Genetics of food allergy

Current Opinion in Pediatrics

Volumn 21, Issue 6, 2009, Pages 770-776

  Hong, Xiumei ^a   Tsai, Hui Ju ^a   Wang, Xiaobin ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

Author keywords

Allergic diseases; Food allergy; Genetics

Indexed keywords

CD45 ANTIGEN; INTERLEUKIN 10; INTERLEUKIN 13; MAJOR HISTOCOMPATIBILITY ANTIGEN; SERINE PROTEINASE INHIBITOR; STAT6 PROTEIN; TRANSCRIPTION FACTOR FOXP3;

ASTHMA; ATOPIC DERMATITIS; DISEASE SEVERITY; EPIGENETICS; FOOD ALLERGY; GENE LOCUS; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC VARIABILITY; GENETICS; GENOTYPE ENVIRONMENT INTERACTION; HEREDITY; HERITABILITY; HUMAN; INCIDENCE; MAJOR HISTOCOMPATIBILITY COMPLEX; PEANUT ALLERGY; PRIORITY JOURNAL; REVIEW; RISK FACTOR;

CHILD; FOOD HYPERSENSITIVITY; GENETIC PREDISPOSITION TO DISEASE; HUMANS; POLYMORPHISM, SINGLE NUCLEOTIDE;

EID: 74549141403     PISSN: 10408703     EISSN: None     Source Type: Journal    
DOI: 10.1097/MOP.0b013e32833252dc     Document Type: Review

References (86)

1. Sampson HA. Update on food allergy. J Allergy Clin Immunol 2004; 113: 805-819; quiz 820.
2. Gupta R, Sheikh A, Strachan DP, Anderson HR. Time trends in allergic disorders in the UK. Thorax 2007; 62:91-96.
3. Bock SA. Prospective appraisal of complaints of adverse reactions to foods in children during the first 3 years of life. Pediatrics 1987; 79:683-688.
4. Sicherer SH, Sampson HA. Food allergy. J Allergy Clin Immunol 2006; 117: S470-475.
5. Vierk KA, Koehler KM, Fein SB, Street DA. Prevalence of self-reported food allergy in American adults and use of food labels. J Allergy Clin Immunol 2007; 119:1504-1510.
6. Ninan TK, Russell G. Respiratory symptoms and atopy in Aberdeen schoolchildren: evidence from two surveys 25 years apart. BMJ 1992; 304:873-875.
7. Peat JK, van den Berg RH, Green WF, et al. Changing prevalence of asthma in Australian children. BMJ 1994; 308:1591-1596.
8. Sears MR, Holdaway MD, Flannery EM, et al. Parental and neonatal risk factors for atopy, airway hyper-responsiveness, and asthma. Arch Dis Child 1996; 75:392-398.
9. Sicherer SH. Clinical update on peanut allergy. Ann Allergy Asthma Immunol 2002; 88:350-361; quiz 361-362, 394.
10. Grundy J, Matthews S, Bateman B, et al. Rising prevalence of allergy to peanut in children: data from 2 sequential cohorts. J Allergy Clin Immunol 2002; 110:784-789.
11. Bjorksten B. Genetic and environmental risk factors for the development of food allergy. Curr Opin Allergy Clin Immunol 2005; 5:249-253.
12. Lack G. Epidemiologic risks for food allergy. J Allergy Clin Immunol 2008; 121:1331-1336.
13. Rona RJ, Keil T, Summers C, et al. The prevalence of food allergy: a metaanalysis. J Allergy Clin Immunol 2007; 120:638-646.
14. Martelli A, Bouygue GR, Isoardi P, et al. Oral food challenges in children in Italy. Allergy 2005; 60:907-911.
15. Sporik R, Hill DJ, Hosking CS. Specificity of allergen skin testing in predicting positive open food challenges to milk, egg and peanut in children. Clin Exp Allergy 2000; 30:1540-1546.
16. Muraro A, Dreborg S, Halken S, et al. Dietary prevention of allergic diseases in infants and small children. Part III: Critical review of published peer-reviewed observational and interventional studies and final recommendations. Pediatr Allergy Immunol 2004; 15:291-307.
17. Venter C, Pereira B, Grundy J, et al. Incidence of parentally reported and clinically diagnosed food hypersensitivity in the first year of life. J Allergy Clin Immunol 2006; 117:1118-1124.
18. Sampson HA. Utility of food-specific IgE concentrations in predicting symptomatic food allergy. J Allergy Clin Immunol 2001; 107:891-896.
19. Boyano Martinez T, Garcia-Ara C, Diaz-Pena JM, et al. Validity of specific IgE antibodies in children with egg allergy. Clin Exp Allergy 2001; 31:1464-1469.
20. Garcia-Ara C, Boyano-Martinez T, Diaz-Pena JM, et al. Specific IgE levels in the diagnosis of immediate hypersensitivity to cows' milk protein in the infant. J Allergy Clin Immunol 2001; 107:185-190.
21. Clark AT, Ewan PW. Interpretation of tests for nut allergy in one thousand patients, in relation to allergy or tolerance. Clin Exp Allergy 2003; 33:1041-1045.
22. Perry TT, Matsui EC, Kay Conover-Walker M, Wood RA. The relationship of allergen-specific IgE levels and oral food challenge outcome. J Allergy Clin Immunol 2004; 114:144-149.
23. Verstege A, Mehl A, Rolinck-Werninghaus C, et al. The predictive value of the skin prick test weal size for the outcome of oral food challenges. Clin Exp Allergy 2005; 35:1220-1226. (Pubitemid 43919469)
24. Ridout S, Matthews S, Gant C, et al. The diagnosis of Brazil nut allergy using history, skin prick tests, serum-specific immunoglobulin E and food challenges. Clin Exp Allergy 2006; 36:226-232.
25. Hourihane JO, Warner JO. Allergy to peanut. Lancet 1996; 348:1523.
26. Hourihane JO, Dean TP, Warner JO. Peanut allergy in relation to heredity, maternal diet, and other atopic diseases: results of a questionnaire survey, skin prick testing, and food challenges. BMJ 1996; 313:518-521.
27. Crespo JF, James JM, Fernandez-Rodriguez C, Rodriguez J. Food allergy: nuts and tree nuts. Br J Nutr 2006; 96 (Suppl 2):S95-S102.
28. Tsai HJ, Kumar R, Pongracic J, et al. Familial aggregation of food allergy and sensitization to food allergens: a family-based study. Clin Exp Allergy 2009; 39:101-109.
29. Sicherer SH, Furlong TJ, Maes HH, et al. Genetics of peanut allergy: a twin study. J Allergy Clin Immunol 2000; 106:53-56.
30. Liu X, Zhang SC, Tsai HJ, et al. Genetic and environmental contributions to allergen sensitization in a Chinese twin study. Clin Exp Allergy 2009; 39:991-998.
31. Howell WM, Turner SJ, Hourihane JO, et al. HLA class II Drb1, Dqb1 and Dpb1 genotypic associations with peanut allergy: evidence from a familybased and case-control study. Clin Exp Allergy 1998; 28:156-162.
32. Senechal H, Geny S, Desvaux FX, et al. Genetics and specific immune response in allergy to birch pollen and food: evidence of a strong, positive association between atopy and the HLA class II allele HLA-Dr7. J Allergy Clin Immunol 1999; 104:395-401.
33. Hand S, Darke C, Thompson J, et al. Human leucocyte antigen polymorphisms in nut-allergic patients in South Wales. Clin Exp Allergy 2004; 34:720-724.
34. Shreffler WG, Charlop-Powers Z, Sicherer SH. Lack of association of HLA class II alleles with peanut allergy. Ann Allergy Asthma Immunol 2006; 96:865-869.
35. Woo JG, Assa'ad A, Heizer AB, et al. The-159 C->T polymorphism of CD14 is associated with nonatopic asthma and food allergy. J Allergy Clin Immunol 2003; 112:438-444.
36. Campos E, Shimojo N, Inoue Y, et al. No association of polymorphisms in the 5' region of the CD14 gene and food allergy in a Japanese population. Allergol Int 2007; 56:23-27.
37. Torgerson TR, Linane A, Moes N, et al. Severe food allergy as a variant of IPEX syndrome caused by a deletion in a noncoding region of the FOXP3 gene. Gastroenterology 2007; 132:1705-1717.
38. Takeda K, Tanaka T, Shi W, et al. Essential role of STAT6 in IL-4 signalling. Nature 1996; 380:627-630.
39. Takeda K, Kamanaka M, Tanaka T, et al. Impaired IL-13-mediated functions of macrophages in Stat6-deficient mice. J Immunol 1996; 157:3220-3222.
40. Amoli MM, Hand S, Hajeer AH, et al. Polymorphism in the STAT6 gene encodes risk for nut allergy. Genes Immun 2002; 3:220-224.
41. Negoro T, Orihara K, Irahara T, et al. Influence of SNPs in cytokine-related genes on the severity of food allergy and atopic eczema in children. Pediatr Allergy Immunol 2006; 17:583-590.
42. Chavanas S, Bodemer C, Rochat A, et al. Mutations in SPINK5, encoding a serine protease inhibitor, cause Netherton syndrome. Nat Genet 2000; 25:141-142.
43. Kusunoki T, Okafuji I, Yoshioka T, et al. SPINK5 polymorphism is associated with disease severity and food allergy in children with atopic dermatitis. J Allergy Clin Immunol 2005; 115:636-638.
44. Yilmaz V, Yentur SP, Saruhan-Direskeneli G. IL-12 and IL-10 polymorphisms and their effects on cytokine production. Cytokine 2005; 30:188-194.
45. Turner DM, Williams DM, Sankaran D, et al. An investigation of polymorphism in the interleukin-10 gene promoter. Eur J Immunogenet 1997; 24:1-8.
46. Alberto EJ, Shimojo N, Suzuki Y, et al. IL-10 gene polymorphism, but not TGFbeta1 gene polymorphisms, is associated with food allergy in a Japanese population. Pediatr Allergy Immunol 2008; 19:716-721.
47. Vercelli D. Discovering susceptibility genes for asthma and allergy. Nat Rev Immunol 2008; 8:169-182.
48. Liu X, Beaty TH, Deindl P, et al. Associations between specific serum IgE response and 6 variants within the genes IL4, IL13, and IL4RA in German children: the German Multicenter Atopy study. J Allergy Clin Immunol 2004; 113:489-495.
49. Rhodes HL, Sporik R, Thomas P, et al. Early life risk factors for adult asthma: a birth cohort study of subjects at risk. J Allergy Clin Immunol 2001; 108: 720-725.
50. Rhodes HL, Thomas P, Sporik R, et al. A birth cohort study of subjects at risk of atopy: twenty-two-year follow-up of wheeze and atopic status. Am J Respir Crit Care Med 2002; 165:176-180.
51. Gustafsson D, Sjoberg O, Foucard T. Development of allergies and asthma in infants and young children with atopic dermatitis-a prospective follow-up to 7 years of age. Allergy 2000; 55:240-245.
52. Bosse Y, Hudson TJ. Toward a comprehensive set of asthma susceptibility genes. Annu Rev Med 2007; 58:171-184.
53. Kiyohara C, Tanaka K, Miyake Y. Genetic susceptibility to atopic dermatitis. Allergol Int 2008; 57:39-56.
54. Li A, Hopkin JM. Atopy phenotype in subjects with variants of the beta subunit of the high affinity IgE receptor. Thorax 1997; 52:654-655.
55. Hizawa N, Maeda Y, Konno S, et al. Genetic polymorphisms at FCER1b and PAI-1 and asthma susceptibility. Clin Exp Allergy 2006; 36:872-876.
56. Shirakawa T, Li A, Dubowitz M, et al. Association between atopy and variants of the beta subunit of the high-affinity immunoglobulin E receptor. Nat Genet 1994; 7:125-129.
57. Nagata H, Mutoh H, Kumahara K, et al. Association between nasal allergy and a coding variant of the Fc epsilon RI beta gene Glu237gly in a Japanese population. Hum Genet 2001; 109:262-266.
58. Hill MR, James AL, Faux JA, et al. Fc epsilon RI-beta polymorphism and risk of atopy in a general population sample. BMJ 1995; 311:776-779.
59. Imboden M, Nicod L, Nieters A, et al. The common G-allele of interleukin-18 single-nucleotide polymorphism is a genetic risk factor for atopic asthma. The Sapaldia Cohort study. Clin Exp Allergy 2006; 36:211-218.
60. Kim E, Lee JE, Namkung JH, et al. Association of the single-nucleotide polymorphism and haplotype of the interleukin 18 gene with atopic dermatitis in Koreans. Clin Exp Allergy 2007; 37:865-871.
61. Kruse S, Kuehr J, Moseler M, et al. Polymorphisms in the IL 18 gene are associated with specific sensitization to common allergens and allergic rhinitis. J Allergy Clin Immunol 2003; 111:117-122.
62. Batra J, Sharma SK, Ghosh B. Arylamine N-acetyltransferase gene polymorphisms: markers for atopic asthma, serum IgE and blood eosinophil counts. Pharmacogenomics 2006; 7:673-682.
63. Zielinska E, Niewiarowski W, Bodalski J, et al. Arylamine N-acetyltransferase (Nat2) gene mutations in children with allergic diseases. Clin Pharmacol Ther 1997; 62:635-642.
64. Howard TD, Postma DS, Hawkins GA, et al. Fine mapping of an IgEcontrolling gene on chromosome 2q: analysis of CTLA4 and CD28. J Allergy Clin Immunol 2002; 110:743-751.
65. Jones G, Wu S, Jang N, et al. Polymorphisms within the CTLA4 gene are associated with infant atopic dermatitis. Br J Dermatol 2006; 154:467-471.
66. Chang JC, Liu CA, Chuang H, et al. Gender-limited association of cytotoxic T-lymphocyte antigen-4 (CTLA-4) polymorphism with cord blood IgE levels. Pediatr Allergy Immunol 2004; 15:506-512.
67. Hirschhorn JN, Daly MJ. Genome-wide association studies for common diseases and complex traits. Nat Rev Genet 2005; 6:95-108.
68. Weidinger S, Gieger C, Rodriguez E, et al. Genome-wide scan on total serum IgE levels identifies FCER1a as novel susceptibility locus. PLoS Genet 2008; 4:e1000166.
69. Moffatt MF, Kabesch M, Liang L, et al. Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma. Nature 2007; 448: 470-473.
70. Murphy A, Weiss ST, Lange C. Screening and replication using the same data set: testing strategies for family-based studies in which all probands are affected. PLoS Genet 2008; 4:e1000197.
71. Esparza-Gordillo J, Weidinger S, Folster-Holst R, et al. A common variant on chromosome 11q13 is associated with atopic dermatitis. Nat Genet 2009; 41:596-601.
72. Gudbjartsson DF, Bjornsdottir US, Halapi E, et al. Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction. Nat Genet 2009; 41:342-347.
73. Valdar W, Solberg LC, Gauguier D, et al. Genetic and environmental effects on complex traits in mice. Genetics 2006; 174:959-984.
74. Melen E, Nyberg F, Lindgren CM, et al. Interactions between glutathione Stransferase P1, tumor necrosis factor, and traffic-related air pollution for development of childhood allergic disease. Environ Health Perspect 2008; 116:1077-1084.
75. Gern JE, Reardon CL, Hoffjan S, et al. Effects of dog ownership and genotype on immune development and atopy in infancy. J Allergy Clin Immunol 2004; 113:307-314.
76. Leynaert B, Guilloud-Bataille M, Soussan D, et al. Association between farm exposure and atopy, according to the CD14 C-159T polymorphism. J Allergy Clin Immunol 2006; 118:658-665.
77. Eder W, Klimecki W, Yu L, et al. Opposite effects of CD 14/-260 on serum IgE levels in children raised in different environments. J Allergy Clin Immunol 2005; 116:601-607.
78. Ege MJ, Bieli C, Frei R, et al. Prenatal farm exposure is related to the expression of receptors of the innate immunity and to atopic sensitization in school-age children. J Allergy Clin Immunol 2006; 117:817-823.
79. Simpson A, John SL, Jury F, et al. Endotoxin exposure, CD14, and allergic disease: an interaction between genes and the environment. Am J Respir Crit Care Med 2006; 174:386-392.
80. Kabesch M, Schedel M, Carr D, et al. IL-4/IL-13 pathway genetics strongly influence serum IgE levels and childhood asthma. J Allergy Clin Immunol 2006; 117:269-274.
81. Miller RL, Ho SM. Environmental epigenetics and asthma: current concepts and call for studies. Am J Respir Crit Care Med 2008; 177:567-573.
82. Agarwal S, Rao A. Modulation of chromatin structure regulates cytokine gene expression during T cell differentiation. Immunity 1998; 9:765-775.
83. Lee DU, Agarwal S, Rao A. Th2 lineage commitment and efficient IL-4 production involves extended demethylation of the IL-4 gene. Immunity 2002; 16:649-660.
84. Jones B, Chen J. Inhibition of IFN-gamma transcription by site-specific methylation during T helper cell development. EMBO J 2006; 25:2443-2452.
85. Liu J, Ballaney M, Al-alem U, et al. Combined inhaled diesel exhaust particles and allergen exposure alter methylation of T helper genes and IgE production in vivo. Toxicol Sci 2008; 102:76-81.
86. Su RC, Becker AB, Kozyrskyj AL, Hayglass KT. Epigenetic regulation of established human type 1 versus type 2 cytokine responses. J Allergy Clin Immunol 2008; 121:57e53-63e53.