Translocation of heme oxygenase-1 to mitochondria is a novel cytoprotective mechanism against non-steroidal anti-inflammatory drug-induced mitochondrial oxidative stress, apoptosis, and gastric mucosal injury

Journal of Biological Chemistry

Volumn 286, Issue 45, 2011, Pages 39387-39402

  Bindu, Samik ^a   Pal, Chinmay ^a   Dey, Sumanta ^a   Goyal, Manish ^a   Alam, Athar ^a   Iqbal, Mohd Shameel ^a   Dutta, Shubham ^a   Sarkar, Souvik ^a   Kumar, Rahul ^a   Maity, Pallab ^a   Bandyopadhyay, Uday ^a  

^a INDIAN INSTITUTE OF CHEMICAL BIOLOGY   (India)

Author keywords

[No Author keywords available]

Indexed keywords

ANTI-INFLAMMATORIES; APOPTOTIC; CHROMATIN IMMUNOPRECIPITATION; ELECTROPHORETIC MOBILITY SHIFT ASSAY; GASTRIC INJURY; GASTRIC MUCOSAL INJURY; HEME OXYGENASE-1; INDOMETHACIN; MECHANISM OF ACTION; MITOCHONDRIAL DYSFUNCTION; MITOCHONDRIAL TRANSLOCATION; NON-STEROIDAL ANTI-INFLAMMATORY DRUGS; NUCLEAR TRANSLOCATIONS; PLAUSIBLE MECHANISMS; PROTOPORPHYRINS; REACTIVE OXYGEN SPECIES; REPAIR MECHANISM; RESPIRATORY CONTROL; TIME-DEPENDENT; TISSUE INJURY; TRANSMEMBRANE POTENTIALS; ZINC PROTOPORPHYRIN;

BIOELECTRIC POTENTIALS; CELL DEATH; COBALT; COMPLEXATION; ELECTROPHORETIC MOBILITY; PORPHYRINS; TISSUE; ZINC;

MITOCHONDRIA;

CASPASE 3; CASPASE 9; HEME; HEME OXYGENASE 1; INDOMETACIN; PROTOPORPHYRIN COBALT; PROTOPORPHYRIN ZINC; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); TRANSCRIPTION FACTOR NRF2;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL PROTECTION; CELLULAR DISTRIBUTION; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME TRANSLOCATION; GEL MOBILITY SHIFT ASSAY; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRIAL OXIDATIVE STRESS; MITOCHONDRIAL RESPIRATION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; RAT; STOMACH MUCOSA INJURY; TISSUE REPAIR;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; APOPTOSIS; GASTRIC MUCOSA; HEME OXYGENASE (DECYCLIZING); INDOMETHACIN; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; NF-E2 TRANSCRIPTION FACTOR; OXIDATIVE STRESS; PROTEIN TRANSPORT; RATS; RATS, SPRAGUE-DAWLEY;

RATTUS;

EID: 80655125027     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.279893     Document Type: Article

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