Soy protein with isoflavones has favorable effects on endothelial function that are independent of lipid and antioxidant effects in healthy postmenopausal women

American Journal of Clinical Nutrition

Volumn 78, Issue 1, 2003, Pages 123-130

  Steinberg, Francene M ^a   Guthrie, Nicole L ^a   Villablanca, Amparo C ^b   Kumar, Kavita ^b   Murray, Michael J ^b,c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c KAISER PERMANENTE MEDICAL CENTER   (United States)

Author keywords

Cardiovascular disease; Endothelial function; Isoflavone; Lipid oxidation; Postmenopausal women; Soy

Indexed keywords

ALKADIENE; ISOFLAVONE DERIVATIVE; MILK PROTEIN; SOYBEAN PROTEIN; ANTIOXIDANT; BIOLOGICAL MARKER; LIPID;

ANTIOXIDANT ACTIVITY; ARTICLE; BLOOD FLOW VELOCITY; BLOOD LEVEL; BLOOD VESSEL REACTIVITY; CARDIOVASCULAR RISK; ENDOTHELIUM; FEMALE; HUMAN; HUMAN EXPERIMENT; INFLAMMATION; NORMAL HUMAN; PROTEIN INTAKE; VASODILATATION; BLOOD; BRACHIAL ARTERY; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DIET; DOUBLE BLIND PROCEDURE; DRUG EFFECT; LIPID METABOLISM; OXIDATION REDUCTION REACTION; PHYSIOLOGY; POSTMENOPAUSE; RANDOMIZED CONTROLLED TRIAL; VASCULAR ENDOTHELIUM;

GLYCINE MAX;

ANTIOXIDANTS; BIOLOGICAL MARKERS; BLOOD FLOW VELOCITY; BRACHIAL ARTERY; CROSS-OVER STUDIES; DIET; DOUBLE-BLIND METHOD; ENDOTHELIUM, VASCULAR; FEMALE; HUMANS; ISOFLAVONES; LIPID METABOLISM; LIPIDS; MILK PROTEINS; OXIDATION-REDUCTION; POSTMENOPAUSE; SOYBEAN PROTEINS;

EID: 0037830976     PISSN: 00029165     EISSN: None     Source Type: Journal    
DOI: 10.1093/ajcn/78.1.123     Document Type: Article

References (56)

1. Desai MM, Zhang P, Hennessy CH. Surveillance for morbidity and mortality among older adults - United States, 1995-1996. CDC Surveillance Summaries. MMWR Mortal Morb Wkly Rep 1999;48(No. SS-8):7-25.
2. Barrett-Conner E, Stuenkel C. Hormones and heart disease in women: heart and estrogen/progestin replacement study in perspective. J Clin Endocrinol Metab 1999;84:1848-53.
3. Joswig M, Hach-Wunderle V, Ziegler R, Nawroth PP. Postmenopausal hormone replacement therapy and the vascular wall: mechanisms of 17 β-estradiol's effects on vascular biology. Exp Clin Endocrinol Diabetes 1999;107:477-87.
4. Stampfer MJ, Colditz GA, Willett WC, et al. Postmenopausal estrogen therapy and cardiovascular disease. Ten-year follow-up from the Nurses' Health Study. N Engl J Med 1991;325:756-62.
5. Hulley S, Grady D, Bush T, et al. Randomized trial of estrogen plus progestin for secondary prevention of coronary heart disease in postmenopausal women. JAMA 1998;280:605-13.
6. Writing Group for the Women's Health Initiative Investigators. Risks and benefits of estrogen plus progestin in healthy postmenopausal women. Principal results from the women's Health Initiative randomized controlled trial. JAMA 2002;288:321-33.
7. Kuiper GG, Lemmen JG, Carlsson B, et al. Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor beta. Endocrinology 1998;139:4252-63.
8. Hodges YK, Tung L, Yan XD, Graham JD, Horwitz LD. Estrogen receptors alpha and beta: prevalence of estrogen receptor beta mRNA in human vascular smooth muscle and transcriptional effects. Circulation 2000;101:1792-8
9. Aavik E, du Toit D, Myburgh E, Frosen J, Hayry P. Estrogen receptor beta dominates in baboon carotid after endothelial denudation injury. Mol Cell Endocrinol 2001;182:91-8.
10. Kapiotis S, Hermann M, Held I, Seelos C, Erhinger H, Gmeiner BMK. Genistein, the dietary-derived angiogenesis inhibitor, prevents LDL oxidation and protects endothelial cells from damage by atherogenic LDL. Arterioscler Thromb Vasc Biol 1997;17:2868-74.
11. Tikkanen MJ, Wahala K, Ojala S, Vihma V, Adlercreutz H. Effect of soybean phytoestrogen intake on low density lipoprotein oxidation resistance. Proc Natl Acad Sci U S A 1998;95:3106-10.
12. 2-isoprostane concentrations and increase resistance of low-density lipoprotein to oxidation in humans. Am J Clin Nutr 2000;72:395-400.
13. Akiyama T, Ishida J, Nakagava S, et al. Genistein, a specific inhibitor of tyrosine-specific protein kinases. J Biol Chem 1987;262:5592-5.
14. Shimokado K, Yokota T, Umezawa K, Sasaguri T, Ogata J. Protein tryosine kinase inhibitors inhibit chemotaxis of vascular smooth muscle cells. Arterioscler Thromb Vasc Biol 1994;14:973-81.
15. Walker HA, Dean TS, Sanders TAB, Jackson G, Ritter JM, Chowienczyk PJ. The phytoestrogen genistein produces acute nitric oxide-dependent dilation of human forearm vasculature with similar potency to 17 β-estradiol. Circulation 2001;103:258-62.
16. Honore ED, Williams JK, Anthony MS, Clarkson TB. Soy isoflavones enhance coronary vascular reactivity in atherosclerotic female macaques. Fertil Steril 1997;67:148-54.
17. Squadrito F, Altavilla D, Squadritio G, et al. Genistein supplementation and estrogen replacement therapy improve endothelial dysfunction induced by ovariectomy in rats. Cardiovasc Res 2000;45:454-62.
18. Williams JK, Anthony MS, Herrington DM. Interactive effects of soy protein and estradiol on coronary artery reactivity in atherosclerotic, ovariectomized monkeys. Menopause 2001;8:307-13.
19. Nestel PJ, Yamashita T, Sasahara T, et al. Soy isoflavones improve systemic arterial compliance but not plasma lipids in menopausal and perimenopausal women. Arterioscler Thromb Vasc Biol 1997;17:3392-8.
20. Squadrito F, Altavilla D, Morabito N, et al. The effect of the phytoestrogen genistein on plasma nitric oxide concentrations, endothelin-1 levels and endothelium dependent vasodilation in postmenopausal women. Atherosclerosis 2002;163:339-47.
21. Simons LA, von Konigsmark M, Simons J, Celermajer DS. Phytoestrogens do not influence lipoprotein levels or endothelial function in healthy, postmenopausal women. Am J Cardiol 2000;85:1297-301.
22. Hale G, Paul-Labrador M, Dwyer JH, Merz CN. Isoflavone supplementation and endothelial function in menopausal women. Clin Endocrinol 2002;56:693-701.
23. Teede HJ, Dalais FS, Kotsopoulos D, Liang YL, Davis S, McGrath BP. Dietary soy has both beneficial and potentially adverse cardiovascular effects: a placebo-controlled study in men and postmenopausal women. J Clin Endocrinol Metab 2001;86:3053-60.
24. Corretti MC, Anderson TJ, Benjamin EJ, et al. Guidelines for the ultrasound assessment of endothelial-dependent flow-mediated vasodilation of the brachial artery. J Am Coll Cardiol 2002;39:257-65.
25. Coward L, Kirk M, Albin N, Barnes S. Analysis of plasma isoflavones by reversed-phase HPLC-multiple reaction ion monitoring-mass spectrometry. Clin Chim Acta 1996;247:121-42.
26. Friedewald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 1972;18:499-502.
27. Kontush A, Spranger T, Reich A, et al. Whole plasma oxidation assay as a measure of lipoprotein oxidizability. Biofactors 1997;6:99-109.
28. Brousseau T, Clavey V, Bard JM, Fruchart JC. Sequential ultracentrifugation micromethod for separation of serum lipoproteins and assays of lipids, apolipoproteins, and lipoprotein particles. Clin Chem 1993;39:960-4.
29. Esterbauer H, Striegl G, Puhl H, Rotheneder M. Continuous monitoring of in vitro oxidation of human low density lipoprotein. Free Radic Res Commun 1989;6:67-75.
30. Gerhard M, Roddy MA, Creager SJ, Creager MA. Aging progressively impairs endothelium-dependent vasodilation in forearm resistance vessels of humans. Hypertension 1996;27:849-53.
31. Perregaux D, Chaudhuri A, Mohanty P, et al. Effect of gender differences and estrogen replacement therapy on vascular reactivity. Metabolism 1999;48:227-32.
32. Lieberman EH, Gerhard MD, Uehata A, et al. Estrogen improves endothelium-dependent, flow-mediated vasodilation in postmenopausal women. Ann Intern Med 1994;121:936-41.
33. Al-Khalili F, Eriksson M, Landgren BM, Schenck-Gustafsson K. Effect of conjugated estrogen on peripheral flow-mediated vasodilation in postmenopausal women. Am J Cardiol 1998;82:215-8.
34. Gerhard M, Walsh BW, Tawakol A, et al. Estradiol therapy combined with progesterone and endothelium-dependent vasodilation in postmenopausal women. Circulation 1998;98:1158-63.
35. Koh KK, Blum A, Hathaway L, et al. Vascular effects of estrogen and vitamin E therapies in postmenopausal women. Circulation 1999;100:1851-7.
36. Sorensen KE, Dorup I, Hermann AP, Mosekilde L. Combined hormone replacement therapy does not protect women against the age-related decline in endothelium-dependent vasomotor function. Circulation 1998;97:1234-8.
37. Cagnacci A, Modena MG, Malmusi S, Muia N, Volpe A. Effect of prolonged administration of transdermal estradiol on flow-mediated endothelium-dependent and endothelium-independent vasodilation in healthy postmenopausal women. Am J Cardiol 1999;84:367-70.
38. Sirtori CR, Lovati MR. Soy proteins and cardiovascular disease. Curr Atheroscler Rep 2001;3:47-53.
39. Crouse JR III, Morgan T, Terry JG, Ellis J, Vitolins M, Burke GL. A randomized trial comparing the effect of casein with that of soy protein containing varying amounts of isoflavones on plasma concentrations of lipids and lipoproteins. Arch Intern Med 1999;159:2070-6.
40. Yildirir A, Tokgozoglu SL, Oduncu T, et al. Soy protein diet significantly improves endothelial function and lipid parameters. Clin Cardiol 2001;24:711-6.
41. Caulin-Glaser T, Farrell WJ, Pfau SE, et al. Modulation of circulating cellular adhesion molecules in postmenopausal women with coronary artery disease. J Am Coll Cardiol 1998;31:1555-60.
42. Jager A, van Hinsbergh VWM, Kostense PJ, et al. Increased levels of soluble vascular cell adhesion molecule 1 are associated with risk of cardiovascular mortality in type 2 diabetes. The Hoorn study. Diabetes 2000;49:485-91.
43. Demerath E, Towne B, Blangero J, Siervogel RM. The relationship of soluble ICAM-1, VCAM-1, P-selectin and E-selectin to cardiovascular disease risk factors in healthy men and women. Ann Human Biol 2001;28:664-78.
44. Koh KK, Bui MN, Mincemoyer R, Cannon RO. Effects of hormone therapy on inflammatory cell adhesion molecules in postmenopausal healthy women. Am J Cardiol 1997;80:1505-7.
45. Cushman M, Legault C, Barrett-Connor E, et al. Effect of postmenopausal hormones on inflammation-sensitive proteins. The Postmenopausal Estrogen/Progestin Intervention (PEPI) study. Circulation 1999;100:717-22.
46. Baum JA, Teng H, Erdman JW Jr, et al. Long-term intake of soy protein improves blood lipid profiles and increases mononuclear cell low-density-lipoprotein receptor messenger RNA in hypercholesterolemic, postmenopausal women. Am J Clin Nutr 1998;68:545-51.
47. Wangen KE, Duncan AM, Xu X, Kurzer MS. Soy isoflavones improve plasma lipids in normocholesterolemic and mildly hypercholesterolemic postmenopausal women. Am J Clin Nutr 2001;73:225-31.
48. Gardner CD, Newell KA, Cherin R, Haskell WL. The effect of soy protein with or without isoflavones relative to milk protein on plasma lipids in hypercholesterolemic postmenopausal women. Am J Clin Nutr 2001;73:728-35.
49. Potter SM, Baum JA, Teng H, Stillman RJ, Shay NF, Erdman JW Jr Soy protein and isoflavones: their effects on blood lipids and bone density in postmenopausal women. Am J Clin Nutr 1998;68(suppl):1375S-9S.
50. Vigna GB, Pansini F, Bonaccorsi G, et al. Plasma lipoproteins in soy-treated postmenopausal women: a double- blind, placebo-controlled trial. Nutr Metab Cardiovasc Dis 2000;10:315-22.
51. Jenkins DAJ, Kendall CWC, Jackson CJC, et al. Effects of high- and low-isoflavone soyfoods on blood lipids, oxidized LDL, homocysteine, and blood pressure in hyperlipidemic men and women. Am J Clin Nutr 2002;76:365-72.
52. Dent SB, Peterson CT, Brace LD, et al. Soy protein intake by perimenopausal women does not affect circulating lipids and lipoproteins or coagulation and fibrinolytic factors. J Nutr 2001;131:2280-7.
53. Meinertz H, Faergeman O, Nilausen K, Chapman MJ, Goldstein S, Laplaud PM. Effects of soy protein and casein in low cholesterol diets on plasma lipoproteins in normolipidemic subjects. Atherosclerosis 1988;72:63-70.
54. Sacks FM, Breslow JL, Wood PG, Kass EH. Lack of an effect of dairy protein (casein) and soy protein on plasma cholesterol of strict vegetarians. An experiment and a critical review. J Lipid Res 1983;24:1012-20.
55. Hsu CS, Shen WW, Hsueh YM, Yeh SL. Soy isoflavone supplementation in postmenopausal women. Effects on plasma lipids, antioxidant enzyme activities and bone density. J Reprod Med 2001;46:221-6.
56. Jenkins DJ, Kendall CW, Garsetti M, et al. Effect of soy protein foods on low-density lipoprotein oxidation and ex vivo sex hormone receptor activity - a controlled crossover trial. Metabolism 2000;49:537-43.