메뉴 건너뛰기




Volumn 9, Issue 5, 2012, Pages 375-379

The development and function of follicular helper T cells in immune responses

Author keywords

autoimmune diseases; follicular helper T cells; systemic lupus erythematousus

Indexed keywords

AUTOIMMUNE DISEASE; CD4+ T LYMPHOCYTE; CELL INTERACTION; CELL MATURATION; FOLLICULAR HELPER T CELL; FOLLICULAR HELPER T CELL DEVELOPMENT; FOLLICULAR HELPER T CELL FUNCTION; GROWTH REGULATION; HELPER CELL; HUMAN; HUMORAL IMMUNITY; IMMUNE RESPONSE; IMMUNOPATHOGENESIS; LIGAND BINDING; LYMPHOCYTE FUNCTION; NONHUMAN; PHENOTYPE; REVIEW;

EID: 84866098957     PISSN: 16727681     EISSN: None     Source Type: Journal    
DOI: 10.1038/cmi.2012.18     Document Type: Review
Times cited : (55)

References (60)
  • 2
    • 58149279490 scopus 로고    scopus 로고
    • ICOSdependent extrafollicular helper T cells elicit IgG production via IL-21 in systemic autoimmunity
    • Odegard JM, Marks BR, DiPlacido LD, Poholek AC, Kono DH, Dong C et al. ICOSdependent extrafollicular helper T cells elicit IgG production via IL-21 in systemic autoimmunity. J Exp Med 2008; 205: 2873-2886.
    • (2008) J Exp Med , vol.205 , pp. 2873-2886
    • Odegard, J.M.1    Marks, B.R.2    DiPlacido, L.D.3    Poholek, A.C.4    Kono, D.H.5    Dong, C.6
  • 3
    • 79961158055 scopus 로고    scopus 로고
    • Follicular regulatory T cells expressing Foxp3 and Bcl-6 suppress germinal center reactions
    • Chung Y, Tanaka S, Chu F, Nurieva RI, Martinez GJ, Rawal S et al. Follicular regulatory T cells expressing Foxp3 and Bcl-6 suppress germinal center reactions. Nat Med 2011; 17: 983-988.
    • (2011) Nat Med , Issue.17 , pp. 983-988
    • Chung, Y.1    Tanaka, S.2    Chu, F.3    Nurieva, R.I.4    Martinez, G.J.5    Rawal, S.6
  • 4
  • 6
    • 74849138095 scopus 로고    scopus 로고
    • Expansion of circulating T cells resembling follicular helper T cells is a fixed phenotype that identifies a subset of severe systemic lupus erythematosus
    • Simpson N, Gatenby PA, Wilson A, Malik S, Fulcher DA, Tangye SG et al. Expansion of circulating T cells resembling follicular helper T cells is a fixed phenotype that identifies a subset of severe systemic lupus erythematosus. Arthritis Rheum 2010; 62: 234-244.
    • (2010) Arthritis Rheum , vol.62 , pp. 234-244
    • Simpson, N.1    Gatenby, P.A.2    Wilson, A.3    Malik, S.4    Fulcher, D.A.5    Tangye, S.G.6
  • 7
    • 0035997908 scopus 로고    scopus 로고
    • T-bet is a STAT1-induced regulator of IL-12R expression in naive CD41 T cells
    • Afkarian M, Sedy JR, Yang J, Jacobson NG, Cereb N, Yang SY et al. T-bet is a STAT1-induced regulator of IL-12R expression in naive CD41 T cells. Nat Immunol 2002; 3: 549-557.
    • (2002) Nat Immunol , vol.3 , pp. 549-557
    • Afkarian, M.1    Sedy, J.R.2    Yang, J.3    Jacobson, N.G.4    Cereb, N.5    Yang, S.Y.6
  • 8
    • 0033427612 scopus 로고    scopus 로고
    • Ectopic expression of activated Stat6 induces the expression of Th2-specific cytokines and transcription factors in developing Th1 cells
    • Kurata H, Lee HJ, O'Garra A, Arai N. Ectopic expression of activated Stat6 induces the expression of Th2-specific cytokines and transcription factors in developing Th1 cells. Immunity 1999; 11: 677-688.
    • (1999) Immunity , vol.11 , pp. 677-688
    • Kurata, H.1    Lee, H.J.2    O'Garra, A.3    Arai, N.4
  • 9
    • 77955949431 scopus 로고    scopus 로고
    • Isolation of purified and live Foxp31 regulatory T cells using FACS sorting on scatter plot
    • Zhou X, Wang J, Shi W, Brand DD, Liu Z, Fan H et al. Isolation of purified and live Foxp31 regulatory T cells using FACS sorting on scatter plot. J Mol Cell Biol 2010; 2: 164-169.
    • (2010) J Mol Cell Biol , Issue.2 , pp. 164-169
    • Zhou, X.1    Wang, J.2    Shi, W.3    Brand, D.D.4    Liu, Z.5    Fan, H.6
  • 10
    • 1242290580 scopus 로고    scopus 로고
    • Natural and induced CD41CD251 cells educate CD41CD252 cells to develop suppressive activity: The role of IL-2, TGF-beta, and IL-10
    • Zheng SG, Wang JH, Gray JD, Soucier H, Horwitz DA. Natural and induced CD41CD251 cells educate CD41CD252 cells to develop suppressive activity: The role of IL-2, TGF-beta, and IL-10. J Immunol 2004; 172: 5213-5221.
    • (2004) J Immunol , vol.172 , pp. 5213-5221
    • Zheng, S.G.1    Wang, J.H.2    Gray, J.D.3    Soucier, H.4    Horwitz, D.A.5
  • 12
    • 77952584843 scopus 로고    scopus 로고
    • The transcription factor PU.1 is required for the development of IL-9-producing T cells and allergic inflammation
    • Chang HC, Sehra S, Goswami R, Yao W, Yu Q, Stritesky GL et al. The transcription factor PU.1 is required for the development of IL-9-producing T cells and allergic inflammation. Nat Immunol 2010; 11: 527-534.
    • (2010) Nat Immunol , vol.11 , pp. 527-534
    • Chang, H.C.1    Sehra, S.2    Goswami, R.3    Yao, W.4    Yu, Q.5    Stritesky, G.L.6
  • 13
    • 77955902281 scopus 로고    scopus 로고
    • Interferon-regulatory factor 4 is essential for the developmental program of T helper 9 cells
    • Staudt V, Bothur E, Klein M, Lingnau K, Reuter S, Grebe N et al. Interferon-regulatory factor 4 is essential for the developmental program of T helper 9 cells. Immunity 2010; 33: 192-202.
    • (2010) Immunity , vol.33 , pp. 192-202
    • Staudt, V.1    Bothur, E.2    Klein, M.3    Lingnau, K.4    Reuter, S.5    Grebe, N.6
  • 14
    • 0034606359 scopus 로고    scopus 로고
    • Follicular B helper T cells express CXC chemokine receptor 5, localize to B cell follicles, and support immunoglobulin production
    • Breitfeld D, Ohl L, Kremmer E, Ellwart J, Sallusto F, LippMet al. Follicular B helper T cells express CXC chemokine receptor 5, localize to B cell follicles, and support immunoglobulin production. J Exp Med 2000; 192: 1545-1452.
    • (2000) J Exp Med , vol.192 , pp. 1545-1452
    • Breitfeld, D.1    Ohl, L.2    Kremmer, E.3    Ellwart, J.4    Sallusto, F.5    Lipp, M.6
  • 15
    • 0034606348 scopus 로고    scopus 로고
    • CXC chemokine receptor 5 expression defines follicular homing T cells with B cell helper function
    • Schaerli P, Willimann K, Lang AB, Lipp M, Loetscher P, Moser B. CXC chemokine receptor 5 expression defines follicular homing T cells with B cell helper function. J Exp Med 2000; 192: 1553-1562.
    • (2000) J Exp Med , vol.192 , pp. 1553-1562
    • Schaerli, P.1    Willimann, K.2    Lang, A.B.3    Lipp, M.4    Loetscher, P.5    Moser, B.6
  • 17
    • 0033214348 scopus 로고    scopus 로고
    • CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs
    • Forster R, Schubel A, Breitfeld D, Kremmer E, Renner-Muller I, Wolf E et al. CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs. Cell 1999; 99: 23-33.
    • (1999) Cell , vol.99 , pp. 23-33
    • Forster, R.1    Schubel, A.2    Breitfeld, D.3    Kremmer, E.4    Renner-Muller, I.5    Wolf, E.6
  • 18
    • 24744448228 scopus 로고    scopus 로고
    • Balanced expression of CXCR5 and CCR7 on follicular T helper cells determines their transient positioning to lymph node follicles and is essential for efficient B-cell help
    • Hardtke S, Ohl L, Forster R. Balanced expression of CXCR5 and CCR7 on follicular T helper cells determines their transient positioning to lymph node follicles and is essential for efficient B-cell help. Blood 2005; 106: 1924-1931.
    • (2005) Blood , vol.106 , pp. 1924-1931
    • Hardtke, S.1    Ohl, L.2    Forster, R.3
  • 19
    • 0141678842 scopus 로고    scopus 로고
    • Chemokines in the systemic organization of immunity
    • Campbell DJ, Kim CH, Butcher EC. Chemokines in the systemic organization of immunity. Immunol Rev 2003; 195: 58-71.
    • (2003) Immunol Rev , vol.195 , pp. 58-71
    • Campbell, D.J.1    Kim, C.H.2    Butcher, E.C.3
  • 20
    • 79951672553 scopus 로고    scopus 로고
    • Regulation of T follicular helper cell formation and function by antigen presenting cells
    • Deenick EK, Ma CS, Brink R, Tangye SG. Regulation of T follicular helper cell formation and function by antigen presenting cells. Curr Opin Immunol 2011; 23: 111-118.
    • (2011) Curr Opin Immunol , Issue.23 , pp. 111-118
    • Deenick, E.K.1    Ma, C.S.2    Brink, R.3    Tangye, S.G.4
  • 21
    • 46749151286 scopus 로고    scopus 로고
    • Generation of T follicular helper cells is mediated by inteleukin-21 but independent of T helper 1 2, or 17 cell lineages
    • Nurieva RI, Chung Y, Hwang D, Yang XO, Kang HS, MaL et al. Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineages. Immunity 2008; 29: 138-149.
    • (2008) Immunity , Issue.29 , pp. 138-149
    • Nurieva, R.I.1    Chung, Y.2    Hwang, D.3    Yang, X.O.4    Kang, H.S.5    Ma, L.6
  • 22
    • 79959328032 scopus 로고    scopus 로고
    • ICOS receptor instructs T follicular helper cell versus effector cell differentiation via induction of the transcriptional repressor Bcl6
    • Choi YS, Kageyama R, Eto D, Escobar TC, Johnston RJ, Monticelli L et al. ICOS receptor instructs T follicular helper cell versus effector cell differentiation via induction of the transcriptional repressor Bcl6. Immunity 2011; 34: 932-946.
    • (2011) Immunity , vol.34 , pp. 932-946
    • Choi, Y.S.1    Kageyama, R.2    Eto, D.3    Escobar, T.C.4    Johnston, R.J.5    Monticelli, L.6
  • 24
    • 78049354525 scopus 로고    scopus 로고
    • B and T lymphocyte attenuator suppresses IL-21 production from follicular Th cells and subsequent humoral immune responses
    • Kashiwakuma D, Suto A, Hiramatsu Y, Ikeda K, Takatori H, Suzuki K et al. B and T lymphocyte attenuator suppresses IL-21 production from follicular Th cells and subsequent humoral immune responses. J Immunol 2010; 185: 2730-2736.
    • (2010) J Immunol , Issue.185 , pp. 2730-2736
    • Kashiwakuma, D.1    Suto, A.2    Hiramatsu, Y.3    Ikeda, K.4    Takatori, H.5    Suzuki, K.6
  • 26
    • 0035908122 scopus 로고    scopus 로고
    • Subspecialization of CXCR51 T cells: B helper activity is focused in a germinal center-localized subset of CXCR51 T cells
    • Kim CH, Rott LS, Clark-Lewis I, Campbell DJ, Wu L, Butcher EC. Subspecialization of CXCR51 T cells: B helper activity is focused in a germinal center-localized subset of CXCR51 T cells. J Exp Med 2001; 193: 1373-1381.
    • (2001) J Exp Med , vol.193 , pp. 1373-1381
    • Kim, C.H.1    Rott, L.S.2    Clark-Lewis, I.3    Campbell, D.J.4    Wu, L.5    Butcher, E.C.6
  • 27
    • 33846400415 scopus 로고    scopus 로고
    • The germinal center response is impaired in the absence of T cell-expressed CXCR5
    • Arnold CN, Campbell DJ, LippM, Butcher EC. The germinal center response is impaired in the absence of T cell-expressed CXCR5. Eur J Immunol 2007; 37: 100-109.
    • (2007) Eur J Immunol , vol.37 , pp. 100-109
    • Arnold, C.N.1    Campbell, D.J.2    Lipp, M.3    Butcher, E.C.4
  • 28
    • 29144519767 scopus 로고    scopus 로고
    • IL-21 induces differentiation of human naive and memory B cells into antibody-secreting plasma cells
    • Ettinger R, Sims GP, Fairhurst AM, Robbins R, da Silva YS, Spolski R et al. IL-21 induces differentiation of human naive and memory B cells into antibody-secreting plasma cells. J Immunol 2005; 175: 7867-7879.
    • (2005) J Immunol , vol.175 , pp. 7867-7879
    • Ettinger, R.1    Sims, G.P.2    Fairhurst, A.M.3    Robbins, R.4    Da Silva, Y.S.5    Spolski, R.6
  • 29
    • 33749531054 scopus 로고    scopus 로고
    • Kinetics of human B cell behavior and amplification of proliferative responses following stimulation with IL-21
    • Good KL, Bryant VL, Tangye SG. Kinetics of human B cell behavior and amplification of proliferative responses following stimulation with IL-21. J Immunol 2006; 177: 5236-5247.
    • (2006) J Immunol , vol.177 , pp. 5236-5247
    • Good, K.L.1    Bryant, V.L.2    Tangye, S.G.3
  • 30
    • 41549131849 scopus 로고    scopus 로고
    • T follicular helper (TFH) cells in normal and dysregulated immune responses
    • King C, Tangye SG, Mackay CR. T follicular helper (TFH) cells in normal and dysregulated immune responses. Annu Rev Immunol 2008; 26: 741-766.
    • (2008) Annu Rev Immunol , vol.26 , pp. 741-766
    • King, C.1    Tangye, S.G.2    Mackay, C.R.3
  • 32
    • 58449124804 scopus 로고    scopus 로고
    • The costimulatory molecule ICOS regulates the expression of c-Maf and IL-21 in the development of follicular T helper cells and TH-17 cells
    • Bauquet AT, Jin H, Paterson AM, Mitsdoerffer M, Ho IC, Sharpe AH et al. The costimulatory molecule ICOS regulates the expression of c-Maf and IL-21 in the development of follicular T helper cells and TH-17 cells. Nat Immunol 2009; 10: 167-175.
    • (2009) Nat Immunol , vol.10 , pp. 167-175
    • Bauquet, A.T.1    Jin, H.2    Paterson, A.M.3    Mitsdoerffer, M.4    Ho, I.C.5    Sharpe, A.H.6
  • 33
    • 65549114338 scopus 로고    scopus 로고
    • IL-4-producing CD41 T cells in reactive lymph nodes during helminth infection are T follicular helper cells
    • King IL, Mohrs M. IL-4-producing CD41 T cells in reactive lymph nodes during helminth infection are T follicular helper cells. J Exp Med 2009; 206: 1001-1007.
    • (2009) J Exp Med , vol.206 , pp. 1001-1007
    • King, I.L.1    Mohrs, M.2
  • 34
    • 62849090439 scopus 로고    scopus 로고
    • Cytokine-secreting follicular T cells shape the antibody repertoire
    • Reinhardt RL, Liang HE, Locksley RM. Cytokine-secreting follicular T cells shape the antibody repertoire. Nat Immunol 2009; 10: 385-393.
    • (2009) Nat Immunol , vol.10 , pp. 385-393
    • Reinhardt, R.L.1    Liang, H.E.2    Locksley, R.M.3
  • 35
    • 65549134481 scopus 로고    scopus 로고
    • T follicular helper cells differentiate from Th2 cells in response to helminth antigens
    • Zaretsky AG, Taylor JJ, King IL, Marshall FA, Mohrs M, Pearce EJ. T follicular helper cells differentiate from Th2 cells in response to helminth antigens. J Exp Med 2009; 206: 991-999.
    • (2009) J Exp Med , vol.206 , pp. 991-999
    • Zaretsky, A.G.1    Taylor, J.J.2    King, I.L.3    Marshall, F.A.4    Mohrs, M.5    Pearce, E.J.6
  • 36
    • 2942755979 scopus 로고    scopus 로고
    • T follicular helper cells express a distinctive transcriptional profile, reflecting their role as non-Th1/Th2 effector cells that provide help for B cells
    • Chtanova T, Tangye SG, Newton R, Frank N, Hodge MR, Rolph MS et al. T follicular helper cells express a distinctive transcriptional profile, reflecting their role as non-Th1/Th2 effector cells that provide help for B cells. J Immunol 2004; 173: 68-78.
    • (2004) J Immunol , vol.173 , pp. 68-78
    • Chtanova, T.1    Tangye, S.G.2    Newton, R.3    Frank, N.4    Hodge, M.R.5    Rolph, M.S.6
  • 37
    • 4644325602 scopus 로고    scopus 로고
    • Unique gene expression program of human germinal center T helper cells
    • Kim CH, Lim HW, Kim JR, Rott L, Hillsamer P, Butcher EC. Unique gene expression program of human germinal center T helper cells. Blood 2004; 104: 1952-1960.
    • (2004) Blood , vol.104 , pp. 1952-1960
    • Kim, C.H.1    Lim, H.W.2    Kim, J.R.3    Rott, L.4    Hillsamer, P.5    Butcher, E.C.6
  • 38
    • 33746256850 scopus 로고    scopus 로고
    • Follicular B helper T cell activity is confined to CXCR5hiICOShi CD4 T cells and is independent of CD57 expression
    • Rasheed AU, Rahn HP, Sallusto F, Lipp M, Muller G. Follicular B helper T cell activity is confined to CXCR5hiICOShi CD4 T cells and is independent of CD57 expression. Eur J Immunol 2006; 36: 1892-1903.
    • (2006) Eur J Immunol , vol.36 , pp. 1892-1903
    • Rasheed, A.U.1    Rahn, H.P.2    Sallusto, F.3    Lipp, M.4    Muller, G.5
  • 39
    • 77955280012 scopus 로고    scopus 로고
    • Germinal center T follicular helper cell IL-4 production is dependent on signaling lymphocytic activation molecule receptor (CD150)
    • Yusuf I, Kageyama R, Monticelli L, Johnston RJ, Ditoro D, Hansen K et al. Germinal center T follicular helper cell IL-4 production is dependent on signaling lymphocytic activation molecule receptor (CD150). J Immunol 2010; 185: 190-202.
    • (2010) J Immunol , Issue.185 , pp. 190-202
    • Yusuf, I.1    Kageyama, R.2    Monticelli, L.3    Johnston, R.J.4    Ditoro, D.5    Hansen, K.6
  • 40
    • 62449202866 scopus 로고    scopus 로고
    • Preferential generation of follicular B helper T cells from Foxp31 T cells in gut Peyer's patches
    • Tsuji M, Komatsu N, Kawamoto S, Suzuki K, Kanagawa O, Honjo T et al. Preferential generation of follicular B helper T cells from Foxp31 T cells in gut Peyer's patches. Science 2009; 323: 1488-1492.
    • (2009) Science , vol.323 , pp. 1488-1492
    • Tsuji, M.1    Komatsu, N.2    Kawamoto, S.3    Suzuki, K.4    Kanagawa, O.5    Honjo, T.6
  • 41
    • 78751690647 scopus 로고    scopus 로고
    • Human blood CXCR51CD41 T cells are counterparts of T follicular cells and contain specific subsets that differentially support antibody secretion
    • Morita R, Schmitt N, Bentebibel SE, Ranganathan R, Bourdery L, Zurawski G et al. Human blood CXCR51CD41 T cells are counterparts of T follicular cells and contain specific subsets that differentially support antibody secretion. Immunity 2011; 34: 108-121.
    • (2011) Immunity , vol.34 , pp. 108-121
    • Morita, R.1    Schmitt, N.2    Bentebibel, S.E.3    Ranganathan, R.4    Bourdery, L.5    Zurawski, G.6
  • 42
    • 79954584830 scopus 로고    scopus 로고
    • A subset of interleukin-211 chemokine receptor CCR91 T helper cells target accessory organs of the digestive system in autoimmunity
    • McGuire HM, Vogelzang A, Ma CS, Hughes WE, Silveira PA, Tangye SG et al. A subset of interleukin-211 chemokine receptor CCR91 T helper cells target accessory organs of the digestive system in autoimmunity. Immunity 2011; 34: 602-615.
    • (2011) Immunity , Issue.34 , pp. 602-615
    • McGuire, H.M.1    Vogelzang, A.2    Ma, C.S.3    Hughes, W.E.4    Silveira, P.A.5    Tangye, S.G.6
  • 43
    • 77955924180 scopus 로고    scopus 로고
    • Follicular helper T cell differentiation requires continuous antigen presentation that is independent of unique B cell signaling
    • Deenick EK, Chan A, Ma CS, Gatto D, Schwartzberg PL, Brink R et al. Follicular helper T cell differentiation requires continuous antigen presentation that is independent of unique B cell signaling. Immunity 2010; 33: 241-253.
    • (2010) Immunity , Issue.33 , pp. 241-253
    • Deenick, E.K.1    Chan, A.2    Ma, C.S.3    Gatto, D.4    Schwartzberg, P.L.5    Brink, R.6
  • 44
    • 0032701695 scopus 로고    scopus 로고
    • In vivoactivated CD4 T cells upregulate CXC chemokine receptor 5 and reprogram their response to lymphoid chemokines
    • Ansel KM, McHeyzer-Williams LJ, Ngo VN, McHeyzer-Williams MG, Cyster JG. In vivoactivated CD4 T cells upregulate CXC chemokine receptor 5 and reprogram their response to lymphoid chemokines. J Exp Med 1999; 190: 1123-1134.
    • (1999) J Exp Med , vol.190 , pp. 1123-1134
    • Ansel, K.M.1    McHeyzer-Williams, L.J.2    Ngo, V.N.3    McHeyzer-Williams, M.G.4    Cyster, J.G.5
  • 45
    • 79959342619 scopus 로고    scopus 로고
    • Germinal center B cell and T follicular helper cell development initiates in the interfollicular zone
    • Kerfoot SM, Yaari G, Patel JR, Johnson KL, Gonzalez DG, KleinsteinSHet al. Germinal center B cell and T follicular helper cell development initiates in the interfollicular zone. Immunity 2011; 34: 947-960.
    • (2011) Immunity , Issue.34 , pp. 947-960
    • Kerfoot, S.M.1    Yaari, G.2    Patel, J.R.3    Johnson, K.L.4    Gonzalez, D.G.5    Kleinstein, S.H.6
  • 46
    • 76949091588 scopus 로고    scopus 로고
    • Optimal germinal center responses require a multistage T cell:B cell adhesion process involving integrins, SLAM-associated protein, and CD84
    • Cannons JL, Qi H, Lu KT, Dutta M, Gomez-Rodriguez J, Cheng J et al. Optimal germinal center responses require a multistage T cell:B cell adhesion process involving integrins, SLAM-associated protein, and CD84. Immunity 2010; 32: 253-265.
    • (2010) Immunity , vol.32 , pp. 253-265
    • Cannons, J.L.1    Qi, H.2    Lu, K.T.3    Dutta, M.4    Gomez-Rodriguez, J.5    Cheng, J.6
  • 47
    • 69249109601 scopus 로고    scopus 로고
    • Bcl6 and Blimp-1 are reciprocal and antagonistic regulators of T follicular helper cell differentiation
    • Johnston RJ, Poholek AC, DiToro D, Yusuf I, Eto D, Barnett B et al. Bcl6 and Blimp-1 are reciprocal and antagonistic regulators of T follicular helper cell differentiation. Science 2009; 325: 1006-1010.
    • (2009) Science , vol.325 , pp. 1006-1010
    • Johnston, R.J.1    Poholek, A.C.2    DiToro, D.3    Yusuf, I.4    Eto, D.5    Barnett, B.6
  • 48
    • 70049101558 scopus 로고    scopus 로고
    • The transcriptional repressor Bcl-6 directs T follicular helper cell lineage commitment
    • Yu D, Rao S, Tsai LM, Lee SK, He Y, Sutcliffe EL et al. The transcriptional repressor Bcl-6 directs T follicular helper cell lineage commitment. Immunity 2009; 31: 457-468.
    • (2009) Immunity , vol.31 , pp. 457-468
    • Yu, D.1    Rao, S.2    Tsai, L.M.3    Lee, S.K.4    He, Y.5    Sutcliffe, E.L.6
  • 49
    • 0345505646 scopus 로고    scopus 로고
    • Inhibition of Th2 differentiation and GATA-3 expression by BCL-6
    • Kusam S, Toney LM, Sato H, Dent AL. Inhibition of Th2 differentiation and GATA-3 expression by BCL-6. J Immunol 2003; 170: 2435-2441.
    • (2003) J Immunol , vol.170 , pp. 2435-2441
    • Kusam, S.1    Toney, L.M.2    Sato, H.3    Dent, A.L.4
  • 50
    • 37549015263 scopus 로고    scopus 로고
    • Germinal centres: Role in B-cell physiology and malignancy
    • Klein U, Dalla-Favera R. Germinal centres: Role in B-cell physiology and malignancy. Nat Rev Immunol 2008; 8: 22-33.
    • (2008) Nat Rev Immunol , vol.8 , pp. 22-33
    • Klein, U.1    Dalla-Favera, R.2
  • 51
    • 79952675131 scopus 로고    scopus 로고
    • Follicular helper CD4 T cells (TFH)
    • Crotty S. Follicular helper CD4 T cells (TFH). Annu Rev Immunol 2011; 29: 621-663.
    • (2011) Annu Rev Immunol , vol.29 , pp. 621-663
    • Crotty, S.1
  • 52
    • 79956198905 scopus 로고    scopus 로고
    • Blockade of b7-h1 (programmed death ligand 1) enhances humoral immunity by positively regulating the generation of T follicular helper cells
    • Hams E, McCarron MJ, Amu S, Yagita H, Azuma M, Chen L et al. Blockade of b7-h1 (programmed death ligand 1) enhances humoral immunity by positively regulating the generation of T follicular helper cells. J Immunol 2011; 186: 5648-5655.
    • (2011) J Immunol , vol.186 , pp. 5648-5655
    • Hams, E.1    McCarron, M.J.2    Amu, S.3    Yagita, H.4    Azuma, M.5    Chen, L.6
  • 53
    • 77956895738 scopus 로고    scopus 로고
    • Inhibition of follicular T-helper cells by CD81 regulatory T cells is essential for self tolerance
    • Kim HJ, Verbinnen B, Tang X, Lu L, Cantor H. Inhibition of follicular T-helper cells by CD81 regulatory T cells is essential for self tolerance. Nature 2010; 467: 328-332.
    • (2010) Nature , vol.467 , pp. 328-332
    • Kim, H.J.1    Verbinnen, B.2    Tang, X.3    Lu, L.4    Cantor, H.5
  • 54
    • 79952148676 scopus 로고    scopus 로고
    • CD81 T regulatory cells express the Ly49 Class I MHC receptor and are defective in autoimmune prone B6-Yaa mice
    • 2010-2015
    • Kim HJ, Wang X, Radfar S, Sproule TJ, Roopenian DC, Cantor H. CD81 T regulatory cells express the Ly49 Class I MHC receptor and are defective in autoimmune prone B6-Yaa mice. Proc Natl Acad Sci USA 2011; 108: 2010-2015.
    • (2011) Proc Natl Acad Sci USA , vol.108
    • Kim, H.J.1    Wang, X.2    Radfar, S.3    Sproule, T.J.4    Roopenian, D.C.5    Cantor, H.6
  • 55
    • 21144438325 scopus 로고    scopus 로고
    • A RINGtype ubiquitin ligase family member required to repress follicular helper T cells and autoimmunity
    • Vinuesa CG, Cook MC, Angelucci C, Athanasopoulos V, Rui L, Hill KM et al. A RINGtype ubiquitin ligase family member required to repress follicular helper T cells and autoimmunity. Nature 2005; 435: 452-458.
    • (2005) Nature , vol.435 , pp. 452-458
    • Vinuesa, C.G.1    Cook, M.C.2    Angelucci, C.3    Athanasopoulos, V.4    Rui, L.5    Hill, K.M.6
  • 56
    • 72949104221 scopus 로고    scopus 로고
    • Dysregulation of germinal centres in autoimmune disease
    • Vinuesa CG, Sanz I, Cook MC. Dysregulation of germinal centres in autoimmune disease. Nat Rev Immunol 2009; 9: 845-857.
    • (2009) Nat Rev Immunol , vol.9 , pp. 845-857
    • Vinuesa, C.G.1    Sanz, I.2    Cook, M.C.3
  • 57
    • 13544259968 scopus 로고    scopus 로고
    • B cell selection and susceptibility to autoimmunity
    • Grimaldi CM, Hicks R, Diamond B. B cell selection and susceptibility to autoimmunity. J Immunol 2005; 174: 1775-1781.
    • (2005) J Immunol , vol.174 , pp. 1775-1781
    • Grimaldi, C.M.1    Hicks, R.2    Diamond, B.3
  • 58
    • 79953160964 scopus 로고    scopus 로고
    • Follicular helper T cells in systemic lupus erythematosus: A potential therapeutic target
    • Dong W, Zhu P, Wang Y, Wang Z. Follicular helper T cells in systemic lupus erythematosus: A potential therapeutic target. Autoimmun Rev 2011; 10: 299-304.
    • (2011) Autoimmun Rev , Issue.10 , pp. 299-304
    • Dong, W.1    Zhu, P.2    Wang, Y.3    Wang, Z.4
  • 59
    • 63149093151 scopus 로고    scopus 로고
    • B7RP-1 blockade ameliorates autoimmunity through regulation of follicular helper T cells
    • Hu YL, Metz DP, Chung J, Siu G, Zhang M. B7RP-1 blockade ameliorates autoimmunity through regulation of follicular helper T cells. J Immunol 2009; 182: 1421-1428.
    • (2009) J Immunol , vol.182 , pp. 1421-1428
    • Hu, Y.L.1    Metz, D.P.2    Chung, J.3    Siu, G.4    Zhang, M.5
  • 60
    • 33947215987 scopus 로고    scopus 로고
    • IL-21 has a pathogenic role in a lupus-prone mouse model and its blockade with IL-21R.Fc reduces disease progression
    • Herber D, Brown TP, Liang S, Young DA, Collins M, Dunussi-Joannopoulos K. IL-21 has a pathogenic role in a lupus-prone mouse model and its blockade with IL-21R.Fc reduces disease progression. J Immunol 2007; 178: 3822-3830.
    • (2007) J Immunol , vol.178 , pp. 3822-3830
    • Herber, D.1    Brown, T.P.2    Liang, S.3    Young, D.A.4    Collins, M.5    Dunussi-Joannopoulos, K.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.