Creation and characterization of a mitochondrial DNA-depleted pancreatic β-cell line: Impaired insulin secretion induced by glucose, leucine, and sulfonylureas

Diabetes

Volumn 47, Issue 4, 1998, Pages 621-631

  Tsuruzoe, Kaku ^a   Araki, Eiichi ^a   Furukawa, Noboru ^a   Shirotani, Tetsuya ^a   Matsumoto, Kazuya ^a   Kaneko, Kengo ^a   Motoshima, Hiroyuki ^a   Yoshizato, Kazuaki ^a   Shirakami, Atsuhisa ^a   Kishikawa, Hideki ^a   Miyazaki, Jun Ichi ^b   Shichiri, Motoaki ^a  

^a KUMAMOTO UNIV SCHOOL OF MEDICINE   (Japan)

^b OSAKA UNIVERSITY MEDICAL SCHOOL   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; CALCIUM ION; CYTOCHROME C OXIDASE; ETHIDIUM BROMIDE; GLIBENCLAMIDE; GLUCOSE; INSULIN; LEUCINE; MITOCHONDRIAL DNA; SULFONYLUREA DERIVATIVE;

ANIMAL CELL; ARTICLE; CALCIUM CELL LEVEL; CONTROLLED STUDY; GLUCOSE UTILIZATION; INSULIN RELEASE; MOUSE; NONHUMAN; OXIDATIVE PHOSPHORYLATION; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL;

ADENOSINE TRIPHOSPHATE; CALCIUM; CELL RESPIRATION; DNA, MITOCHONDRIAL; ETHIDIUM; GLUCOSE; HISTOCYTOCHEMISTRY; HUMANS; INSULIN; INTRACELLULAR FLUID; ISLETS OF LANGERHANS; LEUCINE; MITOCHONDRIA; OXIDATION-REDUCTION; PHOSPHORYLATION; RNA, MESSENGER; SULFONYLUREA COMPOUNDS; TUMOR CELLS, CULTURED;

EID: 17444440352     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.47.4.621     Document Type: Article

References (59)

1. DeFronzo RA: Pathogenesis of type 2 (non-insulin dependent) diabetes mellitus: a balanced overview. Diabetologia 35:389-397, 1992
2. Rorsman P: The pancreatic beta-cell as a fuel sensor, an electrophysiologist's viewpoint. Diabetologia 40:487-495, 1997
3. 2+ channels and insulin-containing secretory granules and its significance for the initiation of exocytosis in mouse pancreatic B-cells. EMBO J 14:50-57, 1995
4. 2+ entry. Diabetes 41:662-670, 1992
5. Ashcroft FM, Ashcroft SJH: Mechanism of insulin secretion. In Insulin: Molecular Biology to Pathology. Ashcroft FM, Ashcroft SJH, Eds. Oxford, IPX Press, 1992, p. 97-150
6. Erecinska M, Bryla J, Michalik M, Meglasson MD, Nelson D: Energy metabolism in islets of Langerhans. Biochim Biophys Acta 1101:273-295, 1992
7. i in single mouse pancreatic β-cells. J Physiol (Lond) 445:173-186, 1992
8. Sakura H, Ämmälä C, Smith PA, Gribble FM, Ashcroft FM: Cloning and functional expression of the cDNA encoding a novel ATP-sensitive potassium channel subunit expressed in pancreatic β-cells, brain, heart and skeletal muscle, FEBS Lett 377:338-344, 1995
9. KATP: an inward rectifier subunit plus the sulfonylurea receptor. Science 270:1166-1170, 1995
10. Yada T: Action mechanisms of amino acids in pancreatic B-cells. In Frontiers of Insulin Secretion and Pancreatic B-Cell Research. Flatt PR, Lenzen S, Eds. London, Smith-Gordon, 1994, p. 129-135
11. McClenaghan NH, Barnett CR, O'Harte FPM, Flatt PR: Mechanisms of amino acid-induced insulin secretion from the glucose-responsive BRIN-BD11 pancreatic B-cell line. J Endocrinol 151:349-357, 1996
12. Malaisse WJ: Branched-chain amino and keto acid metabolism in pancreatic islets. Adv Enzyme Regul 25:203-217, 1986
13. Gerbits K-D, Gempel K, Brdiczka D: Mitochondria and diabetes: genetic, biochemical, and clinical implications of the cellular energy circuit. Diabetes 45:113-126, 1996
14. Kadowaki T, Kadowaki H, Mori Y, Tobe K, Sakuta R, Suzuki Y, Tanabe Y, Sakura H, Awata T, Goto Y-I, Hayakawa T, Matsuoka K, Kawamori R, Kamada T, Horai S, Nonaka I, Hagura R, Akanuma Y, Yazaki Y: A subtype of diabetes mellitus associated with a mutation of mitochondrial DNA. N Engl J Med 330:962-968, 1994
15. Leu(UUR) gene mutation. Diabetes 45:478-487, 1996
16. Leu(UUR) gene. Diabetologia 38:193-200, 1995
17. Chomyn A, Martinuzzi A, Yoneda M, Daga A, Hurko O, Johns D, Lai ST, Nonaki I, Angelini C, Attardi G: MELAS mutation in mtDNA binding site for transcription termination factor causes defects in protein synthesis and in respiration but no change in levels of upstream and downstream mature transcripts. Proc Natl Acad Sci USA 89:4221-4225, 1992
18. Leu(UUR) mutation associated with mitochondrial myopathy, encephalopathy, lactic acidosis, and strokelike episodes. Mol Cell Biol 12:480-490, 1992
19. Hayashi J-I, Ohia S, Kagawa Y, Takai D, Miyabayashi S, Tada K, Fukushima H, Inui K, Okada S, Goto Y-I, Nonaka I: Functional and morphological abnormalities of mitochondria in human cells containing mitochondrial DNA with pathogenic point mutations in tRNA genes. J Biol Chem 269:19060-19066, 1994
20. Miyazaki J-I, Araki K, Yamato E, Ikegami H, Asano T, Shibasaki Y, Oka Y, Yamamura K-I: Establishment of a pancreatic β cell line that retains giucoseinducible insulin secretion: special reference to expression of glucose transporter isoforms. Endocrinology 127:126-132, 1990
21. Ishihara H, Asano T, Tsukuda K, Katagiri H, Inukai K, Anai M, Kikuchi M, Yazaki Y, Miyazaki J-I, Oka Y: Pancreatic beta cell line MIN6 exhibits characteristics of glucose metabolism and glucose-stimulated insulin secretion similar to those of normal islets. Diabetologia 36:1139-1145, 1993
22. 2+/calmodulin-dependent protein kinase II and synapsin I-like protein in mouse insulinoma MIN6 cells. Endocrinology 136:3784-3793, 1995
23. Sakuma N, Ishikawa S, Okada K, Miyazaki J-I, Saito T: Glucose induces calcium-dependent and calcium-independent insulin secretion from the pancreatic beta cell line MIN6. Ear J Endocrinol 133:227-234, 1995
24. King MP, Attardi G: Human cells lacking mtDNA: repopulation with exogenous mitochondria by complementation. Science 246:500-503, 1989
25. Hayashi J-I, Ohta S, Kikuchi A, Takemitsu M, Goto Y-I, Nbnaka I: Introduction of disease-related mitochondrial DNA deletions into Hela cells lacking mitochondrial DNA results in mitochondrial dysfunction. Proc Natl Acad Sci USA 88:10614-10618, 1991
26. Bibb MJ, Van Etten RA, Wright CT, Walberg MW, Clayton DA: Sequence and gene organization of mouse mitochondrial DNA. Cell 26:167-180, 1981
27. Araki E, Sun X-J, Haag BL III, Chuang L-M, Zhang Y, Yang-Feng TL, White MF, Kahn CR: Human skeletal muscle insulin receptor substrate-1: characterization of the cDNA, gene, and chromosomal localization. Diabetes 42:1041-1054, 1993
28. Carter RS, Avadhani NG: Cloning and characterization of the mouse cytochrome c oxidase subunit IV gene. Arch Biochem Biophys 288:97-106, 1991
29. Ishimura-Oka K, Nakamuta M, Chu MJ, Sullivan M, Chan L, Oka K: Partial structure of the mouse glucokinase gene. Genomics 29:751-754, 1995
30. Aguilar-Bryan L, Nichols CG, Wechsler SW, Clement JP IV, Boyd AE III, Gonzalez G, Herrera-Sosa H, Nguy K, Bryan J, Nelson DA: Cloning of a beta cell high-affinity sulfonylurea receptor: a regulator of insulin secretion. Science 268:423-426, 1995
31. Bell GI, Sanchez-Pescador R: Sequence of a cDNA encoding Syrian hamster preproinsulin. Diabetes 33:297-300, 1984
32. Alonso S, Minty A, Bourlet Y, Buckingham ME: Comparison of three actin-coding sequences in the mouse: evolutionary relationships between the actin genes of warm-blooded vertebrates. J Mol Evol 23:11-22, 1986
33. Moraes CT, Schon EA, DiMauro S, Miranda AF: Heteroplasmy of β mitochondrial genomes in clonal cultures from patients with Kearns-Sayre syndrome. Biochem Biophys Res Commun 160:765-771, 1989
34. Ashcroft SJH, Weerasinghe LCC, Randle PJ: Interrelationship of islet metabolism, adenosine triphosphate content and insulin release. Biochem J 132:223-231, 1973
35. Wanders RJA, Ruiter JPN, Wijburg FA: Studies on mitochondrial oxidative phosphorylation in permeabilized human skin fibroblasts: application to mitochondrial encephalomyopathies. Biochim Biophys Acta 1181:219-222, 1993
36. Moore H-PH, Walker MD, Lee F, Kelly RB: Expressing a human proinsulin cDNA in a mouse ACTH-secreting cell: intracellular storage, proteolytic processing, and secretion on stimulation. Cell 35:531-538, 1983
37. Hohmeier HE, BeltrandelRio H, Clark SA, Henkel-Rieger R, Normington K, Newgard C: Regulation of insulin secretion from novel engineered insulinoma cell lines. Diabetes 46:968-977, 1997
38. Ashcroft FM: Mechanisms of the glycaemic effects of sulfonylureas. Horm Metab Res 28:456-163, 1996
39. Aguilar-Bryan L, Nichols CG, Wechsler SW, Clement JP IV, Boyd AE III, Gonzalez G, Herrera-Sosa H, Nguy K, Bryan J, Nelson D: Cloning of the β cell high-affinity sulfonylurea receptor a regulator of insulin secretion. Science 268:423-426, 1995
40. Miller SW, Trimmer PA, Parker WD Jr, Davis RE: Creation and characterization of mitochondrial DNA-depleted cell lines with "neuronal-like" properties. J Neurochem 67:1897-1907, 1996
41. 2+ oscillations in pancreatic β cells exposed to leucine and arginine. Acta Physiol Scand 136:113-119, 1989
42. 2+ concentration in an electrically excitable cell, the insulin-secreting pancreatic B-cell. J Biol Chem 267:20713-20720, 1992
43. i in the fetal rat β-cell. Diabetes 44:118-124, 1995
44. Weinhaus AJ, Poronnik P, Tuch BE, Cook DI: Mechanisms of arginine-induced increase in cytosolic calcium concentration in the beta-cell line NIT-1. Diabetologia 40:374-382, 1997
45. Blachier F, Mourtada A, Sener A, Malaisse WJ: Stimulus-secretion coupling of arginine-induced insulin release: uptake of metabolized and nonmetabolized cationic amino acids by pancreatic islets. Endocrinology 124:134-141, 1989
46. Malaisse WJ, Blachier F, Mourtada A, Camara J, Albor A, Valverde I, Sener A: Stimulus-secretion coupling of arginine-induced insulin release: metabolism of L-arginine and L-ornithine in pancreatic islets. Biochim Biophys Acta 1013:133-143, 1989
47. Schmidt HHHW, Warner TD, Ishii K, Sheng H, Murad F: Insulin secretion from pancreatic B cells caused by L-arginine-derived nitrogen oxides. Science 255:721-723, 1992
48. + channel in human pancreatic islet cells. Diabetes 38:422-427, 1989
49. Niki I, Ashcroft SJH: Possible involvement of protein phosphorylation in the regulation of the sulfonylurea receptor of a pancreatic β-cell line, HIT T15. Biochim Biophys Acta 1133:95-101, 1991
50. + channel-independent glucose action in rat pancreatic β-cell. Am J Physiol 266:C622-C627, 1994
51. + channels in mouse B cells. J Clin Invest 91:871-880, 1993
52. + channels in mouse B cells. J Clin Invest 89:1228-1295, 1992
53. Soejima A, Inoue K, Takai D, Kaneko M, Ishihara H, Oka Y, Hayashi J-I: Mitochondrial DNA is required for regulation of glucose stimulated insulin secretion in a mouse pancreatic beta cell line, MIN6. J Biol Chem 271:26194-26199, 1996
54. Hutton JC, Sener A, Herchuelz A, Atwater I, Kawazu S, Boschero C, Somers G, Devis G, Malaisse WJ: Similarities in the stimulus-secretion coupling mechanisms of glucose- and 2-keto acid-induced insulin release. Endocrinology 106:203-219, 1980
55. Niki I, Ashcroft FM, Ashcroft SJH: The dependence on intracellular ATP concentration of ATP-sensitive K-channels and Na,K-ATPase in intact HTT-T15 β-cells. FEBS Lett 257:361-364, 1989
56. Kiranadi B, Bangham JA, Smith PA: Inhibition of electrical activity in mouse pancreatic β-cells by the ATP/ADP translocase inhibitor, bongkrekic acid. FEBS Lett 283:93-96, 1991
57. Duchen MR, Smith PA, Ashcroft FM: Substrate-dependent changes in mitochondrial function, intracellular free calcium concentration and membrane changes in pancreatic β-cells. Biochem J 294:35-42, 1993
58. Gerbitz K-D, van den Ouweland JMW, Maassen JA Mitochondrial diabetes mellitus: a review. Biochim Biophys Acta 1271:253-260, 1995
59. Kobayashi T, Nakanishi K, Nakase H, Kajio H, Okubo M, Murase T, Kosaka K: In situ characterization of islets in diabetes with a mitochondrial DNA mutation at nucleotide position 3243. Diabetes 46:1567-1571, 1997