Correction: Impact of intravascular hemolysis in malaria on liver dysfunction: Involvement of hepatic free heme overload, NF-κB activation, and neutrophil infiltration (Journal of Biological Chemistry (2012) 287 (26630–26646) DOI: 10.1074/jbc.M112.341255);Impact of intravascular hemolysis in malaria on liver dysfunction: Involvement of hepatic free heme overload, NF-κB activation, and neutrophil infiltration

Journal of Biological Chemistry

Volumn 287, Issue 32, 2012, Pages 26630-26646

  Dey, Sumanta ^a   Bindu, Samik ^a   Goyal, Manish ^a   Pal, Chinmay ^a   Alam, Athar ^a   Iqbal, Mohd Shameel ^a   Kumar, Rahul ^a   Sarkar, Souvik ^a   Bandyopadhyay, Uday ^a  

^a INDIAN INSTITUTE OF CHEMICAL BIOLOGY   (India)

Author keywords

[No Author keywords available]

Indexed keywords

AMINES; BLOOD; CELL ADHESION; CELL DEATH; CHEMICAL ACTIVATION; DISEASES; ELECTROPHORETIC MOBILITY; IRON; MAMMALS; MOLECULES; OXIDANTS;

ANTIOXIDANT PROPERTIES; CHROMATIN IMMUNOPRECIPITATION; ELECTROPHORETIC MOBILITY SHIFT ASSAY; INTERCELLULAR ADHESION MOLECULE-1; MACROPHAGE INFLAMMATORY PROTEINS; NEUTROPHIL INFILTRATION; POSITIVE CORRELATIONS; VASCULAR CELL ADHESION MOLECULE-1;

PORPHYRINS;

ACETYLCYSTEINE; CHEMOATTRACTANT; DEFEROXAMINE; DICHLOROFLUORESCEIN; HEME OXYGENASE 1; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERCELLULAR ADHESION MOLECULE 1; IRON CHELATE; KERATINOCYTE CHEMOATTRACTANT; MACROPHAGE INFLAMMATORY PROTEIN 2; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR ALPHA ANTIBODY; UNCLASSIFIED DRUG; VASCULAR CELL ADHESION MOLECULE 1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; CYTOKINE RELEASE; DEPLETION; DISEASE ASSOCIATION; DISEASE SEVERITY; ENZYME ACTIVITY; FLUORESCENCE; GEL MOBILITY SHIFT ASSAY; INTRAVASCULAR HEMOLYSIS; LEUKOCYTE ADHERENCE; LEUKOCYTE MOTILITY; LIVER CELL; LIVER DYSFUNCTION; LIVER INJURY; LIVER PROTECTION; MALARIA; MALE; MOUSE; NEUTROPHIL CHEMOTAXIS; NEUTROPHIL DEPLETION; NEUTROPHIL EXTRAVASATION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN INTERACTION; TRANSCRIPTION INITIATION; UPREGULATION;

MUS;

EID: 84864543003     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.AAC119.012033     Document Type: Erratum

References (92)

1. Belcher, J. D., Beckman, J. D., Balla, G., Balla, J., and Vercellotti, G. (2010) Heme degradation and vascular injury. Antioxid. Redox Signal. 12, 233-248
2. Kato, G. J., and Taylor, J. G., 6th (2010) Pleiotropic effects of intravascular hemolysis on vascular homeostasis. Br. J. Haematol. 148, 690-701
3. Woollard, K. J., Sturgeon, S., Chin-Dusting, J. P., Salem, H. H., and Jackson, S. P. (2009) Erythrocyte hemolysis and hemoglobin oxidation promote ferric chloride-induced vascular injury. J. Biol. Chem. 284, 13110-13118
4. Qian, Q., Nath, K. A., Wu, Y., Daoud, T. M., and Sethi, S. (2010) Hemolysis and acute kidney failure. Am. J. Kidney Dis. 56, 780-784
5. Yang, F., Haile, D. J., Berger, F. G., Herbert, D. C., Van Beveren, E., and Ghio, A. J. (2003) Haptoglobin reduces lung injury associated with exposure to blood. Am. J. Physiol. Lung Cell Mol. Physiol. 284, L402-L409 (Pubitemid 36164376)
6. Kato, G. J. (2009) Haptoglobin halts hemoglobin's havoc. J. Clin. Invest. 119, 2140-2142
7. Tolosano, E., Fagoonee, S., Hirsch, E., Berger, F. G., Baumann, H., Silengo, L., and Altruda, F. (2002) Enhanced splenomegaly and severe liver inflammation in haptoglobin/hemopexin double-null mice after acute hemolysis. Blood 100, 4201-4208 (Pubitemid 35402055)
8. Smith, A., and Morgan, W. T. (1981) Hemopexin-mediated transport of heme into isolated rat hepatocytes. J. Biol. Chem. 256, 10902-10909
9. Smith, A., and Morgan, W. T. (1984) Hemopexin-mediated heme uptake by liver. Characterization of the interaction of heme-hemopexin with isolated rabbit liver plasma membranes. J. Biol. Chem. 259, 12049-12053 (Pubitemid 14022137)
10. Pal, C., Kundu, M. K., Bandyopadhyay, U., and Adhikari, S. (2011) Synthesis of novel heme-interacting acridone derivatives to prevent free heme-mediated protein oxidation and degradation. Bioorg. Med. Chem. Lett. 21, 3563-3567
11. Pal, C., and Bandyopadhyay, U. (2012) Redox-active antiparasitic drugs. Antioxid. Redox Signal. 17, 555-582
12. Buehler, P. W., and D'Agnillo, F. (2010) Toxicological consequences of extracellular hemoglobin. Biochemical and physiological perspectives. Antioxid. Redox Signal. 12, 275-291
13. Reeder, B. J., Svistunenko, D. A., Cooper, C. E., and Wilson, M. T. (2004) The radical and redox chemistry of myoglobin and hemoglobin. From in vitro studies to human pathology. Antioxid. Redox Signal. 6, 954-966 (Pubitemid 39434932)
14. Kapralov, A., Vlasova, I. I., Feng, W., Maeda, A., Walson, K., Tyurin, V. A., Huang, Z., Aneja, R. K., Carcillo, J., Bayir, H., and Kagan, V. E. (2009) Peroxidase activity of hemoglobin-haptoglobin complexes. Covalent aggregation and oxidative stress in plasma and macrophages. J. Biol. Chem. 284, 30395-30407
15. Kumar, S., and Bandyopadhyay, U. (2005) Free heme toxicity and its detoxification systems in human. Toxicol. Lett. 157, 175-188 (Pubitemid 40726102)
16. Rother, R. P., Bell, L., Hillmen, P., and Gladwin, M. T. (2005) The clinical sequelae of intravascular hemolysis and extracellular plasma hemoglobin. A novel mechanism of human disease. JAMA 293, 1653-1662 (Pubitemid 40471796)
17. Jeney, V., Balla, J., Yachie, A., Varga, Z., Vercellotti, G. M., Eaton, J. W., and Balla, G. (2002) Pro-oxidant and cytotoxic effects of circulating heme. Blood 100, 879-887 (Pubitemid 34832613)
18. Nagababu, E., and Rifkind, J. M. (2004) Heme degradation by reactive oxygen species. Antioxid. Redox Signal. 6, 967-978 (Pubitemid 39434933)
19. Orino, K., Lehman, L., Tsuji, Y., Ayaki, H., Torti, S. V., and Torti, F. M. (2001) Ferritin and the response to oxidative stress. Biochem. J. 357, 241-247 (Pubitemid 32642922)
20. Ryter, S. W., and Tyrrell, R. M. (2000) The heme synthesis and degradation pathways. Role in oxidant sensitivity. Heme oxygenase has both pro- and antioxidant properties. Free Radic. Biol. Med. 28, 289-309 (Pubitemid 30084022)
21. Balla, J., Vercellotti, G. M., Jeney, V., Yachie, A., Varga, Z., Jacob, H. S., Eaton, J. W., and Balla, G. (2007) Heme, heme oxygenase, and ferritin. How the vascular endothelium survives (and dies) in an iron-rich environment. Antioxid. Redox Signal. 9, 2119-2137 (Pubitemid 350059014)
22. Breman, J. G. (2009) Eradicating malaria. Sci. Prog. 92, 1-38
23. Seixas, E., Gozzelino, R., Chora, A., Ferreira, A., Silva, G., Larsen, R., Rebelo, S., Penido, C., Smith, N. R., Coutinho, A., and Soares, M. P. (2009) Heme oxygenase-1 affords protection against noncerebral forms of severe malaria. Proc. Natl. Acad. Sci. U.S.A. 106, 15837-15842
24. Larkin, D., de Laat, B., Jenkins, P. V., Bunn, J., Craig, A. G., Terraube, V., Preston, R. J., Donkor, C., Grau, G. E., van Mourik, J. A., and O'Donnell, J. S. (2009) Severe Plasmodium falciparum malaria is associated with circulating ultra-large von Willebrand multimers and ADAMTS13 inhibition. PLoS Pathog. 5, e1000349
25. Fendel, R., Brandts, C., Rudat, A., Kreidenweiss, A., Steur, C., Appelmann, I., Ruehe, B., Schröder, P., Berdel, W. E., Kremsner, P. G., and Mordmüller, B. (2010) Hemolysis is associated with low reticulocyte production index and predicts blood transfusion in severe malarial anemia. PLoS ONE 5, e10038
26. Haldar, K., Hiller, N. L., van Ooij, C., and Bhattacharjee, S. (2005) Plasmodium parasite proteins and the infected erythrocyte. Trends Parasitol. 21, 402-403 (Pubitemid 41116713)
27. Francis, S. E., Sullivan, D. J., Jr., and Goldberg, D. E. (1997) Hemoglobin metabolism in the malaria parasite Plasmodium falciparum. Annu. Rev. Microbiol. 51, 97-123 (Pubitemid 27433044)
28. Bandyopadhyay, U., and Dey, S. (2011) in Apicomplexan Parasites (Becker, K., ed) pp. 205-234, Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany
29. Pamplona, A., Ferreira, A., Balla, J., Jeney, V., Balla, G., Epiphanio, S., Chora, A., Rodrigues, C. D., Gregoire, I. P., Cunha-Rodrigues, M., Portugal, S., Soares, M. P., and Mota, M. M. (2007) Heme oxygenase-1 and carbon monoxide suppress the pathogenesis of experimental cerebral malaria. Nat. Med. 13, 703-710 (Pubitemid 46889755)
30. Buffet, P. A., Safeukui, I., Deplaine, G., Brousse, V., Prendki, V., Thellier, M., Turner, G. D., and Mercereau-Puijalon, O. (2011) The pathogenesis of Plasmodium falciparum malaria in humans: insights from splenic physiology. Blood 117, 381-392
31. Haldar, K., Murphy, S. C., Milner, D. A., and Taylor, T. E. (2007) Malaria. Mechanisms of erythrocytic infection and pathological correlates of severe disease. Annu. Rev. Pathol. 2, 217-249 (Pubitemid 46448065)
32. Postma, N. S., Mommers, E. C., Eling, W. M., and Zuidema, J. (1996) Oxidative stress in malaria; implications for prevention and therapy. Pharm. World Sci. 18, 121-129 (Pubitemid 26270457)
33. Orjih, A. U., Banyal, H. S., Chevli, R., and Fitch, C. D. (1981) Hemin lyses malaria parasites. Science 214, 667-669 (Pubitemid 12208587)
34. Porto, B. N., Alves, L. S., Fernández, P. L., Dutra, T. P., Figueiredo, R. T., Graça-Souza, A. V., and Bozza, M. T. (2007) Heme induces neutrophil migration and reactive oxygen species generation through signaling pathways characteristic of chemotactic receptors. J. Biol. Chem. 282, 24430-24436 (Pubitemid 47328067)
35. Guha, M., Kumar, S., Choubey, V., Maity, P., and Bandyopadhyay, U. (2006) Apoptosis in liver during malaria. Role of oxidative stress and implication of mitochondrial pathway. FASEB J. 20, 1224-1226
36. Dey, S., Guha, M., Alam, A., Goyal, M., Bindu, S., Pal, C., Maity, P., Mitra, K., and Bandyopadhyay, U. (2009) Malarial infection develops mitochondrial pathology and mitochondrial oxidative stress to promote hepatocyte apoptosis. Free Radic. Biol. Med. 46, 271-281
37. Farombi, E. O., Shrotriya, S., Na, H. K., Kim, S. H., and Surh, Y. J. (2008) Curcumin attenuates dimethylnitrosamine-induced liver injury in rats through Nrf2-mediated induction of heme oxygenase-1. Food Chem. Toxicol. 46, 1279-1287 (Pubitemid 351258204)
38. Bindu, S., Pal, C., Dey, S., Goyal, M., Alam, A., Iqbal, M. S., Dutta, S., Sarkar, S., Kumar, R., Maity, P., and Bandyopadhyay, U. (2011) Translocation of heme oxygenase-1 to mitochondria is a novel cytoprotective mechanism against nonsteroidal anti-inflammatory drug-induced mitochondrial oxidative stress, apoptosis and gastric mucosal injury. J. Biol. Chem. 286, 39387-39402
39. Gonçalves, L. A., Vigário, A. M., and Penha- Gonçalves, C. (2007) Improved isolation of murine hepatocytes for in vitro malaria liver stage studies. Malar. J. 6, 169
40. Lowry, O. H., Rosebrough, N. J., Farr, A. L., and Randall, R. J. (1951) Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193, 265-275
41. Kim, Y. M., de Vera, M. E., Watkins, S. C., and Billiar, T. R. (1997) Nitric oxide protects cultured rat hepatocytes from tumor necrosis factor-α-induced apoptosis by inducing heat shock protein 70 expression. J. Biol. Chem. 272, 1402-1411 (Pubitemid 27034647)
42. Kalyanaraman, B., Darley-Usmar, V., Davies, K. J., Dennery, P. A., Forman, H. J., Grisham, M. B., Mann, G. E., Moore, K., Roberts, L. J., 2nd, and Ischiropoulos, H. (2012) Measuring reactive oxygen and nitrogen species with fluorescent probes. Challenges and limitations. Free Radic. Biol. Med. 52, 1-6
43. Maity, P., Bindu, S., Dey, S., Goyal, M., Alam, A., Pal, C., Mitra, K., and Bandyopadhyay, U. (2009) Indomethacin, a nonsteroidal anti-inflammatory drug, develops gastropathy by inducing reactive oxygen species-mediated mitochondrial pathology and associated apoptosis in gastric mucosa. Anovel role of mitochondrial aconitase oxidation. J. Biol. Chem. 284, 3058-3068
44. Sajan, M. P., Standaert, M. L., Nimal, S., Varanasi, U., Pastoor, T., Mastorides, S., Braun, U., Leitges, M., and Farese, R. V. (2009) The critical role of atypical protein kinase C in activating hepatic SREBP-1c and NF-κB in obesity. J. Lipid Res. 50, 1133-1145
45. Fouad, D., Siendones, E., Costán, G., and Muntané, J. (2004) Role of NF-κB activation and nitric oxide expression during PGE protection against D-galactosamine-induced cell death in cultured rat hepatocytes. Liver Int. 24, 227-236 (Pubitemid 38930862)
46. Russo-Carbolante, E. M., Azzolini, A. E., Polizello, A. C., and Lucisano-Valim, Y. M. (2002) Comparative study of four isolation procedures to obtain rat neutrophils. Comp. Clin. Pathog. 11, 71-76 (Pubitemid 35282773)
47. Wiemer, A. J., Lokuta, M. A., Surfus, J. C., Wernimont, S. A., and Huttenlocher, A. (2010) Calpain inhibition impairs TNF-α-mediated neutrophil adhesion, arrest, and oxidative burst. Mol. Immunol. 47, 894-902
48. Weiss, S. J., Klein, R., Slivka, A., and Wei, M. (1982) Chlorination of taurine by human neutrophils. Evidence for hypochlorous acid generation. J. Clin. Invest. 70, 598-607 (Pubitemid 12054584)
49. Hao, Q., Chen, Y., Zhu, Y., Fan, Y., Palmer, D., Su, H., Young, W. L., and Yang, G. Y. (2007) Neutrophil depletion decreases VEGF-induced focal angiogenesis in the mature mouse brain. J. Cereb. Blood Flow Metab. 27, 1853-1860 (Pubitemid 47624550)
50. Pal, C., Bindu, S., Dey, S., Alam, A., Goyal, M., Iqbal, M. S., Sarkar, S., Kumar, R., Halder, K. K., Debnath, M. C., Adhikari, S., and Bandyopadhyay, U. (2012) Tryptamine-gallic acid hybrid prevents nonsteroidal anti-inflammatory drug-induced gastropathy. Correction of mitochondrial dysfunction and inhibition of apoptosis in gastric mucosal cells. J. Biol. Chem. 287, 3495-3509
51. Guha, M., Maity, P., Choubey, V., Mitra, K., Reiter, R. J., and Bandyopadhyay, U. (2007) Melatonin inhibits free radical-mediated mitochondrially dependent hepatocyte apoptosis and liver damage induced during malarial infection. J. Pineal Res. 43, 372-381 (Pubitemid 47512269)
52. Biswas, K., Bandyopadhyay, U., Chattopadhyay, I., Varadaraj, A., Ali, E., and Banerjee, R. K. (2003) A novel antioxidant and antiapoptotic role of omeprazole to block gastric ulcer through scavenging of hydroxyl radical. J. Biol. Chem. 278, 10993-11001 (Pubitemid 36792647)
53. Pal, C., Bindu, S., Dey, S., Alam, A., Goyal, M., Iqbal, M. S., Maity, P., Adhikari, S. S., and Bandyopadhyay, U. (2010) Gallic acid prevents non-steroidal anti-inflammatory drug-induced gastropathy in rat by blocking oxidative stress and apoptosis. Free Radic. Biol. Med. 49, 258-267
54. Maity, P., Bindu, S., Dey, S., Goyal, M., Alam, A., Pal, C., Reiter, R., and Bandyopadhyay, U. (2009) Melatonin reduces indomethacin-induced gastric mucosal cell apoptosis by preventing mitochondrial oxidative stress and the activation of mitochondrial pathway of apoptosis. J. Pineal Res. 46, 314-323
55. Smith, A., and Morgan, W. T. (1985) Hemopexin-mediated heme transport to the liver. Evidence for a heme-binding protein in liver plasma membranes. J. Biol. Chem. 260, 8325-8329 (Pubitemid 15249836)
56. Eskew, J. D., Vanacore, R. M., Sung, L., Morales, P. J., and Smith, A. (1999) Cellular protection mechanisms against extracellular heme. Heme-hemopexin, but not free heme, activates the N-terminal c-Jun kinase. J. Biol. Chem. 274, 638-648
57. Li, Q., and Verma, I. M. (2002) NF-κB regulation in the immune system. Nat. Rev. Immunol. 2, 725-734
58. Liang, Y., Zhou, Y., and Shen, P. (2004) NF-κB and its regulation on the immune system. Cell. Mol. Immunol. 1, 343-350
59. Kabe, Y., Ando, K., Hirao, S., Yoshida, M., and Handa, H. (2005) Redox regulation of NF-κB activation. Distinct redox regulation between the cytoplasm and the nucleus. Antioxid. Redox Signal. 7, 395-403 (Pubitemid 40279807)
60. Bombini, G., Canetti, C., Rocha, F. A., and Cunha, F. Q. (2004) Tumor necrosis factor-α mediates neutrophil migration to the knee synovial cavity during immune inflammation. Eur. J. Pharmacol. 496, 197-204 (Pubitemid 39024333)
61. Lokuta, M. A., and Huttenlocher, A. (2005) TNF-α promotes a stop signal that inhibits neutrophil polarization and migration via a p38 MAPK pathway. J. Leukocyte Biol. 78, 210-219 (Pubitemid 40979960)
62. Perry, B. C., Soltys, D., Toledo, A. H., and Toledo-Pereyra, L. H. (2011) Tumor necrosis factor-α in liver ischemia/reperfusion injury. J. Invest. Surg. 24, 178-188
63. Kalinowski, D. S., and Richardson, D. R. (2005) The evolution of iron chelators for the treatment of iron overload disease and cancer. Pharmacol. Rev. 57, 547-583 (Pubitemid 43036441)
64. Caraceni, P., Van Thiel, D. H., and Borle, A. B. (1995) Dual effect of deferoxamine on free radical formation and reoxygenation injury in isolated hepatocytes. Am. J. Physiol. 269, G132-G137
65. Sullivan, S. G., Baysal, E., and Stern, A. (1992) Inhibition of hemin-induced hemolysis by desferrioxamine. Binding of hemin to red cell membranes and the effects of alteration of membrane sulfhydryl groups. Biochim. Biophys. Acta 1104, 38-44
66. Santos, L. C., Abreu, C. F., Xerinda, S. M., Tavares, M., Lucas, R., and Sarmento, A. C. (2012) Severe imported malaria in an intensive care unit. A review of 59 cases. Malar. J. 11, 96
67. + T cell-mediated immune pathology. Infect. Immun. 79, 1882-1888
68. Yoshimoto, T., Takahama, Y., Wang, C. R., Yoneto, T., Waki, S., and Nariuchi, H. (1998) A pathogenic role of IL-12 in blood-stage murine malaria lethal strain Plasmodium berghei NK65 infection. J. Immunol. 160, 5500-5505 (Pubitemid 28267842)
69. Seixas, E., Oliveira, P., Moura Nunes, J. F., and Coutinho, A. (2008) An experimental model for fatal malaria due to TNF-α-dependent hepatic damage. Parasitology 135, 683-690 (Pubitemid 351733163)
70. Bubici, C., Papa, S., Dean, K., and Franzoso, G. (2006) Mutual cross-talk between reactive oxygen species and nuclear factor-κB. Molecular basis and biological significance. Oncogene 25, 6731-6748 (Pubitemid 44657849)
71. Schieven, G. L., Kirihara, J. M., Myers, D. E., Ledbetter, J. A., and Uckun, F. M. (1993) Reactive oxygen intermediates activate NF-κB in a tyrosine kinase-dependent mechanism and in combination with vanadate activate the p56lck and p59fyn tyrosine kinases in human lymphocytes. Blood 82, 1212-1220 (Pubitemid 23253996)
72. Schoonbroodt, S., Ferreira, V., Best-Belpomme, M., Boelaert, J. R., Legrand-Poels, S., Korner, M., and Piette, J. (2000) Crucial role of the amino-terminal tyrosine residue 42 and the carboxyl-terminal PEST domain of IκBα in NF-κB activation by an oxidative stress. J. Immunol. 164, 4292-4300 (Pubitemid 30215091)
73. Takada, Y., Mukhopadhyay, A., Kundu, G. C., Mahabeleshwar, G. H., Singh, S., and Aggarwal, B. B. (2003) Hydrogen peroxide activates NF-κB through tyrosine phosphorylation of IκBα and serine phosphorylation of p65. Evidence for the involvement of IκBα kinase and Syk protein-tyrosine kinase. J. Biol. Chem. 278, 24233-24241 (Pubitemid 36830260)
74. Morgan, M. J., and Liu, Z. G. (2011) Cross-talk of reactive oxygen species and NF-κB signaling. Cell Res. 21, 103-115
75. Perkins, N. D., and Gilmore, T. D. (2006) Good cop, bad cop. The different faces of NF-κB. Cell Death Differ. 13, 759-772
76. Baldwin, A. S., Jr. (1996) The NF-κB and IκB proteins. New discoveries and insights. Annu. Rev. Immunol. 14, 649-683
77. Adams, D. H., Ju, C., Ramaiah, S. K., Uetrecht, J., and Jaeschke, H. (2010) Mechanisms of immune-mediated liver injury. Toxicol. Sci. 115, 307-321
78. Dienes, H. P., and Drebber, U. (2010) Pathology of immune-mediated liver injury. Dig. Dis. 28, 57-62
79. Tak, P. P., and Firestein, G. S. (2001) NF-κB. A key role in inflammatory diseases. J. Clin. Invest. 107, 7-11 (Pubitemid 32047405)
80. Nanji, A. A., Jokelainen, K., Rahemtulla, A., Miao, L., Fogt, F., Matsumoto, H., Tahan, S. R., and Su, G. L. (1999) Activation of nuclear factor κB and cytokine imbalance in experimental alcoholic liver disease in the rat. Hepatology 30, 934-943 (Pubitemid 29458282)
81. McDonald, B., and Kubes, P. (2012) Neutrophils and intravascular immunity in the liver during infection and sterile inflammation. Toxicol. Pathol. 40, 157-165
82. Jaeschke, H. (2006) Mechanisms of liver injury. II. Mechanisms of neutrophil-induced liver cell injury during hepatic ischemia-reperfusion and other acute inflammatory conditions. Am. J. Physiol. Gastrointest. Liver Physiol. 290, G1083-L1088
83. Jaramillo, M., Plante, I., Ouellet, N., Vandal, K., Tessier, P. A., and Olivier, M. (2004) Hemozoin-inducible proinflammatory events in vivo. Potential role in malaria infection. J. Immunol. 172, 3101-3110 (Pubitemid 38263700)
84. Griffith, J. W., Sun, T., McIntosh, M. T., and Bucala, R. (2009) Pure Hemozoin is inflammatory in vivo and activates the NALP3 inflammasome via release of uric acid. J. Immunol. 183, 5208-5220
85. Klebanoff, S. J. (2005) Myeloperoxidase. Friend and foe. J. Leukocyte Biol. 77, 598-625
86. Vasilyev, N., Williams, T., Brennan, M. L., Unzek, S., Zhou, X., Heinecke, J. W., Spitz, D. R., Topol, E. J., Hazen, S. L., and Penn, M. S. (2005) Myeloperoxidase-generated oxidants modulate left ventricular remodeling but not infarct size after myocardial infarction. Circulation 112, 2812-2820 (Pubitemid 41643823)
87. Shimakura, A., Kamanaka, Y., Ikeda, Y., Kondo, K., Suzuki, Y., and Umemura, K. (2000) Neutrophil elastase inhibition reduces cerebral ischemic damage in the middle cerebral artery occlusion. Brain Res. 858, 55-60 (Pubitemid 30105781)
88. Ramadori, G., Moriconi, F., Malik, I., and Dudas, J. (2008) Physiology and pathophysiology of liver inflammation, damage, and repair. J. Physiol. Pharmacol. 59, 107-117
89. Portugal, S., Carret, C., Recker, M., Armitage, A. E., Gonçalves, L. A., Epiphanio, S., Sullivan, D., Roy, C., Newbold, C. I., Drakesmith, H., and Mota, M. M. (2011) Host-mediated regulation of superinfection in malaria. Nat. Med. 17, 732-737
90. Cianciulli, P. (2009) Iron chelation therapy in thalassemia syndromes. Mediterr. J. Hematol. Infect. Dis. 1, e2009034
91. Sathish, P., Paramasivan, V., Palani, V., and Sivanesan, K. (2011) N-Acetylcysteine attenuates dimethylnitrosamine-induced oxidative stress in rats. Eur. J. Pharmacol. 654, 181-186
92. Baniasadi, S., Eftekhari, P., Tabarsi, P., Fahimi, F., Raoufy, M. R., Masjedi, M. R., and Velayati, A. A. (2010) Protective effect of N-acetylcysteine on antituberculosis drug-induced hepatotoxicity. Eur. J. Gastroenterol. Hepatol. 22, 1235-1238