Early life precursors, epigenetics, and the development of food allergy

Seminars in Immunopathology

Volumn 34, Issue 5, 2012, Pages 655-669

  Hong, Xiumei ^a   Wang, Xiaobin ^a  

^a JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

Environmental exposure; Epigenetics; Food allergy; Genetics

Indexed keywords

ANTACID AGENT; IMMUNOGLOBULIN E; INTERLEUKIN 10;

AIR POLLUTION; BREAST FEEDING; CD14 GENE; CESAREAN SECTION; CYP24A1 GENE; CYTOKINE RESPONSE; DIET; DISEASE ASSOCIATION; DISEASE CONTROL; ENVIRONMENTAL EXPOSURE; EPIGENETICS; ETHNICITY; FCER1G GENE; FEEDING BEHAVIOR; FLG GENE; FOOD ALLERGY; FOOD INTAKE; FOXP3 GENE; GENE; GENE FUNCTION; GENE IDENTIFICATION; GENE MUTATION; GENETIC ASSOCIATION; GENETIC LINKAGE; GENETIC REGULATION; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; GENOTYPE ENVIRONMENT INTERACTION; HEREDITY; HLA DPB1 GENE; HLA DQB1 GENE; HLA DRB1 GENE; HUMAN; HYGIENE HYPOTHESIS; IL10 GENE; IL12RB1 GENE; IL13 GENE; IL4RA GENE; IMMUNOGLOBULIN PRODUCTION; IMMUNOPATHOGENESIS; IMMUNOREGULATION; LOW BIRTH WEIGHT; MICROBIAL ACTIVITY; MOLECULAR MECHANICS; MS4A2 GENE; NLRP3 GENE; NUTRITION; PREMATURITY; PRIORITY JOURNAL; PUBLIC HEALTH PROBLEM; RACE DIFFERENCE; REVIEW; RISK ASSESSMENT; RISK FACTOR; SLEEP TIME; SMOKING; SPINK5 GENE; STAT6 GENE; TLR9 GENE; TSLP GENE;

ANIMALS; ENVIRONMENTAL EXPOSURE; EPIGENESIS, GENETIC; EPIGENOMICS; FOOD HYPERSENSITIVITY; GENE-ENVIRONMENT INTERACTION; GENETIC PREDISPOSITION TO DISEASE; HUMANS; INFANT, LOW BIRTH WEIGHT; INFANT, NEWBORN; PREMATURE BIRTH; RISK FACTORS; TOBACCO SMOKE POLLUTION;

EID: 84866090489     PISSN: 18632297     EISSN: 18632300     Source Type: Journal    
DOI: 10.1007/s00281-012-0323-y     Document Type: Review

References (228)

1. Boyce JA, Assa'ad A, Burks AW et al (2010) Guidelines for the diagnosis and management of food allergy in the United States: Report of the NIAID-sponsored expert panel. J Allergy Clin Immunol 126(6 Suppl):S1-S58
2. Sampson HA (2004) Update on food allergy. J Allergy Clin Immunol 113(5):805-819, quiz 820
3. Gupta R, Sheikh A, Strachan DP et al (2007) Time trends in allergic disorders in the UK. Thorax 62(1):91-96
4. Chafen JJ, Newberry SJ, Riedl MA et al (2010) Diagnosing and managing common food allergies: A systematic review. JAMA 303(18):1848-1856
5. Primeau MN, Kagan R, Joseph L et al (2000) The psychological burden of peanut allergy as perceived by adults with peanut allergy and the parents of peanut-allergic children. Clin Exp Allergy 30(8):1135-1143
6. Sicherer SH, Noone SA, Munoz-Furlong A (2001) The impact of childhood food allergy on quality of life. Ann Allergy Asthma Immunol 87(6):461-464
7. Avery NJ, King RM, Knight S et al (2003) Assessment of quality of life in children with peanut allergy. Pediatr Allergy Immunol 14(5):378-382
8. Cohen BL, Noone S, Munoz-Furlong A et al (2004) Development of a questionnaire to measure quality of life in families with a child with food allergy. J Allergy Clin Immunol 114(5):1159-1163
9. Sicherer SH (2011) Epidemiology of food allergy. J Allergy Clin Immunol 127(3):594-602
10. Ninan TK, Russell G (1992) Respiratory symptoms and atopy in Aberdeen schoolchildren: Evidence from two surveys 25 years apart. BMJ 304(6831):873-875
11. Peat JK, van den Berg RH, Green WF et al (1994) Changing prevalence of asthma in Australian children. BMJ 308 (6944):1591-1596
12. Holt PG, Rowe J, Kusel M et al (2010) Toward improved prediction of risk for atopy and asthma among preschoolers: A prospective cohort study. J Allergy Clin Immunol 125(3):653-659, 659 e651-659 e657
13. Ege MJ, Bieli C, Frei R et al (2006) Prenatal farm exposure is related to the expression of receptors of the innate immunity and to atopic sensitization in school-age children. J Allergy Clin Immunol 117(4):817-823
14. Furuhjelm C, Warstedt K, Larsson J et al (2009) Fish oil supplementation in pregnancy and lactation may decrease the risk of infant allergy. Acta Paediatr 98(9):1461-1467
15. Kulig M, Luck W, Lau S et al (1999) Effect of pre-and postnatal tobacco smoke exposure on specific sensitization to food and inhalant allergens during the first 3 years of life. multicenter allergy study group, Germany. Allergy 54(3):220-228
16. Nwaru BI, Ahonen S, Kaila M et al (2010) Maternal diet during pregnancy and allergic sensitization in the offspring by 5 years of age: A prospective cohort study. Pediatr Allergy Immunol 21(1 Pt 1):29-37
17. Neaville WA, Tisler C, Bhattacharya A et al (2003) Developmental cytokine response profiles and the clinical and immunologic expression of atopy during the first year of life. J Allergy Clin Immunol 112(4):740-746
18. Lack G (2008) Epidemiologic risks for food allergy. J Allergy Clin Immunol 121(6):1331-1336
19. Saarinen UM, Kajosaari M (1995) Breastfeeding as prophylaxis against atopic disease: Prospective follow-up study until 17 years old. Lancet 346(8982):1065-1069
20. Oddy WH, Holt PG, Sly PD et al (1999) Association between breast feeding and asthma in 6 year old children: Findings of a prospective birth cohort study. BMJ 319(7213):815-819
21. Kramer MS, Chalmers B, Hodnett ED et al (2001) Promotion of Breastfeeding Intervention Trial (PROBIT): A randomized trial in the Republic of Belarus. JAMA 285(4):413-420
22. Kramer MS, Matush L, Vanilovich I et al (2007) Effect of prolonged and exclusive breast feeding on risk of allergy and asthma: Cluster randomised trial. BMJ 335(7624):815
23. Kucukosmanoglu E, Yazi D, Yesil O et al (2008) Prevalence of egg sensitization in Turkish infants based on skin prick test. Allergol Immunopathol (Madr) 36(3):141-144
24. Venter C, Pereira B, Voigt K et al (2009) Factors associated with maternal dietary intake, feeding and weaning practices, and the development of food hypersensitivity in the infant. Pediatr Allergy Immunol 20(4):320-327
25. Nwaru BI, Erkkola M, Ahonen S et al (2010) Age at the introduction of solid foods during the first year and allergic sensitization at age 5 years. Pediatrics 125(1):50-59
26. Lack G, Fox D, Northstone K et al (2003) Factors associated with the development of peanut allergy in childhood. N Engl J Med 348(11):977-985
27. Mihrshahi S, Ampon R, Webb K et al (2007) The association between infant feeding practices and subsequent atopy among children with a family history of asthma. Clin Exp Allergy 37 (5):671-679
28. Linneberg A, Simonsen JB, Petersen J et al (2006) Differential effects of risk factors on infant wheeze and atopic dermatitis emphasize a different etiology. J Allergy Clin Immunol 117 (1):184-189
29. Sears MR, Greene JM,Willan AR et al (2002) Long-term relation between breastfeeding and development of atopy and asthma in children and young adults: A longitudinal study. Lancet 360 (9337):901-907
30. Host A, Halken S, Muraro A et al (2008) Dietary prevention of allergic diseases in infants and small children. Pediatr Allergy Immunol 19(1):1-4
31. Greer FR, Sicherer SH, Burks AW (2008) Effects of early nutritional interventions on the development of atopic disease in infants and children: The role of maternal dietary restriction, breastfeeding, timing of introduction of complementary foods, and hydrolyzed formulas. Pediatrics 121(1):183-191
32. Koplin JJ, Osborne NJ, Wake M et al (2010) Can early introduction of egg prevent egg allergy in infants? A population-based study. J Allergy Clin Immunol 126(4):807-813
33. Katz Y, Rajuan N, Goldberg MR et al (2010) Early exposure to cow's milk protein is protective against IgE-mediated cow's milk protein allergy. J Allergy Clin Immunol 126(1):77-82, e71
34. Du Toit G, Katz Y, Sasieni P et al (2008) Early consumption of peanuts in infancy is associated with a low prevalence of peanut allergy. J Allergy Clin Immunol 122(5):984-991
35. Poole JA, Barriga K, Leung DY et al (2006) Timing of initial exposure to cereal grains and the risk of wheat allergy. Pediatrics 117(6):2175-2182
36. Matheson MC, Erbas B, Balasuriya A et al (2007) Breast-feeding and atopic disease: A cohort study from childhood to middle age. J Allergy Clin Immunol 120(5):1051-1057
37. Mandhane PJ, Greene JM, Sears MR (2007) Interactions between breast-feeding, specific parental atopy, and sex on development of asthma and atopy. J Allergy Clin Immunol 119(6):1359-1366
38. Pesonen M, Kallio MJ, Ranki A et al (2006) Prolonged exclusive breastfeeding is associated with increased atopic dermatitis: A prospective follow-up study of unselected healthy newborns from birth to age 20 years. Clin Exp Allergy 36(8):1011-1018
39. Kumar R, Caruso DM, Arguelles L et al (2010) Early life eczema, food introduction, and risk of food allergy in children. Pediatr Allergy Immunol Pulmonol 23(3):175-182
40. Joseph CL, Ownby DR, Havstad SL et al (2011) Early complementary feeding and risk of food sensitization in a birth cohort. J Allergy Clin Immunol 127(5):1203-1210, e1205
41. Hong X, Wang G, Liu X et al (2011) Gene polymorphisms, breast-feeding, and development of food sensitization in early childhood. J Allergy Clin Immunol 128(2):374-381, e372
42. Adams JS, Hewison M (2008) Unexpected actions of vitamin D: New perspectives on the regulation of innate and adaptive immunity. Nat Clin Pract Endocrinol Metab 4(2):80-90
43. Baeke F, Takiishi T, Korf H et al (2010) Vitamin D: Modulator of the immune system. Curr Opin Pharmacol 10(4):482-496
44. Vassallo MF, Camargo CA Jr (2010) Potential mechanisms for the hypothesized link between sunshine, vitamin D, and food allergy in children. J Allergy Clin Immunol 126(2):217-222
45. Szeles L, Keresztes G, Torocsik D et al (2009) 1,25-dihydroxyvitamin D3 is an autonomous regulator of the transcriptional changes leading to a tolerogenic dendritic cell phenotype. J Immunol 182(4):2074-2083
46. Dimeloe S, Nanzer A, Ryanna K et al (2010) Regulatory T cells, inflammation and the allergic response-the role of glucocorticoids and vitamin D. J Steroid Biochem Mol Biol 120(2-3):86-95
47. Unger WW, Laban S, Kleijwegt FS et al (2009) Induction of Treg by monocyte-derived DC modulated by vitamin D3 or dexamethasone: Differential role for PD-L1. Eur J Immunol 39(11):3147-3159
48. Heine G, Niesner U, Chang HD et al (2008) 1,25-dihydroxyvitamin D(3) promotes IL-10 production in human B cells. Eur J Immunol 38(8):2210-2218
49. Vassallo MF, Banerji A, Rudders SA et al (2010) Season of birth and food allergy in children. Ann Allergy Asthma Immunol 104 (4):307-313
50. Vassallo MF, Banerji A, Rudders SA et al (2010) Season of birth and food-induced anaphylaxis in Boston. Allergy 65(11):1492-1493
51. Camargo CA Jr, Clark S, Kaplan MS et al (2007) Regional differences in EpiPen prescriptions in the United States: The potential role of vitamin D. J Allergy Clin Immunol 120 (1):131-136
52. Mullins RJ, Clark S, Camargo CA Jr (2009) Regional variation in epinephrine autoinjector prescriptions in Australia: More evidence for the vitamin D-anaphylaxis hypothesis. Ann Allergy Asthma Immunol 103(6):488-495
53. Mullins RJ, Clark S, Camargo CA Jr (2010) Regional variation in infant hypoallergenic formula prescriptions in Australia. Pediatr Allergy Immunol 21(2 Pt 2):e413-e420
54. Wjst M, Dharmage S, Andre E et al (2005) Latitude, birth date, and allergy. PLoS Med 2(10):e294
55. Rudders SA, Espinola JA, Camargo CA Jr (2010) North-south differences in US emergency department visits for acute allergic reactions. Ann Allergy Asthma Immunol 104(5):413-416
56. Wjst M, Hypponen E (2007) Vitamin D serum levels and allergic rhinitis. Allergy 62(9):1085-1086
57. Sharief S, Jariwala S, Kumar J et al (2011) Vitamin D levels and food and environmental allergies in the United States: Results from the National Health and Nutrition Examination Survey 2005-2006. J Allergy Clin Immunol 127(5):1195-1202
58. Gale CR, Robinson SM, Harvey NC et al (2008) Maternal vitamin D status during pregnancy and child outcomes. Eur J Clin Nutr 62(1):68-77
59. Wjst M (2008) Allergy risk of vitamin D supplements has been described in various settings. J Allergy Clin Immunol 12 (4):1065-1066, author reply 1066
60. Wjst M, Dold S (1999) Genes, factor X, and allergens: What causes allergic diseases? Allergy 54(7):757-759
61. Litonjua AA, Weiss ST (2007) Is vitamin D deficiency to blame for the asthma epidemic? J Allergy Clin Immunol 12(0):1031-1035
62. Kong J, Zhang Z, Musch MW et al (2008) Novel role of the vitamin D receptor in maintaining the integrity of the intestinal mucosal barrier. Am J Physiol Gastrointest Liver Physiol 294(1): G208-G216
63. Liu X, Wang G, Hong X, et al. (2011) Gene-vitamin D interactions on food sensitization: A prospective birth cohort study. Allergy
64. Betz M, Fox BS (1991) Prostaglandin E2 inhibits production of Th1 lymphokines but not of Th2 lymphokines. J Immunol 146 (1):108-113
65. Snijdewint FG, Kalinski P, Wierenga EA et al (1993) Prostaglandin E2 differentially modulates cytokine secretion profiles of human T helper lymphocytes. J Immunol 150(12):5321-5329
66. Krauss-Etschmann S, Hartl D, Rzehak P et al (2008) Decreased cord blood IL-4, IL-13, and CCR4 and increased TGF-beta levels after fish oil supplementation of pregnant women. J Allergy Clin Immunol 12(2):464-470, e466
67. Kull I, Bergstrom A, Lilja G et al (2006) Fish consumption during the first year of life and development of allergic diseases during childhood. Allergy 61(8):1009-1015
68. Manley BJ, Makrides M, Collins CT et al (2011) High-dose docosahexaenoic acid supplementation of preterm infants: Respiratory and allergy outcomes. Pediatrics 128(1):e71-e77
69. Saarinen UM, Kajosaari M (1980) Does dietary elimination in infancy prevent or only postpone a food allergy? A study of fish and citrus allergy in 375 children. Lancet 1(8161):166-167
70. Anandan C, Nurmatov U, Sheikh A (2009) Omega 3 and 6 oils for primary prevention of allergic disease: Systematic review and meta-analysis. Allergy 64(6):840-848
71. Li-Weber M, Giaisi M, Treiber MK et al (2002) Vitamin E inhibits IL-4 gene expression in peripheral blood T cells. Eur J Immunol 32(9):2401-2408
72. McKeever TM, Lewis SA, Smit H et al (2004) Serum nutrient markers and skin prick testing using data from the third national health and nutrition examination survey. J Allergy Clin Immunol 114(6):1398-1402
73. Patel S, Murray CS,Woodcock A et al (2009) Dietary antioxidant intake, allergic sensitization and allergic diseases in young children. Allergy 64(12):1766-1772
74. Sato Y, Akiyama H, Suganuma H et al (2004) The feeding of beta-carotene down-regulates serum IgE levels and inhibits the type I allergic response in mice. Biol Pharm Bull 27(7):978-984
75. Hoppu U, Rinne M, Salo-Vaananen P et al (2005) Vitamin C in breast milk may reduce the risk of atopy in the infant. Eur J Clin Nutr 59(1):123-128
76. Marmsjo K, Rosenlund H, Kull I et al (2009) Use of multivitamin supplements in relation to allergic disease in 8-y-old children. Am J Clin Nutr 90(6):1693-1698
77. Milner JD, Stein DM, McCarter R et al (2004) Early infant multivitamin supplementation is associated with increased risk for food allergy and asthma. Pediatrics 114(1):27-32
78. Nurmatov U, Devereux G, Sheikh A (2011) Nutrients and foods for the primary prevention of asthma and allergy: Systematic review and meta-analysis. J Allergy Clin Immunol 127(3):724-733, e721-730
79. Hollingsworth JW, Maruoka S, Boon K et al (2008) In utero supplementation with methyl donors enhances allergic airway disease in mice. J Clin Invest 118(10):3462-3469
80. Bekkers MB, Elstgeest LE, Scholtens S, et al. (2011) Maternal use of folic acid supplements during pregnancy and childhood respiratory health and atopy: The PIAMA birth cohort study. Eur Respir J
81. Martinussen MP, Risnes KR, Jacobsen GWet al (2012) Folic acid supplementation in early pregnancy and asthma in children aged 6 years. Am J Obstet Gynecol 206(1):72, e71-77
82. Binkley KE, Leaver C, Ray JG (2011) Antenatal risk factors for peanut allergy in children. Allergy Asthma Clin Immunol 7:17
83. Lannero E, Wickman M, van Hage M et al (2008) Exposure to environmental tobacco smoke and sensitisation in children. Thorax 63(2):172-176
84. Keil T, Lau S, Roll S et al (2009) Maternal smoking increases risk of allergic sensitization and wheezing only in children with allergic predisposition: Longitudinal analysis from birth to 10 years. Allergy 64(3):445-451
85. Raherison C, Penard-Morand C, Moreau D et al (2008) Smoking exposure and allergic sensitization in children according to maternal allergies. Ann Allergy Asthma Immunol 100(4):351-357
86. Strachan DP, Cook DG (1998) Health effects of passive smoking. 5. Parental smoking and allergic sensitisation in children. Thorax 53(2):117-123
87. Metsala J, Lundqvist A, Kaila M et al (2010) Maternal and perinatal characteristics and the risk of cow's milk allergy in infants up to 2 years of age: A case-control study nested in the Finnish population. Am J Epidemiol 171(12):1310-1316
88. Weaver LT, Laker MF, Nelson R (1984) Intestinal permeability in the newborn. Arch Dis Child 59(3):236-241
89. Roberton DM, Paganelli R, Dinwiddie R et al (1982) Milk antigen absorption in the preterm and term neonate. Arch Dis Child 57(5):369-372
90. McNeish AS (1984) Enzymatic maturation of the gastrointestinal tract and its relevance to food allergy and intolerance in infancy. Ann Allergy 53(6 Pt 2):643-648
91. Lucas A, McLaughlan P, Coombs RR (1984) Latent anaphylactic sensitisation of infants of low birth weight to cows' milk proteins. Br Med J (Clin Res Ed) 289(6454):1254-1256
92. Chandran U, Demissie K, Echeverria SE, et al. (2012) Food allergy among low birthweight children in a national survey. Matern Child Health J
93. de Martino M, Donzelli GP, Galli L et al (1989) Food allergy in preterm infants fed human milk. Biol Neonate 56(6):301-305
94. Liem JJ, Kozyrskyj AL, Huq SI et al (2007) The risk of developing food allergy in premature or low-birth-weight children. J Allergy Clin Immunol 119(5):1203-1209
95. Kumar R, Yu Y, Story RE et al (2008) Prematurity, chorioamnionitis, and the development of recurrent wheezing: A prospective birth cohort study. J Allergy Clin Immunol 121(4):878-884, e876
96. Hikino S, Nakayama H, Yamamoto J et al (2001) Food allergy and atopic dermatitis in low birthweight infants during early childhood. Acta Paediatr 90(8):850-855
97. Wold AE (1998) The hygiene hypothesis revised: Is the rising frequency of allergy due to changes in the intestinal flora? Allergy 53(46 Suppl):20-25
98. Noverr MC, Huffnagle GB (2005) The 'microflora hypothesis' of allergic diseases. Clin Exp Allergy 35(12):1511-1520
99. Negele K, Heinrich J, Borte M et al (2004) Mode of delivery and development of atopic disease during the first 2 years of life. Pediatr Allergy Immunol 15(1):48-54
100. Bager P, Wohlfahrt J, Westergaard T (2008) Caesarean delivery and risk of atopy and allergic disease: Meta-analyses. Clin Exp Allergy 38(4):634-642
101. Sanchez-Valverde F, Gil F, Martinez D et al (2009) The impact of caesarean delivery and type of feeding on cow's milk allergy in infants and subsequent development of allergic march in childhood. Allergy 64(6):884-889
102. Eggesbo M, Botten G, Stigum H et al (2003) Is delivery by cesarean section a risk factor for food allergy? J Allergy Clin Immunol 112(2):420-426
103. Dioun AF, Harris SK, Hibberd PL (2003) Is maternal age at delivery related to childhood food allergy? Pediatr Allergy Immunol 14(4):307-311
104. Turner SW, Palmer LJ, Gibson NA et al (2005) The effect of age on the relationship between birth order and immunoglobulin E sensitization. Clin Exp Allergy 35(5):630-634
105. Johnson CC, Ownby DR, Alford SH et al (2005) Antibiotic exposure in early infancy and risk for childhood atopy. J Allergy Clin Immunol 115(6):1218-1224
106. Sandini U, Kukkonen AK, Poussa T et al (2011) Protective and risk factors for allergic diseases in high-risk children at the ages of two and five years. Int Arch Allergy Immunol 156(3):339-348
107. Lewis MC, Inman CF, Patel D, et al. (2012) Direct experimental evidence that early-life farm environment influences regulation of immune responses. Pediatr Allergy Immunol
108. Schaub B, Liu J, Hoppler S et al (2009) Maternal farm exposure modulates neonatal immune mechanisms through regulatory T cells. J Allergy Clin Immunol 123(4):774-782, e775
109. Liu X, Liu L, Owens JA et al (2005) Sleep patterns and sleep problems among schoolchildren in the United States and China. Pediatrics 115(1 Suppl):241-249
110. Ouyang F, Lu BS, Wang B et al (2009) Sleep patterns among rural Chinese twin adolescents. Sleep Med 10(4):479-489
111. Hedley AA, Ogden CL, Johnson CL et al (2004) Prevalence of overweight and obesity among US children, adolescents, and adults, 1999-2002. Jama 291(23):2847-2850
112. Sicherer SH, Munoz-Furlong A, Godbold JH et al (2010) US prevalence of self-reported peanut, tree nut, and sesame allergy: 11-year follow-up. J Allergy Clin Immunol 125(6):1322-1326
113. Rudders SA, Banerji A, Vassallo MF et al (2010) Trends in pediatric emergency department visits for food-induced anaphylaxis. J Allergy Clin Immunol 126(2):385-388
114. Teramoto S, Yamamoto H, Yamaguchi Yet al (2005) Obstructive sleep apnea causes systemic inflammation and metabolic syndrome. Chest 127(3):1074-1075
115. Vgontzas AN, Zoumakis E, Bixler EO et al (2004) Adverse effects of modest sleep restriction on sleepiness, performance, and inflammatory cytokines. J Clin Endocrinol Metab 89 (5):2119-2126
116. Bryant PA, Trinder J, Curtis N (2004) Sick and tired: Does sleep have a vital role in the immune system? Nat Rev Immunol 4 (6):457-467
117. van Leeuwen WM, Lehto M, Karisola P et al (2009) Sleep restriction increases the risk of developing cardiovascular diseases by augmenting proinflammatory responses through IL-17 and CRP. PLoS One 4(2):e4589
118. Acosta-Rodriguez EV, Napolitani G, Lanzavecchia A et al (2007) Interleukins 1beta and 6 but not transforming growth factor-beta are essential for the differentiation of interleukin 17-producing human T helper cells. Nat Immunol 8(9):942-949
119. Kubota T, Fang J, Kushikata T et al (2000) Interleukin-13 and transforming growth factor-beta1 inhibit spontaneous sleep in rabbits.Am J Physiol Regul Integr Comp Physiol 279(3):R786-R792
120. Kushikata T, Fang J, Wang Y et al (1998) Interleukin-4 inhibits spontaneous sleep in rabbits. Am J Physiol 275(4 Pt 2):R1185-R1191
121. Zhang S, Liu X, Kim JS et al (2011) Association between short sleep duration and the risk of sensitization to food and aero allergens in rural Chinese adolescents. Clin Exp Allergy 41 (4):547-555
122. Untersmayr E, Jensen-Jarolim E (2008) The role of protein digestibility and antacids on food allergy outcomes. J Allergy Clin Immunol 121(6):1301-1308, quiz 1309-1310
123. Scholl I, Ackermann U, Ozdemir C et al (2007) Anti-ulcer treatment during pregnancy induces food allergy in mouse mothers and a Th2-bias in their offspring. FASEB J 21(4):1264-1270
124. Scholl I, Untersmayr E, Bakos N et al (2005) Antiulcer drugs promote oral sensitization and hypersensitivity to hazelnut allergens in BALB/c mice and humans. Am J Clin Nutr 81(1):154-160
125. Untersmayr E, Scholl I, Swoboda I et al (2003) Antacid medication inhibits digestion of dietary proteins and causes food allergy: A fish allergy model in BALB/c mice. J Allergy Clin Immunol 112(3):616-623
126. Pali-Scholl I, Herzog R, Wallmann J et al (2010) Antacids and dietary supplements with an influence on the gastric pH increase the risk for food sensitization. Clin Exp Allergy 40(7):1091-1098
127. Untersmayr E, Bakos N, Scholl I et al (2005) Anti-ulcer drugs promote IgE formation toward dietary antigens in adult patients. FASEB J 19(6):656-658
128. Sicherer SH, Wood RA, Stablein D et al (2010) Maternal consumption of peanut during pregnancy is associated with peanut sensitization in atopic infants. J Allergy Clin Immunol 126 (6):1191-1197
129. Liu AH, Jaramillo R, Sicherer SH et al (2010) National prevalence and risk factors for food allergy and relationship to asthma: Results from the National Health and Nutrition Examination Survey 2005-2006. J Allergy Clin Immunol 126(4):798-806, e713
130. Sicherer SH, Munoz-Furlong A, Sampson HA (2004) Prevalence of seafood allergy in the United States determined by a random telephone survey. J Allergy Clin Immunol 114(1):159-165
131. Yaeger R, Avila-Bront A, Abdul K et al (2008) Comparing genetic ancestry and self-described race in African Americans born in the United States and in Africa. Cancer Epidemiol Biomarkers Prev 17(6):1329-1338
132. Goldstein DB, Hirschhorn JN (2004) In genetic control of disease, does 'race' matter? Nat Genet 36(12):1243-1244
133. Hoggart CJ, Parra EJ, Shriver MD et al (2003) Control of confounding of genetic associations in stratified populations. Am J Hum Genet 72(6):1492-1504
134. Rosenberg NA, Li LM, Ward R et al (2003) Informativeness of genetic markers for inference of ancestry. Am J Hum Genet 73 (6):1402-1422
135. Tang H, Peng J, Wang P et al (2005) Estimation of individual admixture: Analytical and study design considerations. Genet Epidemiol 28(4):289-301
136. Kumar R, Tsai HJ, Hong X et al (2011) Race, ancestry, and development of food-allergen sensitization in early childhood. Pediatrics 128(4):e821-e829
137. Visness CM, London SJ, Daniels JL et al (2009) Association of obesity with IgE levels and allergy symptoms in children and adolescents: Results from the national health and nutrition examination survey 2005-2006. J Allergy Clin Immunol 123(5):1163-1169, 1169 e1161-1164
138. Bakos N, Scholl I, Szalai K et al (2006) Risk assessment in elderly for sensitization to food and respiratory allergens. Immunol Lett 107(1):15-21
139. Gruzieva O, Bellander T, Eneroth K et al (2012) Traffic-related air pollution and development of allergic sensitization in children during the first 8 years of life. J Allergy Clin Immunol 129 (1):240-246
140. Kumar R, Ouyang F, Story RE et al (2009) Gestational diabetes, atopic dermatitis, and allergen sensitization in early childhood. J Allergy Clin Immunol 124(5):1031-1038, e1031-1034
141. Keet CA, Wood RA, Matsui EC (2012) Personal and parental nativity as risk factors for food sensitization. J Allergy Clin Immunol 129(1):169-175, e161-165
142. Hong X, Tsai HJ, Wang X (2009) Genetics of food allergy. Curr Opin Pediatr 21(6):770-776
143. Howell WM, Turner SJ, Hourihane JO et al (1998) HLA class II DRB1, DQB1 and DPB1 genotypic associations with peanut allergy: Evidence from a family-based and case-control study. Clin Exp Allergy 28(2):156-162
144. Senechal H, Geny S, Desvaux FX et al (1999) Genetics and specific immune response in allergy to birch pollen and food: Evidence of a strong, positive association between atopy and the HLA class II allele HLA-DR7. J Allergy Clin Immunol 104(2 Pt 1):395-401
145. Woo JG, Assa'ad A, Heizer AB et al (2003) The 159 C→T polymorphism of CD14 is associated with nonatopic asthma and food allergy. J Allergy Clin Immunol 112(2):438-444
146. Bottema RW, Kerkhof M, Reijmerink NE et al (2010) Xchromosome Forkhead Box P3 polymorphisms associate with atopy in girls in three Dutch birth cohorts. Allergy 65(7):865-874
147. Torgerson TR, Linane A, Moes N et al (2007) Severe food allergy as a variant of IPEX syndrome caused by a deletion in a noncoding region of the FOXP3 gene. Gastroenterology 132 (5):1705-1717
148. Amoli MM, Hand S, Hajeer AH et al (2002) Polymorphism in the STAT6 gene encodes risk for nut allergy. Genes Immun 3(4):220-224
149. Sharabrin OI (1968) Changes in the hamatopoietic system in swine with hog cholera. Veterinariia 45(7):38-41
150. Alberto EJ, Shimojo N, Suzuki Y et al (2008) IL-10 gene polymorphism, but not TGF-beta1 gene polymorphisms, is associated with food allergy in a Japanese population. Pediatr Allergy Immunol 19(8):716-721
151. Liu X, Beaty TH, Deindl P et al (2004) Associations between specific serum IgE response and 6 variants within the genes IL4, IL13, and IL4RA in German children: The German Multicenter Atopy Study. J Allergy Clin Immunol 113(3):489-495
152. Hitomi Y, Ebisawa M, Tomikawa M et al (2009) Associations of functional NLRP3 polymorphisms with susceptibility to foodinduced anaphylaxis and aspirin-induced asthma. J Allergy Clin Immunol 124(4):779-785, e776
153. Brown SJ, Asai Y, Cordell HJ et al (2011) Loss-of-function variants in the filaggrin gene are a significant risk factor for peanut allergy. J Allergy Clin Immunol 127(3):661-667
154. Ogbuanu IU, Karmaus WJ, Zhang H et al (2010) Birth order modifies the effect of IL13 gene polymorphisms on serum IgE at age 10 and skin prick test at ages 4, 10 and 18: A prospective birth cohort study. Allergy Asthma Clin Immunol 6(1):6
155. Panasevich S, Lindgren C, Kere J et al (2010) Interaction between early maternal smoking and variants in TNF and GSTP1 in childhood wheezing. Clin Exp Allergy 40(3):458-467
156. Li H, Romieu I, Sienra-Monge JJ et al (2006) Genetic polymorphisms in arginase I and II and childhood asthma and atopy. J Allergy Clin Immunol 117(1):119-126
157. Melen E, Nyberg F, Lindgren CM et al (2008) Interactions between glutathione S-transferase P1, tumor necrosis factor, and traffic-related air pollution for development of childhood allergic disease. Environ Health Perspect 116(8):1077-1084
158. Castro-Giner F, Kunzli N, Jacquemin B et al (2009) Trafficrelated air pollution, oxidative stress genes, and asthma (ECHRS). Environ Health Perspect 117(12):1919-1924
159. Custovic A, Rothers J, Stern D et al (2011) Effect of day care attendance on sensitization and atopic wheezing differs by Tolllike receptor 2 genotype in 2 population-based birth cohort studies. J Allergy Clin Immunol 127(2):390-397, e391-399
160. Eder W, Klimecki W, Yu L et al (2005) Opposite effects of CD 14/-260 on serum IgE levels in children raised in different environments. J Allergy Clin Immunol 116(3):601-607
161. Leynaert B, Guilloud-Bataille M, Soussan D et al (2006) Association between farm exposure and atopy, according to the CD14 C-159T polymorphism. J Allergy Clin Immunol 118(3):658-665
162. Roduit C, Wohlgensinger J, Frei R et al (2011) Prenatal animal contact and gene expression of innate immunity receptors at birth are associated with atopic dermatitis. J Allergy Clin Immunol 127 (1):179-185, 185 e171
163. Penders J, Thijs C, Mommers M et al (2010) Host-microbial interactions in childhood atopy: Toll-like receptor 4 (TLR4), CD14, and fecal Escherichia coli. J Allergy Clin Immunol 125 (1):231-236, e231-235
164. Simpson A, John SL, Jury F et al (2006) Endotoxin exposure, CD14, and allergic disease: An interaction between genes and the environment. Am J Respir Crit Care Med 174(4):386-392
165. Jaenisch R, Bird A (2003) Epigenetic regulation of gene expression: How the genome integrates intrinsic and environmental signals. Nat Genet 33(Suppl):245-254
166. Bird A (2007) Perceptions of epigenetics. Nature 447(7143):396-398
167. Rodriguez A, Griffiths-Jones S, Ashurst JL et al (2004) Identification of mammalian microRNA host genes and transcription units. Genome Res 14(10A):1902-1910
168. Jirtle RL, Skinner MK (2007) Environmental epigenomics and disease susceptibility. Nat Rev Genet 8(4):253-262
169. Ollikainen M, Smith KR, Joo EJ, et al. (2010) DNA methylation analysis of multiple tissues from newborn twins reveals both genetic and intrauterine components to variation in the human neonatal epigenome. Hum Mol Genet
170. Wong CC, Caspi A, Williams B et al (2010) A longitudinal study of epigenetic variation in twins. Epigenetics 5(6)
171. Gluckman PD, Hanson MA, Cooper C et al (2008) Effect of in utero and early-life conditions on adult health and disease. N Engl J Med 359(1):61-73
172. Hanson MA, Gluckman PD (2008) Developmental origins of health and disease: New insights. Basic Clin Pharmacol Toxicol 102(2):90-93
173. Feinberg AP (2007) Phenotypic plasticity and the epigenetics of human disease. Nature 447(7143):433-440
174. Waterland RA, Michels KB (2007) Epigenetic epidemiology of the developmental origins hypothesis. Annu Rev Nutr 27:363-388
175. Reik W, Dean W, Walter J (2001) Epigenetic reprogramming in mammalian development. Science 293(5532):1089-1093
176. Prescott SL, Macaubas C, Smallacombe T et al (1999) Development of allergen-specific T-cell memory in atopic and normal children. Lancet 353(9148):196-200
177. Brand S, Kesper DA, Teich R, et al. (2012) DNA methylation of T(H)1/T(H)2 cytokine genes affects sensitization and progress of experimental asthma. J Allergy Clin Immunol
178. White GP, Hollams EM, Yerkovich ST et al (2006) CpG methylation patterns in the IFNgamma promoter in naive T cells: Variations during Th1 and Th2 differentiation and between atopics and non-atopics. Pediatr Allergy Immunol 17(8):557-564
179. Lee DU, Agarwal S, Rao A (2002) Th2 lineage commitment and efficient IL-4 production involves extended demethylation of the IL-4 gene. Immunity 16(5):649-660
180. Fields PE, Lee GR, Kim ST et al (2004) Th2-specific chromatin remodeling and enhancer activity in the Th2 cytokine locus control region. Immunity 21(6):865-876
181. Polansky JK, Kretschmer K, Freyer J et al (2008) DNA methylation controls Foxp3 gene expression. Eur J Immunol 38 (6):1654-1663
182. Polansky JK, Schreiber L, Thelemann C, et al. (2010) Methylation matters: Binding of Ets-1 to the demethylated Foxp3 gene contributes to the stabilization of Foxp3 expression in regulatory T cells. J Mol Med
183. Huehn J, Polansky JK, Hamann A (2009) Epigenetic control of FOXP3 expression: The key to a stable regulatory T-cell lineage? Nat Rev Immunol 9(2):83-89
184. Liu J, Lluis A, Illi S et al (2010) T regulatory cells in cord blood-FOXP3 demethylation as reliable quantitative marker. PLoS One 5(10):e13267
185. Kim EG, Shin HJ, Lee CG et al (2010) DNA methylation and not allelic variation regulates STAT6 expression in human T cells. Clin Exp Med 10(3):143-152
186. Bhavsar P, Ahmad T, Adcock IM (2008) The role of histone deacetylases in asthma and allergic diseases. J Allergy Clin Immunol 121(3):580-584
187. Wang L, Tao R, Hancock WW (2009) Using histone deacetylase inhibitors to enhance Foxp3(+) regulatory T-cell function and induce allograft tolerance. Immunol Cell Biol 87(3):195-202
188. Tao R, de Zoeten EF, Ozkaynak E et al (2007) Deacetylase inhibition promotes the generation and function of regulatory T cells. Nat Med 13(11):1299-1307
189. de Zoeten EF, Wang L, Butler K et al (2011) Histone deacetylase 6 and heat shock protein 90 control the functions of Foxp3(+) Tregulatory cells. Mol Cell Biol 31(10):2066-2078
190. Taganov KD, Boldin MP, Chang KJ et al (2006) NF-kappaBdependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses. Proc Natl Acad Sci U S A 103(33):12481-12486
191. Thai TH, Calado DP, Casola S et al (2007) Regulation of the germinal center response by microRNA-155. Science 316 (5824):604-608
192. Sonkoly E, Janson P, Majuri ML et al (2010) MiR-155 is overexpressed in patients with atopic dermatitis and modulates T-cell proliferative responses by targeting cytotoxic T lymphocyteassociated antigen 4. J Allergy Clin Immunol 126(3):581-589, e581-520
193. Baltimore D, Boldin MP, O'Connell RM et al (2008) Micro-RNAs: New regulators of immune cell development and function. Nat Immunol 9(8):839-845
194. Mattes J, Collison A, Plank M et al (2009) Antagonism of microRNA-126 suppresses the effector function of TH2 cells and the development of allergic airways disease. Proc Natl Acad Sci U S A 106(44):18704-18709
195. Lu TX, Hartner J, Lim EJ et al (2011) MicroRNA-21 limits in vivo immune response-mediated activation of the IL-12/IFNgamma pathway, Th1 polarization, and the severity of delayedtype hypersensitivity. J Immunol 187(6):3362-3373
196. Li QJ, Chau J, Ebert PJ et al (2007) miR-181a is an intrinsic modulator of T cell sensitivity and selection. Cell 129(1):147-161
197. Haas JD, Nistala K, Petermann F et al (2011) Expression of miRNAs miR-133b and miR-206 in the Il17a/f locus is coregulated with IL-17 production in alphabeta and gammadelta T cells. PLoS One 6(5):e20171
198. Pascual M, Suzuki M, Isidoro-Garcia M et al (2011) Epigenetic changes in B lymphocytes associated with house dust mite allergic asthma. Epigenetics 6(9)
199. Breton CV, Byun HM, Wang X et al (2011) DNA methylation in the arginase-nitric oxide synthase pathway is associated with exhaled nitric oxide in children with asthma. Am J Respir Crit Care Med 184(2):191-197
200. Isidoro-Garcia M, Sanz C, Garcia-Solaesa Vet al (2011) PTGDR gene in asthma: A functional, genetic, and epigenetic study. Allergy 66(12):1553-1562
201. Steegers-Theunissen RP, Obermann-Borst SA, Kremer D et al (2009) Periconceptional maternal folic acid use of 400 microg per day is related to increased methylation of the IGF2 gene in the very young child. PLoS One 4(11):e7845
202. Waterland RA, Jirtle RL (2004) Early nutrition, epigenetic changes at transposons and imprinted genes, and enhanced susceptibility to adult chronic diseases. Nutrition 20(1):63-68
203. Kovacheva VP, Mellott TJ, Davison JM et al (2007) Gestational choline deficiency causes global and Igf2 gene DNA hypermethylation by up-regulation of Dnmt1 expression. J Biol Chem 282(43):31777-31788
204. Waterland RA, Lin JR, Smith CA et al (2006) Post-weaning diet affects genomic imprinting at the insulin-like growth factor 2 (Igf2) locus. Hum Mol Genet 15(5):705-716
205. Dolinoy DC, Huang D, Jirtle RL (2007) Maternal nutrient supplementation counteracts bisphenol A-induced DNA hypomethylation in early development. Proc Natl Acad Sci U S A 104 (32):13056-13061
206. Bromer JG, Zhou Y, Taylor MB et al (2010) Bisphenol-A exposure in utero leads to epigenetic alterations in the developmental programming of uterine estrogen response. FASEB J 24(7):2273-2280
207. Weaver IC, Cervoni N, Champagne FA et al (2004) Epigenetic programming by maternal behavior. Nat Neurosci 7(8):847-854
208. Breton CV, Byun HM, Wenten M et al (2009) Prenatal tobacco smoke exposure affects global and gene-specific DNA methylation. Am J Respir Crit Care Med 180(5):462-467
209. Launay JM, Del Pino M, Chironi G et al (2009) Smoking induces long-lasting effects through a monoamine-oxidase epigenetic regulation. PLoS One 4(11):e7959
210. Donkena KV, Young CY, Tindall DJ (2010) Oxidative stress and DNA methylation in prostate cancer. Obstet Gynecol Int 2010:302051
211. Guerrero-Preston R, Goldman LR, Brebi-Mieville P et al (2010) Global DNA hypomethylation is associated with in utero exposure to cotinine and perfluorinated alkyl compounds. Epigenetics 5(6)
212. Terry MB, Ferris JS, Pilsner R et al (2008) Genomic DNA methylation among women in a multiethnic New York City birth cohort. Cancer Epidemiol Biomarkers Prev 17(9):2306-2310
213. Suter M, Abramovici A, Showalter L et al (2010) In utero tobacco exposure epigenetically modifies placental CYP1A1 expression. Metabolism 59(10):1481-1490
214. Michels KB, Harris HR, Barault L (2011) Birthweight, maternal weight trajectories and global DNA methylation of LINE-1 repetitive elements. PLoS One 6(9):e25254
215. Ito K, Lim S, Caramori G et al (2001) Cigarette smoking reduces histone deacetylase 2 expression, enhances cytokine expression, and inhibits glucocorticoid actions in alveolar macrophages. FASEB J 15(6):1110-1112
216. Vuillermin PJ, Ponsonby AL, Saffery R et al (2009) Microbial exposure, interferon gamma gene demethylation in naive T-cells, and the risk of allergic disease. Allergy 64(3):348-353
217. Brand S, Teich R, Dicke T et al (2011) Epigenetic regulation in murine offspring as a novel mechanism for transmaternal asthma protection induced by microbes. J Allergy Clin Immunol 128 (3):618-625, e611-617
218. Baccarelli A, Wright RO, Bollati V et al (2009) Rapid DNA methylation changes after exposure to traffic particles. Am J Respir Crit Care Med 179(7):572-578
219. Perera F, Tang WY, Herbstman J et al (2009) Relation of DNA methylation of 5′-CpG island of ACSL3 to transplacental exposure to airborne polycyclic aromatic hydrocarbons and childhood asthma. PLoS One 4(2):e4488
220. Liu J, Ballaney M, Al-alem U et al (2008) Combined inhaled diesel exhaust particles and allergen exposure altermethylation of T helper genes and IgE production in vivo. Toxicol Sci 102(1):76-81
221. Nadeau K, McDonald-Hyman C, Noth EM et al (2010) Ambient air pollution impairs regulatory T-cell function in asthma. J Allergy Clin Immunol 126(4):845-852, e810
222. Ji H, Khurana Hershey GK (2012) Genetic and epigenetic influence on the response to environmental particulate matter. J Allergy Clin Immunol 129(1):33-41
223. Schalkwyk LC, Meaburn EL, Smith R et al (2010) Allelic skewing of DNA methylation is widespread across the genome. Am J Hum Genet 86(2):196-212
224. Kerkel K, Spadola A, Yuan E et al (2008) Genomic surveys by methylation-sensitive SNP analysis identify sequence-dependent allele-specific DNA methylation. Nat Genet 40(7):904-908
225. Zhang D, Cheng L, Badner JA et al (2010) Genetic control of individual differences in gene-specific methylation in human brain. Am J Hum Genet 86(3):411-419
226. Feinberg AP, Ohlsson R, Henikoff S (2006) The epigenetic progenitor origin of human cancer. Nat Rev Genet 7(1):21-33
227. Munthe-Kaas MC, Torjussen TM, Gervin K et al (2010) CD14 polymorphisms and serum CD14 levels through childhood: A role for gene methylation? J Allergy Clin Immunol 125(6):1361-1368
228. Friso S, Choi SW, Girelli D et al (2002) A common mutation in the 5,10-methylenetetrahydrofolate reductase gene affects genomic DNA methylation through an interaction with folate status. Proc Natl Acad Sci U S A 99(8):5606-5611