Wortmannin-mediated inhibition of phosphatidylinositol 3-kinase activity triggers apoptosis in normal and neoplastic B lymphocytes which are in cell cycle

International Immunology

Volumn 8, Issue 4, 1996, Pages 585-594

  Padmore, Lauren ^a   Radda, George K ^a   Knox, Kirstine A ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Apoptosis; B lymphocyte; Neoplasm; Phosphatidylinositol 3 kinase; Wortmannin

Indexed keywords

IMMUNOGLOBULIN M ANTIBODY; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHORUS 32; TRITIUM; WORTMANNIN;

APOPTOSIS; ARTICLE; B LYMPHOCYTE; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CONTROLLED STUDY; DNA SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; MITOGENESIS; NEOPLASM; PRIORITY JOURNAL;

1-PHOSPHATIDYLINOSITOL 4-KINASE; ANDROSTADIENES; ANTIBODIES, ANTI-IDIOTYPIC; APOPTOSIS; B-LYMPHOCYTES; BLOTTING, WESTERN; BURKITT LYMPHOMA; CELL CYCLE; CELL DIVISION; CELLS, CULTURED; ENZYME INHIBITORS; HUMANS; IMMUNOGLOBULIN M; LIGATION; MICROSCOPY, ELECTRON; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); RECEPTORS, ANTIGEN, B-CELL; TUMOR CELLS, CULTURED;

EID: 0029981627     PISSN: 09538178     EISSN: None     Source Type: Journal    
DOI: 10.1093/intimm/8.4.585     Document Type: Article

References (46)

1. MacLennan, I. C. M. and Gray, D 1986. Antigen-driven selection of virgin and memory B cells Immunol Rev 91.61.
2. MacLennan, I C M., Liu, Y-J. and Ling, N R. 1988 The evolution of B-cell clones. Curr. Top Microbiol. Immunol 141.138.
3. Liu, Y.-J , Joshua, D E., Williams, G. T., Smith, C. A., Gordon, J and MacLennan, I. C M 1989 Mechanism of antigen driven selection in germinal centres. Nature 342 929.
4. Holder, M J., Lui, Y. J., Defrance, T., Flores-Romo, L., MacLennan, I. C M. and Gordon, J. 1992. Growth factor requirements for the stimulation of germinal centre B cells: evidence for an IL-2-dependent pathway of development. Int Immunol. 12 1243
5. Gregory, C. D , Dive, C , Henderson, S., Smith, C A., Williams, G T , Gordon, J and Rickinson, A. B. 1991. Activation of Epstein-Barr virus latent genes protects human B cells from death by apoptosis. Nature 349:612.
6. Bonnefoy-Beard, N., Genestier, L., Flacher, M. and Revillard, J. P 1994. The phosphoprotein phosphatase calcineurin controls calcium-dependent apoptosis in B cell lines Eur. J Immunol. 24.325.
7. Misener, V., Downey, G. P. and Jongstra, J 1991. The immunoglobulin light chain related protein lambda 5 is expressed on the surface of mouse pre-B cell lines and can function as a signal transducing molecule. Int Immunol. 3:1192.
8. Bossy, D , Salamero, J , Olive, D , Fourgereau, M. and Schiff, C. 1993 Structure biosynthesis, and transduction properties of the human mu-psi L complex: similar behaviour of pre-B and intermediate pre-B-B cells in transducing ability. Int Immunol. 5.467
9. Yellen, A Y , Glenn, W , Sukhatme, V. P , Cao, X M and Monroe, J G 1991 Signalling through surface IgM in tolerance-susceptible immature murine B lymphocytes. Developmentally regulated differences in transmembrane signalling in splenic B cells from adult and neonatal mice. J Immunol. 146:1446
10. Liou, L B , Warner, G L and Scott, D W 1992 Can peritoneal B cells be rendered unresponsive? Int Immunol. 4:15
11. Cambier, J C., Bedzyk, W., Campbell, K., Chien, N , Friedrich, J , Harwood, A , Jensen W , Pleiman, C and Clark, M. R. 1993. The B-cell antigen receptor, stucture and function of primary, secondary, tertiary and quaternary components Immunol Rev. 132 85
12. Pleiman, C M , D'Ambrosio, D and Cambier, J C. 1994 The B-cell antigen-receptor complex, structure and signal transduction. Immunol Today 9 393
13. Pleiman, C M , Hertz, W. M and Cambier, J. C 1994 Activation of phosphatidylinositol-3-kinase by Src-family kinase SH3 binding to the p85 subunit Science 263 1609
14. Cantley L C , Auger, K R , Carpenter, C , Duckworth, B., Graziani, A., Kapeller, R and Soltoff, S 1991 Oncogenes and signal transduction Cell 64:281
15. Carpenter, C L , Duckworth, B , Auger, K. R , Cohen, B., Schaffhausen, B S and Cantley, L C 1990 Purification and characterisation of phosphoinositide-3-kinase from rat liver J Biol. Chem 265:19704
16. Panayotou, G and Waterfield, M D 1992 Phosphatidylinositol-3-kinase, a key enzyme in a diverse signalling process Trends Cell Biol. 2:358
17. Chung, J., Kuo, C. J., Crabtree, G. R and Blenis, J 1992. Rapamycin-FKBP specifically blocks growth-dependent activation of signaling by the 70 kd S6 protein kinase. Cell 69:1227
18. Downes, C. P and Carter, A N 1991. Phosphoinositide-3-kinase-a new effector in signal transduction? Cell Signal. 3 501
19. Kanai, F., Ito, K., Todaka, M., Hayashi, H , Kamohara, S , Ishii, K., Okada, T , Hazeki, O , Ui, M and Ebina, Y. 1993 Insulin-stimulated Glut4 translocation is relevant to the phosphorylation of IRS-1 and the activity of PI3-kinase Biochem Biophys Res Commun. 195:762.
20. Arcado, A. and Wyman, M. P. 1993 Wortmannin is a potent phosphatidylinositol 3-kinase inhibitor the role of phosphatidylinositol 3,4,5-trisphosphate in neutrophil responses. Biochem J 296.297
21. Powis, G., Bonpuklian, R , Berggren, M., Gallegos, A., Abraham, R., Ashendel, C., Zalkow, L., Matter, W. F., Dodge, J., Grindley, G and Vlahos, C. J 1994 Wortmannin, a potent and selective inhibitor of phosphatidylinositol-3-kinase Cancer Res. 54:2419
22. Klein, G., Giovanella, B., Westman, A., Stehlin, J. and Mumford, D. 1975. An EBV genome-negative cell line established from an American Burkitt lymphoma, receptor characteristics. EBV infectibility and permanent conversion into EBV-positive sublines by in vitro infection Intervirology 5.319.
23. Magrath, I T , Pizzo, P A , Whang-Peng, J., Douglass, E. C , Alabaster, O., Gerber, P., Freeman, C B and Nivikovs, L 1980. Characterisation of lymphoma-derived cell lines: comparison of cell lines postive and negative for Epstein-Barr virus nuclear antigen. I Physical, cytogenic and growth characteristics. J Natl Cancer Inst 64.465
24. Magrath, I T., Freeman, C. B., Pizzo, P. A., Gadek, J., Jaffe, E , Santaella, M , Hammer, C , Frank, M , Reaman, G and Novikovs, L 1980. Characterisation of lymphoma-derived cell lines: comparison of cell lines postive and negative for Epstein-Barr virus nuclear antigen II Surface markers J. Natl Cancer Inst 64:477
25. Gordon, J , Guy, G and Walker, L 1985. Autocrine models of B-lymphocyte growth. I. Role of cell contact and soluble factors in T-independent B-cell responses. Immunol 56 329
26. Knox, K A , Finney, M. Milner, A E , Gregory, C. D , Wakelam, M. J O., Michell, R. H and Gordon, J. 1992. Second-messenger pathways involved in the regulation of survival in germinal-centre B cells and Burkitt lymphoma lines Int J. Cancer 5.1085.
27. Telford, W. G., King, L E. and Fraker, P J. 1992. Comparative evaluation of several DNA binding dyes in the detection of apoptosis-associated chromatin degradation by flow cytometry Cytometry 13:137
28. Gold, M R., Chan, V W-F., Turck, C. W and DeFranco, A L. 1992. Membrane Ig cross-linking regulates phosphatidylinositol 3-kinase in B lymphocytes J Immunol 148:2012.
29. Gold, M. R , Duronio, V , Saxena, S. P., Schrader, J W. and Aebersold, R 1994 Multiple cytokines activate phosphatidylinositol 3-kinase in hemopoietic cells. J Biol Chem 269:5403
30. Kelly K and Knox, K A 1995 Differential regulatory effects of cAMP-elevating agents on human normal and neoplastic B cell functional response following ligation of surface immunoglobulin and CD40 Cell Immunol 166 93
31. Gold, M R and Aebersold, R 1994 Phosphatidylinositol-3-kinase and phosphatidylinositol-4-kinase products are increased by antigen receptor signaling in B cells J Immunol 152.42
32. Yamanashi, Y , Fukui, Y , Wongsasant, B., Kinoshita, Y , Ichimori, Y , Toyoshima, K. and Yamamoto, T 1992. Activation of Src-like protein-tyrosine kinase Lyn and its association with phosphatidylinositol-3-kinase upon B cell antigen receptor-mediated signalling Proc. Natl Acad Sci. USA 89 1118
33. Lu, Y. Phillips, C A and Trevillyan, J M 1995 Phosphatidylinositol 3-kinae activity is not essential for CD28 costimulatory activity in Jurkat T cells: studies with a selective inhibitor, wortmannin. Eur J Immunol 25:533
34. Woscholski, R. Kodaki, T., McKinnon, M. Waterfield, M D and Parker, P J 1994 A comparison of demethoxyviridin and wortmannin as inhibitors of phosphatidylinositol 3-kinase FEBS Lett 342:109
35. Scheid, M P , Lauener, R W and Duronio, V. 1995 Role of phosphatidylinositol 3-OH-kinase in the inhibtion of apoptosis in haemapoietic cells phosphatidylinositol 3-OH-kinase inhibitors reveal a difference in signalling between interleukin-3 and granulocyte-macrophage colony stimulating factor Biochem J. 312.159
36. Yao, R. and Cooper, G. M 1995 Requirement for phosphatidylinositol-3 kinase in the prevention of apoptosis by nerve growth factor Science 267 2003
37. Vlahos, C J , Matter, W F , Hui, K. Y. and Brown, R F 1994 A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4al-1-benzopyran-4-one (LY294002) J Biol Chem 269:5241
38. S6K activation mediated by phosphatidylinositol-3-OH kinase Nature 370:71.
39. Kotani, K , Yonezawa, K , Hara, K , Ueda, H , Kitamura, Y , Sakaue, H., Ando, A , Chavanieu, A., Calas, B , Grigorescu, F , Nishiyama, M , Waterfield, M D. and Kasuga, M 1994 Involvment of phosphatidylinositol 3-kinase in insulin- or IGF-1-induced membrane ruffling. EMBO J. 13.2313.
40. Parker, P J. and Waterfield, M D. 1992. Phosphatidylinositol 3-kinase a novel effector. Cell Growth Different 3:747.
41. Otsu, M , Hiles, I , Gout, I , Fry, M J , Ruiz-Larrea, F , Panayotou, G., Thompson, A , Dhand, R., Hsuan, J , Totty, N , Smith, A D., Morgan, S. J , Courtneidge, S. A , Parker, P J. and Waterfield, M D 1991. Characterisation of two related 85 kd proteins containing SH2 and SH3 domains that bind to receptor tyrosine kinases and polyoma virus middle T antigen/pp60c-src complexes, and associate with phosphatidylinositol 3-kinase Cell 65 91.
42. Hu, P., Mondino, A , Skolnok, E Y and Sclessinger, J. 1993. Cloning of a novel, ubiquitously expressed human phosphatidylinositol 3-kinase and identification of its binding site on p85 Mol Cell Biol, 13 7677
43. Rodriguez-Viciana P., Warne, P A., Dhand, R., Vanhaesebroeck, B, Gout, I., Fry, M. J., Waterfield, M. D and Downward, J 1994 Phosphatidylinositol-3-OH kinase as a direct target of ras. Nature 370:527.
44. Kodaki, T , Woscholski, R , Hallberg, B , Rodriguez-Viciana, P., Downward, J and Parker, P J 1994 The activation of phosphatidylinositol 3-kinase by ras Curr Biol 9 798
45. Stephens, L , Smrcka, A., Cooke, F T , Jackson, T R., Sternweis, P. C and Hawkins, P T 1994 A novel phosphoinositide-3 kinase-activity in myeloid-derived cells is activated by G-protein beta-gamma-subunits Cell 77 83
46. Thomason, P A , James, S R., Casey, P J and Downes, C P 1994 AG-protein βγ-subunit-responsive phosphoinositide 3-kinase activity in human platelet cytosol J. Biol Chem. 269 16525.