-
1
-
-
79958206937
-
Franklin H. Epstein Lecture: sirtuins, aging, and medicine
-
Guarente, L. 2011. Franklin H. Epstein Lecture: sirtuins, aging, and medicine. N. Engl. J. Med. 364: 2235-2244.
-
(2011)
N. Engl. J. Med.
, vol.364
, pp. 2235-2244
-
-
Guarente, L.1
-
3
-
-
3142740860
-
Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase
-
Cohen, H.Y. et al. 2004. Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase. Science 305: 390-392.
-
(2004)
Science
, vol.305
, pp. 390-392
-
-
Cohen, H.Y.1
-
4
-
-
45549098657
-
SirT1 regulates energy metabolism and response to caloric restriction in mice
-
Boily, G. et al. 2008. SirT1 regulates energy metabolism and response to caloric restriction in mice. PLoS One 3: e1759.
-
(2008)
PLoS One
, vol.3
-
-
Boily, G.1
-
5
-
-
20444444649
-
Mechanism of human SIRT1 activation by resveratrol
-
Borra, M.T., B.C. Smith & J.M. Denu. 2005. Mechanism of human SIRT1 activation by resveratrol. J. Biol. Chem. 280: 17187-17195.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 17187-17195
-
-
Borra, M.T.1
Smith, B.C.2
Denu, J.M.3
-
6
-
-
33751072349
-
Resveratrol improves health and survival of mice on a high-calorie diet
-
Baur, J.A. et al. 2006. Resveratrol improves health and survival of mice on a high-calorie diet. Nature 444: 337-342.
-
(2006)
Nature
, vol.444
, pp. 337-342
-
-
Baur, J.A.1
-
7
-
-
33846583673
-
SIR2: a potential target for calorie restriction mimetics
-
Chen, D. & L. Guarente. 2007. SIR2: a potential target for calorie restriction mimetics. Trends Mol. Med. 13: 64-71.
-
(2007)
Trends Mol. Med.
, vol.13
, pp. 64-71
-
-
Chen, D.1
Guarente, L.2
-
8
-
-
84860477354
-
SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function
-
Price, N.L. et al. 2012. SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function. Cell Metab. 15: 675-690.
-
(2012)
Cell Metab.
, vol.15
, pp. 675-690
-
-
Price, N.L.1
-
9
-
-
0034677535
-
Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase
-
Imai, S. et al. 2000. Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase. Nature 403: 795-800.
-
(2000)
Nature
, vol.403
, pp. 795-800
-
-
Imai, S.1
-
10
-
-
77949887506
-
Mammalian sirtuins: biological insights and disease relevance
-
Haigis, M.C. & D.A. Sinclair. 2010. Mammalian sirtuins: biological insights and disease relevance. Annu. Rev. Pathol. 5: 253-295.
-
(2010)
Annu. Rev. Pathol.
, vol.5
, pp. 253-295
-
-
Haigis, M.C.1
Sinclair, D.A.2
-
11
-
-
0035913903
-
hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase
-
Vaziri, H. et al. 2001. hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase. Cell 107: 149-159.
-
(2001)
Cell
, vol.107
, pp. 149-159
-
-
Vaziri, H.1
-
12
-
-
49349107518
-
Lysine acetylation: codified crosstalk with other posttranslational modifications
-
Yang, X.J. & E. Seto. 2008. Lysine acetylation: codified crosstalk with other posttranslational modifications. Mol. Cell 31: 449-461.
-
(2008)
Mol. Cell
, vol.31
, pp. 449-461
-
-
Yang, X.J.1
Seto, E.2
-
13
-
-
35349011726
-
Active regulator of SIRT1 cooperates with SIRT1 and facilitates suppression of p53 activity
-
Kim, E.J. et al. 2007. Active regulator of SIRT1 cooperates with SIRT1 and facilitates suppression of p53 activity. Mol. Cell. 28: 277-290.
-
(2007)
Mol. Cell.
, vol.28
, pp. 277-290
-
-
Kim, E.J.1
-
14
-
-
38749088678
-
DBC1 is a negative regulator of SIRT1
-
Kim, J.E., J. Chen & Z. Lou. 2008. DBC1 is a negative regulator of SIRT1. Nature 451: 583-586.
-
(2008)
Nature
, vol.451
, pp. 583-586
-
-
Kim, J.E.1
Chen, J.2
Lou, Z.3
-
15
-
-
35748962613
-
SIRT1 sumoylation regulates its deacetylase activity and cellular response to genotoxic stress
-
Yang, Y. et al. 2007. SIRT1 sumoylation regulates its deacetylase activity and cellular response to genotoxic stress. Nat. Cell Biol. 9: 1253-1262.
-
(2007)
Nat. Cell Biol.
, vol.9
, pp. 1253-1262
-
-
Yang, Y.1
-
16
-
-
58149202185
-
Phosphorylation regulates SIRT1 function
-
Sasaki, T. et al. 2008. Phosphorylation regulates SIRT1 function. PLoS One 3: e4020.
-
(2008)
PLoS One
, vol.3
-
-
Sasaki, T.1
-
17
-
-
77949539030
-
JNK1 phosphorylates SIRT1 and promotes its enzymatic activity
-
Nasrin, N. et al. 2009. JNK1 phosphorylates SIRT1 and promotes its enzymatic activity. PLoS One 4: e8414.
-
(2009)
PLoS One
, vol.4
-
-
Nasrin, N.1
-
18
-
-
0035913911
-
Negative control of p53 by Sir2alpha promotes cell survival under stress
-
Luo, J. et al. 2001. Negative control of p53 by Sir2alpha promotes cell survival under stress. Cell 107: 137-148.
-
(2001)
Cell
, vol.107
, pp. 137-148
-
-
Luo, J.1
-
19
-
-
33847647624
-
SIRT1 promotes DNA repair activity and deacetylation of Ku70
-
Jeong, J. et al. 2007. SIRT1 promotes DNA repair activity and deacetylation of Ku70. Exp. Mol. Med. 39: 8-13.
-
(2007)
Exp. Mol. Med.
, vol.39
, pp. 8-13
-
-
Jeong, J.1
-
20
-
-
34948883324
-
SIRT1 deacetylates and positively regulates the nuclear receptor LXR
-
Li, X. et al. 2007. SIRT1 deacetylates and positively regulates the nuclear receptor LXR. Mol. Cell 28: 91-106.
-
(2007)
Mol. Cell
, vol.28
, pp. 91-106
-
-
Li, X.1
-
21
-
-
14544282413
-
Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1
-
Rodgers, J.T. et al. 2005. Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1. Nature 434: 113-118.
-
(2005)
Nature
, vol.434
, pp. 113-118
-
-
Rodgers, J.T.1
-
22
-
-
18144411313
-
SIRT1 functionally interacts with the metabolic regulator and transcriptional coactivator PGC-1{alpha}
-
Nemoto, S., M.M. Fergusson & T. Finkel. 2005. SIRT1 functionally interacts with the metabolic regulator and transcriptional coactivator PGC-1{alpha}. J. Biol. Chem. 280: 16456-16460.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 16456-16460
-
-
Nemoto, S.1
Fergusson, M.M.2
Finkel, T.3
-
23
-
-
84859635458
-
Emerging avenues linking inflammation and cancer
-
Kundu, J.K. & Y.J. Surh. 2012. Emerging avenues linking inflammation and cancer. Free Radic. Biol. Med. 52: 2013-2037.
-
(2012)
Free Radic. Biol. Med.
, vol.52
, pp. 2013-2037
-
-
Kundu, J.K.1
Surh, Y.J.2
-
24
-
-
80055113353
-
Activation of Sirt1 by resveratrol inhibits TNF-alpha induced inflammation in fibroblasts
-
Zhu, X. et al. 2011. Activation of Sirt1 by resveratrol inhibits TNF-alpha induced inflammation in fibroblasts. PLoS One 6: e27081.
-
(2011)
PLoS One
, vol.6
-
-
Zhu, X.1
-
25
-
-
78650648938
-
Roles of SIRT1 in the acute and restorative phases following induction of inflammation
-
Zhang, Z. et al. 2010. Roles of SIRT1 in the acute and restorative phases following induction of inflammation. J. Biol. Chem. 285: 41391-41401.
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 41391-41401
-
-
Zhang, Z.1
-
26
-
-
77349087078
-
SIRT1 inhibits inflammatory pathways in macrophages and modulates insulin sensitivity
-
Yoshizaki, T. et al. 2010. SIRT1 inhibits inflammatory pathways in macrophages and modulates insulin sensitivity. Am. J. Physiol. Endocrinol. Metab. 298: E419-E428.
-
(2010)
Am. J. Physiol. Endocrinol. Metab.
, vol.298
-
-
Yoshizaki, T.1
-
27
-
-
63449112017
-
Hepatocyte-specific deletion of SIRT1 alters fatty acid metabolism and results in hepatic steatosis and inflammation
-
Purushotham, A. et al. 2009. Hepatocyte-specific deletion of SIRT1 alters fatty acid metabolism and results in hepatic steatosis and inflammation. Cell Metab. 9: 327-338.
-
(2009)
Cell Metab.
, vol.9
, pp. 327-338
-
-
Purushotham, A.1
-
28
-
-
77954515012
-
Lack of SIRT1 (Mammalian Sirtuin 1) activity leads to liver steatosis in the SIRT1+/- mice: a role of lipid mobilization and inflammation
-
Xu, F. et al. 2010. Lack of SIRT1 (Mammalian Sirtuin 1) activity leads to liver steatosis in the SIRT1+/- mice: a role of lipid mobilization and inflammation. Endocrinology 151: 2504-2514.
-
(2010)
Endocrinology
, vol.151
, pp. 2504-2514
-
-
Xu, F.1
-
29
-
-
42649146208
-
SIRT1, an antiinflammatory and antiaging protein, is decreased in lungs of patients with chronic obstructive pulmonary disease
-
Rajendrasozhan, S. et al. 2008. SIRT1, an antiinflammatory and antiaging protein, is decreased in lungs of patients with chronic obstructive pulmonary disease. Am. J. Respir Crit. Care Med. 177: 861-870.
-
(2008)
Am. J. Respir Crit. Care Med.
, vol.177
, pp. 861-870
-
-
Rajendrasozhan, S.1
-
30
-
-
3242719545
-
Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase
-
Yeung, F. et al. 2004. Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase. EMBO J. 23: 2369-2380.
-
(2004)
EMBO J.
, vol.23
, pp. 2369-2380
-
-
Yeung, F.1
-
31
-
-
77249089947
-
Resveratrol (trans-3,5,4'-trihydroxystilbene) induces silent mating type information regulation-1 and down-regulates nuclear transcription factor-kappaB activation to abrogate dextran sulfate sodium-induced colitis
-
Singh, U.P. et al. 2010. Resveratrol (trans-3, 5, 4'-trihydroxystilbene) induces silent mating type information regulation-1 and down-regulates nuclear transcription factor-kappaB activation to abrogate dextran sulfate sodium-induced colitis. J. Pharmacol. Exp. Ther. 332: 829-839.
-
(2010)
J. Pharmacol. Exp. Ther.
, vol.332
, pp. 829-839
-
-
Singh, U.P.1
-
32
-
-
70350500225
-
STATs in cancer inflammation and immunity: a leading role for STAT3
-
Yu, H., D. Pardoll & R. Jove. 2009. STATs in cancer inflammation and immunity: a leading role for STAT3. Nat. Rev. Cancer 9: 798-809.
-
(2009)
Nat. Rev. Cancer
, vol.9
, pp. 798-809
-
-
Yu, H.1
Pardoll, D.2
Jove, R.3
-
33
-
-
64049109876
-
STAT3 inhibition of gluconeogenesis is downregulated by SirT1
-
Nie, Y. et al. 2009. STAT3 inhibition of gluconeogenesis is downregulated by SirT1. Nat. Cell Biol. 11: 492-500.
-
(2009)
Nat. Cell Biol.
, vol.11
, pp. 492-500
-
-
Nie, Y.1
-
34
-
-
79954569231
-
STAT3-dependent effects of IL-22 in human keratinocytes are counterregulated by sirtuin 1 through a direct inhibition of STAT3 acetylation
-
Sestito, R. et al. 2011. STAT3-dependent effects of IL-22 in human keratinocytes are counterregulated by sirtuin 1 through a direct inhibition of STAT3 acetylation. FASEB J. 25: 916-927.
-
(2011)
FASEB J.
, vol.25
, pp. 916-927
-
-
Sestito, R.1
-
35
-
-
53449090280
-
Inhibition of transcriptional activity of c-JUN by SIRT1
-
Gao, Z. & J. Ye. 2008. Inhibition of transcriptional activity of c-JUN by SIRT1. Biochem. Biophys. Res. Commun. 376: 793-796.
-
(2008)
Biochem. Biophys. Res. Commun.
, vol.376
, pp. 793-796
-
-
Gao, Z.1
Ye, J.2
-
36
-
-
67651210858
-
SIRT1 promotes cell survival under stress by deacetylation-dependent deactivation of poly(ADP-ribose) polymerase 1
-
Rajamohan, S.B. et al. 2009. SIRT1 promotes cell survival under stress by deacetylation-dependent deactivation of poly(ADP-ribose) polymerase 1. Mol. Cell Biol. 29: 4116-4129.
-
(2009)
Mol. Cell Biol.
, vol.29
, pp. 4116-4129
-
-
Rajamohan, S.B.1
-
37
-
-
78651105018
-
Regulation of global genome nucleotide excision repair by SIRT1 through xeroderma pigmentosum C
-
Ming, M. et al. 2010. Regulation of global genome nucleotide excision repair by SIRT1 through xeroderma pigmentosum C. Proc. Natl. Acad. Sci. U. S. A. 107: 22623-22628.
-
(2010)
Proc. Natl. Acad. Sci. U. S. A.
, vol.107
, pp. 22623-22628
-
-
Ming, M.1
-
38
-
-
56749156405
-
SIRT1 redistribution on chromatin promotes genomic stability but alters gene expression during aging
-
Oberdoerffer, P. et al. 2008. SIRT1 redistribution on chromatin promotes genomic stability but alters gene expression during aging. Cell 135: 907-918.
-
(2008)
Cell
, vol.135
, pp. 907-918
-
-
Oberdoerffer, P.1
-
39
-
-
78650747994
-
SIRT1 contributes to telomere maintenance and augments global homologous recombination
-
Palacios, J.A. et al. 2010. SIRT1 contributes to telomere maintenance and augments global homologous recombination. J. Cell Biol. 191: 1299-1313.
-
(2010)
J. Cell Biol.
, vol.191
, pp. 1299-1313
-
-
Palacios, J.A.1
-
40
-
-
65349096174
-
A c-Myc-SIRT1 feedback loop regulates cell growth and transformation
-
Yuan, J., K. Minter-Dykhouse & Z. Lou. 2009. A c-Myc-SIRT1 feedback loop regulates cell growth and transformation. J. Cell Biol. 185: 203-211.
-
(2009)
J. Cell Biol.
, vol.185
, pp. 203-211
-
-
Yuan, J.1
Minter-Dykhouse, K.2
Lou, Z.3
-
41
-
-
67650563916
-
SirT1 is an inhibitor of proliferation and tumor formation in colon cancer
-
Kabra, N. et al. 2009. SirT1 is an inhibitor of proliferation and tumor formation in colon cancer. J. Biol. Chem. 284: 18210-18217.
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 18210-18217
-
-
Kabra, N.1
-
42
-
-
67650677845
-
Resveratrol induces senescence-like growth inhibition of U-2 OS cells associated with the instability of telomeric DNA and upregulation of BRCA1
-
Rusin, M., A. Zajkowicz & D. Butkiewicz. 2009. Resveratrol induces senescence-like growth inhibition of U-2 OS cells associated with the instability of telomeric DNA and upregulation of BRCA1. Mech. Ageing Dev. 130: 528-537.
-
(2009)
Mech. Ageing Dev.
, vol.130
, pp. 528-537
-
-
Rusin, M.1
Zajkowicz, A.2
Butkiewicz, D.3
-
43
-
-
53149144656
-
Interplay among BRCA1, SIRT1, and Survivin during BRCA1-associated tumorigenesis
-
Wang, R.H. et al. 2008. Interplay among BRCA1, SIRT1, and Survivin during BRCA1-associated tumorigenesis. Mol. Cell 32: 11-20.
-
(2008)
Mol. Cell
, vol.32
, pp. 11-20
-
-
Wang, R.H.1
-
44
-
-
79551521179
-
Disruption of a Sirt1-dependent autophagy checkpoint in the prostate results in prostatic intraepithelial neoplasia lesion formation
-
Powell, M.J. et al. 2011. Disruption of a Sirt1-dependent autophagy checkpoint in the prostate results in prostatic intraepithelial neoplasia lesion formation. Cancer Res. 71: 964-975.
-
(2011)
Cancer Res.
, vol.71
, pp. 964-975
-
-
Powell, M.J.1
-
45
-
-
77955499804
-
Sirtuin 1 modulates cellular responses to hypoxia by deacetylating hypoxia-inducible factor 1alpha
-
Lim, J.H. et al. 2010. Sirtuin 1 modulates cellular responses to hypoxia by deacetylating hypoxia-inducible factor 1alpha. Mol. Cell 38: 864-878.
-
(2010)
Mol. Cell
, vol.38
, pp. 864-878
-
-
Lim, J.H.1
-
46
-
-
70349324812
-
A protein deacetylase SIRT1 is a negative regulator of metalloproteinase-9
-
Nakamaru, Y. et al. 2009. A protein deacetylase SIRT1 is a negative regulator of metalloproteinase-9. FASEB J. 23: 2810-2819.
-
(2009)
FASEB J.
, vol.23
, pp. 2810-2819
-
-
Nakamaru, Y.1
-
47
-
-
59149085705
-
Hyaluronan-mediated CD44 interaction with p300 and SIRT1 regulates beta-catenin signaling and NFkappaB-specific transcription activity leading to MDR1 and Bcl-xL gene expression and chemoresistance in breast tumor cells
-
Bourguignon, L.Y., W. Xia & G. Wong. 2009. Hyaluronan-mediated CD44 interaction with p300 and SIRT1 regulates beta-catenin signaling and NFkappaB-specific transcription activity leading to MDR1 and Bcl-xL gene expression and chemoresistance in breast tumor cells. J. Biol. Chem. 284: 2657-2671.
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 2657-2671
-
-
Bourguignon, L.Y.1
Xia, W.2
Wong, G.3
-
48
-
-
53149137486
-
Impaired DNA damage response, genome instability, and tumorigenesis in SIRT1 mutant mice
-
Wang, R.H. et al. 2008. Impaired DNA damage response, genome instability, and tumorigenesis in SIRT1 mutant mice. Cancer Cell. 14: 312-323.
-
(2008)
Cancer Cell.
, vol.14
, pp. 312-323
-
-
Wang, R.H.1
-
49
-
-
44849096876
-
The SIRT1 deacetylase suppresses intestinal tumorigenesis and colon cancer growth
-
Firestein, R. et al. 2008. The SIRT1 deacetylase suppresses intestinal tumorigenesis and colon cancer growth. PLoS One 3: e2020.
-
(2008)
PLoS One
, vol.3
-
-
Firestein, R.1
-
50
-
-
34547100073
-
SIRT1 is significantly elevated in mouse and human prostate cancer
-
Huffman, D.M. et al. 2007. SIRT1 is significantly elevated in mouse and human prostate cancer. Cancer Res. 67: 6612-6618.
-
(2007)
Cancer Res.
, vol.67
, pp. 6612-6618
-
-
Huffman, D.M.1
-
51
-
-
59649126261
-
Deacetylation of cortactin by SIRT1 promotes cell migration
-
Zhang, Y. et al. 2009. Deacetylation of cortactin by SIRT1 promotes cell migration. Oncogene 28: 445-460.
-
(2009)
Oncogene
, vol.28
, pp. 445-460
-
-
Zhang, Y.1
-
52
-
-
84865143188
-
SIRT1 promotes tumorigenesis and resistance to chemotherapy in hepatocellular carcinoma and its expression predicts poor prognosis
-
Chen, H.C. et al. 2012. SIRT1 promotes tumorigenesis and resistance to chemotherapy in hepatocellular carcinoma and its expression predicts poor prognosis. Ann. Surg. Oncol. 19: 2011-2019.
-
(2012)
Ann. Surg. Oncol. 19: 2011-2019.
-
-
Chen, H.C.1
-
53
-
-
77954647009
-
Balance between SIRT1 and DBC1 expression is lost in breast cancer
-
Sung, J.Y. et al. 2010. Balance between SIRT1 and DBC1 expression is lost in breast cancer. Cancer Sci. 101: 1738-1744.
-
(2010)
Cancer Sci.
, vol.101
, pp. 1738-1744
-
-
Sung, J.Y.1
-
54
-
-
84860253067
-
Expression of SIRT1 in gastric cardiac cancer and its clinicopathologic significance
-
Feng, A.N. et al. 2011. Expression of SIRT1 in gastric cardiac cancer and its clinicopathologic significance. Int. J. Surg. Pathol 19: 743-750.
-
(2011)
Int. J. Surg. Pathol
, vol.19
, pp. 743-750
-
-
Feng, A.N.1
-
55
-
-
80052600926
-
SIRT1 RNAi knockdown induces apoptosis and senescence, inhibits invasion and enhances chemosensitivity in pancreatic cancer cells
-
Zhao, G. et al. 2011. SIRT1 RNAi knockdown induces apoptosis and senescence, inhibits invasion and enhances chemosensitivity in pancreatic cancer cells. Gene Ther. 18: 920-928.
-
(2011)
Gene Ther.
, vol.18
, pp. 920-928
-
-
Zhao, G.1
-
56
-
-
36549044009
-
Function of the SIRT1 protein deacetylase in cancer
-
Stunkel, W. et al. 2007. Function of the SIRT1 protein deacetylase in cancer. Biotechnol. J. 2: 1360-1368.
-
(2007)
Biotechnol. J.
, vol.2
, pp. 1360-1368
-
-
Stunkel, W.1
-
57
-
-
84864549056
-
Loss of SIRT1 histone deacetylase expression associates with tumour progression in colorectal adenocarcinoma
-
Jang, S.H. et al. 2012. Loss of SIRT1 histone deacetylase expression associates with tumour progression in colorectal adenocarcinoma. J. Clin. Pathol. 65: 735-739.
-
(2012)
J. Clin. Pathol.
, vol.65
, pp. 735-739
-
-
Jang, S.H.1
-
58
-
-
53449083751
-
SIRT1 expression is associated with poor prognosis of diffuse large B-cell lymphoma
-
Jang, K.Y. et al. 2008. SIRT1 expression is associated with poor prognosis of diffuse large B-cell lymphoma. Am. J. Surg. Pathol. 32: 1523-1531.
-
(2008)
Am. J. Surg. Pathol.
, vol.32
, pp. 1523-1531
-
-
Jang, K.Y.1
-
59
-
-
68849097673
-
Expression and prognostic significance of SIRT1 in ovarian epithelial tumours
-
Jang, K.Y. et al. 2009. Expression and prognostic significance of SIRT1 in ovarian epithelial tumours. Pathology. 41: 366-371.
-
(2009)
Pathology.
, vol.41
, pp. 366-371
-
-
Jang, K.Y.1
-
60
-
-
67650348173
-
Expression of DBC1 and SIRT1 is associated with poor prognosis of gastric carcinoma
-
Cha, E.J. et al. 2009. Expression of DBC1 and SIRT1 is associated with poor prognosis of gastric carcinoma. Clin. Cancer Res. 15: 4453-4459.
-
(2009)
Clin. Cancer Res.
, vol.15
, pp. 4453-4459
-
-
Cha, E.J.1
-
61
-
-
34249817549
-
Transactivation of miR-34a by p53 broadly influences gene expression and promotes apoptosis
-
Chang, T.C. et al. 2007. Transactivation of miR-34a by p53 broadly influences gene expression and promotes apoptosis. Mol. Cell 26: 745-752.
-
(2007)
Mol. Cell
, vol.26
, pp. 745-752
-
-
Chang, T.C.1
-
62
-
-
77953292238
-
SIRT1 and p53, effect on cancer, senescence and beyond
-
Yi, J. & J. Luo. 2010. SIRT1 and p53, effect on cancer, senescence and beyond. Biochim. Biophys. Acta. 1804: 1684-1689.
-
(2010)
Biochim. Biophys. Acta.
, vol.1804
, pp. 1684-1689
-
-
Yi, J.1
Luo, J.2
-
63
-
-
27544434763
-
Tumor suppressor HIC1 directly regulates SIRT1 to modulate p53-dependent DNA-damage responses
-
Chen, W.Y. et al. 2005. Tumor suppressor HIC1 directly regulates SIRT1 to modulate p53-dependent DNA-damage responses. Cell 123: 437-448.
-
(2005)
Cell
, vol.123
, pp. 437-448
-
-
Chen, W.Y.1
-
64
-
-
35748949600
-
Deacetylation of the retinoblastoma tumour suppressor protein by SIRT1
-
Wong, S. & J.D. Weber. 2007. Deacetylation of the retinoblastoma tumour suppressor protein by SIRT1. Biochem J. 407: 451-460.
-
(2007)
Biochem J.
, vol.407
, pp. 451-460
-
-
Wong, S.1
Weber, J.D.2
-
65
-
-
52049102233
-
PTEN acetylation modulates its interaction with PDZ domain
-
Ikenoue, T. et al. 2008. PTEN acetylation modulates its interaction with PDZ domain. Cancer Res. 68: 6908-6912.
-
(2008)
Cancer Res.
, vol.68
, pp. 6908-6912
-
-
Ikenoue, T.1
-
67
-
-
84856384698
-
The c-MYC oncoprotein, the NAMPT enzyme, the SIRT1-inhibitor DBC1, and the SIRT1 deacetylase form a positive feedback loop
-
Menssen, A. et al. 2012. The c-MYC oncoprotein, the NAMPT enzyme, the SIRT1-inhibitor DBC1, and the SIRT1 deacetylase form a positive feedback loop. Proc. Natl. Acad. Sci. USA 109: E187-196.
-
(2012)
Proc. Natl. Acad. Sci. USA
, vol.109
-
-
Menssen, A.1
-
68
-
-
80053377582
-
Sirt1 deacetylates c-Myc and promotes c-Myc/Max association
-
Mao, B. et al. 2011. Sirt1 deacetylates c-Myc and promotes c-Myc/Max association. Int. J. Biochem. Cell Biol. 43: 1573-1581.
-
(2011)
Int. J. Biochem. Cell Biol.
, vol.43
, pp. 1573-1581
-
-
Mao, B.1
-
69
-
-
79959837062
-
SIRT1 promotes N-Myc oncogenesis through a positive feedback loop involving the effects of MKP3 and ERK on N-Myc protein stability
-
Marshall, G.M. et al. 2011. SIRT1 promotes N-Myc oncogenesis through a positive feedback loop involving the effects of MKP3 and ERK on N-Myc protein stability. PLoS Genet. 7: e1002135.
-
(2011)
PLoS Genet.
, vol.7
-
-
Marshall, G.M.1
-
70
-
-
84863116364
-
Activation of stress response gene SIRT1 by BCR-ABL promotes leukemogenesis
-
Yuan, H. et al. 2012. Activation of stress response gene SIRT1 by BCR-ABL promotes leukemogenesis. Blood 119: 1904-1914.
-
(2012)
Blood
, vol.119
, pp. 1904-1914
-
-
Yuan, H.1
-
71
-
-
79960620082
-
The deacetylase SIRT1 promotes membrane localization and activation of Akt and PDK1 during tumorigenesis and cardiac hypertrophy
-
Sundaresan, N.R. et al. 2011. The deacetylase SIRT1 promotes membrane localization and activation of Akt and PDK1 during tumorigenesis and cardiac hypertrophy. Sci. Signal. 4: ra46.
-
(2011)
Sci. Signal.
, vol.4
-
-
Sundaresan, N.R.1
-
72
-
-
30544445468
-
Sirt1 inhibitor, Sirtinol, induces senescence-like growth arrest with attenuated Ras-MAPK signaling in human cancer cells
-
Ota, H. et al. 2006. Sirt1 inhibitor, Sirtinol, induces senescence-like growth arrest with attenuated Ras-MAPK signaling in human cancer cells. Oncogene. 25: 176-185.
-
(2006)
Oncogene.
, vol.25
, pp. 176-185
-
-
Ota, H.1
-
73
-
-
84863011183
-
Activation of p53 by SIRT1 inhibition enhances elimination of CML leukemia stem cells in combination with imatinib
-
Li, L. et al. 2012. Activation of p53 by SIRT1 inhibition enhances elimination of CML leukemia stem cells in combination with imatinib. Cancer Cell 21: 266-281.
-
(2012)
Cancer Cell
, vol.21
, pp. 266-281
-
-
Li, L.1
-
74
-
-
47249154705
-
A role for SIRT1 in cell growth and chemoresistance in prostate cancer PC3 and DU145 cells
-
Kojima, K. et al. 2008. A role for SIRT1 in cell growth and chemoresistance in prostate cancer PC3 and DU145 cells. Biochem. Biophys. Res. Commun. 373: 423-428.
-
(2008)
Biochem. Biophys. Res. Commun.
, vol.373
, pp. 423-428
-
-
Kojima, K.1
-
75
-
-
60149091562
-
Salermide, a Sirtuin inhibitor with a strong cancer-specific proapoptotic effect
-
Lara, E. et al. 2009. Salermide, a Sirtuin inhibitor with a strong cancer-specific proapoptotic effect. Oncogene. 28: 781-791.
-
(2009)
Oncogene.
, vol.28
, pp. 781-791
-
-
Lara, E.1
-
76
-
-
77950835404
-
SIRT inhibitors induce cell death and p53 acetylation through targeting both SIRT1 and SIRT2
-
Peck, B. et al. 2010. SIRT inhibitors induce cell death and p53 acetylation through targeting both SIRT1 and SIRT2. Mol. Cancer Ther. 9: 844-855.
-
(2010)
Mol. Cancer Ther.
, vol.9
, pp. 844-855
-
-
Peck, B.1
-
77
-
-
79958787784
-
Sirtuin 1 is upregulated in a subset of hepatocellular carcinomas where it is essential for telomere maintenance and tumor cell growth
-
Chen, J. et al. 2011. Sirtuin 1 is upregulated in a subset of hepatocellular carcinomas where it is essential for telomere maintenance and tumor cell growth. Cancer Res. 71: 4138-4149.
-
(2011)
Cancer Res.
, vol.71
, pp. 4138-4149
-
-
Chen, J.1
-
78
-
-
28544444366
-
Cancer-specific functions of SIRT1 enable human epithelial cancer cell growth and survival
-
Ford, J., M. Jiang & J. Milner. 2005. Cancer-specific functions of SIRT1 enable human epithelial cancer cell growth and survival. Cancer Res. 65: 10457-10463.
-
(2005)
Cancer Res.
, vol.65
, pp. 10457-10463
-
-
Ford, J.1
Jiang, M.2
Milner, J.3
-
80
-
-
79960391940
-
miR-200a regulates SIRT1 expression and epithelial to mesenchymal transition (EMT)-like transformation in mammary epithelial cells
-
Eades, G. et al. 2011. miR-200a regulates SIRT1 expression and epithelial to mesenchymal transition (EMT)-like transformation in mammary epithelial cells. J. Biol. Chem. 286: 25992-26002.
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 25992-26002
-
-
Eades, G.1
-
81
-
-
84867901275
-
SIRT1 induces EMT by cooperating with EMT transcription factors and enhances prostate cancer cell migration and metastasis
-
Jan 16. doi:10.1038/onc.2011.612. [Epub ahead of print].
-
Byles, V. et al. 2012. SIRT1 induces EMT by cooperating with EMT transcription factors and enhances prostate cancer cell migration and metastasis. Oncogene. Jan 16. doi:10.1038/onc.2011.612. [Epub ahead of print].
-
(2012)
Oncogene.
-
-
Byles, V.1
-
82
-
-
77952714326
-
SIRT1 regulates Dishevelled proteins and promotes transient and constitutive Wnt signaling
-
Holloway, K.R. et al. 2010. SIRT1 regulates Dishevelled proteins and promotes transient and constitutive Wnt signaling. Proc. Natl. Acad. Sci. U. S. A. 107: 9216-9221.
-
(2010)
Proc. Natl. Acad. Sci. U. S. A.
, vol.107
, pp. 9216-9221
-
-
Holloway, K.R.1
-
83
-
-
28544451205
-
Control of multidrug resistance gene mdr1 and cancer resistance to chemotherapy by the longevity gene sirt1
-
Chu, F. et al. 2005. Control of multidrug resistance gene mdr1 and cancer resistance to chemotherapy by the longevity gene sirt1. Cancer Res. 65: 10183-10187.
-
(2005)
Cancer Res.
, vol.65
, pp. 10183-10187
-
-
Chu, F.1
-
84
-
-
53349091778
-
SIRT1 contributes in part to cisplatin resistance in cancer cells by altering mitochondrial metabolism
-
Liang, X.J. et al. 2008. SIRT1 contributes in part to cisplatin resistance in cancer cells by altering mitochondrial metabolism. Mol. Cancer Res. 6: 1499-1506.
-
(2008)
Mol. Cancer Res.
, vol.6
, pp. 1499-1506
-
-
Liang, X.J.1
-
85
-
-
77958126835
-
Amurensin G, a potent natural SIRT1 inhibitor, rescues doxorubicin responsiveness via down-regulation of multidrug resistance 1
-
Oh, W.K. et al. 2010. Amurensin G, a potent natural SIRT1 inhibitor, rescues doxorubicin responsiveness via down-regulation of multidrug resistance 1. Mol. Pharmacol. 78: 855-864.
-
(2010)
Mol. Pharmacol.
, vol.78
, pp. 855-864
-
-
Oh, W.K.1
-
86
-
-
84873408603
-
SIRT1 deacetylase promotes acquisition of genetic mutations for drug resistance in CML cells
-
Mar 12. doi:10.1038/onc.2012.83. [Epub ahead of print].
-
Wang, Z. et al. 2012. SIRT1 deacetylase promotes acquisition of genetic mutations for drug resistance in CML cells. Oncogene. Mar 12. doi:10.1038/onc.2012.83. [Epub ahead of print].
-
(2012)
Oncogene.
-
-
Wang, Z.1
-
87
-
-
34548598664
-
Downregulation of Sirt1 by antisense oligonucleotides induces apoptosis and enhances radiation sensitization in A549 lung cancer cells
-
Sun, Y. et al. 2007. Downregulation of Sirt1 by antisense oligonucleotides induces apoptosis and enhances radiation sensitization in A549 lung cancer cells. Lung Cancer 58: 21-29.
-
(2007)
Lung Cancer
, vol.58
, pp. 21-29
-
-
Sun, Y.1
-
88
-
-
34250365395
-
Nucleocytoplasmic shuttling of the NAD+-dependent histone deacetylase SIRT1
-
Tanno, M. et al. 2007. Nucleocytoplasmic shuttling of the NAD+-dependent histone deacetylase SIRT1. J. Biol. Chem. 282: 6823-6832.
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 6823-6832
-
-
Tanno, M.1
-
89
-
-
25144454432
-
Increased dosage of mammalian Sir2 in pancreatic beta cells enhances glucose-stimulated insulin secretion in mice
-
Moynihan, K.A. et al. 2005. Increased dosage of mammalian Sir2 in pancreatic beta cells enhances glucose-stimulated insulin secretion in mice. Cell Metab. 2: 105-117.
-
(2005)
Cell Metab.
, vol.2
, pp. 105-117
-
-
Moynihan, K.A.1
-
90
-
-
36348974168
-
The direct involvement of SirT1 in insulin-induced insulin receptor substrate-2 tyrosine phosphorylation
-
Zhang, J. 2007. The direct involvement of SirT1 in insulin-induced insulin receptor substrate-2 tyrosine phosphorylation. J. Biol. Chem. 282: 34356-34364.
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 34356-34364
-
-
Zhang, J.1
-
91
-
-
78650048197
-
Aberrant cytoplasm localization and protein stability of SIRT1 is regulated by PI3K/IGF-1R signaling in human cancer cells
-
Byles, V. et al. 2010. Aberrant cytoplasm localization and protein stability of SIRT1 is regulated by PI3K/IGF-1R signaling in human cancer cells. Int. J. Biol. Sci. 6: 599-612.
-
(2010)
Int. J. Biol. Sci.
, vol.6
, pp. 599-612
-
-
Byles, V.1
-
92
-
-
69249161792
-
MYC insertions in diffuse-type gastric adenocarcinoma
-
Calcagno, D.Q. et al. 2009. MYC insertions in diffuse-type gastric adenocarcinoma. Anticancer Res. 29: 2479-2483.
-
(2009)
Anticancer Res.
, vol.29
, pp. 2479-2483
-
-
Calcagno, D.Q.1
-
93
-
-
0842269247
-
The importance of p53 location: nuclear or cytoplasmic zip code
-
O'Brate, A. & P. Giannakakou. 2003. The importance of p53 location: nuclear or cytoplasmic zip code Drug Resist. Updat. 6: 313-322.
-
(2003)
Drug Resist. Updat.
, vol.6
, pp. 313-322
-
-
O'Brate, A.1
Giannakakou, P.2
-
94
-
-
65949083750
-
Cytoplasmic functions of the tumour suppressor p53
-
Green, D.R. & G. Kroemer. 2009. Cytoplasmic functions of the tumour suppressor p53. Nature 458: 1127-1130.
-
(2009)
Nature
, vol.458
, pp. 1127-1130
-
-
Green, D.R.1
Kroemer, G.2
-
95
-
-
79953898189
-
Sirtuin 1 in lipid metabolism and obesity
-
Schug, T.T. & X. Li. 2011. Sirtuin 1 in lipid metabolism and obesity. Ann. Med. 43: 198-211.
-
(2011)
Ann. Med.
, vol.43
, pp. 198-211
-
-
Schug, T.T.1
Li, X.2
-
96
-
-
80052638751
-
Sirtinol treatment reduces inflammation in human dermal microvascular endothelial cells
-
Orecchia, A. et al. 2011. Sirtinol treatment reduces inflammation in human dermal microvascular endothelial cells. PLoS One 6: e24307.
-
(2011)
PLoS One
, vol.6
-
-
Orecchia, A.1
-
97
-
-
77953724950
-
Protein deacetylase SIRT1 in the cytoplasm promotes nerve growth factor-induced neurite outgrowth in PC12 cells
-
Sugino, T. et al. 2010. Protein deacetylase SIRT1 in the cytoplasm promotes nerve growth factor-induced neurite outgrowth in PC12 cells. FEBS Lett. 584: 2821-2826.
-
(2010)
FEBS Lett.
, vol.584
, pp. 2821-2826
-
-
Sugino, T.1
|