-
1
-
-
33745454125
-
Synthetic biology: New engineering rules for an emerging discipline
-
doi:10.1038/msb4100073
-
Andrianantoandro E, Basu S, Karig DK, Weiss R (2006) Synthetic biology: new engineering rules for an emerging discipline. Mol Syst Biol 2:2006.0028. doi:10.1038/msb4100073
-
(2006)
Mol Syst Biol
, vol.2
, Issue.2006
, pp. 0028
-
-
Andrianantoandro, E.1
Basu, S.2
Karig, D.K.3
Weiss, R.4
-
2
-
-
0031784044
-
A genome-based approach for the identification of essential bacterial genes
-
doi:10.1038/nbt0998-851
-
Arigoni F, Talabot F, Peitsch M et al (1998) A genome-based approach for the identification of essential bacterial genes. Nat Biotechnol 16:851-856. doi:10.1038/nbt0998-851
-
(1998)
Nat Biotechnol
, vol.16
, pp. 851-856
-
-
Arigoni, F.1
Talabot, F.2
Peitsch, M.3
-
3
-
-
78650007030
-
Genetic architecture of metabolic rate: Environment specific epistasis between mitochondrial and nuclear genes in an insect
-
doi:10.1111/j.1558-5646.2010.01135.x
-
Arnqvist G, Dowling DK, Eady P et al (2010) Genetic architecture of metabolic rate: environment specific epistasis between mitochondrial and nuclear genes in an insect. Evolution 64:3354-3363. doi:10.1111/j.1558-5646.2010.01135. x
-
(2010)
Evolution
, vol.64
, pp. 3354-3363
-
-
Arnqvist, G.1
Dowling, D.K.2
Eady, P.3
-
4
-
-
33644745138
-
Sexual reproduction selects for robustness and negative epistasis in artificial gene networks
-
doi:10.1038/nature04488
-
Azevedo RBR, Lohaus R, Srinivasan S et al (2006) Sexual reproduction selects for robustness and negative epistasis in artificial gene networks. Nature 440:87-90. doi:10.1038/nature04488
-
(2006)
Nature
, vol.440
, pp. 87-90
-
-
Rbr, A.1
Lohaus, R.2
Srinivasan, S.3
-
5
-
-
43249117094
-
Functional maps of protein complexes from quantitative genetic interaction data
-
doi: 10.1371/journal.pcbi.1000065
-
Bandyopadhyay S, Kelley R, Krogan NJ, Ideker T (2008) Functional maps of protein complexes from quantitative genetic interaction data. PLoS Comput Biol 4:e1000065. doi: 10.1371/journal.pcbi.1000065
-
(2008)
PLoS Comput Biol
, vol.4
-
-
Bandyopadhyay, S.1
Kelley, R.2
Krogan, N.J.3
Ideker, T.4
-
7
-
-
2342627280
-
Thermodynamic constraints for biochemical networks
-
doi:10.1016/j.jtbi.2004.01.008
-
Beard DA, Babson E, Curtis E, Qian H (2004) Thermodynamic constraints for biochemical networks. J Theor Biol 228:327-333. doi:10.1016/j.jtbi.2004.01.008
-
(2004)
J Theor Biol
, vol.228
, pp. 327-333
-
-
Beard, D.A.1
Babson, E.2
Curtis, E.3
Qian, H.4
-
8
-
-
21344458620
-
Synthetic biology
-
doi:10.1038/nrg1637
-
Benner SA, Sismour AM (2005) Synthetic biology. Nat Rev Genet 6:533-543. doi:10.1038/nrg1637
-
(2005)
Nat Rev Genet
, vol.6
, pp. 533-543
-
-
Benner, S.A.1
Sismour, A.M.2
-
9
-
-
33845864966
-
Robustness-epistasis link shapes the fitness landscape of a randomly drifting protein
-
doi:10.1038/nature05385
-
Bershtein S, Segal M, Bekerman R et al (2006) Robustness-epistasis link shapes the fitness landscape of a randomly drifting protein. Nature 444:929-932. doi:10.1038/nature05385
-
(2006)
Nature
, vol.444
, pp. 929-932
-
-
Bershtein, S.1
Segal, M.2
Bekerman, R.3
-
10
-
-
80054969621
-
A multi-tissue type genome-scale metabolic network for analysis of whole-body physiology
-
doi:10. 1186/1752-0509-5-180
-
Bordbar A, Feist AM, Usaite-Black R et al (2011) A multi-tissue type genome-scale metabolic network for analysis of whole-body physiology. BMC Syst Biol 5:180. doi:10. 1186/1752-0509-5-180
-
(2011)
BMC Syst Biol
, vol.5
, pp. 180
-
-
Bordbar, A.1
Feist, A.M.2
Usaite-Black, R.3
-
11
-
-
13444306165
-
The landscape of genetic complexity across 5,700 gene expression traits in yeast
-
doi:10.1073/pnas. 0408709102
-
Brem RB, Kruglyak L (2005) The landscape of genetic complexity across 5,700 gene expression traits in yeast. Proc Natl Acad Sci USA 102:1572-1577. doi:10.1073/pnas. 0408709102
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 1572-1577
-
-
Brem, R.B.1
Kruglyak, L.2
-
12
-
-
0037177625
-
Genetic dissection of transcriptional regulation in budding yeast
-
doi:10.1126/science.1069516
-
Brem RB, Yvert G, Clinton R, Kruglyak L (2002) Genetic dissection of transcriptional regulation in budding yeast. Science 296:752-755. doi:10.1126/science.1069516
-
(2002)
Science
, vol.296
, pp. 752-755
-
-
Brem, R.B.1
Yvert, G.2
Clinton, R.3
Kruglyak, L.4
-
13
-
-
0242542705
-
Patterns of epistasis in RNA viruses: A review of the evidence from vaccine design
-
doi:10.1046/j.1420-9101.2003. 00632.x
-
Burch CL, Turner PE, Hanley KA (2003) Patterns of epistasis in RNA viruses: a review of the evidence from vaccine design. J Evol Biol 16:1223-1235. doi:10.1046/j.1420-9101.2003. 00632.x
-
(2003)
J Evol Biol
, vol.16
, pp. 1223-1235
-
-
Burch, C.L.1
Turner, P.E.2
Hanley, K.A.3
-
14
-
-
3442894519
-
Epistasis: Too often neglected in complex trait studies?
-
doi:10.1038/nrg1407
-
Carlborg O, Haley CS (2004) Epistasis: too often neglected in complex trait studies? Nat Rev Genet 5:618-625. doi:10.1038/nrg1407
-
(2004)
Nat Rev Genet
, vol.5
, pp. 618-625
-
-
Carlborg, O.1
Haley, C.S.2
-
15
-
-
77954474131
-
A systems-biology approach to modular genetic complexity
-
doi:10.1063/1.3455183
-
Carter GW, Rush CG, Uygun F et al (2010) A systems-biology approach to modular genetic complexity. Chaos 20:026102. doi:10.1063/1.3455183
-
(2010)
Chaos
, vol.20
, pp. 026102
-
-
Carter, G.W.1
Rush, C.G.2
Uygun, F.3
-
16
-
-
34247277741
-
Antibiotic interactions that select against resistance
-
doi:10.1038/nature05685
-
Chait R, Craney A, Kishony R (2007) Antibiotic interactions that select against resistance. Nature 446:668-671. doi:10.1038/nature05685
-
(2007)
Nature
, vol.446
, pp. 668-671
-
-
Chait, R.1
Craney, A.2
Kishony, R.3
-
18
-
-
79957958115
-
Diminishing returns epistasis among beneficial mutations decelerates adaptation
-
(New York, NY) doi:10.1126/science.1203799
-
Chou H-H, Chiu H-C, Delaney NF et al (2011) Diminishing returns epistasis among beneficial mutations decelerates adaptation. Science (New York, NY) 332:1190-1192. doi:10.1126/science.1203799
-
(2011)
Science
, vol.332
, pp. 1190-1192
-
-
Chou, H.-H.1
Chiu, H.-C.2
Delaney, N.F.3
-
19
-
-
33747367151
-
A strategy for extracting and analyzing large-scale quantitative epistatic interaction data
-
doi:10.1186/gb-2006-7-7-r63
-
Collins SR, Schuldiner M, Krogan NJ, Weissman JS (2006) A strategy for extracting and analyzing large-scale quantitative epistatic interaction data. Genome Biol 7:R63. doi:10.1186/gb-2006-7-7-r63
-
(2006)
Genome Biol
, vol.7
-
-
Collins, S.R.1
Schuldiner, M.2
Krogan, N.J.3
Weissman, J.S.4
-
20
-
-
67650470272
-
Epistasis in sporadic Alzheimers disease
-
doi:10.1016/j.neurobiolaging.2007.11. 027
-
Combarros O, Cortina-Borja M, Smith AD, Lehmann DJ (2009) Epistasis in sporadic Alzheimers disease. Neurobiol Aging 30:1333-1349. doi:10.1016/j. neurobiolaging.2007.11. 027
-
(2009)
Neurobiol Aging
, vol.30
, pp. 1333-1349
-
-
Combarros, O.1
Cortina-Borja, M.2
Smith, A.D.3
Lehmann, D.J.4
-
21
-
-
40149109210
-
Expression profiles reveal parallel evolution of epistatic interactions involving the CRP regulon in Escherichia coli
-
doi:10.1371/journal.pgen.0040035
-
Cooper TF, Remold SK, Lenski RE, Schneider D (2008) Expression profiles reveal parallel evolution of epistatic interactions involving the CRP regulon in Escherichia coli. PLoS Genet 4:e35. doi:10.1371/journal.pgen.0040035
-
(2008)
PLoS Genet
, vol.4
-
-
Cooper, T.F.1
Remold, S.K.2
Lenski, R.E.3
Schneider, D.4
-
22
-
-
0036797562
-
Epistasis: What it means, what it doesnt mean, and statistical methods to detect it in humans
-
doi:10.1093/hmg/11.20.2463
-
Cordell HJ (2002) Epistasis: what it means, what it doesnt mean, and statistical methods to detect it in humans. Hum Mol Genet 11:2463-2468. doi:10.1093/hmg/11.20.2463
-
(2002)
Hum Mol Genet
, vol.11
, pp. 2463-2468
-
-
Cordell, H.J.1
-
23
-
-
75649111192
-
The genetic landscape of a cell
-
doi:10.1126/science.1180823
-
Costanzo M, Baryshnikova A, Bellay J et al (2010) The genetic landscape of a cell. Science 327:425-431. doi:10.1126/science.1180823
-
(2010)
Science
, vol.327
, pp. 425-431
-
-
Costanzo, M.1
Baryshnikova, A.2
Bellay, J.3
-
24
-
-
79551559547
-
Charting the genetic interaction map of a cell
-
doi:10.1016/j.copbio.2010.11.001
-
Costanzo M, Baryshnikova A, Myers CL et al (2011) Charting the genetic interaction map of a cell. Curr Opin Biotechnol 22:66-74. doi:10.1016/j.copbio. 2010.11.001
-
(2011)
Curr Opin Biotechnol
, vol.22
, pp. 66-74
-
-
Costanzo, M.1
Baryshnikova, A.2
Myers, C.L.3
-
25
-
-
23144432213
-
Optimality and evolutionary tuning of the expression level of a protein
-
doi:10.1038/nature03842
-
Dekel E, Alon U (2005) Optimality and evolutionary tuning of the expression level of a protein. Nature 436:588-592. doi:10.1038/nature03842
-
(2005)
Nature
, vol.436
, pp. 588-592
-
-
Dekel, E.1
Alon, U.2
-
26
-
-
33748352373
-
Multiple knockout analysis of genetic robustness in the yeast metabolic network
-
doi:10.1038/ng1856
-
Deutscher D, Meilijson I, Kupiec M, Ruppin E (2006) Multiple knockout analysis of genetic robustness in the yeast metabolic network. Nat Genet 38:993-998. doi:10.1038/ng1856
-
(2006)
Nat Genet
, vol.38
, pp. 993-998
-
-
Deutscher, D.1
Meilijson, I.2
Kupiec, M.3
Ruppin, E.4
-
27
-
-
48249142459
-
Can single knockouts accurately single out gene functions?
-
doi:10.1186/1752-0509-2-50
-
Deutscher D,Meilijson I, Schuster S, Ruppin E (2008) Can single knockouts accurately single out gene functions? BMC Syst Biol 2:50. doi:10.1186/1752- 0509-2-50
-
(2008)
BMC Syst Biol
, vol.2
, pp. 50
-
-
Deutscher Dmeilijson, I.1
Schuster, S.2
Ruppin, E.3
-
28
-
-
79955377903
-
Epistasis increases the rate of conditionally neutral substitution in an adapting population
-
doi:10.1534/genetics.110. 125997
-
Draghi JA, Parsons TL, Plotkin JB (2011) Epistasis increases the rate of conditionally neutral substitution in an adapting population. Genetics 187:1139-52. doi:10.1534/genetics.110. 125997
-
(2011)
Genetics
, vol.187
, pp. 1139-1152
-
-
Draghi, J.A.1
Parsons, T.L.2
Plotkin, J.B.3
-
29
-
-
3843128481
-
Reconstruction and validation of Saccharomyces cerevisiae iND750, a fully compartmentalized genome-scale metabolic model
-
doi:10.1101/gr.2250904
-
Duarte NC, Herrgard MJ, Palsson B (2004) Reconstruction and validation of Saccharomyces cerevisiae iND750, a fully compartmentalized genome-scale metabolic model. Genome Res 14(7):1298-1309. doi:10.1101/gr.2250904
-
(2004)
Genome Res
, vol.14
, Issue.7
, pp. 1298-1309
-
-
Duarte, N.C.1
Herrgard, M.J.2
Palsson, B.3
-
30
-
-
34247560771
-
Direct quantitative trait locus mapping of mammalian metabolic phenotypes in diabetic and normoglycemic rat models
-
doi:10.1038/ng2026
-
Dumas M-E, Wilder SP, Bihoreau M-T et al (2007) Direct quantitative trait locus mapping of mammalian metabolic phenotypes in diabetic and normoglycemic rat models. Nat Genet 39:666-672. doi:10.1038/ng2026
-
(2007)
Nat Genet
, vol.39
, pp. 666-672
-
-
Dumas, M.-E.1
Wilder, S.P.2
Bihoreau, M.-T.3
-
31
-
-
0035125986
-
In silico predictions of Escherichia coli metabolic capabilities are consistent with experimental data
-
doi:10.1038/84379
-
Edwards JS, Ibarra RU, Palsson BO (2001) In silico predictions of Escherichia coli metabolic capabilities are consistent with experimental data. Nat Biotechnol 19:125-130. doi:10.1038/84379
-
(2001)
Nat Biotechnol
, vol.19
, pp. 125-130
-
-
Edwards, J.S.1
Ibarra, R.U.2
Palsson, B.O.3
-
32
-
-
0036001069
-
Metabolic modelling of microbes: The flux-balance approach
-
doi:10.1046/j.1462-2920.2002.00282.x
-
Edwards JS, Covert M, Palsson B (2002) Metabolic modelling of microbes: the flux-balance approach. Environ Microbiol 4:133-140. doi:10.1046/j.1462-2920. 2002.00282.x
-
(2002)
Environ Microbiol
, vol.4
, pp. 133-140
-
-
Edwards, J.S.1
Covert, M.2
Palsson, B.3
-
33
-
-
77951210494
-
Pathway analysis of GWAS provides new insights into genetic susceptibility to 3 inflammatory diseases
-
doi: 10.1371/journal.pone.0008068
-
Eleftherohorinou H, Wright V, Hoggart C et al (2009) Pathway analysis of GWAS provides new insights into genetic susceptibility to 3 inflammatory diseases. PLoS ONE 4:e8068. doi: 10.1371/journal.pone.0008068
-
(2009)
PLoS ONE
, vol.4
-
-
Eleftherohorinou, H.1
Wright, V.2
Hoggart, C.3
-
34
-
-
84924919448
-
Simple genomes, complex interactions: Epistasis in RNA virus
-
doi:10.1063/1.3449300
-
Elena SF, Soĺe RV, Sardanýes J (2010) Simple genomes, complex interactions: epistasis in RNA virus. Chaos 20:026106. doi:10.1063/1.3449300
-
(2010)
Chaos
, vol.20
, pp. 026106
-
-
Elena, S.F.1
Soĺe, R.V.2
Sardanýes, J.3
-
35
-
-
77955363536
-
Genome-wide scoring of positive and negative epistasis through decomposition of quantitative genetic interaction fitness matrices
-
doi:10.1371/journal.pone.0011611
-
Eronen V-P, Lind́en RO, Lindroos A et al (2010) Genome-wide scoring of positive and negative epistasis through decomposition of quantitative genetic interaction fitness matrices. PLoS ONE 5:e11611. doi:10.1371/journal. pone.0011611
-
(2010)
PLoS ONE
, vol.5
-
-
Eronen, V.-P.1
Lind́en, R.O.2
Lindroos, A.3
-
36
-
-
0037313750
-
Genome-scale reconstruction of the Saccharomyces cerevisiae metabolic network
-
doi:10.1101/gr.234503. complex
-
Famili I, Fu P, Palsson BO, Nielsen J (2003) Genome-scale reconstruction of the Saccharomyces cerevisiae metabolic network. Genome Res 13(2):244-253. doi:10.1101/gr.234503. complex
-
(2003)
Genome Res
, vol.13
, Issue.2
, pp. 244-253
-
-
Famili, I.1
Fu, P.2
Palsson, B.O.3
Nielsen, J.4
-
37
-
-
34347332311
-
A genome-scale metabolic reconstruction for Escherichia coli K-12MG1655 that accounts for 1260 ORFs and thermodynamic information
-
doi:10.1038/msb4100155
-
Feist AM, Henry CS, Reed JL et al (2007) A genome-scale metabolic reconstruction for Escherichia coli K-12MG1655 that accounts for 1260 ORFs and thermodynamic information. Mol Syst Biol 3:121. doi:10.1038/msb4100155
-
(2007)
Mol Syst Biol
, vol.3
, pp. 121
-
-
Feist, A.M.1
Henry, C.S.2
Reed, J.L.3
-
38
-
-
84898877069
-
Predicting selective drug targets in cancer through metabolic networks
-
doi:10.1038/msb.2011.35
-
Folger O, Jerby L, Frezza C et al (2011) Predicting selective drug targets in cancer through metabolic networks. Mol Syst Biol 7:501. doi:10.1038/msb.2011.35
-
(2011)
Mol Syst Biol
, vol.7
, pp. 501
-
-
Folger, O.1
Jerby, L.2
Frezza, C.3
-
39
-
-
0042816453
-
Large-scale evaluation of in silico gene deletions in Saccharomyces cerevisiae
-
doi:10.1089/153623103322246584
-
Forster J, Famili I, Palsson B, Nielsen J (2003) Large-scale evaluation of in silico gene deletions in Saccharomyces cerevisiae. OMICS 7:193-202. doi:10.1089/153623103322246584
-
(2003)
OMICS
, vol.7
, pp. 193-202
-
-
Forster, J.1
Famili, I.2
Palsson, B.3
Nielsen, J.4
-
40
-
-
80052580351
-
Haem oxygenase is synthetically lethal with the tumour suppressor fumarate hydratase
-
doi:10.1038/nature10363
-
Frezza C, Zheng L, Folger O et al (2011) Haem oxygenase is synthetically lethal with the tumour suppressor fumarate hydratase. Nature 477:225-228. doi:10.1038/nature10363
-
(2011)
Nature
, vol.477
, pp. 225-228
-
-
Frezza, C.1
Zheng, L.2
Folger, O.3
-
41
-
-
77950614421
-
On the classification of epistatic interactions
-
doi:10.1534/genetics.109.111120
-
Gao H, Granka JM, Feldman MW (2010) On the classification of epistatic interactions. Genetics 184:827-837. doi:10.1534/genetics.109.111120
-
(2010)
Genetics
, vol.184
, pp. 827-837
-
-
Gao, H.1
Granka, J.M.2
Feldman, M.W.3
-
42
-
-
0035344246
-
The flexible genome
-
doi:10.1038/35072018
-
Greenspan RJ (2001) The flexible genome. Nat Rev Genet 2:383-387. doi:10.1038/35072018
-
(2001)
Nat Rev Genet
, vol.2
, pp. 383-387
-
-
Greenspan, R.J.1
-
43
-
-
77954498581
-
Recursive expectation-maximization clustering: A method for identifying buffering mechanisms composed of phenomic modules
-
doi:10.1063/1.3455188
-
Guo J, Tian D, McKinney BA, Hartman JL (2010) Recursive expectation-maximization clustering: a method for identifying buffering mechanisms composed of phenomic modules. Chaos 20:026103. doi:10.1063/1.3455188
-
(2010)
Chaos
, vol.20
, pp. 026103
-
-
Guo, J.1
Tian, D.2
McKinney, B.A.3
Hartman, J.L.4
-
44
-
-
33847780769
-
Plasticity of genetic interactions in metabolic networks of yeast
-
doi:10.1073/pnas.0607153104
-
Harrison R, Papp B, Ṕal C et al (2007) Plasticity of genetic interactions in metabolic networks of yeast. Proc Natl Acad Sci USA 104:2307-2312. doi:10.1073/pnas.0607153104
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 2307-2312
-
-
Harrison, R.1
Papp, B.2
Ṕal, C.3
-
46
-
-
79957944389
-
Cryptic genetic variation promotes rapid evolutionary adaptation in an RNA enzyme
-
doi:10.1038/nature10083
-
Hayden EJ, Ferrada E, Wagner A (2011) Cryptic genetic variation promotes rapid evolutionary adaptation in an RNA enzyme. Nature 474:92-95. doi:10.1038/nature10083
-
(2011)
Nature
, vol.474
, pp. 92-95
-
-
Hayden, E.J.1
Ferrada, E.2
Wagner, A.3
-
47
-
-
53749085229
-
A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology
-
doi:10.1038/nbt1492
-
Herrgard MJ, Swainston N, Dobson P et al (2008) A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology. Nat Biotechnol 26:1155-1160. doi:10.1038/nbt1492
-
(2008)
Nat Biotechnol
, vol.26
, pp. 1155-1160
-
-
Herrgard, M.J.1
Swainston, N.2
Dobson, P.3
-
48
-
-
57449115476
-
The future of mouse QTL mapping to diagnose disease in mice in the age of whole-genome association studies
-
doi:10.1146/annurev.genet.42.110807.091659
-
Hunter KW, Crawford NPS (2008) The future of mouse QTL mapping to diagnose disease in mice in the age of whole-genome association studies. Ann Rev Genet 42:131-141. doi:10. 1146/annurev.genet.42.110807.091659
-
(2008)
Ann Rev Genet
, vol.42
, pp. 131-141
-
-
Hunter, K.W.1
Nps, C.2
-
49
-
-
44149128882
-
Exploiting the pathway structure of metabolism to reveal highorder epistasis
-
doi:10.1186/1752-0509-2-40
-
Imielinski M, Belta C (2008) Exploiting the pathway structure of metabolism to reveal highorder epistasis. BMC Syst Biol 2:40. doi:10.1186/1752-0509-2-40
-
(2008)
BMC Syst Biol
, vol.2
, pp. 40
-
-
Imielinski, M.1
Belta, C.2
-
50
-
-
77954460687
-
Deep epistasis in human metabolism
-
doi:10. 1063/1.3456056
-
Imielinski M, Belta C (2010) Deep epistasis in human metabolism. Chaos 20:026104. doi:10. 1063/1.3456056
-
(2010)
Chaos
, vol.20
, pp. 026104
-
-
Imielinski, M.1
Belta, C.2
-
51
-
-
62949089924
-
Investigating the genomic basis of metabolic robustness through in silico flux analysis
-
doi:10.1109/cdc.2008.4739459
-
Imielinski M, Klitgord N, Belta C (2008) Investigating the genomic basis of metabolic robustness through in silico flux analysis. IEEE Conf Decis Contr 47:793-798. doi:10.1109/cdc.2008.4739459
-
(2008)
IEEE Conf Decis Contr
, vol.47
, pp. 793-798
-
-
Imielinski, M.1
Klitgord, N.2
Belta, C.3
-
52
-
-
0142122303
-
Advances in flux balance analysis
-
doi:10.1016/j.copbio.2003.08.001
-
Kauffman KJ, Prakash P, Edwards JS (2003) Advances in flux balance analysis. Curr Opin Biotechnol 14:491-496. doi:10.1016/j.copbio.2003.08.001
-
(2003)
Curr Opin Biotechnol
, vol.14
, pp. 491-496
-
-
Kauffman, K.J.1
Prakash, P.2
Edwards, J.S.3
-
53
-
-
33747893452
-
Quantitative analysis of genetic and neuronal multi-perturbation experiments
-
doi:10.1371/journal.pcbi.0010064
-
Kaufman A, Keinan A, Meilijson I et al (2005) Quantitative analysis of genetic and neuronal multi-perturbation experiments. PLoS Comput Biol 1:e64. doi:10.1371/journal.pcbi.0010064
-
(2005)
PLoS Comput Biol
, vol.1
-
-
Kaufman, A.1
Keinan, A.2
Meilijson, I.3
-
54
-
-
78649716727
-
Manufacturing molecules through metabolic engineering
-
(New York, NY) doi:10.1126/science.1193990
-
Keasling JD (2010) Manufacturing molecules through metabolic engineering. Science (New York, NY) 330:1355-1358. doi:10.1126/science.1193990
-
(2010)
Science
, vol.330
, pp. 1355-1358
-
-
Keasling, J.D.1
-
55
-
-
22844450110
-
Systematic interpretation of genetic interactions using protein networks
-
doi:10.1038/nbt1096
-
Kelley R, Ideker T (2005) Systematic interpretation of genetic interactions using protein networks. Nat Biotechnol 23:561-566. doi:10.1038/nbt1096
-
(2005)
Nat Biotechnol
, vol.23
, pp. 561-566
-
-
Kelley, R.1
Ideker, T.2
-
56
-
-
79957948242
-
Negative epistasis between beneficial mutations in an evolving bacterial population
-
doi:10.1126/science.1203801
-
Khan AI, Dinh DM, Schneider D et al (2011) Negative epistasis between beneficial mutations in an evolving bacterial population. Science 332:1193-1196. doi:10.1126/science.1203801
-
(2011)
Science
, vol.332
, pp. 1193-1196
-
-
Khan, A.I.1
Dinh, D.M.2
Schneider, D.3
-
57
-
-
0346328227
-
Metabolic engineering for drug discovery and development
-
doi:10.1038/nrd1256
-
Khosla C (2003) Metabolic engineering for drug discovery and development. Nat Rev Drug Discov 2:1019-1025. doi:10.1038/nrd1256
-
(2003)
Nat Rev Drug Discov
, vol.2
, pp. 1019-1025
-
-
Khosla, C.1
-
58
-
-
0041853578
-
Environmental stresses can alleviate the average deleterious effect of mutations
-
doi:10.1186/1475-4924-2-14
-
Kishony R, Leibler S (2003) Environmental stresses can alleviate the average deleterious effect of mutations. J Biol 2(2):14. doi:10.1186/1475-4924- 2-14
-
(2003)
J Biol
, vol.2
, Issue.2
, pp. 14
-
-
Kishony, R.1
Leibler, S.2
-
59
-
-
1042269472
-
Minimal cut sets in biochemical reaction networks
-
doi:10.1093/bioinformatics/btg395
-
Klamt S, Gilles ED (2004) Minimal cut sets in biochemical reaction networks. Bioinformatics 20:226-234. doi:10.1093/bioinformatics/btg395
-
(2004)
Bioinformatics
, vol.20
, pp. 226-234
-
-
Klamt, S.1
Gilles, E.D.2
-
60
-
-
67049098922
-
Hypergraphs and cellular networks
-
doi:10.1371/journal.pcbi.1000385
-
Klamt S, Haus U-U, Theis F (2009) Hypergraphs and cellular networks. PLoS Comput Biol 5:e1000385. doi:10.1371/journal.pcbi.1000385
-
(2009)
PLoS Comput Biol
, vol.5
-
-
Klamt, S.1
Haus, U.-U.2
Theis, F.3
-
61
-
-
69949161748
-
Advancing genetic theory and application by metabolic quantitative trait loci analysis
-
doi:10.1105/tpc.109.067611
-
Kliebenstein D (2009) Advancing genetic theory and application by metabolic quantitative trait loci analysis. Plant Cell 21:1637-1646. doi:10.1105/tpc.109.067611
-
(2009)
Plant Cell
, vol.21
, pp. 1637-1646
-
-
Kliebenstein, D.1
-
62
-
-
78649677586
-
Environments that induce synthetic microbial ecosystems
-
doi:10.1371/journal.pcbi.1001002
-
Klitgord N, Segr̀e D (2010) Environments that induce synthetic microbial ecosystems. PLoS Comput Biol 6:e1001002. doi:10.1371/journal.pcbi. 1001002
-
(2010)
PLoS Comput Biol
, vol.6
-
-
Klitgord, N.1
Segr̀e, D.2
-
63
-
-
79960939957
-
Ecosystems biology of micrbial metabolism
-
doi:10.1016/j.copbio.2011.04.018
-
Klitgord N, Segr̀e D (2011) Ecosystems biology of micrbial metabolism. Curr Opin Biotechnol 22:541-546. doi:10.1016/j.copbio.2011.04.018
-
(2011)
Curr Opin Biotechnol
, vol.22
, pp. 541-546
-
-
Klitgord, N.1
Segr̀e, D.2
-
65
-
-
0023737547
-
Deleterious mutations and the evolution of sexual reproduction
-
doi:10.1038/336435a0
-
Kondrashov AS (1988) Deleterious mutations and the evolution of sexual reproduction. Nature 336:435-440. doi:10.1038/336435a0
-
(1988)
Nature
, vol.336
, pp. 435-440
-
-
Kondrashov, A.S.1
-
66
-
-
0035834126
-
Multidimensional epistasis and the disadvantage of sex
-
doi:10.1073/pnas.211214298
-
Kondrashov FA, Kondrashov AS (2001) Multidimensional epistasis and the disadvantage of sex. PNAS 98:12089-12092. doi:10.1073/pnas.211214298
-
(2001)
PNAS
, vol.98
, pp. 12089-12092
-
-
Kondrashov, F.A.1
Kondrashov, A.S.2
-
67
-
-
79955590028
-
Reciprocal sign epistasis between frequently experimentally evolved adaptive mutations causes a rugged fitness landscape
-
doi: 10.1371/journal.pgen.1002056
-
Kvitek DJ, Sherlock G (2011) Reciprocal sign epistasis between frequently experimentally evolved adaptive mutations causes a rugged fitness landscape. PLoS Genet 7:e1002056. doi: 10.1371/journal.pgen.1002056
-
(2011)
PLoS Genet
, vol.7
-
-
Kvitek, D.J.1
Sherlock, G.2
-
68
-
-
49449101097
-
High-order combination effects and biological robustness
-
doi:10.1038/msb.2008.51
-
Leh́ar J, Krueger AS, Zimmermann G, Borisy A (2008) High-order combination effects and biological robustness. Mol Syst Biol 4:215. doi:10.1038/msb.2008.51
-
(2008)
Mol Syst Biol
, vol.4
, pp. 215
-
-
Leh́ar, J.1
Krueger, A.S.2
Zimmermann, G.3
Borisy, A.4
-
69
-
-
67650488269
-
Synergistic drug combinations tend to improve therapeutically relevant selectivity
-
doi:10.1038/nbt.1549
-
Leh́ar J, Krueger AS, Avery W et al (2009) Synergistic drug combinations tend to improve therapeutically relevant selectivity. Nat Biotechnol 27:659-66. doi:10.1038/nbt.1549
-
(2009)
Nat Biotechnol
, vol.27
, pp. 659-666
-
-
Leh́ar, J.1
Krueger, A.S.2
Avery, W.3
-
70
-
-
37349008452
-
The molecular underpinnings of genetic phenomena
-
doi:10.1038/sj.hdy.6801053
-
Lehman N (2008) The molecular underpinnings of genetic phenomena. Heredity 100:6-12. doi:10.1038/sj.hdy.6801053
-
(2008)
Heredity
, vol.100
, pp. 6-12
-
-
Lehman, N.1
-
71
-
-
1842687878
-
The yeast cell-cycle network is robustly designed
-
doi:10.1073/pnas.0305937101
-
Li F, Long T, Lu Y et al (2004) The yeast cell-cycle network is robustly designed. PNAS 101:4781-4786. doi:10.1073/pnas.0305937101
-
(2004)
PNAS
, vol.101
, pp. 4781-4786
-
-
Li, F.1
Long, T.2
Lu, Y.3
-
72
-
-
40549123412
-
Identification of metabolic and biomass QTL in Arabidopsis thaliana in a parallel analysis of RIL and IL populations
-
doi:10.1111/j.1365-313X.2007.03383.x
-
Lisec J, Meyer RC, Steinfath M et al (2008) Identification of metabolic and biomass QTL in Arabidopsis thaliana in a parallel analysis of RIL and IL populations. Plant J 53:960-972. doi:10.1111/j.1365-313X.2007.03383.x
-
(2008)
Plant J
, vol.53
, pp. 960-972
-
-
Lisec, J.1
Meyer, R.C.2
Steinfath, M.3
-
73
-
-
34547890683
-
Coevolution of robustness, epistasis, and recombination favors asexual reproduction
-
doi:10.1073/pnas.0705455104
-
MacCarthy T, Bergman A (2007) Coevolution of robustness, epistasis, and recombination favors asexual reproduction. PNAS 104:12801-12806. doi:10.1073/pnas.0705455104
-
(2007)
PNAS
, vol.104
, pp. 12801-12806
-
-
MacCarthy, T.1
Bergman, A.2
-
74
-
-
1642457253
-
The effects of alternate optimal solutions in constraintbased genome-scale metabolic models
-
doi:10.1016/j.ymben.2003.09.002
-
Mahadevan R, Schilling CH (2003) The effects of alternate optimal solutions in constraintbased genome-scale metabolic models.Metab Eng 5:264-276. doi:10.1016/j.ymben.2003.09. 002
-
(2003)
Metab Eng
, vol.5
, pp. 264-276
-
-
Mahadevan, R.1
Ch, S.2
-
75
-
-
42149137884
-
Defining genetic interaction
-
doi:10.1073/pnas.0712255105
-
Mani R, St Onge RP, Hartman JL et al (2008) Defining genetic interaction. PNAS 105:3461-3466. doi:10.1073/pnas.0712255105
-
(2008)
PNAS
, vol.105
, pp. 3461-3466
-
-
Mani, R.1
St Onge, R.P.2
Hartman, J.L.3
-
76
-
-
34047099379
-
Distributions of epistasis in microbes fit predictions from a fitness landscape model
-
doi:10.1038/ng1998
-
Martin G, Elena SF, Lenormand T (2007) Distributions of epistasis in microbes fit predictions from a fitness landscape model. Nat Genet 39:555-560. doi:10.1038/ng1998
-
(2007)
Nat Genet
, vol.39
, pp. 555-560
-
-
Martin, G.1
Elena, S.F.2
Lenormand, T.3
-
77
-
-
79952474742
-
Protein complexes are central in the yeast genetic landscape
-
doi:10.1371/journal.pcbi.1001092
-
Michaut M, Baryshnikova A, Costanzo M et al (2011) Protein complexes are central in the yeast genetic landscape. PLoS Comput Biol 7:e1001092. doi:10.1371/journal.pcbi.1001092
-
(2011)
PLoS Comput Biol
, vol.7
-
-
Michaut, M.1
Baryshnikova, A.2
Costanzo, M.3
-
78
-
-
79960741228
-
Epistasis: The key to understanding immunological disease?
-
doi:10.1002/eji.201141811
-
Mitchison NA, Rose AM (2011) Epistasis: the key to understanding immunological disease? Eur J Immunol 41:2152-2154. doi:10.1002/eji.201141811
-
(2011)
Eur J Immunol
, vol.41
, pp. 2152-2154
-
-
Mitchison, N.A.1
Rose, A.M.2
-
79
-
-
65649126379
-
Connecting extracellular metabolomic measurements to intracellular flux states in yeast
-
doi:10.1186/1752-0509-3-37
-
Mo ML, Palsson BO, Herrgard MJ (2009) Connecting extracellular metabolomic measurements to intracellular flux states in yeast. BMC Syst Biol 3:37. doi:10.1186/1752-0509-3- 37
-
(2009)
BMC Syst Biol
, vol.3
, Issue.37
-
-
Mo, M.L.1
Palsson, B.O.2
Herrgard, M.J.3
-
80
-
-
0345411335
-
The ubiquitous nature of epistasis in determining susceptibility to common human diseases
-
doi:10.1159/000073735
-
Moore JH (2003) The ubiquitous nature of epistasis in determining susceptibility to common human diseases. Hum Hered 56:73-82. doi:10.1159/000073735
-
(2003)
Hum Hered
, vol.56
, pp. 73-82
-
-
Moore, J.H.1
-
81
-
-
11244293921
-
A global view of epistasis
-
doi:10.1038/ng0105-13
-
Moore JH (2005) A global view of epistasis. Nat Genet 37:13-14. doi:10.1038/ng0105-13
-
(2005)
Nat Genet
, vol.37
, pp. 13-14
-
-
Moore, J.H.1
-
82
-
-
21244459227
-
Traversing the conceptual divide between biological and statistical epistasis: Systems biology and a more modern synthesis
-
doi:10.1002/bies.20236
-
Moore JH, Williams SM (2005) Traversing the conceptual divide between biological and statistical epistasis: systems biology and a more modern synthesis. BioEssays 27:637-646. doi:10.1002/bies.20236
-
(2005)
BioEssays
, vol.27
, pp. 637-646
-
-
Moore, J.H.1
Williams, S.M.2
-
83
-
-
77749320898
-
What is flux balance analysis?
-
doi:10.1038/nbt.1614
-
Orth JD, Thiele I, Palsson BO (2010) What is flux balance analysis? Nat Biotechnol 28:245-248. doi:10.1038/nbt.1614
-
(2010)
Nat Biotechnol
, vol.28
, pp. 245-248
-
-
Orth, J.D.1
Thiele, I.2
Palsson, B.O.3
-
84
-
-
80054069179
-
A comprehensive genome-scale reconstruction of Escherichia coli metabolism - 2011
-
doi:10.1038/msb.2011.65
-
Orth JD, Conrad TM, Na J et al (2011) A comprehensive genome-scale reconstruction of Escherichia coli metabolism - 2011. Mol Syst Biol 7:1-9. doi:10.1038/msb.2011.65
-
(2011)
Mol Syst Biol
, vol.7
, pp. 1-9
-
-
Orth, J.D.1
Conrad, T.M.2
Na, J.3
-
85
-
-
2942624207
-
Metabolic network analysis of the causes and evolution of enzyme dispensability in yeast
-
doi:10.1038/nature02636
-
Papp B, Ṕal C, Hurst LD (2004) Metabolic network analysis of the causes and evolution of enzyme dispensability in yeast. Nature 429:661-664. doi:10.1038/nature02636
-
(2004)
Nature
, vol.429
, pp. 661-664
-
-
Papp, B.1
Ṕal, C.2
Hurst, L.D.3
-
86
-
-
0347473810
-
Integration of chemical-genetic and genetic interaction data links bioactive compounds to cellular target pathways
-
doi:10.1038/nbt919
-
Parsons AB, Brost RL, Ding H et al (2004) Integration of chemical-genetic and genetic interaction data links bioactive compounds to cellular target pathways. Nat Biotechnol 22:62-69. doi:10.1038/nbt919
-
(2004)
Nat Biotechnol
, vol.22
, pp. 62-69
-
-
Parsons, A.B.1
Brost, R.L.2
Ding, H.3
-
87
-
-
77952304845
-
Artificial immune systems for epistasis analysis in human genetics
-
doi:10.1007/978-3-642-12211-817
-
Penrod N, Greene CS, Granizo-MacKenzie D, Moore JH (2010) Artificial immune systems for epistasis analysis in human genetics. Lect Notes Comp Sci 6023:194-204. doi:10.1007/978-3-642-12211-8 17
-
(2010)
Lect Notes Comp Sci
, vol.6023
, pp. 194-204
-
-
Penrod, N.1
Greene, C.S.2
Granizo-Mackenzie, D.3
Moore, J.H.4
-
88
-
-
0031827525
-
The language of gene interaction
-
Phillips PC (1998) The language of gene interaction. Genetics 1171:1167-1171
-
(1998)
Genetics
, vol.1171
, pp. 1167-1171
-
-
Phillips, P.C.1
-
89
-
-
54149088214
-
Epistasis - The essential role of gene interactions in the structure and evolution of genetic systems
-
doi:10.1038/nrg2452
-
Phillips PC (2008) Epistasis - the essential role of gene interactions in the structure and evolution of genetic systems. Nature Rev Genet 9:855-867. doi:10.1038/nrg2452
-
(2008)
Nature Rev Genet
, vol.9
, pp. 855-867
-
-
Phillips, P.C.1
-
90
-
-
78650592680
-
Reciprocal sign epistasis is a necessary condition for multi-peaked fitness landscapes
-
doi:10. 1016/j.jtbi.2010.12.015
-
Poelwijk FJ, Tanase-Nicola S, Kiviet DJ, Tans SJ (2011) Reciprocal sign epistasis is a necessary condition for multi-peaked fitness landscapes. J Theor Biol 272:141-144. doi:10. 1016/j.jtbi.2010.12.015
-
(2011)
J Theor Biol
, vol.272
, pp. 141-144
-
-
Poelwijk, F.J.1
Tanase-Nicola, S.2
Kiviet, D.J.3
Tans, S.J.4
-
91
-
-
67449096729
-
Flux balance analysis of biological systems: Applications and challenges
-
doi:10.1093/bib/bbp011
-
Raman K, Chandra N (2009) Flux balance analysis of biological systems: applications and challenges. Brief Bioinformatics 10:435-449. doi:10.1093/bib/bbp011
-
(2009)
Brief Bioinformatics
, vol.10
, pp. 435-449
-
-
Raman, K.1
Chandra, N.2
-
92
-
-
34447523907
-
Systematic evaluation of objective functions for predicting intracellular fluxes in Escherichia coli
-
doi:10.1038/msb4100162
-
Schuetz R, Kuepfer L, Sauer U (2007) Systematic evaluation of objective functions for predicting intracellular fluxes in Escherichia coli.Mol Syst Biol 3:119. doi:10.1038/msb4100162
-
(2007)
Mol Syst Biol
, vol.3
, pp. 119
-
-
Schuetz, R.1
Kuepfer, L.2
Sauer, U.3
-
93
-
-
26844489762
-
Exploration of the function and organization of the yeast early secretory pathway through an epistatic miniarray profile
-
doi:10.1016/j.cell.2005.08.031
-
Schuldiner M, Collins SR, Thompson NJ et al (2005) Exploration of the function and organization of the yeast early secretory pathway through an epistatic miniarray profile. Cell 123:507-519. doi:10.1016/j.cell.2005.08.031
-
(2005)
Cell
, vol.123
, pp. 507-519
-
-
Schuldiner, M.1
Collins, S.R.2
Thompson, N.J.3
-
94
-
-
0037069467
-
Analysis of optimality in natural and perturbed metabolic networks
-
doi:10.1073/pnas.232349399
-
Segr̀e D, Vitkup D, Church GM (2002) Analysis of optimality in natural and perturbed metabolic networks. Proc Natl Acad Sci USA 99:15112-15117. doi:10.1073/pnas.232349399
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 15112-15117
-
-
Segr̀e, D.V.1
-
95
-
-
11244297914
-
Modular epistasis in yeast metabolism
-
doi:10.1038/ng1489
-
Segr̀e D, Deluna A, Church GM, Kishony R (2005) Modular epistasis in yeast metabolism. Nature Genet 37:77-83. doi:10.1038/ng1489
-
(2005)
Nature Genet
, vol.37
, pp. 77-83
-
-
Segr̀e, D.D.1
-
96
-
-
58149396842
-
Genetic architecture of complex traits: Large phenotypic effects and pervasive epistasis
-
doi:10.1073/pnas. 0810388105
-
Shao H, Burrage LC, Sinasac DS et al (2008) Genetic architecture of complex traits: large phenotypic effects and pervasive epistasis. PNAS 105:19910-19914. doi:10.1073/pnas. 0810388105
-
(2008)
PNAS
, vol.105
, pp. 19910-19914
-
-
Shao, H.1
Burrage, L.C.2
Sinasac, D.S.3
-
97
-
-
35948940481
-
Systematic condition-dependent annotation of metabolic genes
-
doi:10.1101/gr.6678707
-
Shlomi T, Herrgard MJ, Portnoy V et al (2007) Systematic condition-dependent annotation of metabolic genes. Genome Res 17:1626-1633. doi:10.1101/gr.6678707
-
(2007)
Genome Res
, vol.17
, pp. 1626-1633
-
-
Shlomi, T.1
Herrgard, M.J.2
Portnoy, V.3
-
98
-
-
64049098787
-
Optimality criteria for the prediction of metabolic fluxes in yeast mutants
-
International Conference on Genome Informatics
-
Snitkin ES, Segr̀e D (2008) Optimality criteria for the prediction of metabolic fluxes in yeast mutants. Genome Inform 20:123-34; International Conference on Genome Informatics
-
(2008)
Genome Inform
, vol.20
, pp. 123-134
-
-
Snitkin, E.S.1
Segr̀e, D.2
-
99
-
-
79952257690
-
Epistatic Interaction Maps Relative to Multiple Metabolic Phenotypes
-
doi:20.1371/journal.pgen.1001294
-
Snitkin ES, Segr̀e D (2011) Epistatic Interaction Maps Relative to Multiple Metabolic Phenotypes. PLoS Genet 7(2):e1001294. doi:20.1371/journal. pgen.1001294
-
(2011)
PLoS Genet
, vol.7
, Issue.2
-
-
Snitkin, E.S.1
Segr̀e, D.2
-
100
-
-
55349112223
-
Model-driven analysis of experimentally determined growth phenotypes for 465 yeast gene deletion mutants under 16 different conditions
-
doi:10.1186/gb-2008-9-9-r140
-
Snitkin ES, Dudley AM, Janse DM et al (2008) Model-driven analysis of experimentally determined growth phenotypes for 465 yeast gene deletion mutants under 16 different conditions. Genome Biol 9:R140. doi:10.1186/gb-2008-9-9-r140
-
(2008)
Genome Biol
, vol.9
-
-
Snitkin, E.S.1
Dudley, A.M.2
Janse, D.M.3
-
101
-
-
4544346660
-
Robustness of cellular functions
-
doi:10.1016/j.cell.2004.09.008
-
Stelling J, Sauer U, Szallasi Z et al (2004) Robustness of cellular functions. Cell 118:675-685. doi:10.1016/j.cell.2004.09.008
-
(2004)
Cell
, vol.118
, pp. 675-685
-
-
Stelling, J.1
Sauer, U.2
Szallasi, Z.3
-
102
-
-
79959687662
-
An integrated approach to characterize genetic interaction networks in yeast metabolism
-
doi:10.1038/ng. 846
-
Szappanos B, Kov́acs K, Szamecz B et al (2011) An integrated approach to characterize genetic interaction networks in yeast metabolism. Nat Genet 43:656-662. doi:10.1038/ng. 846
-
(2011)
Nat Genet
, vol.43
, pp. 656-662
-
-
Szappanos, B.1
Kov́acs, K.2
Szamecz, B.3
-
103
-
-
0035861532
-
Systematic genetic analysis with ordered arrays of yeast deletion mutants
-
doi:10.1126/science.1065810
-
Tong AHY, Evangelista M, Parsons AB et al (2001) Systematic genetic analysis with ordered arrays of yeast deletion mutants. Science 294:2364-2368. doi:10.1126/science.1065810
-
(2001)
Science
, vol.294
, pp. 2364-2368
-
-
Ahy, T.1
Evangelista, M.2
Parsons, A.B.3
-
104
-
-
10744230485
-
Global mapping of the yeast genetic interaction network
-
doi:10.1126/science.1091317
-
Tong AHY, Lesage G, Bader GD et al (2004) Global mapping of the yeast genetic interaction network. Science 303:808-813. doi:10.1126/science.1091317
-
(2004)
Science
, vol.303
, pp. 808-813
-
-
Ahy, T.1
Lesage, G.2
Bader, G.D.3
-
105
-
-
68249108837
-
Positive epistasis drives the acquisition of multidrug resistance
-
doi:10.1371/journal.pgen.1000578
-
Trindade S, Sousa A, Xavier KB et al (2009) Positive epistasis drives the acquisition of multidrug resistance. PLoS Genet 5:e1000578. doi:10.1371/journal.pgen.1000578
-
(2009)
PLoS Genet
, vol.5
-
-
Trindade, S.1
Sousa, A.2
Xavier, K.B.3
-
106
-
-
0028146781
-
Stoichiometric flux balance models quantitatively predict growth and metabolic by-product secretion in wild-type Escherichia coli W3110
-
doi:10.1128/AEM.00027-0254
-
Varma A, Palsson BO (1994) Stoichiometric flux balance models quantitatively predict growth and metabolic by-product secretion in wild-type Escherichia coli W3110. Appl Environ Microbiol 60:3724-3731. doi:10.1128/AEM.00027-0254
-
(1994)
Appl Environ Microbiol
, vol.60
, pp. 3724-3731
-
-
Varma, A.1
Palsson, B.O.2
-
107
-
-
10744228524
-
Perspective: Evolution and detection of genetic robustness
-
doi:10.1111/j.0014-3820.2003.tb00377.x
-
de Visser JAGM, Hermisson J, Wagner GP et al (2003) Perspective: evolution and detection of genetic robustness. Evolution 57(9):1959-1972. doi:10.1111/j.0014-3820.2003.tb00377.x
-
(2003)
Evolution
, vol.57
, Issue.9
, pp. 1959-1972
-
-
De Visser Jagm1
Hermisson, J.2
Wagner, G.P.3
-
108
-
-
80855127462
-
The causes of epistasis
-
doi:10.1098/rspb.2011.1537
-
de Visser JAGM, Cooper TF, Elena SF (2011) The causes of epistasis. Proc Roy Soc B. 278: 3617-3624. doi:10.1098/rspb.2011.1537
-
(2011)
Proc Roy Soc B.
, vol.278
, pp. 3617-3624
-
-
De Visser Jagm1
Cooper, T.F.2
Elena, S.F.3
-
109
-
-
14344263352
-
Distributed robustness versus redundancy as causes of mutational robustness
-
doi:10.1002/bies.20170
-
Wagner A (2005) Distributed robustness versus redundancy as causes of mutational robustness. BioEssays 27:176-188. doi:10.1002/bies.20170
-
(2005)
BioEssays
, vol.27
, pp. 176-188
-
-
Wagner, A.1
-
110
-
-
21044435697
-
Sign epistasis and genetic constraint on evolutionary trajectories
-
doi:10.1111/j.0014-3820.2005.tb01768.x
-
Weinreich DM, Watson RA, Chao L (2005) Sign epistasis and genetic constraint on evolutionary trajectories. Evolution 59:1165-1174. doi:10.1111/j.0014-3820.2005.tb01768.x
-
(2005)
Evolution
, vol.59
, pp. 1165-1174
-
-
Weinreich, D.M.1
Watson, R.A.2
Chao, L.3
-
111
-
-
33645666942
-
Darwinian evolution can follow only very few mutational paths to fitter proteins
-
doi:10.1126/science. 1123539
-
Weinreich DM, Delaney NF, DePristo MA, Hartl DL (2006) Darwinian evolution can follow only very few mutational paths to fitter proteins. Science 312:111. doi:10.1126/science. 1123539
-
(2006)
Science
, vol.312
, pp. 111
-
-
Weinreich, D.M.1
Delaney, N.F.2
DePristo, M.A.3
Hartl, D.L.4
-
112
-
-
77956415336
-
Emergent cooperation in microbial metabolism
-
doi:10.1038/msb.2010.66
-
Wintermute EH, Silver PA (2010) Emergent cooperation in microbial metabolism. Mol Syst Biol 6:1-7. doi:10.1038/msb.2010.66
-
(2010)
Mol Syst Biol
, vol.6
, pp. 1-7
-
-
Wintermute, E.H.1
Silver, P.A.2
-
113
-
-
0033529707
-
Functional characterization of the S. cerevisiae genome by gene deletion and parallel analysis
-
doi:10.1126/science.285.5429.901
-
Winzeler EA, Shoemaker DD, Astromoff A et al (1999) Functional characterization of the S. cerevisiae genome by gene deletion and parallel analysis. Science 285:901-906. doi:10.1126/science.285.5429.901
-
(1999)
Science
, vol.285
, pp. 901-906
-
-
Winzeler, E.A.1
Shoemaker, D.D.2
Astromoff, A.3
-
115
-
-
15544382418
-
Joint mapping of quantitative trait loci for multiple binary characters
-
doi:10.1534/genetics.103.019406
-
Xu C, Li Z, Xu S (2005) Joint mapping of quantitative trait loci for multiple binary characters. Genetics 169:1045-1059. doi:10.1534/genetics.103. 019406
-
(2005)
Genetics
, vol.169
, pp. 1045-1059
-
-
Xu, C.1
Li, Z.2
Xu, S.3
-
116
-
-
33645396484
-
Functional classification of drugs by properties of their pairwise interactions
-
doi:10.1038/ng1755
-
Yeh P, Tschumi AI, Kishony R (2006) Functional classification of drugs by properties of their pairwise interactions. Nat Genet 38:489-494. doi:10.1038/ng1755
-
(2006)
Nat Genet
, vol.38
, pp. 489-494
-
-
Yeh, P.1
Tschumi, A.I.2
Kishony, R.3
-
117
-
-
65649124513
-
Drug interactions and the evolution of anibiotic resistance
-
doi:10.1038/nrmicro2133
-
Yeh PJ, Hegreness MJ, Aiden AP, Kishony R (2011) Drug interactions and the evolution of anibiotic resistance. Nat Rev Microbiol 11:330. doi:10.1038/nrmicro2133
-
(2011)
Nat Rev Microbiol
, vol.11
, pp. 330
-
-
Yeh, P.J.1
Hegreness, M.J.2
Aiden, A.P.3
Kishony, R.4
-
118
-
-
0036239186
-
Dependence of epistasis on environment and mutation severity as revealed by in silico mutagenesis of phage t7
-
You L, Yin J (2002) Dependence of epistasis on environment and mutation severity as revealed by in silico mutagenesis of phage t7. Genetics 160:1273-1281
-
(2002)
Genetics
, vol.160
, pp. 1273-1281
-
-
You, L.1
Yin, J.2
-
119
-
-
0029661743
-
QTL mapping and quantitative disease resistance in plants
-
doi:10.1146/annurev.phyto.34.1.479
-
Young ND (1996) QTL mapping and quantitative disease resistance in plants. Ann Rev Phytopathol 34:479-501. doi:10.1146/annurev.phyto.34.1.479
-
(1996)
Ann Rev Phytopathol
, vol.34
, pp. 479-501
-
-
Young, N.D.1
|