Dracorhodin perchlorate inhibits PI3K/Akt and NF-κB activation, up-regulates the expression of p53, and enhances apoptosis

Apoptosis

Volumn 17, Issue 10, 2012, Pages 1104-1119

  Rasul, Azhar ^a,b   Ding, Chuan ^b   Li, Xiaomeng ^b   Khan, Muhammad ^a   Yi, Fei ^a   Ali, Muhammad ^c   Ma, Tonghui ^a,b  

^a THE SECOND HOSPITAL OF JILIN UNIVERSITY   (China)

^b NORTHEAST NORMAL UNIVERSITY   (China)

^c BAHAUDDIN ZAKARIYA UNIVERSITY   (Pakistan)

Author keywords

Dracorhodin perchlorate; NF B; p53; PI3K Akt; SGC 7901 cells

Indexed keywords

ANTINEOPLASTIC AGENT; CASPASE 3; DRACORHODIN PERCHLORATE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PHOSPHATIDYLINOSITOL 3 KINASE; PLANT EXTRACT; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BCL XL; PROTEIN KINASE B; PROTEIN P21; PROTEIN P53; RETINOBLASTOMA PROTEIN; SOMATOMEDIN C; TRANSCRIPTION FACTOR E2F1; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG; WORTMANNIN;

APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL CYCLE ARREST; CELL KILLING; CELL LEVEL; CELL VIABILITY; CONTROLLED STUDY; CYTOPATHOGENIC EFFECT; DNA FRAGMENTATION; DRUG EFFICACY; DRUG MECHANISM; DRUG SELECTIVITY; DRUG TARGETING; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; MITOCHONDRIAL MEMBRANE POTENTIAL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INDUCTION; SIGNAL TRANSDUCTION; STOMACH ADENOCARCINOMA; TRANSCRIPTION REGULATION; UPREGULATION;

ANDROSTADIENES; ANIMALS; APOPTOSIS; BENZOPYRANS; CELL SURVIVAL; CHO CELLS; CRICETINAE; CRICETULUS; DRUG SYNERGISM; DRUGS, CHINESE HERBAL; G1 PHASE; HUMANS; MEMBRANE POTENTIAL, MITOCHONDRIAL; NF-KAPPA B; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS C-AKT; STOMACH NEOPLASMS; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEIN P53; UP-REGULATION;

EID: 84868126155     PISSN: 13608185     EISSN: 1573675X     Source Type: Journal    
DOI: 10.1007/s10495-012-0742-1     Document Type: Article

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