Synaptic scaffolding protein Homer1a protects against chronic inflammatory pain

Nature Medicine

Volumn 12, Issue 6, 2006, Pages 677-681

  Tappe, Anke ^a   Klugmann, Matthias ^a,b   Luo, Ceng ^a   Hirlinger, David ^a   Agarwal, Nitin ^a   Benrath, Justus ^c   Ehrengruber, Markus U ^d,e   During, Matthew J ^b,f   Kuner, Rohini ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b UNIVERSITY OF AUCKLAND   (New Zealand)

^c MEDICAL UNIVERSITY OF VIENNA   (Austria)

^d UNIVERSITY OF ZURICH   (Switzerland)

^e Kantonsschule Hohe Promenade   (Switzerland)

^f WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUTAMATE RECEPTOR; HOMER1A PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; SCAFFOLD PROTEIN; SHORT HAIRPIN RNA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CALCIUM MOBILIZATION; CHRONIC INFLAMMATION; CHRONIC PAIN; CONTROLLED STUDY; ENZYME ACTIVATION; FEEDBACK SYSTEM; GENE TRANSFER; HYPERALGESIA; IN VIVO STUDY; MALE; MOUSE; NERVE CELL; NONHUMAN; NUCLEOTIDE SEQUENCE; PLASTICITY; PRIORITY JOURNAL; PROTEIN FUNCTION; RAT; SPINAL CORD; UPREGULATION;

ANIMALS; CALCIUM; CARRIER PROTEINS; CHRONIC DISEASE; DEPENDOVIRUS; ENZYME ACTIVATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FEEDBACK, BIOCHEMICAL; INFLAMMATION; MALE; MICE; MICE, INBRED C57BL; NEURONS; NUCLEIC ACID CONFORMATION; PAIN; PROTEIN ISOFORMS; RATS; RATS, WISTAR; RECEPTORS, GLUTAMATE; RECEPTORS, N-METHYL-D-ASPARTATE; RECOMBINANT FUSION PROTEINS; RNA; SIGNAL TRANSDUCTION; SPINAL CORD; SYNAPSES;

EID: 33744985563     PISSN: 10788956     EISSN: 1546170X     Source Type: Journal    
DOI: 10.1038/nm1406     Document Type: Article

References (20)

1. Sandkuhler, J. Learning and memory in pain pathways. Pain 88, 113-118 (2000).
2. Woolf, C.J. & Salter, M.W. Neuronal plasticity: increasing the gain in pain. Science 288, 1765-1768 (2000).
3. Xiao, B., Cheng, T.J. & Worley, P.F. Homer: a link between neural activity and glutamate receptor function. Curr. Opin. Neurobiol. 10, 370-374 (2000).
4. Ehrengruber, M.U., Kato, A., Inokuchi, K. & Hennou, S. Homer/Vesl proteins and their roles in CNS neurons. Mol. Neurobiol. 29, 213-228 (2004).
5. 3 receptors. Neuron 21, 717-726 (1998).
6. 3 receptors. Cell 114, 777-789 (2003).
7. 2+ stores and ion channels in neurons. Trends Neurosci. 23, 80-88 (2000).
8. Feng, W. et al. Homer regulates gain of ryanodine receptor type 1 channel complex. J. Biol. Chem. 277, 44722-44730 (2002).
9. Tu, J.C. et al. Coupling of mGluR/Homer and PSD-95 complexes by the Shank family of postsynaptic density proteins. Neuron 23, 583-592 (1999).
10. Hargreaves, K., Dubner, F., Brown, F., Flores, C. & Joris, J. A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia. Pain 32, 77-88 (1988).
11. During, M.J., Young, D., Baer, K., Lawlor, P. & Klugmann, M. Development and optimization of adeno-associated virus vector transfer into the central nervous system. Methods Mol. Med. 76, 221-236 (2003).
12. Bottai, D. et al. Synaptic activity-induced conversion of intronic to exonic sequence in Homer 1 immediate early gene expression. J. Neurosci. 22, 167-175 (2002).
13. Tjolsen, A., Berge, O.G., Hunskaar, S., Rosland, J.H. & Hole, K. The formalin test: an evaluation of the method. Pain 51, 5-17 (1992).
14. Hennou, S. et al. Homer-1a/Vesl-1S enhances hippocampal synaptic transmission. Eur. J. Neurosci. 18, 811-819 (2003).
15. Klugmann, M. et al. AAV-mediated hippocampal expression of short and long Homer 1 proteins differentially affect cognition and seizure activity in adult rats. Mol. Cell. Neurosci. 28, 347-360 (2005).
16. Ango, F. et al. Agonist-independent activation of metabotropic glutamate receptors by the intracellular protein Homer. Nature 411, 962-965 (2001).
17. 2+-independent signaling pathway to extracellular signal-regulated protein kinase by coactivation of NMDA receptors and metabotropic glutamate receptor 5 in neurons. J. Neurosci. 24, 10846-10857 (2004).
18. Ji, R.R., Baba, H., Brenner, G.J. & Woolf, C.J. Nociceptive-specific activation of ERK in spinal neurons contributes to pain hypersensitivity. Nat. Neurosci. 2, 1114-1119 (1999).
19. Hartmann, B. et al. The AMPA receptor subunits GluR-a and GluR-b reciprocally modulate spinal synaptic plasticity and inflammatory pain. Neuron 44, 637-650 (2004).
20. 2+ indicators with greatly improved fluorescence properties. J. Biol. Chem. 260, 3440-3450 (1985).