6327 6337
63. C. Sala, V. Piech, N.R. Wilson, M. Passafaro, G. Liu, and M. Sheng Regulation of dendritic spine morphology and synaptic function by Shank and Homer Neuron 31 2001 115 130
64. D.J. Selkoe, and D. Schenk Alzheimer's disease: molecular understanding predicts amyloid-based therapeutics Annu. Rev. Pharmacol. Toxicol. 43 2003 545 584
65. A. Serge, L. Fourgeaud, A. Hemar, and D. Choquet Receptor activation and homer differentially control the lateral mobility of metabotropic glutamate receptor 5 in the neuronal membrane J. Neurosci. 22 2002 3910 3920
66. Y. Shiraishi-Yamaguchi, and T. Furuichi The Homer family proteins Genome Biol. 8 2007 206
67. Y. Shiraishi, A. Mizutani, S. Yuasa, K. Mikoshiba, and T. Furuichi Differential expression of Homer family proteins in the developing mouse brain J. Comp. Neurol. 473 2004 582 599
68. I. Spellmann, D. Rujescu, R. Musil, A. Mayr, I. Giegling, J. Genius, P. Zill, S. Dehning, M. Opgen-Rhein, A. Cerovecki, A.M. Hartmann, M. Schafer, B. Bondy, N. Muller, H.J. Moller, and M. Riedel Homer-1 polymorphisms are associated with psychopathology and response to treatment in schizophrenic patients J. Psychiatr. Res. 45 2011 234 241
69. J. Sun, S. Tadokoro, T. Imanaka, S.D. Murakami, M. Nakamura, K. Kashiwada, J. Ko, W. Nishida, and K. Sobue Isolation of PSD-Zip45, a novel Homer/vesl family protein containing leucine zipper motifs, from rat brain FEBS Lett. 437 1998 304 308
70. K.K. Szumlinski, K.D. Lominac, M.J. Kleschen, E.B. Oleson, M.H. Dehoff, M.K. Schwarz, P.H. Seeburg, P.F. Worley, and P.W. Kalivas Behavioral and neurochemical phenotyping of Homer1 mutant mice: possible relevance to schizophrenia Genes Brain Behav. 4 2005 273 288
71. S. Tadokoro, T. Tachibana, T. Imanaka, W. Nishida, and K. Sobue Involvement of unique leucine-zipper motif of PSD-Zip45 (Homer 1c/vesl-1L) in group 1 metabotropic glutamate receptor clustering Proc. Natl. Acad. Sci. USA 96 1999 13801 13806
72. A. Tappe-Theodor, Y. Fu, R. Kuner, and V. Neugebauer Homer1a signaling in the amygdala counteracts pain-related synaptic plasticity, mGluR1 function and pain behaviors Mol. Pain 7 2011 38
73. A. Tappe, M. Klugmann, C. Luo, D. Hirlinger, N. Agarwal, J. Benrath, M.U. Ehrengruber, M.J. During, and R. Kuner Synaptic scaffolding protein Homer1a protects against chronic inflammatory pain Nat. Med. 12 2006 677 681
74. J.C. Tu, B. Xiao, J.P. Yuan, A.A. Lanahan, K. Leoffert, M. Li, D.J. Linden, and P.F. Worley Homer binds a novel proline-rich motif and links group 1 metabotropic glutamate receptors with IP3 receptors Neuron 21 1998 717 726
75. A. Vazdarjanova, B.L. McNaughton, C.A. Barnes, P.F. Worley, and J.F. Guzowski Experience-dependent coincident expression of the effector immediate-early genes arc and Homer 1a in hippocampal and neocortical neuronal networks J. Neurosci. 22 2002 10067 10071
76. B. Xiao, J.C. Tu, R.S. Petralia, J.P. Yuan, A. Doan, C.D. Breder, A. Ruggiero, A.A. Lanahan, R.J. Wenthold, and P.F. Worley Homer regulates the association of group 1 metabotropic glutamate receptors with multivalent complexes of homer-related, synaptic proteins Neuron 21 1998 707 716
77. K. Yamamoto, Y. Ueta, L. Wang, R. Yamamoto, N. Inoue, K. Inokuchi, A. Aiba, H. Yonekura, and N. Kato Suppression of a Neocortical Potassium Channel Activity by Intracellular Amyloid-{beta} and Its Rescue with Homer1a J. Neurosci. 31 2011 11100 11109
78. Y.X. Yao, Z. Jiang, and Z.Q. Zhao Knockdown of synaptic scaffolding protein Homer 1b/c attenuates secondary hyperalgesia induced by complete Freund's adjuvant in rats Anesth. Analg. 113 2011 1501 1508
79. Y. Yu, C. Maureira, X. Liu, and D. McCormick P/Q and N channels control baseline and spike-triggered calcium levels in neocortical axons and synaptic boutons J. Neurosci. 30 2010 11858 11869
80. J.P. Yuan, K. Kiselyov, D.M. Shin, J. Chen, N. Shcheynikov, S.H. Kang, M.H. Dehoff, M.K. Schwarz, P.H. Seeburg, S. Muallem, and P.F. Worley Homer binds TRPC family channels and is required for gating of TRPC1 by IP3 receptors Cell 114 2003 777 789
81. G.C. Zhang, L.M. Mao, X.Y. Liu, N.K. Parelkar, A. Arora, L. Yang, M. Hains, E.E. Fibuch, and J.Q. Wang In vivo regulation of Homer1a expression in the striatum by cocaine Mol. Pharmacol. 71 2007 1148 1158