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Volumn 10, Issue 6, 2011, Pages 299-304

Follicular helper T cells in systemic lupus erythematosus: A potential therapeutic target

Author keywords

Autoantibody; Follicular helper T cell; Germinal center; Plasma cell; Systemic lupus erythematosus; Tolerance

Indexed keywords

ALPHA INTERFERON; AUTOANTIBODY; B CELL ACTIVATING FACTOR; CD4 ANTIGEN; GAMMA INTERFERON; INTERLEUKIN 12; INTERLEUKIN 17; INTERLEUKIN 21; INTERLEUKIN 6; PROGRAMMED DEATH 1 RECEPTOR;

EID: 79953160964     PISSN: 15689972     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.autrev.2010.11.004     Document Type: Review
Times cited : (42)

References (73)
  • 1
    • 40049093765 scopus 로고    scopus 로고
    • Systemic lupus erythematosus
    • Rahman A., Isenberg D.A. Systemic lupus erythematosus. N Engl J Med 2008, 358:929-939.
    • (2008) N Engl J Med , vol.358 , pp. 929-939
    • Rahman, A.1    Isenberg, D.A.2
  • 3
    • 0345824714 scopus 로고    scopus 로고
    • Abnormal germinal center reactions in systemic lupus erythematosus demonstrated by blockade of CD154-CD40 interactions
    • Grammer A.C., Slota R., Fischer R., Gur H., Girschick H., Yarboro C., et al. Abnormal germinal center reactions in systemic lupus erythematosus demonstrated by blockade of CD154-CD40 interactions. J Clin Invest 2003, 112:1506-1520.
    • (2003) J Clin Invest , vol.112 , pp. 1506-1520
    • Grammer, A.C.1    Slota, R.2    Fischer, R.3    Gur, H.4    Girschick, H.5    Yarboro, C.6
  • 4
    • 27644452293 scopus 로고    scopus 로고
    • Germinal center exclusion of autoreactive B cells is defective in human systemic lupus erythematosus
    • Cappione A., Anolik J.H., Pugh-Bernard A., Barnard J., Dutcher P., Silverman G., et al. Germinal center exclusion of autoreactive B cells is defective in human systemic lupus erythematosus. J Clin Invest 2005, 115:3205-3216.
    • (2005) J Clin Invest , vol.115 , pp. 3205-3216
    • Cappione, A.1    Anolik, J.H.2    Pugh-Bernard, A.3    Barnard, J.4    Dutcher, P.5    Silverman, G.6
  • 5
    • 72949104221 scopus 로고    scopus 로고
    • Dysregulation of germinal centres in autoimmune disease
    • Vinuesa C.G., Sanz I., Cook M.C. Dysregulation of germinal centres in autoimmune disease. Nat Rev Immunol 2009, 9:845-857.
    • (2009) Nat Rev Immunol , vol.9 , pp. 845-857
    • Vinuesa, C.G.1    Sanz, I.2    Cook, M.C.3
  • 6
    • 55649091999 scopus 로고    scopus 로고
    • Novel treatment strategies for antibody-mediated diseases: targeting long-lived plasma cells
    • Voll R.E., Neubert K., Meister S., Gückel E., Kalden J.R. Novel treatment strategies for antibody-mediated diseases: targeting long-lived plasma cells. Future Rheumatol 2008, 3:311-315.
    • (2008) Future Rheumatol , vol.3 , pp. 311-315
    • Voll, R.E.1    Neubert, K.2    Meister, S.3    Gückel, E.4    Kalden, J.R.5
  • 7
    • 2942635727 scopus 로고    scopus 로고
    • Short-lived plasmablasts and long-lived plasma cells contribute to chronic humoral autoimmunity in NZB/W Mice
    • Hoyer B.F., Moser K., Hauser A.E., Peddinghaus A., Voigt C., Eilat D., et al. Short-lived plasmablasts and long-lived plasma cells contribute to chronic humoral autoimmunity in NZB/W Mice. J Exp Med 2004, 199:1577-1584.
    • (2004) J Exp Med , vol.199 , pp. 1577-1584
    • Hoyer, B.F.1    Moser, K.2    Hauser, A.E.3    Peddinghaus, A.4    Voigt, C.5    Eilat, D.6
  • 8
    • 13444291211 scopus 로고    scopus 로고
    • Pathogenic autoantibodies in lupus nephritis
    • Waldman M., Madaio M.P. Pathogenic autoantibodies in lupus nephritis. Lupus 2005, 14:19-24.
    • (2005) Lupus , vol.14 , pp. 19-24
    • Waldman, M.1    Madaio, M.P.2
  • 9
    • 78149360607 scopus 로고    scopus 로고
    • Autoimmunity and chronic inflammation - Two clearance-related steps in the etiopathogenesis of SLE
    • Muñoz L.E., Janko C., Schulze C., Schorn C., Sarter K., Schett G., et al. Autoimmunity and chronic inflammation - Two clearance-related steps in the etiopathogenesis of SLE. Autoimmun Rev 2010, 10:38-42.
    • (2010) Autoimmun Rev , vol.10 , pp. 38-42
    • Muñoz, L.E.1    Janko, C.2    Schulze, C.3    Schorn, C.4    Sarter, K.5    Schett, G.6
  • 10
    • 75149167803 scopus 로고    scopus 로고
    • Lupus nephritis: lessons from murine models
    • Davidson A., Aranow C. Lupus nephritis: lessons from murine models. Nat Rev Rheumatol 2010, 6:13-20.
    • (2010) Nat Rev Rheumatol , vol.6 , pp. 13-20
    • Davidson, A.1    Aranow, C.2
  • 11
    • 77953212872 scopus 로고    scopus 로고
    • Basophils and the T helper 2 environment can promote the development of lupus nephritis
    • Charles N., Hardwick D., Daugas E., Illei G.G., Rivera J. Basophils and the T helper 2 environment can promote the development of lupus nephritis. Nat Med 2010, 16:701-707.
    • (2010) Nat Med , vol.16 , pp. 701-707
    • Charles, N.1    Hardwick, D.2    Daugas, E.3    Illei, G.G.4    Rivera, J.5
  • 12
    • 0034606359 scopus 로고    scopus 로고
    • Follicular B helper T cells express CXC chemokine receptor 5, localize to B cell follicles, and support immunoglobulin production
    • Breitfeld D., Ohl L., Kremmer E., Ellwart J., Sallusto F., Lipp M., et al. Follicular B helper T cells express CXC chemokine receptor 5, localize to B cell follicles, and support immunoglobulin production. J Exp Med 2000, 192:1545-1551.
    • (2000) J Exp Med , vol.192 , pp. 1545-1551
    • Breitfeld, D.1    Ohl, L.2    Kremmer, E.3    Ellwart, J.4    Sallusto, F.5    Lipp, M.6
  • 13
    • 0034606348 scopus 로고    scopus 로고
    • CXC chemokine receptor 5 expression defines follicular homing T cells with B cell helper function
    • Schaerli P., Willimann K., Lang A.B., Lipp M., Loetscher P., Moser B. CXC chemokine receptor 5 expression defines follicular homing T cells with B cell helper function. J Exp Med 2000, 192:1553-1562.
    • (2000) J Exp Med , vol.192 , pp. 1553-1562
    • Schaerli, P.1    Willimann, K.2    Lang, A.B.3    Lipp, M.4    Loetscher, P.5    Moser, B.6
  • 18
    • 77149122105 scopus 로고    scopus 로고
    • IL-21 acts directly on B cells to regulate Bcl-6 expression and germinal center responses
    • Linterman M.A., Beaton L., Yu D., Ramiscal R.R., Srivastava M., Hogan J.J., et al. IL-21 acts directly on B cells to regulate Bcl-6 expression and germinal center responses. J Exp Med 2010, 207:353-363.
    • (2010) J Exp Med , vol.207 , pp. 353-363
    • Linterman, M.A.1    Beaton, L.2    Yu, D.3    Ramiscal, R.R.4    Srivastava, M.5    Hogan, J.J.6
  • 19
    • 77149142640 scopus 로고    scopus 로고
    • IL-21 regulates germinal center B cell differentiation and proliferation through a B cell-intrinsic mechanism
    • Zotos D., Coquet J.M., Zhang Y., Light A., D'Costa K., Kallies A., et al. IL-21 regulates germinal center B cell differentiation and proliferation through a B cell-intrinsic mechanism. J Exp Med 2010, 207:365-378.
    • (2010) J Exp Med , vol.207 , pp. 365-378
    • Zotos, D.1    Coquet, J.M.2    Zhang, Y.3    Light, A.4    D'Costa, K.5    Kallies, A.6
  • 20
    • 21144438325 scopus 로고    scopus 로고
    • A RING-type ubiquitin ligase family member required to repress follicular helper T cells and autoimmunity
    • Vinuesa C.G., Cook M.C., Angelucci C., Athanasopoulos V., Rui L., Hill K.M., et al. A RING-type ubiquitin ligase family member required to repress follicular helper T cells and autoimmunity. Nature 2005, 435:452-458.
    • (2005) Nature , vol.435 , pp. 452-458
    • Vinuesa, C.G.1    Cook, M.C.2    Angelucci, C.3    Athanasopoulos, V.4    Rui, L.5    Hill, K.M.6
  • 22
    • 74849138095 scopus 로고    scopus 로고
    • Expansion of circulating T cells resembling follicular helper T cells is a fixed phenotype that identifies a subset of severe systemic lupus erythematosus
    • Simpson N., Gatenby P.A., Wilson A., Malik S., Fulcher D.A., Tangye S.G., et al. Expansion of circulating T cells resembling follicular helper T cells is a fixed phenotype that identifies a subset of severe systemic lupus erythematosus. Arthritis Rheum 2010, 62:234-244.
    • (2010) Arthritis Rheum , vol.62 , pp. 234-244
    • Simpson, N.1    Gatenby, P.A.2    Wilson, A.3    Malik, S.4    Fulcher, D.A.5    Tangye, S.G.6
  • 23
    • 13544259968 scopus 로고    scopus 로고
    • B cell selection and susceptibility to autoimmunity
    • Grimaldi C.M., Hicks R., Diamond B. B cell selection and susceptibility to autoimmunity. J Immunol 2005, 174:1775-1781.
    • (2005) J Immunol , vol.174 , pp. 1775-1781
    • Grimaldi, C.M.1    Hicks, R.2    Diamond, B.3
  • 24
    • 77958138084 scopus 로고    scopus 로고
    • T follicular helper cells during immunity and tolerance
    • Linterman M.A., Vinuesa C.G. T follicular helper cells during immunity and tolerance. Prog Mol Biol Trans Sci 2010, 92:207-248.
    • (2010) Prog Mol Biol Trans Sci , vol.92 , pp. 207-248
    • Linterman, M.A.1    Vinuesa, C.G.2
  • 26
    • 77955898582 scopus 로고    scopus 로고
    • T cells and follicular dendritic cells in germinal center B-cell formation and selection
    • Vinuesa C.G., Linterman M.A., Goodnow C.C., Randall K.L. T cells and follicular dendritic cells in germinal center B-cell formation and selection. Immunol Rev 2010, 237:72-89.
    • (2010) Immunol Rev , vol.237 , pp. 72-89
    • Vinuesa, C.G.1    Linterman, M.A.2    Goodnow, C.C.3    Randall, K.L.4
  • 27
    • 0037144519 scopus 로고    scopus 로고
    • Evolution of autoantibody responses via somatic hypermutation outside of germinal centers
    • William J., Euler C., Christensen S., Shlomchik M.J. Evolution of autoantibody responses via somatic hypermutation outside of germinal centers. Science 2002, 297:2066-2077.
    • (2002) Science , vol.297 , pp. 2066-2077
    • William, J.1    Euler, C.2    Christensen, S.3    Shlomchik, M.J.4
  • 28
    • 58149279490 scopus 로고    scopus 로고
    • ICOS-dependent extrafollicular helper T cells elicit IgG production via IL-21 in systemic autoimmunity
    • Odegard J.M., Marks B.R., DiPlacido L.D., Poholek A.C., Kono D.H., Dong C., et al. ICOS-dependent extrafollicular helper T cells elicit IgG production via IL-21 in systemic autoimmunity. J Exp Med 2008, 205:2873-2886.
    • (2008) J Exp Med , vol.205 , pp. 2873-2886
    • Odegard, J.M.1    Marks, B.R.2    DiPlacido, L.D.3    Poholek, A.C.4    Kono, D.H.5    Dong, C.6
  • 29
    • 77957256910 scopus 로고    scopus 로고
    • The elusive identity of T follicular helper cells
    • Yu D., Vinuesa C.G. The elusive identity of T follicular helper cells. Trends Immunol 2010, 31:377-383.
    • (2010) Trends Immunol , vol.31 , pp. 377-383
    • Yu, D.1    Vinuesa, C.G.2
  • 30
    • 46749151286 scopus 로고    scopus 로고
    • Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineages
    • Nurieva R.I., Chung Y., Hwang D., Yang X.O., Kang H.S., Ma L., et al. Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineages. Immunity 2008, 29:138-149.
    • (2008) Immunity , vol.29 , pp. 138-149
    • Nurieva, R.I.1    Chung, Y.2    Hwang, D.3    Yang, X.O.4    Kang, H.S.5    Ma, L.6
  • 32
    • 70049101558 scopus 로고    scopus 로고
    • The transcriptional repressor Bcl-6 directs T follicular helper cell lineage commitment
    • Yu D., Rao S., Tsai L.M., Lee S.K., He Y., Sutcliffe E.L., et al. The transcriptional repressor Bcl-6 directs T follicular helper cell lineage commitment. Immunity 2009, 31:457-468.
    • (2009) Immunity , vol.31 , pp. 457-468
    • Yu, D.1    Rao, S.2    Tsai, L.M.3    Lee, S.K.4    He, Y.5    Sutcliffe, E.L.6
  • 33
    • 65549134481 scopus 로고    scopus 로고
    • T follicular helper cells differentiate from Th2 cells in response to helminth antigens
    • Zaretsky A.G., Taylor J.J., King I.L., Marshall F.A., Mohrs M., Pearce E.J. T follicular helper cells differentiate from Th2 cells in response to helminth antigens. J Exp Med 2009, 206:991-999.
    • (2009) J Exp Med , vol.206 , pp. 991-999
    • Zaretsky, A.G.1    Taylor, J.J.2    King, I.L.3    Marshall, F.A.4    Mohrs, M.5    Pearce, E.J.6
  • 34
    • 62449202866 scopus 로고    scopus 로고
    • Preferential generation of follicular B helper T cells from Foxp3+ T cells in gut Peyer's patches
    • Tsuji M., Komatsu N., Kawamoto S., Suzuki K., Kanagawa O., Honjo T., et al. Preferential generation of follicular B helper T cells from Foxp3+ T cells in gut Peyer's patches. Science 2009, 323:1488-1492.
    • (2009) Science , vol.323 , pp. 1488-1492
    • Tsuji, M.1    Komatsu, N.2    Kawamoto, S.3    Suzuki, K.4    Kanagawa, O.5    Honjo, T.6
  • 35
    • 46749115446 scopus 로고    scopus 로고
    • A fundamental role for interleukin-21 in the generation of T follicular helper cells
    • Vogelzang A., McGuire H.M., Yu D., Sprent J., Mackay C.R., King C. A fundamental role for interleukin-21 in the generation of T follicular helper cells. Immunity 2008, 29:127-137.
    • (2008) Immunity , vol.29 , pp. 127-137
    • Vogelzang, A.1    McGuire, H.M.2    Yu, D.3    Sprent, J.4    Mackay, C.R.5    King, C.6
  • 36
    • 34548390650 scopus 로고    scopus 로고
    • IL-21 promotes T lymphocyte survival by activating the phosphatidylinositol-3 kinase signaling cascade
    • Ostiguy V., Allard E.L., Marquis M., Leignadier J., Labrecque N. IL-21 promotes T lymphocyte survival by activating the phosphatidylinositol-3 kinase signaling cascade. J Leukoc Biol 2007, 82:645-656.
    • (2007) J Leukoc Biol , vol.82 , pp. 645-656
    • Ostiguy, V.1    Allard, E.L.2    Marquis, M.3    Leignadier, J.4    Labrecque, N.5
  • 37
    • 20444485767 scopus 로고    scopus 로고
    • Cellular and genetic mechanisms of self tolerance and autoimmunity
    • Goodnow C.C., Sprent J., Fazekas de St Groth B, Vinuesa C.G. Cellular and genetic mechanisms of self tolerance and autoimmunity. Nature 2005, 435:590-597.
    • (2005) Nature , vol.435 , pp. 590-597
    • Goodnow, C.C.1    Sprent, J.2    Fazekas de St Groth, B.3    Vinuesa, C.G.4
  • 38
    • 70749147691 scopus 로고    scopus 로고
    • Insights into the genetic basis and immunopathogenesis of systemic lupus erythematosus from the study of mouse models
    • Cheung Y.H., Loh C., Pau E., Kim J., Wither J. Insights into the genetic basis and immunopathogenesis of systemic lupus erythematosus from the study of mouse models. Semin Immunol 2009, 21:372-382.
    • (2009) Semin Immunol , vol.21 , pp. 372-382
    • Cheung, Y.H.1    Loh, C.2    Pau, E.3    Kim, J.4    Wither, J.5
  • 39
    • 0032546352 scopus 로고    scopus 로고
    • Dendritic cells and the control of immunity
    • Banchereau J., Steinman R.M. Dendritic cells and the control of immunity. Nature 1998, 392:245-252.
    • (1998) Nature , vol.392 , pp. 245-252
    • Banchereau, J.1    Steinman, R.M.2
  • 40
    • 68249158536 scopus 로고    scopus 로고
    • Human dendritic cells induce the differentiation of interleukin-21-producing T follicular helper-like cells through interleukin-12
    • Schmitt N., Morita R., Bourdery L., Bentebibel S.E., Zurawski S.M., Banchereau J., et al. Human dendritic cells induce the differentiation of interleukin-21-producing T follicular helper-like cells through interleukin-12. Immunity 2009, 31:158-169.
    • (2009) Immunity , vol.31 , pp. 158-169
    • Schmitt, N.1    Morita, R.2    Bourdery, L.3    Bentebibel, S.E.4    Zurawski, S.M.5    Banchereau, J.6
  • 41
    • 70249131137 scopus 로고    scopus 로고
    • Type I interferon signaling in dendritic cells stimulates the development of lymph-node-resident T follicular helper cells
    • Cucak H., Yrlid U., Reizis B., Kalinke U., Johansson-Lindbom B. Type I interferon signaling in dendritic cells stimulates the development of lymph-node-resident T follicular helper cells. Immunity 2009, 31:491-501.
    • (2009) Immunity , vol.31 , pp. 491-501
    • Cucak, H.1    Yrlid, U.2    Reizis, B.3    Kalinke, U.4    Johansson-Lindbom, B.5
  • 42
    • 33750348046 scopus 로고    scopus 로고
    • Aberrant phenotype and function of myeloid dendritic cells in systemic lupus erythematosus
    • Ding D., Mehta H., McCune W.J., Kaplan M.J. Aberrant phenotype and function of myeloid dendritic cells in systemic lupus erythematosus. J Immunol 2006, 177:5878-5889.
    • (2006) J Immunol , vol.177 , pp. 5878-5889
    • Ding, D.1    Mehta, H.2    McCune, W.J.3    Kaplan, M.J.4
  • 43
    • 77955004621 scopus 로고    scopus 로고
    • Blood dendritic cells in systemic lupus erythematosus exhibit altered activation state and chemokine receptor function
    • Gerl V., Lischka A., Panne D., Grossmann P., Berthold R., Hoyer B.F., et al. Blood dendritic cells in systemic lupus erythematosus exhibit altered activation state and chemokine receptor function. Ann Rheum Dis 2010, 69:1370-1377.
    • (2010) Ann Rheum Dis , vol.69 , pp. 1370-1377
    • Gerl, V.1    Lischka, A.2    Panne, D.3    Grossmann, P.4    Berthold, R.5    Hoyer, B.F.6
  • 44
    • 58149466086 scopus 로고    scopus 로고
    • Toll-like receptors in systemic lupus erythematosus; prospects for therapeutic intervention
    • Kim W.U., Sreih A., Bucala R. Toll-like receptors in systemic lupus erythematosus; prospects for therapeutic intervention. Autoimmun Rev 2009, 8:204-208.
    • (2009) Autoimmun Rev , vol.8 , pp. 204-208
    • Kim, W.U.1    Sreih, A.2    Bucala, R.3
  • 45
    • 77954339436 scopus 로고    scopus 로고
    • Abnormalities in circulating plasmacytoid dendritic cells in patients with systemic lupus erythematosus
    • Jin O., Kavikondala S., Mok M.Y., Sun L., Gu J., Fu R., et al. Abnormalities in circulating plasmacytoid dendritic cells in patients with systemic lupus erythematosus. Arthritis Res Ther 2010, 12:R137.
    • (2010) Arthritis Res Ther , vol.12
    • Jin, O.1    Kavikondala, S.2    Mok, M.Y.3    Sun, L.4    Gu, J.5    Fu, R.6
  • 47
    • 77954622264 scopus 로고    scopus 로고
    • Trafficking properties of plasmacytoid dendritic cells in health and disease
    • Sozzani S., Vermi W., Del Prete A., Facchett F. Trafficking properties of plasmacytoid dendritic cells in health and disease. Trends Immunol 2010, 31:270-277.
    • (2010) Trends Immunol , vol.31 , pp. 270-277
    • Sozzani, S.1    Vermi, W.2    Del Prete, A.3    Facchett, F.4
  • 48
    • 77955343903 scopus 로고    scopus 로고
    • Myeloid cells, BAFF, and IFN-gamma establish an inflammatory loop that exacerbates autoimmunity in Lyn-deficient mice
    • Scapini P., Hu Y., Chu C.L., Migone T.S., Defranco A.L., Cassatella M.A., et al. Myeloid cells, BAFF, and IFN-gamma establish an inflammatory loop that exacerbates autoimmunity in Lyn-deficient mice. J Exp Med 2010, 207:1757-1773.
    • (2010) J Exp Med , vol.207 , pp. 1757-1773
    • Scapini, P.1    Hu, Y.2    Chu, C.L.3    Migone, T.S.4    Defranco, A.L.5    Cassatella, M.A.6
  • 49
    • 1542269691 scopus 로고    scopus 로고
    • BAFF production by antigen-presenting cells provides T cell co-stimulation
    • Huard B., Arlettaz L., Ambrose C., Kindler V., Mauri D., Roosnek E., et al. BAFF production by antigen-presenting cells provides T cell co-stimulation. Int Immunol 2004, 16:467-475.
    • (2004) Int Immunol , vol.16 , pp. 467-475
    • Huard, B.1    Arlettaz, L.2    Ambrose, C.3    Kindler, V.4    Mauri, D.5    Roosnek, E.6
  • 50
    • 3142671331 scopus 로고    scopus 로고
    • B cell-activating factor belonging to the TNF family (BAFF)-R is the principal BAFF receptor facilitating BAFF costimulation of circulating T and B cells
    • Ng L.G., Sutherland A.P., Newton R., Qian F., Cachero T.G., Scott M.L., et al. B cell-activating factor belonging to the TNF family (BAFF)-R is the principal BAFF receptor facilitating BAFF costimulation of circulating T and B cells. J Immunol 2004, 173:807-817.
    • (2004) J Immunol , vol.173 , pp. 807-817
    • Ng, L.G.1    Sutherland, A.P.2    Newton, R.3    Qian, F.4    Cachero, T.G.5    Scott, M.L.6
  • 51
    • 0025990288 scopus 로고
    • Elevated levels of endogenous IL-6 in systemic lupus erythematosus. A putative role in pathogenesis
    • Linker-Israeli M., Deans R.J., Wallace D.J., Prehn J., Ozeri-Chen T., Klinenberg J.R. Elevated levels of endogenous IL-6 in systemic lupus erythematosus. A putative role in pathogenesis. J Immunol 1991, 147:117-123.
    • (1991) J Immunol , vol.147 , pp. 117-123
    • Linker-Israeli, M.1    Deans, R.J.2    Wallace, D.J.3    Prehn, J.4    Ozeri-Chen, T.5    Klinenberg, J.R.6
  • 52
    • 78649447854 scopus 로고    scopus 로고
    • Regulatory T cells: The suppressor arm of the immune system
    • Langier S., Sade K., Kivity S. Regulatory T cells: The suppressor arm of the immune system. Autoimmun Rev 2010, 10.1016/j.autrev.2010.08.013.
    • (2010) Autoimmun Rev
    • Langier, S.1    Sade, K.2    Kivity, S.3
  • 53
    • 78149361779 scopus 로고    scopus 로고
    • Tolerogenic dendritic cells in autoimmune diseases: crucial players in induction and prevention of autoimmunity
    • Torres-Aguilar H., Blank M., Jara L.J., Shoenfeld Y. Tolerogenic dendritic cells in autoimmune diseases: crucial players in induction and prevention of autoimmunity. Autoimmun Rev 2010, 10:8-17.
    • (2010) Autoimmun Rev , vol.10 , pp. 8-17
    • Torres-Aguilar, H.1    Blank, M.2    Jara, L.J.3    Shoenfeld, Y.4
  • 54
    • 73949090666 scopus 로고    scopus 로고
    • Inducible costimulator promotes helper T-cell differentiation through phosphoinositide 3-kinase
    • Gigoux M., Shang J., Pak Y., Xu M., Choe J., Mak T.W., et al. Inducible costimulator promotes helper T-cell differentiation through phosphoinositide 3-kinase. Proc Natl Acad Sci USA 2009, 106:20371-20376.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 20371-20376
    • Gigoux, M.1    Shang, J.2    Pak, Y.3    Xu, M.4    Choe, J.5    Mak, T.W.6
  • 55
    • 77958134778 scopus 로고    scopus 로고
    • Phosphoinositide 3-kinase activity in T cells regulates the magnitude of the germinal center reaction
    • Rolf J., Bell S.E., Kovesdi D., Janas M.L., Soond D.R., Webb L.M., et al. Phosphoinositide 3-kinase activity in T cells regulates the magnitude of the germinal center reaction. J Immunol 2010, 185:4042-4052.
    • (2010) J Immunol , vol.185 , pp. 4042-4052
    • Rolf, J.1    Bell, S.E.2    Kovesdi, D.3    Janas, M.L.4    Soond, D.R.5    Webb, L.M.6
  • 56
    • 0037455003 scopus 로고    scopus 로고
    • Expression of ICOS in vivo defines CD4 effector T cells with high inflammatory potential and a strong bias for secretion of interleukin 10
    • Löhning M., Hutloff A., Kallinich T., Mages H.W., Bonhagen K., Radbruch A., et al. Expression of ICOS in vivo defines CD4 effector T cells with high inflammatory potential and a strong bias for secretion of interleukin 10. J Exp Med 2003, 197:181-193.
    • (2003) J Exp Med , vol.197 , pp. 181-193
    • Löhning, M.1    Hutloff, A.2    Kallinich, T.3    Mages, H.W.4    Bonhagen, K.5    Radbruch, A.6
  • 57
    • 73149085517 scopus 로고    scopus 로고
    • IL-21 and IL-10 have redundant roles but differential capacities at different stages of plasma cell generation from human germinal center B cells
    • Yoon S.O., Zhang X., Berner P., Choi Y.S. IL-21 and IL-10 have redundant roles but differential capacities at different stages of plasma cell generation from human germinal center B cells. J Leukoc Biol 2009, 86:1311-1318.
    • (2009) J Leukoc Biol , vol.86 , pp. 1311-1318
    • Yoon, S.O.1    Zhang, X.2    Berner, P.3    Choi, Y.S.4
  • 60
    • 63149093151 scopus 로고    scopus 로고
    • B7RP-1 blockade ameliorates autoimmunity through regulation of follicular helper T cells
    • Hu Y.L., Metz D.P., Chung J., Siu G., Zhang M. B7RP-1 blockade ameliorates autoimmunity through regulation of follicular helper T cells. J Immunol 2009, 182:1421-1428.
    • (2009) J Immunol , vol.182 , pp. 1421-1428
    • Hu, Y.L.1    Metz, D.P.2    Chung, J.3    Siu, G.4    Zhang, M.5
  • 63
    • 38349178776 scopus 로고    scopus 로고
    • Interleukin 17-producing T helper cells and interleukin 17 orchestrate autoreactive germinal center development in autoimmune BXD2 mice
    • Hsu H.C., Yang P., Wang J., Wu Q., Myers R., Chen J., et al. Interleukin 17-producing T helper cells and interleukin 17 orchestrate autoreactive germinal center development in autoimmune BXD2 mice. Nat Immunol 2008, 9:166-175.
    • (2008) Nat Immunol , vol.9 , pp. 166-175
    • Hsu, H.C.1    Yang, P.2    Wang, J.3    Wu, Q.4    Myers, R.5    Chen, J.6
  • 64
    • 45249097325 scopus 로고    scopus 로고
    • Hyperproduction of IL-23 and IL-17 in patients with systemic lupus erythematosus: implications for Th17-mediated inflammation in auto-immunity
    • Wong C.K., Lit L.C., Tam L.S., Li E.K., Wong P.T., Lam C.W. Hyperproduction of IL-23 and IL-17 in patients with systemic lupus erythematosus: implications for Th17-mediated inflammation in auto-immunity. Clin Immunol 2008, 127:385-393.
    • (2008) Clin Immunol , vol.127 , pp. 385-393
    • Wong, C.K.1    Lit, L.C.2    Tam, L.S.3    Li, E.K.4    Wong, P.T.5    Lam, C.W.6
  • 65
    • 70349238893 scopus 로고    scopus 로고
    • The role of IL-23/IL-17 axis in lupus nephritis
    • Zhang Z., Kyttaris V.C., Tsokos G.C. The role of IL-23/IL-17 axis in lupus nephritis. J Immunol 2009, 183:3160-3169.
    • (2009) J Immunol , vol.183 , pp. 3160-3169
    • Zhang, Z.1    Kyttaris, V.C.2    Tsokos, G.C.3
  • 66
    • 64249119894 scopus 로고    scopus 로고
    • ICOS controls effector function but not trafficking receptor expression of kidney-infiltrating effector T cells in murine lupus
    • Odegard J.M., DiPlacido L.D., Greenwald L., Kashgarian M., Kono D.H., Dong C., et al. ICOS controls effector function but not trafficking receptor expression of kidney-infiltrating effector T cells in murine lupus. J Immunol 2009, 182:4076-4084.
    • (2009) J Immunol , vol.182 , pp. 4076-4084
    • Odegard, J.M.1    DiPlacido, L.D.2    Greenwald, L.3    Kashgarian, M.4    Kono, D.H.5    Dong, C.6
  • 67
    • 36849036211 scopus 로고    scopus 로고
    • IL-21 is produced by Th17 cells and drives IL-17 production in a STAT3-dependent manner
    • Wei L., Laurence A., Elias K.M., O'Shea J.J. IL-21 is produced by Th17 cells and drives IL-17 production in a STAT3-dependent manner. J Biol Chem 2007, 282:34605-34610.
    • (2007) J Biol Chem , vol.282 , pp. 34605-34610
    • Wei, L.1    Laurence, A.2    Elias, K.M.3    O'Shea, J.J.4
  • 68
    • 60849107595 scopus 로고    scopus 로고
    • A critical role for IL-21 receptor signaling in the pathogenesis of systemic lupus erythematosus in BXSB-Yaa mice
    • Bubier J.A., Sproule T.J., Foreman O., Spolski R., Shaffer D.J., Morse H.C.3rd., et al. A critical role for IL-21 receptor signaling in the pathogenesis of systemic lupus erythematosus in BXSB-Yaa mice. Proc Natl Acad Sci USA 2009, 106:1518-1523.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 1518-1523
    • Bubier, J.A.1    Sproule, T.J.2    Foreman, O.3    Spolski, R.4    Shaffer, D.J.5    Morse, H.C.3.6
  • 69
    • 33947215987 scopus 로고    scopus 로고
    • IL-21 has a pathogenic role in a lupus-prone mouse model and its blockade with IL-21R.Fc reduces disease progression
    • Herber D., Brown T.P., Liang S., Young D.A., Collins M., Dunussi-Joannopoulos K. IL-21 has a pathogenic role in a lupus-prone mouse model and its blockade with IL-21R.Fc reduces disease progression. J Immunol 2007, 178:3822-3830.
    • (2007) J Immunol , vol.178 , pp. 3822-3830
    • Herber, D.1    Brown, T.P.2    Liang, S.3    Young, D.A.4    Collins, M.5    Dunussi-Joannopoulos, K.6
  • 70
    • 0033180181 scopus 로고    scopus 로고
    • Development of lupus-like autoimmune diseases by disruption of the PD-1 gene encoding an ITIM motif-carrying immunoreceptor
    • Nishimura H., Nose M., Hiai H., Minato N., Honjo T. Development of lupus-like autoimmune diseases by disruption of the PD-1 gene encoding an ITIM motif-carrying immunoreceptor. Immunity 1999, 11:141-151.
    • (1999) Immunity , vol.11 , pp. 141-151
    • Nishimura, H.1    Nose, M.2    Hiai, H.3    Minato, N.4    Honjo, T.5
  • 72
    • 77649163290 scopus 로고    scopus 로고
    • Regulatory T cells and human myeloid dendritic cells promote tolerance via programmed death ligand-1
    • Amarnath S., Costanzo C.M., Mariotti J., Ullman J.L., Telford W.G., Kapoor V., et al. Regulatory T cells and human myeloid dendritic cells promote tolerance via programmed death ligand-1. PLoS Biol 2010, 8:e1000302.
    • (2010) PLoS Biol , vol.8
    • Amarnath, S.1    Costanzo, C.M.2    Mariotti, J.3    Ullman, J.L.4    Telford, W.G.5    Kapoor, V.6
  • 73
    • 77952557954 scopus 로고    scopus 로고
    • PD-1 regulates germinal center B cell survival and the formation and affinity of long-lived plasma cells
    • Good-Jacobson K.L., Szumilas C.G., Chen L., Sharpe A.H., Tomayko M.M., Shlomchik M.J. PD-1 regulates germinal center B cell survival and the formation and affinity of long-lived plasma cells. Nat Immunol 2010, 11:535-542.
    • (2010) Nat Immunol , vol.11 , pp. 535-542
    • Good-Jacobson, K.L.1    Szumilas, C.G.2    Chen, L.3    Sharpe, A.H.4    Tomayko, M.M.5    Shlomchik, M.J.6


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