Impact of food matrix on isoflavone metabolism and cardiovascular biomarkers in adults with hypercholesterolemia

Food and Function

Volumn 3, Issue 10, 2012, Pages 1051-1058

  Ahn Jarvis, Jennifer ^a   Clinton, Steven K ^a,b   Riedl, Kenneth M ^a   Vodovotz, Yael ^a   Schwartz, Steven J ^a  

^a OHIO STATE UNIVERSITY   (United States)

^b THE OHIO STATE UNIVERSITY WEXNER MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FOOD PRODUCTS; METABOLISM; METABOLITES; PHYSIOLOGY;

AGLYCONES; APOLIPOPROTEIN A-I; CROSSOVER DESIGN; FOOD MATRIXES; HYPERCHOLESTEROLEMIA; ISOFLAVONES; ISOFLAVONOIDS; LDL CHOLESTEROL; SOY FOODS; SOY PROTEIN;

FLAVONOIDS;

GLYCINE MAX;

APOLIPOPROTEIN A1; BIOLOGICAL MARKER; DAIDZEIN; GENISTEIN; ISOFLAVONE DERIVATIVE; LOW DENSITY LIPOPROTEIN CHOLESTEROL; SOYBEAN PROTEIN; TRIACYLGLYCEROL;

ADOLESCENT; ADULT; AGED; ARTICLE; BLOOD; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DIET; FEMALE; HUMAN; HYPERCHOLESTEROLEMIA; MALE; METABOLISM; MIDDLE AGED; OXIDATIVE STRESS; PATHOPHYSIOLOGY; RANDOMIZED CONTROLLED TRIAL; SOYBEAN; URINE;

ADOLESCENT; ADULT; AGED; APOLIPOPROTEIN A-I; BIOLOGICAL MARKERS; CHOLESTEROL, LDL; CROSS-OVER STUDIES; DIET; FEMALE; GENISTEIN; HUMANS; HYPERCHOLESTEROLEMIA; ISOFLAVONES; MALE; MIDDLE AGED; OXIDATIVE STRESS; SOY FOODS; SOYBEAN PROTEINS; TRIGLYCERIDES; YOUNG ADULT;

EID: 84867010320     PISSN: 20426496     EISSN: 2042650X     Source Type: Journal    
DOI: 10.1039/c2fo10284f     Document Type: Article

References (74)

1. H. Adlercreutz Western diet and western diseases: Some hormonal and biochemical mechanisms and associations Scand. J. Clin. Lab. Invest. 1990 201 3 23 (Pubitemid 20271058)
2. L. W. Lissin J. P. Cooke Phytoestrogens and cardiovascular health J. Am. Coll. Cardiol. 2000 35 1403 1410 (Pubitemid 30307479)
3. D. B. Fournier J. W. Erdman Jr G. B. Gordon Soy, its components, and cancer prevention: A review of the in vitro, animal, and human data Cancer Epidemiol Biomarkers Prev. 1998 7 1055 1065 (Pubitemid 28514109)
4. K. D. Setchell E. Lydeking-Olsen Dietary phytoestrogens and their effect on bone: Evidence from in vitro and in vivo human observational and dietary intervention studies Am J Clin Nutr. 2003 78 593S 609
5. N. R. Matthan S. M. Jalbert L. M. Ausman J. T. Kuvin R. H. Karas A. H. Lichtenstein Effect of soy protein from differently processed products on cardiovascular disease risk factors and vascular endothelial function in hypercholesterolemic subjects Am J Clin Nutr. 2007 85 960 966 (Pubitemid 46557909)
6. F. K. Welty K. S. Lee N. S. Lew J. R. Zhou Effect of soy nuts on blood pressure and lipid levels in hypertensive, prehypertensive, and normotensive postmenopausal women Arch. Intern. Med. 2007 167 1060 1067 (Pubitemid 46835794)
7. M. Messina C. Nagata A. H. Wu Estimated Asian adult soy protein and isoflavone intakes Nutr. Cancer 2006 55 1 12 (Pubitemid 44477039)
8. M. Messina Western soy intake is too low to produce health effects Am J Clin Nutr 2004 80
9. J. R. Barrett The science of soy: What do we really know? Environ. Health Perspect. 2006 114 352 358
10. S. Barnes T. Peterson L. Coward Rationale for the use of genistein-containing soy matrices in chemoprevention trials for breast and prostate cancer J. Cell. Biochem. Supp. 1995 22 181 187
11. P. Golbitz, J. Jordon. Soyfoods: Market and products. In:, MN Riaz, editor. Soy Applications in Food. Boca Raton, Fla.; London: CRC; Taylor & Francis; 2006. p. 1-20
12. P. Golbitz Traditional soyfoods: Processing and products J Nutr 1995 125 570S 572S
13. M. L. Ricketts D. D. Moore W. J. Banz O. Mezei N. F. Shay Molecular mechanisms of action of the soy isoflavones includes activation of promiscuous nuclear receptors J. Nutr. Biochem. 2005 16 321 330 (Pubitemid 40776040)
14. K. D. Setchell A. Cassidy Dietary isoflavones: Biological effects and relevance to human health J Nutr 1999 129 758S 767S
15. M. S. Anthony T. B. Clarkson J. K. Williams Effects of soy isoflavones on atherosclerosis: Potential mechanisms Am J Clin Nutr 1998 68 1390S 1393S (Pubitemid 28550918)
16. J. R. Crouse III T. Morgan J. G. Terry J. Ellis M. Vitolins G. L. Burke A randomized trial comparing the effect of casein with that of soy protein containing varying amounts of isoflavones on plasma concentrations of lipids and lipoproteins Arch. Intern. Med. 1999 159 2070 2076 (Pubitemid 29453595)
17. M. J. Tikkanen K. Wahala S. Ojala V. Vihma H. Adlercreutz Effect of soybean phytoestrogen intake on low density lipoprotein oxidation resistance Proc. Natl. Acad. Sci. U. S. A. 1998 95 3106 3110 (Pubitemid 28135862)
18. Z. Djuric G. Chen D. R. Doerge L. K. Heilbrun O. Kucuk Effect of soy isoflavone supplementation on markers of oxidative stress in men and women Cancer Lett. 2001 172 1 6 (Pubitemid 32823466)
19. A. M. Cuevas V. L. Irribarra O. A. Castillo M. D. Yanez A. M. Germain Isolated soy protein improves endothelial function in postmenopausal hypercholesterolemic women Eur. J. Clin. Nutr. 2003 57 889 894 (Pubitemid 36987236)
20. A. Yildirir S. L. Tokgozoglu T. Oduncu A. Oto I. Haznedaroglu D. Akinci G. Koksal E. Sade S. Kirazli S. Kes Soy protein diet significantly improves endothelial function and lipid parameters Clin. Cardiol. 2001 24 711 716 (Pubitemid 33027554)
21. C. H. Takimoto K. Glover X. Huang S. A. Hayes L. Gallot M. Quinn B. D. Jovanovic A. Shapiro L. Hernandez et al. Phase I pharmacokinetic and pharmacodynamic analysis of unconjugated soy isoflavones administered to individuals with cancer Cancer Epidemiol Biomarkers Prev 2003 1 12 1213 1221 (Pubitemid 37499447)
22. M. Lakshman L. Xu V. Ananthanarayanan J. Cooper C. H. Takimoto I. Helenowski J. C. Pelling R. C. Bergan Dietary genistein inhibits metastasis of human prostate cancer in mice Cancer Res. 2008 68 2024 2032 (Pubitemid 351416590)
23. V. Breinholt A. Hossaini G. W. Svendsen C. Brouwer E. Nielsen Estrogenic activity of flavonoids in mice. the importance of estrogen receptor distribution, metabolism and bioavailability Food Chem. Toxicol. 2000 38 555 564 (Pubitemid 30624135)
24. D. Kostelac G. Rechkemmer K. Briviba Phytoestrogens modulate binding response of estrogen receptors alpha and beta to the estrogen response element J. Agric. Food Chem. 2003 51 7632 7635
25. C. L. Frankenfeld A. McTiernan W. K. Thomas K. LaCroix L. McVarish V. L. Holt S. M. Schwartz J. W. Lampe Postmenopausal bone mineral density in relation to soy isoflavone-metabolizing phenotypes Maturitas 2006 53 315 324 (Pubitemid 43163067)
26. K. D. Setchell N. M. Brown E. Lydeking-Olsen The clinical importance of the metabolite equol - a clue to the effectiveness of soy and its isoflavones J Nutr 2002 132 3577 3584 (Pubitemid 35435031)
27. A. M. Duncan B. E. Merz-Demlow X. Xu W. R. Phipps M. S. Kurzer Premenopausal equol excretors show plasma hormone profiles associated with lowered risk of breast cancer Cancer Epidemiol Biomarkers Prev 2000 9 581 586 (Pubitemid 30396180)
28. D. M. Tham C. D. Gardner W. L. Haskell Potential health benefits of dietary phytoestrogens: A review of the clinical, epidemiological, and mechanistic evidence J. Clin. Endocrinol. Metab. 1998 83 2223 2235 (Pubitemid 28503006)
29. L. Lu K. Anderson Sex and long-term soy diets affect the metabolism and excretion of soy isoflavones in humans Am J Clin Nutr. 1998 68 1500S 1504S (Pubitemid 28550937)
30. S. Heinonen A. Hoikkala K. Wähälä H. Adlercreutz Metabolism of the soy isoflavones daidzein, genistein and glycitein in human subjects. Identification of new metabolites having an intact isoflavonoid skeleton J. Steroid Biochem. Mol. Biol. 2003 87 285 299 (Pubitemid 38036964)
31. X. Xu K. S. Harris H. J. Wang P. A. Murphy S. Hendrich Bioavailability of soybean isoflavones depends upon gut microflora in women J Nutr 1995 125 2307 2315
32. C. Atkinson C. L. Frankenfeld J. W. Lampe Gut bacterial metabolism of the soy isoflavone daidzein: Exploring the relevance to human health Exp Biol Med 2005 230 155 170 (Pubitemid 40293689)
33. G. E. Joannou G. E. Kelly A. Y. Reeder M. Waring C. Nelson A urinary profile study of dietary phytoestrogens. the identification and mode of metabolism of new isoflavonoids J Steroid Biochem Mol Biol. 1995 54 167 184
34. R. A. King D. B. Bursill Plasma and urinary kinetics of the isoflavones daidzein and genistein after a single soy meal in humans Am J Clin Nutr 1998 67 867 872 (Pubitemid 28196660)
35. Y. C. Chang M. G. Nair Metabolism of daidzein and genistein by intestinal bacteria J. Nat. Prod. 1995 58 1892 1896 (Pubitemid 26071145)
36. N. J. Turner B. M. Thomson I. C. Shaw Bioactive isoflavones in functional foods: The importance of gut microflora on bioavailability Nutr. Rev. 2003 61 204 213 (Pubitemid 37259938)
37. X. Xu H. J. Wang P. A. Murphy S. Hendrich Neither background diet nor type of soy food affects short-term isoflavone bioavailability in women J Nutr 2000 130 798 801 (Pubitemid 30173664)
38. S. de Pascual-Teresa J. Hallund D. Talbot J. Schroot C. M. Williams S. Bugel A. Cassidy Absorption of isoflavones in humans: Effects of food matrix and processing J. Nutr. Biochem. 2006 17 257 264
39. M. Faughnan A. Hawdon E. Ah-Singh J. Brown D. J. Millward A. Cassidy Urinary isoflavone kinetics: The effect of age, gender, food matrix and chemical composition Br. J. Nutr. 2004 91 567 574 (Pubitemid 38584780)
40. A. Cassidy J. Brown A. Hawdon M. Faughnan L. J. King J. Millward L. Zimmer-Nechemias B. Wolfe K. D. R. Setchell Factors affecting the bioavailability of soy isoflavones in humans after ingestion of physiologically relevant levels from different soy foods J Nutr 2006 136 45 51 (Pubitemid 43156483)
41. H. Huang H. Liang K. Kwok Effect of thermal processing on genistein, daidzein and glycitein content in soymilk J. Sci. Food Agric. 2006 86 1110 1114
42. L. Coward M. Smith M. Kirk S. Barnes Chemical modification of isoflavones in soy foods during cooking and processing Am J Clin Nutr. 1998 68 1486S 1491S (Pubitemid 28550934)
43. H. J. Wang P. A. Murphy Mass balance study of isoflavones during soybean processing J. Agric. Food Chem. 1996 44 2377 2383 (Pubitemid 126454467)
44. P. A. Murphy K. Barua C. C. Hauck Solvent extraction selection in the determination of isoflavones in soy foods J. Chromatogr., B: Anal. Technol. Biomed. Life Sci. 2002 777 129 138 (Pubitemid 35257867)
45. A. Achouri I. J. Boye D. Belanger Soybean isoflavones: Efficacy of extraction conditions and effect of food type on extractability Food Res. Int. 2005 38 1199 1204 (Pubitemid 41097559)
46. M. G. Busby A. R. Jeffcoat L. T. Bloedon M. A. Koch T. Black K. J. Dix W. D. Heizer B. F. Thomas J. M. Hill et al. Clinical characteristics and pharmacokinetics of purified soy isoflavones: Single-dose administration to healthy men Am J Clin Nutr 2002 75 126 136 (Pubitemid 34013498)
47. H. Wang P. A. Murphy Isoflavone content in commercial soybean foods J. Agric. Food Chem. 1994 42 1666 1673
48. A. A. Franke L. J. Custer L. R. Wilkens L. L. Le Marchand A. M. Nomura M. T. Goodman L. N. Kolonel Liquid chromatographic-photodiode array mass spectrometric analysis of dietary phytoestrogens from human urine and blood J. Chromatogr., B: Anal. Technol. Biomed. Life Sci. 2002 777 45 59 (Pubitemid 35257861)
49. C. C. Allain L. S. Poon C. S. G. Chan W. Richmond P. C. Fu Enzymatic determination of total serum cholesterol Clin Chem 1974 20 470
50. G. Bucolo H. David 1973. Quantitative determination of serum triglycerides by the use of enzymes Clin. Chem. 1973 19 476 482
51. W. T. Friedewald R. I. Levy D. S. Fredrickson Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge Clin Chem. 1972 18 499 502
52. J. H. Contois J. R. McNamara C. J. Lammi-Keefe P. W. F. Wilson T. Massov E. J. Schaefer Reference intervals for plasma apolipoprotein B determined with a standardized commercial immunoturbidimetric assay: results from the Framingham Offspring Study Clin Chem 1996 42 515 523 (Pubitemid 26111868)
53. J. H. Contois J. R. McNamara C. J. Lammi-Keefe P. W. F. Wilson T. Massov E. J. Schaefer Reference intervals for plasma apolipoprotein A-I determined with a standardized commercial immunoturbidimetric assay: results from the Framingham Offspring Study Clin Chem 1996 42 507 514 (Pubitemid 26111867)
54. C. W. Hadley S. K. Clinton S. J. Schwartz The consumption of processed tomato products enhances plasma lycopene concentrations in association with a reduced lipoprotein sensitivity to oxidative damage J Nutr 2003 133 727 732 (Pubitemid 36268346)
55. Common Terminology Criteria [Internet]. Bethesda: Cancer Therapy Evaluation Program; c2003-2010 (updated 2010 Feb 26; cited 2010 May 16). Available from: http://ctep.cancer.gov/protocolDevelopment/electronic- applications/docs/ctcaev3.pdf
56. M. J. Messina Legumes and soybeans: overview of their nutritional profiles and health effects Am J Clin Nutr 1999 70 439S 450S (Pubitemid 29407122)
57. L. Coward N. C. Barnes K. D. Setchell S. Barnes Genistein, daidzein, and their beta-glycoside conjugates: Antitumor isoflavones in soybean foods from American and Asian diets J. Agric. Food Chem. 1993 41 1961 1967 (Pubitemid 2007019)
58. F. M. Steinberg N. L. Guthrie A. C. Villablanca K. Kumar M. J. Murray Soy protein with isoflavones has favorable effects on endothelial function that are independent of lipid and antioxidant effects in healthy postmenopausal women Am J Clin Nutr. 2003 78 123 130 (Pubitemid 39655257)
59. Food and Drug Administration Health and Human Services. Food labeling: Health claims; soy protein and coronary heart disease: Final rule Fed Reg 1999 64 57699 57733
60. Y. Zhang G. Wang T. T. Song P. A. Murphy S. Hendrich Urinary disposition of the soybean isoflavones daidzein, genistein and glycitein differs among humans with moderate fecal isoflavone degradation activity J Nutr 1999 129 957 962
61. G. E. Kelly G. E. Joannou A. Y. Reeder C. Nelson M. A. Waring The variable metabolic response to dietary isoflavones in humans Proc Soc Exp Biol Med. 1995 208 40 43
62. A. A. Franke L. A. Ashburn K. Kakazu S. Suzuki L. R. Wilkens B. M. Halm Apparent bioavailability of isoflavones after intake of liquid and solid soya foods Br. J. Nutr. 2009 102 1203 1210
63. I. Rowland H. Wiseman T. Sanders H. Adlercreutz E. Bowey Metabolism of oestrogens and phytoestrogens: Role of the gut microflora Biochem Soc Trans. 1999 27 304 308 (Pubitemid 29086054)
64. S. Heinonen K. Wähälä H. Adlercreutz Identification of isoflavone metabolites dihydrodaidzein, dihydrogenistein, 6'-OH-O-dma, and cis-4-OH-equol in human urine by gas chromatography-mass spectroscopy using authentic reference compounds Anal. Biochem. 1999 274 211 219 (Pubitemid 29489491)
65. D. J. Jenkins T. M. Wolever A. R. Leeds M. A. Gassull P. Haisman J. Dilawari D. V. Goff G. L. Metz K. G. Alberti Dietary fibres, fibre analogues, and glucose tolerance: Importance of viscosity Br. Med. J. 1978 1 1392 1394 (Pubitemid 8334007)
66. Y. Zheng J. Hu P. A. Murphy D. L. Alekel W. D. Franke S. Hendrich Rapid gut transit time and slow fecal isoflavone disappearance phenotype are associated with greater genistein bioavailability in women J Nutr 2003 133 3110 3116 (Pubitemid 37222224)
67. M. S. Kurzer Hormonal effects of soy in premenopausal women and men J Nutr 2002 132 570S 573S (Pubitemid 34208772)
68. L. W. Lu S. Lin J. J. Grady M. Nagamani K. E. Anderson Altered kinetics and extent of urinary daidzein and genistein excretion in women during chronic soya exposure Nutr. Cancer 1996 26 289 302 (Pubitemid 26362067)
69. L. T. Bloedon A. R. Jeffcoat W. Lopaczynski M. J. Schell T. M. Black K. J. Dix B. F. Thomas C. Albright M. G. Busby J. A. Crowell S. H. Zeisel Safety and pharmacokinetics of purified soy isoflavones: single-dose administration to postmenopausal women Am J Clin Nutr 2002 76 1126 1137 (Pubitemid 35244688)
70. E. P. Castle J. B. Thrasher The role of soy phytoestrogens in prostate cancer Urol Clin North Am 2002 29 71 81 (Pubitemid 34733103)
71. B. J. Trock L. Hilakivi-Clarke R. Clarke Meta-analysis of soy intake and breast cancer risk J. Natl. Cancer Inst. 2006 98 459 471
72. C. R. Sirtori Risks and benefits of soy phytoestrogens in cardiovascular diseases, cancer, climacteric symptoms and osteoporosis Drug Saf. 2001 24 665 682 (Pubitemid 32758568)
73. C. L. Frankenfeld C. Atkinson W. K. Thomas A. Gonzalez T. Jokela S. M. Schwartz K. Wähälä S. S. Li J. W. Lampe Familial aggregation of daidzein-metabolizing phenotypes (poster abstracts) J Nutr 2004 134 1284S 1285S
74. H. Akaza N. Miyanaga N. Takashima S. Naito Y. Hirao T. Tsukamoto T. Fujioka M. Mori W. Kim et al., Comparisons of percent equol producers between prostate cancer patients and controls: Case-controlled studies of isoflavones in Japanese, Korean and American residents Jpn. J. Clin. Oncol. 2004 34 86 89 (Pubitemid 43115325)