Targeting metabolism and autophagy in the context of haematologic malignancies

International Journal of Cell Biology

Volumn , Issue , 2012, Pages

  Banerji, Versha ^a,b,c   Gibson, Spencer B ^a,b,c  

^a UNIVERSITY OF MANITOBA   (Canada)

^b UNIVERSITY OF MANITOBA   (Canada)

^c CANCERCARE MANITOBA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

3 METHYLADENINE; ADENYLATE KINASE; ARSENIC TRIOXIDE; BORTEZOMIB; CHLOROQUINE; DOXORUBICIN; EVEROLIMUS; HYDROXYCHLOROQUINE; MAMMALIAN TARGET OF RAPAMYCIN; METFORMIN; RESVERATROL; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND; VORINOSTAT;

ACUTE GRANULOCYTIC LEUKEMIA; ANTINEOPLASTIC ACTIVITY; AUTOPHAGY; CELL METABOLISM; CELL PROLIFERATION; CELL SURVIVAL; CLINICAL TRIAL (TOPIC); DRUG MECHANISM; DRUG POTENTIATION; HEMATOLOGIC MALIGNANCY; HEMATOPOIESIS; HUMAN; METABOLIC STRESS; PRIORITY JOURNAL; PROMYELOCYTIC LEUKEMIA; PROTEIN TARGETING; REGULATORY MECHANISM; REVIEW;

EID: 84864940873     PISSN: 16878876     EISSN: 16878884     Source Type: Journal    
DOI: 10.1155/2012/595976     Document Type: Review

References (104)

1. Glick D., Barth S., Macleod K. F., Autophagy: cellular and molecular mechanisms Journal of Pathology 2010 221 1 3 12
2. Corcelle E. A., Puustinen P., Jttel M., Apoptosis and autophagy: targeting autophagy signalling in cancer cellstrick or treats? FEBS Journal 2009 276 21 6084 6096
3. Thumm M., Isolation of autophagocytosis mutants of Saccharomyces cerevisiae FEBS Letters 1994 349 2 275 280 (Pubitemid 24263277)
4. Tsukada M., Ohsumi Y., Isolation and characterization of autophagy-defective mutants of Saccharomyces cerevisiae FEBS Letters 1993 333 1-2 169 174 (Pubitemid 23306962)
5. Mehrpour M., Esclatine A., Beau I., Codogno P., Overview of macroautophagy regulation in mammalian cells Cell Research 2010 20 7 748 762
6. Di Bartolomeo S., Corazzari M., Nazio F., Oliverio S., Lisi G., Antonioli M., Pagliarini V., Matteoni S., Fuoco C., Giunta L., D'Amelio M., Nardacci R., Romagnoli A., Piacentini M., Cecconi F., Fimia G. M., The dynamic interaction of AMBRA1 with the dynein motor complex regulates mammalian autophagy Journal of Cell Biology 2010 191 1 155 168
7. Liang C., Sir D., Lee S., Ou J. H. J., Jung J. U., Beyond autophagy: the role of UVRAG in membrane trafficking Autophagy 2008 4 6 817 820
8. Tanida I., Autophagy basics Microbiology and Immunology 2011 55 1 1 11
9. Mizushima N., The role of the Atg1/ULK1 complex in autophagy regulation Current Opinion in Cell Biology 2010 22 2 132 139
10. Mizushima N., Levine B., Autophagy in mammalian development and differentiation Nature Cell Biology 2010 12 9 823 830
11. Yi C., Ma M., Ran L., Zheng J., Tong J., Zhu J., Ma C., Sun Y., Zhang S., Feng W., Zhu L., Le Y., Gong X., Yan X., Hong B., Jiang F.-J., Xie Z., Miao D., Deng H., Yu L., Function and molecular mechanism of acetylation in autophagy regulation Science 2012 336 6080 474 477
12. Daz-Troya S., Pérez-Pérez M. E., Florencio F. J., Crespo J. L., The role of TOR in autophagy regulation from yeast to plants and mammals Autophagy 2008 4 7 851 865
13. Sun S. Y., Enhancing perifosine's anticancer efficacy by preventing autophagy Autophagy 2010 6 1 184 185
14. Shaw R. J., LKB1 and AMP-activated protein kinase control of mTOR signalling and growth Acta Physiologica 2009 196 1 65 80
15. Lin S.-Y., Li T. Y., Liu Q., Zhang C., Li X., Chen Y., Zhang S.-M., Lian G., Liu Q., Ruan K., Wang Z., Zhang C.-S., Chien K.-Y., Wu J., Li Q., Han J., Lin S.-C., GSK3-TIP60-ULK1 signaling pathway links growth factor deprivation to autophagy Science 2012 336 6080 477 481
16. Zhang H., Kong X., Kang J., Su J., Li Y., Zhong J., Sun L., Oxidative stress induces parallel autophagy and mitochondria dysfunction in human glioma U251 cells Toxicological Sciences 2009 110 2 376 388
17. Johansen T., Lamark T., Selective autophagy mediated by autophagic adapter proteins Autophagy 2011 7 3 279 296
18. Dice J. F., Chaperone-mediated autophagy Autophagy 2007 3 4 295 299 (Pubitemid 46986334)
19. Kundu M., Lindsten T., Yang C. Y., Wu J., Zhao F., Zhang J., Selak M. A., Ney P. A., Thompson C. B., Ulk1 plays a critical role in the autophagic clearance of mitochondria and ribosomes during reticulocyte maturation Blood 2008 112 4 1493 1502
20. Sandoval H., Thiagarajan P., Dasgupta S. K., Schumacher A., Prchal J. T., Chen M., Wang J., Essential role for Nix in autophagic maturation of erythroid cells Nature 2008 454 7201 232 235 (Pubitemid 351969889)
21. Colosetti P., Puissant A., Robert G., Luciano F., Jacquel A., Gounon P., Cassuto J. P., Auberger P., Autophagy is an important event for megakaryocytic differentiation of the chronic myelogenous leukemia K562 cell line Autophagy 2009 5 8 1092 1098
22. Pua H. H., Dzhagalov I., Chuck M., Mizushima N., He Y. W., A critical role for the autophagy gene Atg5 in T cell survival and proliferation Journal of Experimental Medicine 2007 204 1 25 31 (Pubitemid 46148752)
23. Miller B. C., Zhao Z., Stephenson L. M., Cadwell K., Pua H. H., Lee H. K., Mizushima N., Iwasaki A., He Y. W., Swat W., Virgin H. W., The autophagy gene ATG5 plays an essential role in B lymphocyte development Autophagy 2008 4 3 309 314 (Pubitemid 351458091)
24. Bomken S., Fier K., Heidenreich O., Vormoor J., Understanding the cancer stem cell British Journal of Cancer 2010 103 4 439 445
25. Crowley J. E., Scholz J. L., Quinn W. J. III, Stadanlick J. E., Treml J. F., Treml L. S., Hao Y., Goenka R., O'Neill P. J., Matthews A. H., Parsons R. F., Cancro M. P., Homeostatic control of B lymphocyte subsets Immunologic Research 2008 42 13 75 83
26. Huntly B. J. P., Gilliland D. G., Leukaemia stem cells and the evolution of cancer-stem-cell research Nature Reviews Cancer 2005 5 4 311 321 (Pubitemid 40488636)
27. Mortensen M., Soilleux E. J., Djordjevic G., Tripp R., Lutteropp M., Sadighi-Akha E., Stranks A. J., Glanville J., Knight S., Jacobsen S. E. W., Kranc K. R., Simon A. K., The autophagy protein Atg7 is essential for hematopoietic stem cell maintenance Journal of Experimental Medicine 2011 208 3 455 467
28. Mortensen M., Watson A. S., Simon A. K., Lack of autophagy in the hematopoietic system leads to loss of hematopoietic stem cell function and dysregulated myeloid proliferation Autophagy 2011 7 9 1069 1070
29. Hippert M. M., O'Toole P. S., Thorburn A., Autophagy in cancer: good, bad, or both? Cancer Research 2006 66 19 9349 9351
30. Jin S., White E., Role of autophagy in cancer: management of metabolic stress Autophagy 2007 3 1 28 31 (Pubitemid 46100707)
31. Boya P., Gonzlez-Polo R. A., Casares N., Perfettini J. L., Dessen P., Larochette N., Métivier D., Meley D., Souquere S., Yoshimori T., Pierron G., Codogno P., Kroemer G., Inhibition of macroautophagy triggers apoptosis Molecular and Cellular Biology 2005 25 3 1025 1040 (Pubitemid 40165810)
32. Degenhardt K., Mathew R., Beaudoin B., Bray K., Anderson D., Chen G., Mukherjee C., Shi Y., Gélinas C., Fan Y., Nelson D. A., Jin S., White E., Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis Cancer Cell 2006 10 1 51 64
33. Lum J. J., Bauer D. E., Kong M., Harris M. H., Li C., Lindsten T., Thompson C. B., Growth factor regulation of autophagy and cell survival in the absence of apoptosis Cell 2005 120 2 237 248 (Pubitemid 40174766)
34. Moore M. N., Allen J. I., Somerfield P. J., Autophagy: role in surviving environmental stress Marine Environmental Research 2006 62 supplement 1 S420 S425
35. Wolozin B., Behl C., Mechanisms of neurodegenerative disorders. Part 1: protein aggregates Archives of Neurology 2000 57 6 793 796 (Pubitemid 30397180)
36. Watson A. S., Mortensen M., Simon A. K., Autophagy in the pathogenesis of myelodysplastic syndrome and acute myeloid leukemia Cell Cycle 2011 10 11 1719 1725
37. Green A. S., Chapuis N., Maciel T. T., Willems L., Lambert M., Arnoult C., Boyer O., Bardet V., Park S., Foretz M., Viollet B., Ifrah N., Dreyfus F., Hermine O., Moura I. C., Lacombe C., Mayeux P., Bouscary D., Tamburini J., The LKB1/AMPK signaling pathway has tumor suppressor activity in acute myeloid leukemia through the repression of mTOR-dependent oncogenic mRNA translation Blood 2010 116 20 4262 4273
38. Calabretta B., Salomoni P., Inhibition of autophagy: a new strategy to enhance sensitivity of chronic myeloid leukemia stem cells to tyrosine kinase inhibitors Leukemia and Lymphoma 2011 52 1 54 59
39. Liang X. H., Jackson S., Seaman M., Brown K., Kempkes B., Hibshoosh H., Levine B., Induction of autophagy and inhibition of tumorigenesis by beclin 1 Nature 1999 402 6762 672 676 (Pubitemid 129516338)
40. Yue Z., Jin S., Yang C., Levine A. J., Heintz N., Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor Proceedings of the National Academy of Sciences of the United States of America 2003 100 25 15077 15082 (Pubitemid 37518019)
41. Feng Z., Zhang H., Levine A. J., Jin S., The coordinate regulation of the p53 and mTOR pathways in cells Proceedings of the National Academy of Sciences of the United States of America 2005 102 23 8204 8209 (Pubitemid 40800067)
42. Ding Z. B., Shi Y. H., Zhou J., Qiu S. J., Xu Y., Dai Z., Shi G. M., Wang X. Y., Ke A. W., Wu B., Fan J., Association of autophagy defect with a malignant phenotype and poor prognosis of hepatocellular carcinoma Cancer Research 2008 68 22 9167 9175
43. Fujii S., Mitsunaga S., Yamazaki M., Hasebe T., Ishii G., Kojima M., Kinoshita T., Ueno T., Esumi H., Ochiai A., Autophagy is activated in pancreatic cancer cells and correlates with poor patient outcome Cancer Science 2008 99 9 1813 1819
44. Pirtoli L., Cevenini G., Tini P., Vannini M., Oliveri G., Marsili S., Mourmouras V., Rubino G., Miracco C., The prognostic role of Beclin 1 protein expression in high-grade gliomas Autophagy 2009 5 7 930 936
45. Arico S., Petiot A., Bauvy C., Dubbelhuis P. F., Meijer A. J., Codogno P., Ogier-Denis E., The tumor suppressor PTEN positively regulates macroautophagy by inhibiting the phosphatidylinositol 3-kinase/protein kinase B pathway The Journal of Biological Chemistry 2001 276 38 35243 35246
46. Klionsky D. J., Abeliovich H., Agostinis P., Agrawal D. K., Aliev G., Askew D. S., Baba M., Baehrecke E. H., Bahr B. A., Ballabio A., Bamber B. A., Bassham D. C., Bergamini E., Bi X., Biard-Piechaczyk M., Blum J. S., Bredesen D. E., Brodsky J. L., Brumell J. H., Brunk U. T., Bursch W., Camougrand N., Cebollero E., Cecconi F., Chen Y., Chin L.-S., Choi A., Chu C. T., Chung J., Clarke P. G. H., Clark R. S. B., Clarke S. G., Clavé C., Cleveland J. L., Codogno P., Colombo M. I., Cotomontes A., Cregg J. M., Cuervo A. M., Debnath J., Demarchi F., Dennis P. B., Dennis P. A., Deretic V., Devenish R. J., Di Sano F., Dice J. F., DiFiglia M., Dinesh-Kumar S., Distelhorst C. W., Djavaheri-Mergny M., Dorsey F. C., Drge W., Dron M., Dunn Jr. W. A., Duszenko M., Eissa N. T., Elazar Z., Esclatine A., Eskelinen E.-L., Féss L., Finley K. D., Fuentes J. M., Fueyo J., Fujisaki K., Galliot B., Gao F.-B., Gewirtz D. A., Gibson S. B., Gohla A., Goldberg A. L., Gonzalez R., Gonzlez-Estévez C., Gorski S., Gottlieb R. A., Hussinger D., He Y.-W., Heidenreich K., Hill J. A., Hyer-Hansen M., Hu X., Huang W.-P., Iwasaki A., Jttel M., Jackson W. T., Jiang X., Jin S., Johansen T., Jung J. U., Kadowaki M., Kang C., Kelekar A., Kessel D. H., Kiel J. A. K. W., Hong P. K., Kimchi A., Kinsella T. J., Kiselyov K., Kitamoto K., Knecht E., Komatsu M., Kominami E., Kondo S., Kovcs A. L., Kroemer G., Kuan C.-Y., Kumar R., Kundu M., Landry J., Laporte M., Le W., Lei H.-Y., Lenardo M. J., Levine B., Lieberman A., Lim K.-L., Lin F.-C., Liou W., Liu L. F., Lopez-Berestein G., Lpez-Otn C., Lu B., Macleod K. F., Malorni W., Martinet W., Matsuoka K., Mautner J., Meijer A. J., Meléndez A., Michels P., Miotto G., Mistiaen W. P., Mizushima N., Mograbi B., Monastyrska I., Moore M. N., Moreira P. I., Moriyasu Y., Motyl T., Mnz C., Murphy L. O., Naqvi N. I., Neufeld T. P., Nishino I., Nixon R. A., Noda T., Nrnberg B., Ogawa M., Oleinick N. L., Olsen L. J., Ozpolat B., Paglin S., Palmer G. E., Papassideri I., Parkes M., Perlmutter D. H., Perry G., Piacentini M., Pinkas-Kramarski R., Prescott M., Proikascezanne T., Raben N., Rami A., Reggiori F., Rohrer B., Rubinsztein D. C., Ryan K. M., Sadoshima J., Sakagami H., Sakai Y., Sandri M., Sasakawa C., Sass M., Schneider C., Seglen P. O., Seleverstov O., Settleman J., Shacka J. J., Shapiro I. M., Sibirny A., Silva-Zacarin E. C. M., Simon H.-U., Simone C., Simonsen A., Smith M. A., Spanel-Borowski K., Srinivas V., Steeves M., Stenmark H., Stromhaug P. E., Subauste C. S., Sugimoto S., Sulzer D., Suzuki T., Swanson M. S., Tabas I., Takeshita F., Talbot N. J., Tallczy Z., Tanaka K., Tanaka K., Tanida I., Taylor G. S., Taylor J. P., Terman A., Tettamanti G., Thompson C. B., Thumm M., Tolkovsky A. M., Tooze S. A., Truant R., Tumanovska L. V., Uchiyama Y., Ueno T., Uzctegui N. L., Van Der Klei I., Vaquero E. C., Vellai T., Vogel M. W., Wang H.-G., Webster P., Wiley J. W., Xi Z., Xiao G., Yahalom J., Yang J.-M., Yap G., Yin X.-M., Yoshimori T., Yu L., Yue Z., Yuzaki M., Zabirnyk O., Zheng X., Zhu X., Deter R. L., Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes Autophagy 2008 4 2 151 175 (Pubitemid 351231180)
47. Hoare M., Young A. R. J., Narita M., Autophagy in cancer: having your cake and eating it Seminars in Cancer Biology 2011 21 6 397 404
48. Henson E. S., Johnston J. B., Gibson S. B., The role of TRAIL death receptors in the treatment of hematological malignancies Leukemia and Lymphoma 2008 49 1 27 35 (Pubitemid 351146879)
49. Fulda S., Cell death in hematological tumors Apoptosis 2009 14 4 409 423
50. Adam-Vizi V., Chinopoulos C., Bioenergetics and the formation of mitochondrial reactive oxygen species Trends in Pharmacological Sciences 2006 27 12 639 645 (Pubitemid 44767940)
51. Chen Y., Gibson S. B., Is mitochondrial generation of reactive oxygen species a trigger for autophagy? Autophagy 2008 4 2 246 248 (Pubitemid 351231192)
52. Lambeth J. D., Nox enzymes, ROS, and chronic disease: an example of antagonistic pleiotropy Free Radical Biology and Medicine 2007 43 3 332 347 (Pubitemid 46992767)
53. Fruehauf J. P., Meyskens F. L., Reactive oxygen species: a breath of life or death? Clinical Cancer Research 2007 13 3 789 794 (Pubitemid 46340350)
54. Simon H. U., Haj-Yehia A., Levi-Schaffer F., Role of reactive oxygen species (ROS) in apoptosis induction Apoptosis 2000 5 5 415 418 (Pubitemid 32162623)
55. Lyu B. N., Ismailov S. B., Ismailov B., Lyu M. B., Mitochondrial concept of leukemogenesis: key role of oxygen-peroxide effects Theoretical Biology and Medical Modelling 2008 5, article 23
56. Ohsumi Y., Molecular dissection of autophagy: two ubiquitin-like systems Nature Reviews Molecular Cell Biology 2001 2 3 211 216 (Pubitemid 33675746)
57. Scherz-Shouval R., Shvets E., Fass E., Shorer H., Gil L., Elazar Z., Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4 The EMBO Journal 2007 26 7 1749 1760 (Pubitemid 46624042)
58. Yu L., Wan F., Dutta S., Welsh S., Liu Z., Freundt E., Baehrecke E. H., Lenardo M., Autophagic programmed cell death by selective catalase degradation Proceedings of the National Academy of Sciences of the United States of America 2006 103 13 4952 4957
59. Storz G., Polla B. S., Transcriptional regulators of oxidative stress-inducible genes in prokaryotes and eukaryotes EXS 1996 77 239 254
60. Li J., Liu R., Lei Y., Wang K., Lau Q. C., Xie N., Zhou S., Nie C., Chen L., Wei Y., Huang C., Proteomic analysis revealed association of aberrant ROS signaling with suberoylanilide hydroxamic acid-induced autophagy in jurkat T-leukemia cells Autophagy 2010 6 6 711 724
61. Wallington-Beddoe C. T., Hewson J., Bradstock K. F., Bendall L. J., FTY720 produces caspase-independent cell death of acute lymphoblastic leukemia cells Autophagy 2011 7 7 707 715
62. Ghavami S., Asoodeh A., Klonisch T., Halayko A. J., Kadkhoda K., Kroczak T. J., Gibson S. B., Booy E. P., Naderi-Manesh H., Los M., Brevinin-2R1 semi-selectively kills cancer cells by a distinct mechanism, which involves the lysosomal-mitochondrial death pathway Journal of Cellular and Molecular Medicine 2008 12 3 1005 1022 (Pubitemid 351718078)
63. Itoh T., Ohguchi K., Nozawa Y., Akao Y., Intracellular glutathione regulates sesquiterpene lactone-induced conversion of autophagy to apoptosis in human leukemia HL60 cells Anticancer Research 2009 29 4 1449 1457
64. Itoh T., Ito Y., Ohguchi K., Ohyama M., Iinuma M., Otsuki Y., Nozawa Y., Akao Y., Eupalinin A isolated from Eupatorium chinense L. induces autophagocytosis in human leukemia HL60 cells Bioorganic and Medicinal Chemistry 2008 16 2 721 731 (Pubitemid 351163064)
65. Lozy F., Karantza V., Autophagy and cancer cell metabolism Seminars in Cell and Developmental Biology 2012 23 4 395 401
66. Yuneva M., Zamboni N., Oefner P., Sachidanandam R., Lazebnik Y., Deficiency in glutamine but not glucose induces MYC-dependent apoptosis in human cells Journal of Cell Biology 2007 178 1 93 105 (Pubitemid 47026405)
67. Eng C. H., Abraham R. T., Glutaminolysis yields a metabolic by-product that stimulates autophagy Autophagy 2010 6 7 968 970
68. Sommermann T. G., Mack H. I. D., Cahir-McFarland E., Autophagy prolongs survival after NF B inhibition in B-cell lymphomas Autophagy 2012 8 2 252 264
69. Lo Re A. E., Fernandez-Barrena M. G., Almada L. L., A novel AKT1-GLI3-VMP1 pathway mediates KRAS-induced autophagy in cancer cells. The Journal of Biological Chemistry. In press
70. White E., Deconvoluting the context-dependent role for autophagy in cancer Nature Reviews Cancer 2012 12 6 401 410
71. Bensaad K., Cheung E. C., Vousden K. H., Modulation of intracellular ROS levels by TIGAR controls autophagy The EMBO Journal 2009 28 19 3015 3026
72. Tasdemir E., Maiuri M. C., Morselli E., Criollo A., D'Amelio M., Djavaheri-Mergny M., Cecconi F., Tavernarakis N., Kroemer G., A dual role of p53 in the control of autophagy Autophagy 2008 4 6 810 814
73. Budanov A. V., Lee J. H., Karin M., Stressin' Sestrins take an aging fight EMBO Molecular Medicine 2010 2 10 388 400
74. Pani G., Galeotti T., Role of MnSOD and p66shc in mitochondrial response to p53 Antioxidants and Redox Signaling 2011 15 6 1715 1727
75. Bensaad K., Tsuruta A., Selak M. A., Vidal M. N. C., Nakano K., Bartrons R., Gottlieb E., Vousden K. H., TIGAR, a p53-inducible regulator of glycolysis and apoptosis Cell 2006 126 1 107 120 (Pubitemid 44040989)
76. Hu W., Zhang C., Wu R., Sun Y., Levine A., Feng Z., Glutaminase 2, a novel p53 target gene regulating energy metabolism and antioxidant function Proceedings of the National Academy of Sciences of the United States of America 2010 107 16 7455 7460
77. Suzuki S., Tanaka T., Poyurovsky M. V., Nagano H., Mayama T., Ohkubo S., Lokshin M., Hosokawa H., Nakayama T., Suzuki Y., Sugano S., Sato E., Nagao T., Yokote K., Tatsuno I., Prives C., Phosphate-activated glutaminase (GLS2), a p53-inducible regulator of glutamine metabolism and reactive oxygen species Proceedings of the National Academy of Sciences of the United States of America 2010 107 16 7461 7466
78. Budanov A. V., Karin M., p53 target genes sestrin1 and sestrin2 connect genotoxic stress and mTOR signaling Cell 2008 134 3 451 460
79. Tasdemir E., Maiuri M. C., Galluzzi L., Vitale I., Djavaheri-Mergny M., D'Amelio M., Criollo A., Morselli E., Zhu C., Harper F., Nannmark U., Samara C., Pinton P., Vicencio J. M., Carnuccio R., Moll U. M., Madeo F., Paterlini-Brechot P., Rizzuto R., Szabadkai G., Pierron G., Blomgren K., Tavernarakis N., Codogno P., Cecconi F., Kroemer G., Regulation of autophagy by cytoplasmic p53 Nature Cell Biology 2008 10 6 676 687 (Pubitemid 351772933)
80. Lai K. P., Leong W. F., Chau J. F. L., Jia D., Zeng L., Liu H., He L., Hao A., Zhang H., Meek D., Velagapudi C., Habib S. L., Li B., S6K1 is a multifaceted regulator of Mdm2 that connects nutrient status and DNA damage response The EMBO Journal 2010 29 17 2994 3006
81. Livesey K. M., Kang R., Vernon P., Buchser W., Loughran P., Watkins S. C., Zhang L., Manfredi J. J., Zeh III H. J., Li L., Lotze M. T., Tang D., p53/HMGB1 complexes regulate autophagy and apoptosis Cancer Research 2012 72 8 1996 2005
82. Liu J., Xia H., Kim M., Xu L., Li Y., Zhang L., Cai Y., Norberg H. V., Zhang T., Furuya T., Jin M., Zhu Z., Wang H., Yu J., Li Y., Hao Y., Choi A., Ke H., Ma D., Yuan J., Beclin1 controls the levels of p53 by regulating the deubiquitination activity of USP10 and USP13 Cell 2011 147 1 223 234
83. Maiuri M. C., Galluzzi L., Morselli E., Kepp O., Malik S. A., Kroemer G., Autophagy regulation by p53 Current Opinion in Cell Biology 2010 22 2 181 185
84. Mathew R., White E., Autophagy, stress, and cancer metabolism: what doesn't kill you makes you stronger Cold Spring Harbor Symposia on Quantitative Biology 2011 76 389 396
85. Amaravadi R. K., Lippincott-Schwartz J., Yin X. M., Weiss W. A., Takebe N., Timmer W., DiPaola R. S., Lotze M. T., White E., Principles and current strategies for targeting autophagy for cancer treatment Clinical Cancer Research 2011 17 4 654 666
86. White E., DiPaola R. S., The double-edged sword of autophagy modulation in cancer Clinical Cancer Research 2009 15 17 5308 5316
87. Amaravadi R. K., Yu D., Lum J. J., Bui T., Christophorou M. A., Evan G. I., Thomas-Tikhonenko A., Thompson C. B., Autophagy inhibition enhances therapy-induced apoptosis in a Myc-induced model of lymphoma The Journal of Clinical Investigation 2007 117 2 326 336 (Pubitemid 46203961)
88. Maclean K. H., Dorsey F. C., Cleveland J. L., Kastan M. B., Targeting lysosomal degradation induces p53-dependent cell death and prevents cancer in mouse models of lymphomagenesis The Journal of Clinical Investigation 2008 118 1 79 88
89. Goussetis D. J., Altman J. K., Glaser H., McNeer J. L., Tallman M. S., Platanias L. C., Autophagy is a critical mechanism for the induction of the antileukemic effects of arsenic trioxide The Journal of Biological Chemistry 2010 285 39 29989 29997
90. Qian W., Liu J., Jin J., Ni W., Xu W., Arsenic trioxide induces not only apoptosis but also autophagic cell death in leukemia cell lines via up-regulation of Beclin-1 Leukemia Research 2007 31 3 329 339 (Pubitemid 46073178)
91. Charoensuk V., Gati W. P., Weinfeld M., Le X. C., Differential cytotoxic effects of arsenic compounds in human acute promyelocytic leukemia cells Toxicology and Applied Pharmacology 2009 239 1 64 70
92. Isakson P., Bjrs M., Be S. O., Simonsen A., Autophagy contributes to therapy-induced degradation of the PML/RARA oncoprotein Blood 2010 116 13 2324 2331
93. Chiarini F., Grimaldi C., Ricci F., Tazzari P. L., Evangelisti C., Ognibene A., Battistelli M., Falcieri E., Melchionda F., Pession A., Pagliaro P., McCubrey J. A., Martelli A. M., Activity of the novel dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor NVP-BEZ235 against T-cell acute lymphoblastic leukemia Cancer Research 2010 70 20 8097 8107
94. Crazzolara R., Bradstock K. F., Bendall L. J., RAD001 (everolimus) induces autophagy in acute lymphoblastic leukemia Autophagy 2009 5 5 727 728
95. Crazzolara R., Cisterne A., Thien M., Hewson J., Baraz R., Bradstock K. F., Bendall L. J., Potentiating effects of RAD001 (Everolimus) on vincristine therapy in childhood acute lymphoblastic leukemia Blood 2009 113 14 3297 3306
96. Puissant A., Auberger P., AMPK- and p62/SQSTM1-dependent autophagy mediate resveratrol-induced cell death in chronic myelogenous leukemia Autophagy 2010 6 5 655 657
97. Puissant A., Robert G., Auberger P., Targeting autophagy to fight hematopoietic malignancies Cell Cycle 2010 9 17 3470 3478
98. Carew J. S., Nawrocki S. T., Giles F. J., Cleveland J. L., Targeting autophagy: a novel anticancer strategy with therapeutic implications for imatinib resistance Biologics 2008 2 2 201 204
99. Carew J. S., Nawrocki S. T., Kahue C. N., Zhang H., Yang C., Chung L., Houghton J. A., Huang P., Giles F. J., Cleveland J. L., Targeting autophagy augments the anticancer activity of the histone deacetylase inhibitor SAHAto overcome Bcr-Abl-mediated drug resistance Blood 2007 110 1 313 322 (Pubitemid 47026849)
100. Burns T. A., Luberto C., Sphingolipid metabolism and leukemia: a potential for novel therapeutic approaches Anti-Cancer Agents in Medicinal Chemistry 2011 11 9 863 881
101. Grandér D., Kharaziha P., Laane E., Pokrovskaja K., Panaretakis T., Autophagy as the main means of cytotoxicity by glucocorticoids in hematological malignancies Autophagy 2009 5 8 1198 1200
102. Tomic T., Botton T., Cerezo M., Robert G., Luciano F., Puissant A., Gounon P., Allegra M., Bertolotto C., Bereder J.-M., Tartare-Deckert S., Bahadoran P., Auberger P., Ballotti R., Rocchi S., Metformin inhibits melanoma development through autophagy and apoptosis mechanisms Cell Death and Disease 2011 2 9, article e199
103. Shi W.-Y., Xiao D., Wang L., Dong L.-H., Yan Z.-X., Shen Z.-X., Chen S.-J., Chen Y., Zhao W.-L., Therapeutic metformin/AMPK activation blocked lymphoma cell growth via inhibition of mTOR pathway and induction of autophagy Cell Death and Disease 2012 3 3, article e275
104. Grimaldi C., Chiarini F., Tabellini G., Ricci F., Tazzari P. L., Battistelli M., Falcieri E., Bortul R., Melchionda F., Iacobucci I., Pagliaro P., Martinelli G., Pession A., Barata J. T., McCubrey J. A., Martelli A. M., AMP-dependent kinase/mammalian target of rapamycin complex 1 signaling in T-cell acute lymphoblastic leukemia: therapeutic implications Leukemia 2012 26 1 91 100