Wortmannin Reduces Insulin Signaling and Death in Seizure-Prone Pcmt1-/- Mice

PLoS ONE

Volumn 7, Issue 10, 2012, Pages

  MacKay, Kennen B ^a   Lowenson, Jonathan D ^a   Clarke, Steven G ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DIMETHYL SULFOXIDE; INSULIN; ISOASPARTYL (DEXTRO ASPARTYL) O METHYLTRANSFERASE; MAMMALIAN TARGET OF RAPAMYCIN; METHYLTRANSFERASE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE 1; PROTEIN KINASE B; UNCLASSIFIED DRUG; WORTMANNIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN DISEASE; BRAIN ENLARGEMENT; BRAIN SIZE; BRAIN WEIGHT; CATALYSIS; CONTROLLED STUDY; DEATH; DISEASE PREDISPOSITION; DRUG MECHANISM; ENZYME INHIBITION; FEMALE; IMMUNOBLOTTING; KNOCKOUT MOUSE; LIFE EXTENSION; MALE; MOUSE; MOUSE STRAIN; NONHUMAN; PROTEIN PHOSPHORYLATION; SEIZURE; SEX DIFFERENCE; SIGNAL TRANSDUCTION; SURVIVAL RATE; TONIC CLONIC SEIZURE; WEIGHT REDUCTION; WILD TYPE;

ADMINISTRATION, ORAL; ANDROSTADIENES; ANIMALS; ASPARAGINE; ASPARTIC ACID; BRAIN; FEMALE; INSULIN; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MICE; MICE, KNOCKOUT; ORGAN SIZE; PHOSPHATIDYLINOSITOL 3-KINASES; PHOSPHOPROTEINS; PROTEIN D-ASPARTATE-L-ISOASPARTATE METHYLTRANSFERASE; PROTEIN PROCESSING, POST-TRANSLATIONAL; SEIZURES; SIGNAL TRANSDUCTION;

ANIMALIA; MUS;

EID: 84867148645     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0046719     Document Type: Article

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