Mouse pancreatic β-cells exhibit preserved glucose competence after disruption of the glucagon-like peptide-1 receptor gene

Diabetes

Volumn 47, Issue 4, 1998, Pages 646-652

  Flamez, Daisy ^a   Van Breusegem, An ^a   Scrocchi, Louise A ^b   Quartier, Erik ^a   Pipeleers, Daniel ^a   Drucker, Daniel J ^b   Schuit, Frans ^a  

^a DIABETES RESEARCH CENTER   (Belgium)

^b UNIVERSITY HEALTH NETWORK   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCAGON LIKE PEPTIDE 1; GLUCOSE; HORMONE RECEPTOR; INSULIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; FEMALE; INSULIN RELEASE; MALE; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN BINDING;

ANIMALS; FEMALE; GLUCAGON; GLUCAGON-LIKE PEPTIDE 1; GLUCOSE; INSULIN; ISLETS OF LANGERHANS; MALE; MICE; ORGAN SPECIFICITY; PEPTIDE FRAGMENTS; PROTEIN PRECURSORS; RECEPTORS, GLUCAGON; RNA, MESSENGER;

EID: 0031898957     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.47.4.646     Document Type: Article

References (29)

1. Pipeleers D, in't Veld P, Maes E, Van De Winkel M: Glucose-induced insulin release depends on functional cooperation between islet cells. Proc Natl Acad Sci USA 79:7322-7325, 1982
2. Pipeleers DG, Schuit FC, in't Veld P, Maes E, Hooghe-Peters EL, Van De Winkel M, Gepts W: Interplay of nutrients and hormones in the regulation of insulin release. Endocrinology 117:824-833, 1985
3. Pipeleers D: The biosociology of pancreatic β cells. Diabetologia 30:277-291, 1987
4. Schult FC: Factors determining the glucose sensitivity and glucose responsiveness of pancreatic beta cells. Horn Res 46:99-106, 1996
5. Schuit FC, Pipeleers DG: Regulation of adenosine 3′,5′-monophosphate levels in the pancreatic β cell. Endocrinology 117:834-840, 1985
6. Moens K, Heimberg H, Flamez D, Huypens P, Quartier E, Ling Z, Pipeleers D, Gremlich S, Thorens B, Schuit F: Expression and functional activity of glucagon, glucagon-like peptide 1, and glucose-dependent insulinotropic peptide receptors in rat pancreatic islet cells. Diabetes 45:257-261, 1996
7. Henquin JC, Bozem M, Schmeer W, Nenquin M: Distinct mechanisms for two amplification systems of insulin release. Biochem J 246:393-399, 1987
8. 2+ influx by cAMP- and protein kinase C-dependent signal transduction pathways. J Biol Chem 268:7785-7791, 1993
9. Ämmälä C, Ashcroft FM, Rorsman P: Calcium-independent potentiation of insulin release by cyclic AMP in single β-cells. Nature 363:356-358, 1993
10. Creutzfeldt W: The incretin concept today. Diabetologia 16:15-85, 1979
11. Weir GC, Mojsov S, Hendrick GK, Habener JF: Giucagonlike peptide I(7-37) actions on endocrine pancreas. Diabetes 38:338-342, 1989
12. Kreymann B, Ghatei MA, Williams G, Bloom SR: Glucagon-like peptide-I 7-36: a physiological incretin in man. Lancet 5:1300-1304, 1987
13. Thorens B: Expression cloning of the pancreatic β cell receptor for the gluco-incretin hormone glucagon-like peptide 1. Proc Natl Acad Sci USA 89:8641-8645, 1992
14. Göke R, Fehmann HC, Linn T, Schmidt H, Krause M, Eng J, Göke B: Exendin-4 is a high potency agonist and truncated exendin-(9-39)-amide an antagonist at the glucagon-like peptide 1-(7-36)-amide receptor of insulin-secreting β-cells. J Biol Chem 268:19650-19655, 1993
15. Kolligs F, Fehmann HC, Göke R, Göke B: Reduction of the incretin effect in rats by the glucagon-like peptide 1 receptor antagonist exendin (9-39) amide. Diabetes 44:16-19, 1995
16. Scrocchi LA, Brown TJ, Maclusky N, Brubaker PL, Auerbach AB, Joyner AL, Drucker DJ: Glucose intolerance but normal satiety in mice with a null mutation in the glucagon-like peptide 1 receptor gene. Nature Med 2:1254-1258, 1996
17. Turton MD, O'Shea D, Gunn I, Beak SA, Edwards CMB, Meeran K, Choi SJ, Taylor GM, Heath MM, Lambert PD, Wilding JPH, Smith DM, Ghatei MA, Herbert J, Bloom SR: A role for glucagon-like peptide-1 in the central regulation of feeding. Nature 379:69-72, 1996
18. Schirra J, Katschinsky M, Weldmann C, Schäfer T, Wank U, Arnold R, Göke B: Gastric emptying and release of incretin hormones after glucose ingestion in humans. J Clin Invest 97:92-103, 1996
19. Morales M, Lopez-Delgado MI, Alcantara A, Luque MA, Clemente F; Marquez L, Puente J, Vinambres C, Malaisse WJ, Villanueva-Penacarrillo ML, Valverde I: Preserved GLP-1 effects on glycogen synthase a activity and glucose metabolism in isolated hepatocytes and skeletal muscle from diabetic rats. Diabetes 46:1264-1269, 1997
20. Holz GG IV, Kühtreiber WM, Habener JF: Pancreatic beta-cells are rendered glucose-competent by the insulinotropic hormone glucagon-like peptide-1(7-37). Nature 361:362-365, 1993
21. Schuit FC, in't Veld PA, Pipeleers DG: Glucose stimulates proinsulin biosynthesis by a dose-dependent recruitment of pancreatic beta cells. Proc Natl Acad Sci USA 85:3865-3869, 1988
22. Van Schravendijk CFH, Kiekens R, Pipeleers DG: Pancreatic β cell heterogeneity in glucose-induced insulin secretion. J Biol Chem 267:21344-21348, 1992
23. 2+ and secretion. EMBO J 9:53-60, 1990
24. Ling Z, Kiekens R, Mahler T, Schuit FC, Pipeleers-Marichal M, Sener A, Kloppel G, Malaisse WJ, Pipeleers DG: Effects of chronically elevated glucose levels on the functional properties of rat pancreatic β-cells. Diabetes 45:1774-1782, 1996
25. Lomedico P, Rosenthal N, Efstratiadis A, Gilbert W, Kolodner R, Tizard R: The structure and evolution of the two nonallelic rat preproinsulin genes. Cell 18:545-558, 1979
26. Gutniak M, Orskov C, Hoist JJ, Ahrén B, Efendic S: Antidiabetogenic effects of glucagon-like peptide-1 (7-36)amide in normal subjects and patients with diabetes mellitus. N Engl J Med 326:1316-1322, 1992
27. Nauck MA, Heimesaat MM, Orskov C, Hoist JJ, Ebert R, Creutzfeldt W: Preserved incretin activity of glucagon-like peptide 1 (7-36 amide) but not of synthetic human gastric inhibitory polypeptide in patients with type-2 diabetes mellitus. J Clin Invest 91:301-307, 1993
28. Urlaub G, Mitchell P, Chiudad C, Chasin L: Nonsense mutations in the dihydrofolate reductase gene affect RNA processing. Mol Cell Biol 9:2868-2880, 1989
29. Moens K, Flamez D, Van Schravendijk C, Ling Z, Pipeleers D, Schuit F: Dual glucagon recognition by pancreatic β-cells via glucagon and GLP-l receptors. Diabetes 47:66-72, 1998