SIRT1 RNAi knockdown induces apoptosis and senescence, inhibits invasion and enhances chemosensitivity in pancreatic cancer cells

Gene Therapy

Volumn 18, Issue 9, 2011, Pages 920-928

  Zhao, G ^a   Cui, J ^a   Zhang, J G ^a   Qin, Q ^a   Chen, Q ^a   Yin, T ^a   Deng, S C ^a   Liu, Y ^a   Liu, L ^a   Wang, B ^a   Tian, K ^a   Wang, G B ^a   Wang, C Y ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

apoptosis; pancreatic cancer; proliferation; RNAi; SIRT1

Indexed keywords

FLUOROURACIL; GEMCITABINE; MESSENGER RNA; SHORT HAIRPIN RNA; SIRTUIN 1; TRANSCRIPTION FACTOR FKHRL1;

ADULT; APOPTOSIS; ARTICLE; CANCER CELL; CARCINOGENESIS; CELL CYCLE ARREST; CELL CYCLE G1 PHASE; CELL PROLIFERATION; CHEMOSENSITIVITY; DISEASE SEVERITY; FEMALE; GENE EXPRESSION; GENE OVEREXPRESSION; GENE SILENCING; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; LIVER METASTASIS; LYMPH NODE METASTASIS; MALE; MOUSE; NONHUMAN; PANCREAS CANCER; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; RNA INTERFERENCE; SENESCENCE;

ANIMALS; APOPTOSIS; CELL LINE, TUMOR; CELL PROLIFERATION; FEMALE; FLUOROURACIL; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE KNOCKDOWN TECHNIQUES; HUMANS; MALE; MICE; MICE, NUDE; MIDDLE AGED; NEOPLASM INVASIVENESS; NEOPLASM TRANSPLANTATION; PANCREATIC NEOPLASMS; SIRTUIN 1;

EID: 80052600926     PISSN: 09697128     EISSN: 14765462     Source Type: Journal    
DOI: 10.1038/gt.2011.81     Document Type: Article

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