Nucleo-cytosolic shuttling of FoxO1 directly regulates mouse Ins2 but not Ins1 gene expression in pancreatic beta cells (MIN6

Journal of Biological Chemistry

Volumn 286, Issue 15, 2011, Pages 13647-13656

  Meur, Gargi ^a   Qian, Qingwen ^a   Da Silva Xavier, Gabriela ^a   Pullen, Timothy J ^a   Tsuboi, Takashi ^d   McKinnon, Caroline ^a,b   Fletcher, Laura ^b   Tavaré, Jeremy M ^b   Hughes, Stephen ^c   Johnson, Paul ^c   Rutter, Guy A ^a  

^a Faculty of Medicine   (United Kingdom)

^b UNIVERSITY OF BRISTOL   (United Kingdom)

^c JOHN RADCLIFFE HOSPITAL   (United Kingdom)

^d UNIVERSITY OF TOKYO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CHROMATIN IMMUNOPRECIPITATION; CONFOCAL IMAGING; CONSTITUTIVELY ACTIVES; CYTOSOLIC; CYTOSOLS; GLUCOSE-RESPONSIVE; GLYCOGEN SYNTHASE KINASE-3; HUMAN ISLETS; INSULIN SECRETION; NUCLEAR EXPORT; NUCLEAR IMPORT; NUCLEAR SHUTTLING; OVER-EXPRESSION; PANCREATIC BETA CELLS; PHOSPHATIDYLINOSITOL 3-KINASE; PHYSICAL INTERACTIONS; PROTEIN KINASE; S6 KINASE; TIME-DEPENDENT;

BINDING SITES; BIOCHEMISTRY; CLONE CELLS; ENZYMES; GENES; GLUCOSE; INSULIN; MAMMALS; PHOSPHORYLATION; TRANSCRIPTION FACTORS;

TRANSCRIPTION;

PROTEIN KINASE B; TRANSCRIPTION FACTOR FKHR; TRANSCRIPTION FACTOR PDX 1;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; BINDING SITE; CELL GROWTH; CELL PROLIFERATION; CONTROLLED STUDY; CYTOSOL; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; GENE; GENE EXPRESSION; GENE SILENCING; GENE TRANSLOCATION; HUMAN; IMMUNOPRECIPITATION; INS1 GENE; INS2 GENE; INSULIN RELEASE; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROMOTER REGION;

ACTIVE TRANSPORT, CELL NUCLEUS; ANIMALS; CELL LINE; CELL NUCLEUS; CYTOSOL; FORKHEAD TRANSCRIPTION FACTORS; GENE EXPRESSION REGULATION; GLUCOSE; GLYCOGEN SYNTHASE KINASE 3; HOMEODOMAIN PROTEINS; HUMANS; INSULIN; INSULIN-SECRETING CELLS; MICE; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS C-AKT; RECOMBINANT FUSION PROTEINS; RESPONSE ELEMENTS; SWEETENING AGENTS; TRANS-ACTIVATORS;

MAMMALIA; RODENTIA;

EID: 79953840839     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.204248     Document Type: Article

References (53)

1. Rutter, G. A., Tavare, J. M., and Palmer, D. G. (2000) News Physiol. Sci. 15, 149-154
2. Melloul, D., Marshak, S., and Cerasi, E. (2002) Diabetologia 45, 309-326
3. Kulkarni, R. N., Brüning, J. C., Winnay, J. N., Postic, C., Magnuson, M. A., and Kahn, C. R. (1999) Cell 96, 329-339
4. Leibiger, B., Moede, T., Schwarz, T., Brown, G. R., Köhler, M., Leibiger, I. B., and Berggren, P. O. (1998) Proc. Natl. Acad. Sci. U.S.A. 95, 9307-9312
5. Rutter, G. A. (1999) Curr. Biol. 9, R443-R445
6. da Silva, Xavier, G., Varadi, A., Ainscow, E. K., and Rutter, G. A. (2000) J. Biol. Chem. 275, 36269-36277
7. Andreolas, C., da Silva, Xavier, G., Diraison, F., Zhao, C., Varadi, A., Lopez-Casillas, F., Ferré, P., Foufelle, F., and Rutter, G. A. (2002) Diabetes 51, 2536-2545
8. da Silva, Xavier, G., Qian, Q., Cullen, P. J., and Rutter, G. A. (2004) Biochem. J. 377, 149-158
9. Bouche, C., Lopez, X., Fleischman, A., Cypess, A. M., O'Shea, S., Stefanovski, D., Bergman, R. N., Rogatsky, E., Stein, D. T., Kahn, C. R., Kulkarni, R. N., and Goldfine, A. B. (2010) Proc. Natl. Acad. Sci. U.S.A. 107, 4770-4775
10. Lantz, K. A., and Kaestner, K. H. (2005) Clin. Sci. 108, 195-204
11. Nakae, J., Biggs, W. H., 3rd, Kitamura, T., Cavenee, W. K., Wright, C. V., Arden, K. C., and Accili, D. (2002) Nat. Genet. 32, 245-253
12. Cahill, C. M., Tzivion, G., Nasrin, N., Ogg, S., Dore, J., Ruvkun, G., and Alexander-Bridges, M. (2001) J. Biol. Chem. 276, 13402-13410
13. Trümper, A., Trümper, K., Trusheim, H., Arnold, R., Göke, B., and Hörsch, D. (2001) Mol. Endocrinol. 15, 1559-1570
14. Rena, G., Guo, S., Cichy, S. C., Unterman, T. G., and Cohen, P. (1999) J. Biol. Chem. 274, 17179-17183
15. Matsuzaki, H., Daitoku, H., Hatta, M., Tanaka, K., and Fukamizu, A. (2003) Proc. Natl. Acad. Sci. U.S.A. 100, 11285-11290
16. Brunet, A., Bonni, A., Zigmond, M. J., Lin, M. Z., Juo, P., Hu, L. S., Anderson, M. J., Arden, K. C., Blenis, J., and Greenberg, M. E. (1999) Cell 96, 857-868
17. McKinnon, C. M., Ravier, M. A., and Rutter, G. A. (2006) J. Biol. Chem. 281, 39358-39369
18. Xuan, S., Kitamura, T., Nakae, J., Politi, K., Kido, Y., Fisher, P. E., Morroni, M., Cinti, S., White, M. F., Herrera, P. L., Accili, D., and Efstratiadis, A. (2002) J. Clin. Invest. 110, 1011-1019
19. Buteau, J., Shlien, A., Foisy, S., and Accili, D. (2007) J. Biol. Chem. 282, 287-293
20. Kitamura, T., Nakae, J., Kitamura, Y., Kido, Y., Biggs, W. H., 3rd, Wright, C. V., White, M. F., Arden, K. C., and Accili, D. (2002) J. Clin. Invest. 110, 1839-1847
21. Martinez, S. C., Cras-Méneur, C., Bernal-Mizrachi, E., and Permutt, M. A. (2006) Diabetes 55, 1581-1591
22. Ainscow, E. K., and Rutter, G. A. (2001) Biochem. J. 353, 175-180
23. Kennedy, H. J., Viollet, B., Rafiq, I., Kahn, A., and Rutter, G. A. (1997) J. Biol. Chem. 272, 20636-20640
24. Rafiq, I., da Silva, Xavier, G., Hooper, S., and Rutter, G. A. (2000) J. Biol. Chem. 275, 15977-15984
25. Dhand, R., Hara, K., Hiles, I., Bax, B., Gout, I., Panayotou, G., Fry, M. J., Yonezawa, K., Kasuga, M., and Waterfield, M. D. (1994) EMBO J. 13, 511-521
26. Miyazaki, J., Araki, K., Yamato, E., Ikegami, H., Asano, T., Shibasaki, Y., Oka, Y., and Yamamura, K. (1990) Endocrinology 127, 126-132
27. Cross, S. E., Hughes, S. J., Partridge, C. J., Clark, A., Gray, D. W., and Johnson, P. R. (2008) Transplantation 86, 907-911
28. Ravier, M. A., and Rutter, G. A. (2005) Diabetes 54, 1789-1797
29. Meur, G., Simon, A., Harun, N., Virally, M., Dechaume, A., Bonnefond, A., Fetita, S., Tarasov, A. I., Guillausseau, P. J., Boesgaard, T. W., Pedersen, O., Hansen, T., Polak, M., Gautier, J. F., Froguel, P., Rutter, G. A., and Vaxillaire, M. (2010) Diabetes 59, 653-661
30. Noordeen, N. A., Khera, T. K., Sun, G., Longbottom, E. R., Pullen, T. J., da Silva, Xavier, G., Rutter, G. A., and Leclerc, I. (2010) Diabetes 59, 153-160
31. Elayat, A. A., el-Naggar, M. M., and Tahir, M. (1995) J. Anat. 186, 629-637
32. da Silva, Xavier, G., Leclerc, I., Varadi, A., Tsuboi, T., Moule, S. K., and Rutter, G. A. (2003) Biochem. J. 371, 761-774
33. Briaud, I., Lingohr, M. K., Dickson, L. M., Wrede, C. E., and Rhodes, C. J. (2003) Diabetes 52, 974-983
34. Lingohr, M. K., Dickson, L. M., McCuaig, J. F., Hugl, S. R., Twardzik, D. R., and Rhodes, C. J. (2002) Diabetes 51, 966-976
35. Coghlan, M. P., Culbert, A. A., Cross, D. A., Corcoran, S. L., Yates, J. W., Pearce, N. J., Rausch, O. L., Murphy, G. J., Carter, P. S., Roxbee, C. L., Mills, D., Brown, M. J., Haigh, D., Ward, R. W., Smith, D. G., Murray, K. J., Reith, A. D., and Holder, J. C. (2000) Chem. Biol. 7, 793-803
36. Lee, C. S., Sund, N. J., Vatamaniuk, M. Z., Matschinsky, F. M., Stoffers, D. A., and Kaestner, K. H. (2002) Diabetes 51, 2546-2551
37. Kitamura, Y. I., Kitamura, T., Kruse, J. P., Raum, J. C., Stein, R., Gu, W., and Accili, D. (2005) Cell Metab. 2, 153-163
38. Finlay, D., Patel, S., Dickson, L. M., Shpiro, N., Marquez, R., Rhodes, C. J., and Sutherland, C. (2004) BMC. Mol. Biol. 5, 15
39. Shih, D. Q., Heimesaat, M., Kuwajima, S., Stein, R., Wright, C. V., and Stoffel, M. (2002) Proc. Natl. Acad. Sci. U.S.A. 99, 3818-3823
40. Rafiq, I., Kennedy, H. J., and Rutter, G. A. (1998) J. Biol. Chem. 273, 23241-23247
41. Guillemain, G., da, Silva, Xavier, G., Rafiq, I., Leturque, A., and Rutter, G. A. (2004) Biochem. J. 378, 219-227
42. Leroux, L., Desbois, P., Lamotte, L., Duvillié, B., Cordonnier, N., Jackerott, M., Jami, J., Bucchini, D., and Joshi, R. L. (2001) Diabetes. 50, S150-S153
43. Leibiger, I. B., Leibiger, B., Moede, T., and Berggren, P. O. (1998) Mol. Cell 1, 933-938
44. Hettiarachchi, K. D., Zimmet, P. Z., and Myers, M. A. (2006) Cell Biol. Toxicol. 22, 169-181
45. Furuyama, T., Nakazawa, T., Nakano, I., and Mori, N. (2000) Biochem. J. 349, 629-634
46. Durham, S. K., Suwanichkul, A., Scheimann, A. O., Yee, D., Jackson, J. G., Barr, F. G., and Powell, D. R. (1999) Endocrinology 140, 3140-3146
47. Boam, D. S., Clark, A. R., and Docherty, K. (1990) J. Biol. Chem. 265, 8285-8296
48. German, M., Ashcroft, S., Docherty, K., Edlund, H., Edlund, T., Goodison, S., Imura, H., Kennedy, G., Madsen, O., Melloul, D., Moss, L., Olson, K., Permutt, M. A., Philippe, J., Robertson, R. P., Rutter, W. J., Serup, P., Stein, R., and Steiner, D. (1995) Diabetes 44, 1002-1004
49. Soares, M. B., Schon, E., Henderson, A., Karathanasis, S. K., Cate, R., Zeitlin, S., Chirgwin, J., and Efstratiadis, A. (1985) Mol. Cell. Biol. 5, 2090-2103
50. Deltour, L., Vandamme, J., Jouvenot, Y., Duvillié, B., Kelemen, K., Schaerly, P., Jami, J., and Paldi, A. (2004) Gene Expr. Patterns 5, 297-300
51. Bengtsson, M., Ståhlberg, A., Rorsman, P., and Kubista, M. (2005) Genome Res. 15, 1388-1392
52. Gannon, M., Shiota, C., Postic, C., Wright, C. V., and Magnuson, M. (2000) Genesis 26, 139-142
53. Wicksteed, B., Brissova, M., Yan, W., Opland, D. M., Plank, J. L., Reinert, R. B., Dickson, L. M., Tamarina, N. A., Philipson, L. H., Shostak, A., Bernal-Mizrachi, E., Elghazi, L., Roe, M. W., Labosky, P. A., Myers, M. M., Jr., Gannon, M., Powers, A. C., and Dempsey, P. J. (2010) Diabetes 59, 3090-3098