Tetrameric hub structure of postsynaptic scaffolding protein Homer

Journal of Neuroscience

Volumn 26, Issue 33, 2006, Pages 8492-8501

  Hayashi, Mariko Kato ^a   Ames, Heather M ^a,b   Hayashi, Yasunori ^a  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

Coiled coil; Homer; Metabotropic glutamate receptor; Quaternary structure; Scaffolding protein; Synapse

Indexed keywords

DIMER; LIGAND; PROTEIN HOMER; PROTEIN SUBUNIT; SCAFFOLD PROTEIN; TETRAMER; UNCLASSIFIED DRUG;

ARTICLE; BIOPHYSICS; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DENDRITIC SPINE; FLUORESCENCE RESONANCE ENERGY TRANSFER; NONHUMAN; OLIGOMERIZATION; POSTSYNAPTIC MEMBRANE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN STRUCTURE; STRUCTURE ACTIVITY RELATION; YEAST;

ANIMALS; BIOPHYSICS; CARRIER PROTEINS; CERCOPITHECUS AETHIOPS; COS CELLS; DENDRITIC SPINES; FLUORESCENCE RESONANCE ENERGY TRANSFER; HUMANS; LIGANDS; PROTEIN CONFORMATION; PROTEIN ENGINEERING; PROTEIN ISOFORMS; PROTEIN STRUCTURE, QUATERNARY; PROTEIN STRUCTURE, TERTIARY; RATS; RECEPTORS, METABOTROPIC GLUTAMATE; STRUCTURE-ACTIVITY RELATIONSHIP; SYNAPSES; TIME FACTORS;

EID: 33748126215     PISSN: 02706474     EISSN: 02706474     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.2731-06.2006     Document Type: Article

References (36)

1. Ango F, Prézeau L, Muller T, Tu JC, Xiao B, Worley PF, Pin JP, Bockaert J, Fagni L (2001) Agonist-independent activation of metabotropic glutamate receptors by the intracellular protein Homer. Nature 411:962-965.
2. Barzik M, Carl UD, Schubert WD, Frank R, Wehland J, Heinz DW (2001) The N-terminal domain of Homer/Vesl is a new class II EVH1 domain. J Mol Biol 309:155-169.
3. Beneken J, Tu JC, Xiao B, Nuriya M, Yuan JP, Worley PF, Leahy DJ (2000) Structure of the Homer EVH1 domain-peptide complex reveals a new twist in polyproline recognition. Neuron 26:143-154.
4. Brakeman PR, Lanahan AA, O'Brien R, Roche K, Barnes CA, Huganir RL, Worley PF (1997) Homer: a protein that selectively binds metabotropic glutamate receptors. Nature 386:284-288.
5. Dam J, Schuck P (2004) Calculating sedimentation coefficient distributions by direct modeling of sedimentation velocity concentration profiles. Methods Enzymol 384:185-212.
6. Fagni L, Worley PF, Ango F (2002) Homer as both a scaffold and transduction molecule. Sci STKE 2002:RE8.
7. Guex N, Peitsch MC (1997) SWISS-MODEL and the Swiss-PdbViewer: an environment for comparative protein modeling. Electrophoresis 18:2714-2723.
8. Harbury PB, Zhang T, Kim PS, Alber T (1993) A switch between two-, three-, and four-stranded coiled coils in GCN4 leucine zipper mutants. Science 262:1401-1407.
9. Heyduk T (2002) Measuring protein conformational changes by FRET/LRET. Curr Opin Biotechnol 13:292-296.
10. Im YJ, Lee JH, Park SH, Park SJ, Rho SH, Kang GB, Kim E, Eom SH (2003) Crystal structure of the Shank PDZ-ligand complex reveals a class I PDZ interaction and a novel PDZ-PDZ dimerization. J Biol Chem 278:48099-48104.
11. Irie K, Nakatsu T, Mitsuoka K, Miyazawa A, Sobue K, Hiroaki Y, Doi T, Fujiyoshi Y, Kato H (2002) Crystal structure of the Homer 1 family conserved region reveals the interaction between the EVH1 domain and own proline-rich motif. J Mol Biol 318:1117-1126.
12. Ishibashi T, Ogawa S, Hashiguchi Y, Inoue Y, Udo H, Ohzono H, Kato A, Minakami R, Sugiyama H (2005) Anovel protein specifically interacting with Homer2 regulates ubiquitin-proteasome systems. J Biochem (Tokyo) 137:617-623.
13. + channel. Nature 423:33-41.
14. Johnson ML, Correia JJ, Yphantis DA, Halvorson HR (1981) Analysis of data from the analytical ultracentrifuge by nonlinear least-squares techniques. Biophys J 36:575-588.
15. Jong YJ, Kumar V, Kingston AE, Romano C, O'Malley KL (2005) Functional metabotropic glutamate receptors on nuclei from brain and primary cultured striatal neurons. Role of transporters in delivering ligand. J Biol Chem 280:30469-30480.
16. Laue TM, Shah BD, Ridgeway TM, Pelletier SL (1992) Computer-aided interpretation of analytical sedimentation data for proteins. In: Analytical ultracentrifugation in biochemistry and polymer science (Harding SE, Rowe AJ, Horton JC, eds). Cambridge, UK: Royal Society of Chemistry.
17. Minakami R, Kato A, Sugiyama H (2000) Interaction of Vesl-1L/Homer 1c with syntaxin 13. Biochem Biophys Res Commun 272:466-471.
18. Okamoto K, Nagai T, Miyawaki A, Hayashi Y (2004) Rapid and persistent modulation of actin dynamics regulates postsynaptic reorganization underlying bidirectional plasticity. Nat Neurosci 7:1104-1112.
19. 2+ changes in heterologous cell types and neurons. J Biol Chem 278:28210-28219.
20. 2+/calmodulin- dependent protein kinase II at the PSD. J Neurosci 23:11270-11278.
21. Roche KW, Tu JC, Petralia RS, Xiao B, Wenthold RJ, Worley PF (1999) Homer 1b regulates the trafficking of group I metabotropic glutamate receptors. J Biol Chem 274:25953-25957.
22. Sala C, Piech V, Wilson NR, Passafaro M, Liu G, Sheng M (2001) Regulation of dendritic spine morphology and synaptic function by Shank and Homer. Neuron 31:115-130.
23. Sala C, Futai K, Yamamoto K, Worley PF, Hayashi Y, Sheng M (2003) Inhibition of dendritic spine morphogenesis and synaptic transmission by activity-inducible protein Homer1a. J Neurosci 23:6327-6337.
24. Sato C, Hamada K, Ogura T, Miyazawa A, Iwasaki K, Hiroaki Y, Tani K, Terauchi A, Fujiyoshi Y, Mikoshiba K (2004) Inositol 1,4,5-trisphosphate receptor contains multiple cavities and L-shaped ligand-binding domains. J Mol Biol 336:155-164.
25. Schuck P (2000) Size-distribution analysis of macromolecules by sedimentation velocity ultracentrifugation and lamm equation modeling. Biophys J 78:1606-1619.
26. Shiraishi Y, Mizutani A, Bito H, Fujisawa K, Narumiya S, Mikoshiba K, Furuichi T (1999) Cupidin, an isoform of Homer/Vesl, interacts with the actin cytoskeleton and activated rho family small GTPases and is expressed in developing mouse cerebellar granule cells. J Neurosci 19:8389-8400.
27. Sutton RB, Fasshauer D, Jahn R, Brunger AT (1998) Crystal structure of a SNARE complex involved in synaptic exocytosis at 2.4 Å resolution. Nature 395:347-353.
28. Tadokoro S, Tachibana T, Imanaka T, Nishida W, Sobue K (1999) Involvement of unique leucine-zipper motif of PSD-Zip45 (Homer 1c/vesl-1L) in group 1 metabotropic glutamate receptor clustering. Proc Natl Acad Sci USA 96:13801-13806.
29. Thomas U (2002) Modulation of synaptic signalling complexes by Homer proteins. J Neurochem 81:407-413.
30. 3 receptors. Neuron 21:717-726.
31. Tu JC, Xiao B, Naisbitt S, Yuan JP, Petralia RS, Brakeman P, Doan A, Aakalu VK, Lanahan AA, Sheng M, Worley PF (1999) Coupling of mGluR/Homer and PSD-95 complexes by the Shank family of postsynaptic density proteins. Neuron 23:583-592.
32. van Holde KE (1985) Physical biochemistry. Englewood Cliffs, NJ: Prentice-Hall.
33. Wolf E, Kim PS, Berger B (1997) MultiCoil: a program for predicting two-and three-stranded coiled coils. Protein Sci 6:1179-1189.
34. Xiao B, Tu JC, Petralia RS, Yuan JP, Doan A, Breder CD, Ruggiero A, Lanahan AA, Wenthold RJ, Worley PF (1998) Homer regulates the association of group 1 metabotropic glutamate receptors with multivalent complexes of homer-related, synaptic proteins. Neuron 21:707-716.
35. Xiao B, Tu JC, Worley PF (2000) Homer: a link between neural activity and glutamate receptor function. Curr Opin Neurobiol 10:370-374.
36. 3 receptors. Cell 114:777-789.