Melatonin reduces indomethacin-induced gastric mucosal cell apoptosis by preventing mitochondrial oxidative stress and the activation of mitochondrial pathway of apoptosis

Journal of Pineal Research

Volumn 46, Issue 3, 2009, Pages 314-323

  Maity, Pallab ^b   Bindu, Samik ^b   Dey, Sumanta ^b   Goyal, Manish ^b   Alam, Athar ^b   Pal, Chinmay ^b   Reiter, Russel ^c   Bandyopadhyay, Uday ^a,b  

^a Department of Infectious Diseases and Immunology ^*  (India)

^b INDIAN INSTITUTE OF CHEMICAL BIOLOGY   (India)

^c UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

Author keywords

Apoptosis; Gastric damage; Indomethacin; Melatonin; Mitochondria

Indexed keywords

CASPASE 3; CASPASE 9; CYTOCHROME C; INDOMETACIN; MELATONIN; NONSTEROID ANTIINFLAMMATORY AGENT; PROTEIN BAK; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BCL X; REACTIVE OXYGEN METABOLITE; SCAVENGER;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME RELEASE; HISTOLOGY; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRIAL RESPIRATION; MOLECULE; NICK END LABELING; NONHUMAN; OXIDATIVE STRESS; PROTEIN EXPRESSION; PROTEIN TRANSPORT; RAT; STOMACH DISEASE; STOMACH INJURY; STOMACH MUCOSA; UPREGULATION;

ANALYSIS OF VARIANCE; ANIMALS; ANTIOXIDANTS; APOPTOSIS; BCL-2 HOMOLOGOUS ANTAGONIST-KILLER PROTEIN; BCL-2-ASSOCIATED X PROTEIN; BCL-X PROTEIN; CASPASE 3; CASPASE 9; CYCLOOXYGENASE INHIBITORS; GASTRIC MUCOSA; IN SITU NICK-END LABELING; INDOMETHACIN; MELATONIN; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; OXIDATIVE STRESS; PROTO-ONCOGENE PROTEINS C-BCL-2; RATS; RATS, SPRAGUE-DAWLEY;

EID: 62449189195     PISSN: 07423098     EISSN: 1600079X     Source Type: Journal    
DOI: 10.1111/j.1600-079X.2009.00663.x     Document Type: Article

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