Inhibitory effect of wortmannin on phosphatidylinositol 3-kinase-mediated cellular events

Journal of Lipid Mediators and Cell Signalling

Volumn 14, Issue 1-3, 1996, Pages 259-261

  Hazeki, Osamu ^a   Hazeki, Kaoru ^b   Katada, Toshiaki ^a   Ui, Michio ^b  

^a UNIVERSITY OF TOKYO   (Japan)

^b INST OF PHYS AND CHEMICAL RESEARCH   (Japan)

Author keywords

G protein subunits; inhibitor; phosphoinositide 3 kinase; wortmannin

Indexed keywords

ENZYME INHIBITOR; GUANINE NUCLEOTIDE BINDING PROTEIN; IODINE 125; ISOENZYME; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN SUBUNIT; WORTMANNIN;

AFFINITY LABELING; ANIMAL TISSUE; CELL FUNCTION; CONFERENCE PAPER; ENZYME PURIFICATION; LIVER; MOLECULAR WEIGHT; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 0030250021     PISSN: 09297855     EISSN: None     Source Type: Journal    
DOI: 10.1016/0929-7855(96)00534-2     Document Type: Conference Paper

References (8)

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2. Kimura, K. et al. (1994) Neurite outgrowth of PC12 cells is supported by wortmannin, a specific inhibitor of phosphatidylinositol 3-kinase. J. Biol. Chem. 269, 18961-18967.
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4. Okada, T. et al. (1994a) Blockage of chemotactic peptide-induced stimulation of neutrophils by worthmannin as a result of selective inhibition of phosphatidylinositol 3-kinase. J. Biol. Chem. 269, 3563-3567.
5. Okada, T. et al. (1994b) Essential role of phosphatidylinositol 3-kinase in insulin-induced glucose transport and antilipolysis in rat adipocytes. Studies with a selective inhibitor wortmannin. J. Biol. Chem. 269, 3568-3573.
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8. Yano, H. et al. (1993) Inhibition of histamine secretion by wortmannin through the blockade of phosphatidylinositol 3-kinase in RBL-2H3 cells. J. Biol. Chem. 268, 25846-25856.