Ameliorative effect of wortmannin and rapamycin treatment on obesity markers in high fat diet feed rats

Indian Journal of Pharmaceutical Education and Research

Volumn 45, Issue 4, 2011, Pages 333-338

  Jindal, Ankur ^a   Mahesh, Radhakrishnan ^a   Singh, Kulwinder ^b   Bhatt, Shvetank ^a   Gautam, Baldev ^a   Pandey, Dilip Kumar ^a   Lal Sharma, Pyare ^b  

^a BIRLA INSTITUTE OF TECHNOLOGY AND SCIENCE   (India)

^b ISF COLLEGE OF PHARMACY   (India)

Author keywords

Anthropometrical parameters; BMI Body mass index; Fat pads; LI Lee index HFD High fat diet; Obesity; Rapamycin; Wortmannin

Indexed keywords

RAPAMYCIN; WORTMANNIN;

ADIPOSE TISSUE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTHROPOMETRIC PARAMETERS; ARTICLE; BODY MASS; BODY WEIGHT; CONTROLLED STUDY; DRUG ACTIVITY; DRUG EFFICACY; FOOD INTAKE; LIPID DIET; LIVER WEIGHT; MALE; NONHUMAN; OBESITY; RAT;

EID: 83055170741     PISSN: 00195464     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (45)

1. World Health Organization Report of a WHO consultation on obesity, Obesity: preventing and managing the global epidemic. World Health Organization Geneva;1998.
2. Sowers J R. Update on the cardio-metabolic syndrome. Clin Cornerstone 2001;4:17-23.
3. Hall J E, Crook E D, Jones D W, Wofford M R, Dubbert P M. Mechanisms of obesity associated cardiovascular and renal disease. Am J Med Sci 2002;324:127-37.
4. Flier J S. Obesity Wars: Molecular progress confronts an expanding epidemic. Cell 2004;116:337-50.
5. Haslam DW, James WPT. Obesity. Lancet 2005;366:1197-99.
6. Cypess A M, Lehman S, Williams G et al. Identification and importance of brown adipose tissue in adult humans. N Engl J Med 2009;360:509-17.
7. Swinburn BA, Sacks G, Lo S K, et al. Estimating the changes in energy flux that characterize the rise in obesity prevalence. Am J Clin Nutr 2009; 89:1723-8.
8. Bjorntorp P. Adipose tissue distribution and function. Int J Obes 1991;15:67-81.
9. Kim J E, Shepherd P R, Chaussade C. Investigating the role of class-IA PI 3-kinase isoforms in adipocyte differentiation. Biochem Biophys Res Commun 2009;379:830-34.
10. Haffner S M. Pre-diabetes insulin resistance inflammation and CVD risk. Diabetes. Res Clin Pract 2003;61:S9-S18.
11. Despres J P, Lemieux I, Almeras N. Contribution of CB1 blockade to the management of high-risk abdominal obesity. Int J Obes (Lond) 2006;30:S44-S52.
12. Flegal K M, Graubard B I, Williamson D F, Gail M H. Cause-specific excess deaths associated with underweight overweight and obesity. JAMA 2007;298:2028-37.
13. Eckel R H. Nonsurgical management of obesity in adults. N Engl J Med 2008;358:1941-50.
14. Katso R, Okkenhaug K, Ahmadi K, White S, Timms J, Waterfield M D. Cellular function of phosphoinositide 3-kinases: implications for development homeostasis and cancer. Annu Rev Cell Dev Biol 2001;17:615-75.
15. Cantley L C. The phosphoinositide 3-kinase pathway. Science 2002;296:1655-57.
16. Patton D T, Garcon F, Okkenhaug K. The PI3K p110delta controls T-cell development differentiation and regulation. Biochem Soc Trans 2007;35:167-71.
17. Parcellier A, Tintignac L A, Zhuravleva E, Hemmings B A. PKB and the mitochondria: AKTing on apoptosis. Cell Signal 2008;20:21-30.
18. Luo J, Sobkiw C L, Hirshman M F et al. Loss of class IA PI3K signaling in muscle leads to impaired muscle growthinsulin response and hyperlipidemia. Cell Metab 2006;3:355-66.
19. Zhang L, Reidy SP, Nicholson TE et al. The role of AEBP1 in sex-specific diet-induced obesity. Mol Med 2005;11:39-47.
20. Kim J E, Chen J. Regulation of peroxisome proliferator-activated receptor-gamma activity by mammalian target of rapamycin and amino acids in adipogenesis. Diabetes 2004;53:2748-56.
21. Kim Y K, Choi H Y, Kim N H et al. Reversine stimulates adipocyte differentiation and down regulates Akt and p70(s6k) signaling pathways in 3T3-L1 cells. Biochem Biophys Res Commun 2007;358:553-8.
22. Tsang C K, Qi H, Liu L F, Zheng X F S. Targeting mammalian target of rapamycin (mTOR) for health and diseases. Drug Discov Today 2007;12:112-24.
23. Dennis P B, Jaeschke A, Saitoh M, Fowler B, Kozma S C, Thomas G. Mammalian TOR: a homeostatic ATP sensor. Science 2001;294:1102-5.
24. Manning B D. Balancing Akt with S6K: implications for both metabolic diseases and tumorigenesis. J Cell Biol 2004;167:399-403.
25. Inoki K, Corradetti M N, Guan K L. Dysregulation of the TSC-mTOR pathway in human disease. Nat Genet 2005;37:19-24.
26. Xia X, Serrero G. Inhibition of adipose differentiation inhibitors. J Cell by phosphatidylinositol 3-kinase Physiol 1999;178:9-16.
27. Yu W, Chen Z, Zhang J et al. Critical role of phosphoinositide 3-kinase cascade in adipogenesis of human mesenchymal stem cells. Mol Cell Biochem 2008;310:11-8.
28. Srinivasan K, Viswanad B, Asrat L, Kaul C L, Ramarao P. Combination of high-fat diet-fed and low-dose streptozotocin-treated rat: A model for type 2 diabetes and pharmacological screening. Pharmacol Res 2005;52:313-20.
29. Zdychová J, Kazdová L, Pelikanová T, Lindsley J N, Anderson S, Komers R. Renal activity of Akt kinase in obese Zucker rats. Exp Biol Med (Maywood) 2008;233:1231-41.
30. Lynch C J, Gern B, Lloyd C, Hutson S M, Eicher R, Vary T C. Leucine in Food mediates some of the postprandial rise in plasma leptin concentrations. Am J Physiol Endocrinol Metab 2006;91: E621.
31. Novellie L B, Diniz Y S, Galhardi C M et al. Anthropometrical parameters and markers of obesity in rats. Lab Animals 2007;41:111-19.
32. Bernardis L L, Luboshitsky R, Bellingerâ L L, Mcewen G. Nutritional studies in the weanling rat with normophagic hypothalamic obesity. J Nutr 1982;112:1441-55.
33. Ainslie D A, Proietto J, Fam B C, Thorburn A W. Short-term high-fat diets lower circulating leptin concentrations in rats. Am J Clin Nutr 2000;71:438-42.
34. Kim J H, Hahm D H, Yang D C, Kim J H, Lee H J, Shim I. Effect of crude saponin of Korean red ginseng on high-fat diet-induced obesity in the rat. J Pharmacol Sci 2005;97:124-31.
35. De Wit N J, Bosch-Vermeulen H, de Groot P J et al. The role of the small intestine in the development of dietary fat-induced obesity and insulin resistance in C57BL/6J mice. BMC Med Genomics 2008;1:14.
36. Saiki R, Okazaki M, Iwai S, Kumai T, Kobayashi S, Oguchi K. Effects of pioglitazone on increases in visceral fat accumulation and oxidative stress in spontaneously hypertensive hyperlipidemic rats fed a high-fat diet and sucrose solution. J Pharmacol Sci 2007;105:157-67.
37. Um S H, Frigerio F, Watanabe M et al. Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensititivity. Nature 2004;431:200-5.
38. Rosenbaum M, Leibel R L, Hirsch J. Obesity. N Engl J Med 1997;337:396-407.
39. Le Bacquer O, Petroulakis E, Paglialunga S et al. Elevated sensitivity to diet-induced obesity and insulin resistance in mice lacking 4E-BP1 and 4E-BP2. J Clin Invest 2007;117:387-96.
40. Skurk T, Alberti-Huber C, Herder C, Hauner H. Relationship between adipocyte size and adipokine expression and secretion. J Clin Endocrinol Metab 2007;92:1023-33.
41. Kawaguchi M, Koshimura K, Murakami Y, Tsumori M, Gonda T, Kato Y. Antihypertensive effect of insulin via nitric oxide production in the Zucker diabetic fatty rat an animal model for non insulin-dependent diabetes mellitus. Eur J Endocrinol 1999;140:341-9.
42. Von Manteuffel S R, Gingras A C, Ming X F, Sonenberg N, Thomas G. 4E-BP1 phosphorylation is mediated by the FRAP- p70s6k pathway and is Independent of mitogen-activated protein kinase. Proc Natl Acad Sci 1996;93:4076-80.
43. Gingras A C, Kennedy S G, O'Leary M A, Sonenberg N, Hay N. 4E-BP1 a repressor of mRNA translation is phosphorylated and inactivated by the Akt(PKB) signaling pathway. Genes & Dev 1998;12:502-13.
44. Han J W, Pearson R B, Dennis P B, Thomas G. Rapamycin wortmannin and the methylxanthine SQ20006 inactivate p70s6k by inducing dephosphorylation of the same subset of sites. J Biol Chem 1995;270:21396-403.
45. Morley J E, Flood J F. Effect of competitive antagonism of NO synthetase on weight and food intake in obese and diabetic mice. Am J Physiol 1994;266:R164-R168.