Periconceptional maternal folic acid use of 400 μg per day is related to increased methylation of the IGF2 gene in the very young child

PLoS ONE

Volumn 4, Issue 11, 2009, Pages

  Steegers Theunissen, Régine P ^a   Obermann Borst, Sylvia A ^a   Kremer, Dennis ^b   Lindemans, Jan ^a   Siebel, Cissy ^c   Steegers, Eric A ^a   Slagboom, P Eline ^b   Heijman, Bastiaan T ^b  

^a ERASMUS MEDICAL CENTER   (Netherlands)

^b LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^c Child Health Care Center CAREYN   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

FOLIC ACID; S ADENOSYLMETHIONINE; SOMATOMEDIN B; S ADENOSYLHOMOCYSTEINE;

AMINO ACID BLOOD LEVEL; ARTICLE; BIRTH WEIGHT; CHILD; CONTROLLED STUDY; CPG ISLAND; DNA METHYLATION; EPIGENETICS; FEMALE; HUMAN; MALE; MASS SPECTROMETRY; PRENATAL DEVELOPMENT; PRENATAL GROWTH; ADULT; BIOSYNTHESIS; BLOOD; CROSS-SECTIONAL STUDY; GENE EXPRESSION REGULATION; GENETIC EPIGENESIS; GENETICS; INFANT; MATERNAL CARE; PREGNANCY;

ADULT; BIRTH WEIGHT; CPG ISLANDS; CROSS-SECTIONAL STUDIES; DNA METHYLATION; EPIGENESIS, GENETIC; FEMALE; FOLIC ACID; GENE EXPRESSION REGULATION; HUMANS; INFANT; INSULIN-LIKE GROWTH FACTOR II; MALE; PRECONCEPTION CARE; PREGNANCY; S-ADENOSYLHOMOCYSTEINE; S-ADENOSYLMETHIONINE;

EID: 70649097099     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0007845     Document Type: Article

References (34)

1. Lumley J, Watson L, Watson M, Bower C (2001) Modelling the potential impact of population-wide periconceptional folate/multivitamin supplementation on multiple births. BJOG 108: 937-942.
2. CDC (1992) Recommendations for the use of folic acid to reduce the number of cases of spina bifida and other neural tube defects. MMWR Recomm Rep 41: 1-7.
3. Honein MA, Paulozzi LJ, Mathews TJ, Erickson JD, Wong LY (2001) Impact of folic acid fortification of the US food supply on the occurrence of neural tube defects. JAMA 285: 2981-2986.
4. Godwin KA, Sibbald B, Bedard T, Kuzeljevic B, Lowry RB, et al. (2008) Changes in frequencies of select congenital anomalies since the onset of folic acid fortification in a Canadian birth defect registry. Can J Public Health 99: 271-275.
5. Ray JG, Meier C, Vermeulen MJ, Wyatt PR, Cole DE (2003) Association between folic acid food fortification and congenital orofacial clefts. J Pediatr 143: 805-807.
6. Sayed AR, Bourne D, Pattinson R, Nixon J, Henderson B (2008) Decline in the prevalence of neural tube defects following folic acid fortification and its cost-benefit in South Africa. Birth Defects Res A Clin Mol Teratol 82: 211-216.
7. De Wals P, Rusen ID, Lee NS, Morin P, Niyonsenga T (2003) Trend in prevalence of neural tube defects in Quebec. Birth Defects Res A Clin Mol Teratol 67: 919-923.
8. Roberfroid D, Huybregts L, Lanou H, Henry MC, Meda N, et al. (2008) Effects of maternal multiple micronutrient supplementation on fetal growth: a double-blind randomized controlled trial in rural Burkina Faso. Am J Clin Nutr 88: 1330-1340.
9. Trollmann R, Strehl E, Maier-Brandt B, Drexler S, Dorr HG (1996) Effects of GnRH analogues in the treatment of precocious puberty in children with myelomeningocele - preliminary results. Eur J Pediatr Surg 6 Suppl 1: 42-43.
10. Smith AD, Kim YI, Refsum H (2008) Is folic acid good for everyone? Am J Clin Nutr 87: 517-533.
11. Yajnik CS, Deshmukh US (2008) Maternal nutrition, intrauterine programming and consequential risks in the offspring. Rev Endocr Metab Disord 9: 203-211.
12. Gluckman PD, Hanson MA, Cooper C, Thornburg KL (2008) Effect of in utero and early-life conditions on adult health and disease. N Engl J Med 359: 61-73.
13. Sinclair KD, Lea RG, Rees WD, Young LE (2007) The developmental origins of health and disease: current theories and epigenetic mechanisms. Soc Reprod Fertil Suppl 64: 425-443.
14. Jaenisch R, Bird A (2003) Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals. Nat Genet 33 Suppl: 245-254.
15. Yi P, Melnyk S, Pogribna M, Pogribny IP, Hine RJ, et al. (2000) Increase in plasma homocysteine associated with parallel increases in plasma S-adenosylhomocysteine and lymphocyte DNA hypomethylation. J Biol Chem 275: 29318-29323.
16. Friso S, Choi SW (2002) Gene-nutrient interactions and DNA methylation. J Nutr 132: 2382S-2387S.
17. Waterland RA (2003) Do maternal methyl supplements in mice affect DNA methylation of offspring? J Nutr 133: 238; author reply 239.
18. Heijmans BT, Tobi EW, Stein AD, Putter H, Blauw GJ, et al. (2008) Persistent epigenetic differences associated with prenatal exposure to famine in humans. Proc Natl Acad Sci U S A 105: 17046-17049.
19. Gluckman PD, Pinal CS (2003) Regulation of fetal growth by the somatotrophic axis. J Nutr 133: 1741S-1746S.
20. Cui H, Cruz-Correa M, Giardiello FM, Hutcheon DF, Kafonek DR, et al. (2003) Loss of IGF2 imprinting: a potential marker of colorectal cancer risk. Science 299: 1753-1755.
21. Heijmans BT, Kremer D, Tobi EW, Boomsma DI, Slagboom PE (2007) Heritable rather than age-related environmental and stochastic factors dominate variation in DNA methylation of the human IGF2/H19 locus. Hum Mol Genet 16: 547-554.
22. Sinclair KD, Allegrucci C, Singh R, Gardner DS, Sebastian S, et al. (2008) DNA methylation, insulin resistance, and blood pressure in offspring determined by maternal periconceptional B vitamin and methionine status. Proc Natl Acad Sci USA 104: 19351-19356.
23. Waterland RA, Dolinoy DC, Lin JR, Smith CA, Shi X, et al. (2006) Maternal methyl supplements increase offspring DNA methylation at Axin Fused. Genesis 44: 401-406.
24. Lillycrop KA, Phillips ES, Torrens C, Hanson MA, Jackson AA, et al. (2008) Feeding pregnant rats a protein-restricted diet persistently alters the methylation of specific cytosines in the hepatic PPAR alpha promoter of the offspring. Br J Nutr 100: 278-282.
25. Eggenschwiler J, Ludwig T, Fisher P, Leighton PA, Tilghman SM, et al. (1997) Mouse mutant embryos overexpressing IGF-II exhibit phenotypic features of the Beckwith-Wiedemann and Simpson-Golabi-Behmel syndromes. Genes Dev 11: 3128-3142.
26. Arosio M, Cortelazzi D, Persani L, Palmieri E, Casati G, et al. (1995) Circulating levels of growth hormone, insulin-like growth factor-I and prolactin in normal, growth retarded and anencephalic human fetuses. J Endocrinol Invest 18: 346-353.
27. DeBaun MR, Niemitz EL, McNeil DE, Brandenburg SA, Lee MP, et al. (2002) Epigenetic alterations of H19 and LIT1 distinguish patients with Beckwith-Wiedemann syndrome with cancer and birth defects. Am J Hum Genet 70: 604-611.
28. Mason JB, Dickstein A, Jacques PF, Haggarty P, Selhub J, et al. (2007) A temporal association between folic acid fortification and an increase in colorectal cancer rates may be illuminating important biological principles: a hypothesis. Cancer Epidemiol Biomarkers Prev 16: 1325-1329.
29. Scholl TO, Hediger ML, Schall JI, Khoo CS, Fischer RL (1996) Dietary and serum folate: their influence on the outcome of pregnancy. Am J Clin Nutr 63: 520-525.
30. Fawzi WW, Msamanga GI, Urassa W, Hertzmark E, Petraro P, et al. (2007) Vitamins and perinatal outcomes among HIV-negative women in Tanzania. N Engl J Med 356: 1423-1431.
31. Nurk E, Tell GS, Vollset SE, Nygard O, Refsum H, et al. (2004) Changes in lifestyle and plasma total homocysteine: the Hordaland Homocysteine Study. Am J Clin Nutr 79: 812-819.
32. Willet W (1998) Nature of variation in diet. In: Willet W, ed. Nutritional epidemiology. 2nd ed. New York: Oxford University Press. pp 38-50.
33. Verkleij-Hagoort AC, Verlinde M, Ursem NT, Lindemans J, Helbing WA, et al. (2006) Maternal hyperhomocysteinaemia is a risk factor for congenital heart disease. BJOG 113: 1412-1418.
34. van Driel LM, de Jonge R, Helbing WA, van Zelst BD, Ottenkamp J, et al. (2008) Maternal global methylation status and risk of congenital heart diseases. Obstet Gynecol 112: 277-283.