Indomethacin, a non-steroidal anti-inflammatory drug, develops gastropathy by inducing reactive oxygen species-mediated mitochondrial pathology and associated apoptosis in gastric mucosa: A novel role of mitochondrial aconitase oxidation

Journal of Biological Chemistry

Volumn 284, Issue 5, 2009, Pages 3058-3068

  Maity, Pallab ^a   Bindu, Samik ^a   Dey, Sumanta ^a   Goyal, Manish ^a   Alam, Athar ^a   Pal, Chinmay ^a   Mitra, Kalyan ^b   Bandyopadhyay, Uday ^a  

^a INDIAN INSTITUTE OF CHEMICAL BIOLOGY   (India)

^b CENTRAL DRUG RESEARCH INSTITUTE   (India)

Author keywords

[No Author keywords available]

Indexed keywords

BIOELECTRIC POTENTIALS; CARBONYLATION; DIMETHYL SULFOXIDE; OXYGEN; PATHOLOGY; SULFUR;

ACONITASE; APOPTOSIS; CASPASE; CASPASE-3; DEHYDROGENASE ACTIVITIES; FLUORESCENCE IMAGING; GASTRIC MUCOSAL CELLS; GASTRIC MUCOSAS; IMMUNOBLOTTING; IMMUNOPRECIPITATION; IN-VIVO; INDOMETHACIN; IRON-SULFUR CLUSTERS; MICROSCOPIC STUDIES; MITOCHONDRIAL ACONITASE; MITOCHONDRIAL DYSFUNCTIONS; MITOCHONDRIAL PATHWAYS; MITOCHONDRIAL ULTRASTRUCTURES; NON-STEROIDAL ANTI-INFLAMMATORY DRUGS; REACTIVE OXYGEN SPECIES; TRANSMEMBRANE POTENTIALS; TRANSMISSION ELECTRONS; ULTRASTRUCTURAL CHANGES;

CELL DEATH;

CASPASE 3; CASPASE 9; DIMETHYL SULFOXIDE; HYDROGEN PEROXIDE; INDOMETACIN; IRON SULFUR PROTEIN; MITOCHONDRIAL ACOTINASE; MITOCHONDRIAL ENZYME; OXIDOREDUCTASE; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; CARBONYLATION; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; ENZYME ACTIVITY; ENZYME METABOLISM; MEMBRANE POTENTIAL; MITOCHONDRION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN FUNCTION; RAT; STOMACH DISEASE; STOMACH MUCOSA; TRANSMISSION ELECTRON MICROSCOPY; WESTERN BLOTTING;

ACONITATE HYDRATASE; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; APOPTOSIS; BLOTTING, WESTERN; CASPASE 3; CASPASE 9; GASTRIC MUCOSA; IMMUNOPRECIPITATION; INDOMETHACIN; MEMBRANE POTENTIALS; MITOCHONDRIA; OXIDATION-REDUCTION; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES;

RATTUS;

EID: 59149086582     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M805329200     Document Type: Article

References (58)

1. Regula, J., Butruk, E., Dekkers, C. P., de Boer, S. Y., Raps, D., Simon, L., Terjung, A., Thomas, K. B., Luhmann, R., and Fischer, R. (2006) Am. J. Gastroenterol. 101, 1747-1755
2. Cha, Y. I., and Dubois, R. N. (2007) Annu. Rev. Med. 58, 239-252
3. Chan, J. M., Feraco, A., Shuman, M., and Hernandez-Diaz, S. (2006) Hematol. Oncol. Clin. North Am. 20, 797-809
4. Eli, Y., Przedecki, F., Levin, G., Kariv, N., and Raz, A. (2001) Biochem. Pharmacol. 61, 565-571
5. Wallace, J. L. (2001) Best Pract. Res. Clin. Gastroenterol. 15, 691-703
6. Fujii, Y., Matsura, T., Kai, M., Matsui, H., Kawasaki, H., and Yamada, K. (2000) Proc. Soc. Exp. Biol. Med. 224, 102-108
7. Maity, P., Bindu, S., Choubey, V., Alam, A., Mitra, K., Goyal, M., Dey, S., Guha, M., Pal, C., and Bandyopadhyay, U. (2008) J. Biol. Chem. 283, 14391-14401
8. Tanaka, K., Tomisato, W., Hoshino, T., Ishihara, T., Namba, T., Aburaya, M., Katsu, T., Suzuki, K., Tsutsumi, S., and Mizushima, T. (2005) J. Biol. Chem. 280, 31059-31067
9. Chiou, S. K., Tanigawa, T., Akahoshi, T., Abdelkarim, B., Jones, M. K., and Tarnawski, A. S. (2005) Gastroenterology 128, 63-73
10. Aggarwal, S., Taneja, N., Lin, L., Orringer, M. B., Rehemtulla, A., and Beer, D. G. (2000) Neoplasia 2, 346-356
11. Gu, Q., Wang, J. D., Xia, H. H., Lin, M. C., He, H., Zou, B., Tu, S. P., Yang, Y., Liu, X. G., Lam, S. K., Wong, W. M., Chan, A. O., Yuen, M. F., Kung, H. F., and Wong, B. C. (2005) Carcinogenesis 26, 541-546
12. de Groot, D. J., Timmer, T., Spierings, D. C., Le, T. K., de Jong, S., and de Vries, E. G. (2005) Br. J. Cancer 92, 1459-1466
13. Zhang, G., Tu, C., Zhang, G., Zhou, G., and Zheng, W. (2000) Leuk. Res. 24, 385-392
14. Ong, M. M., Wang, A. S., Leow, K. Y., Khoo, Y. M., and Boelsterli, U. A. (2006) Free Radic. Biol. Med. 40, 420-429
15. Chang, J. K., Wu, S. C., Wang, G. J., Cho, M. H., and Ho, M. L. (2006) Toxicology 228, 111-123
16. Redlak, M. J., Power, J. J., and Miller, T. A. (2005) Am. J. Physiol. Gastrointest. Liver Physiol. 289, 731-738
17. Tarnawski, A. S. (2005) Dig. Dis. Sci. 50, Suppl. 1, 24-33
18. Kroemer, G., Galluzzi, L., and Brenner, C. (2007) Physiol. Rev. 87, 99-163
19. Zimmermann, K. C., Bonzon, C., and Green, D. R. (2001) Pharmacol. Ther. 92, 57-70
20. Gulbins, E., Dreschers, S., and Bock, J. (2003) Exp. Physiol. 88, 85-90
21. Jiang, X., and Wang, X. (2004) Annu. Rev. Biochem. 73, 87-106
22. Orrenius, S., Gogvadze, V., and Zhivotovsky, B. (2007) Annu. Rev. Pharmacol. Toxicol. 47, 143-183
23. Bandyopadhyay, U., Biswas, K., Chatterjee, R., Bandyopadhyay, D., Chattopadhyay, I., Ganguly, C. K., Chakraborty, T., Bhattacharya, K., and Banerjee, R. K. (2002) Life Sci. 71, 2845-2865
24. Biswas, K., Bandyopadhyay, U., Chattopadhyay, I., Varadaraj, A., Ali, E., and Banerjee, R. K. (2003) J. Biol. Chem. 278, 10993-11001
25. Chattopadhyay, I., Bandyopadhyay, U., Biswas, K., Maity, P., and Banerjee, R. K. (2006) Free Radic. Biol. Med. 40, 1397-1408
26. Guha, M., Kumar, S., Choubey, V., Maity, P., and Bandyopadhyay, U. (2006) FASEB J. 20, 1224-1226
27. Guha, M., Maity, P., Choubey, V., Mitra, K., Reiter, R. J., and Bandyopadhyay, U. (2007) J. Pineal. Res. 43, 372-381
28. Rousou, A. J., Ericsson, M., Federman, M., Levitsky, S., and McCully, J. D. (2004) Am. J. Physiol. Heart Circ. Physiol. 287, 1967-1976
29. Terano, A., Ivey, K. J., Stachura, J., Sekhon, S., Hosojima, H., McKenzie, W. N., Jr., Krause, W. J., and Wyche, J. H. (1982) Gastroenterology 83, 1280-1291
30. Babbs, C. F., and Steiner, M. G. (1990) Methods Enzymol. 186, 137-147
31. Zheng, W., Ren, S., and Graziano, J. H. (1998) Brain Res. 799, 334-342
32. Gardner, P. R. (2002) Methods Enzymol. 349, 9-23
33. Andersson, U., Leighton, B., Young, M. E., Blomstrand, E., and Newsholme, E. A. (1998) Biochem. Biophys. Res. Commun. 249, 512-516
34. Fariss, M. W., Chan, C. B., Patel, M., Van Houten, B., and Orrenius, S. (2005) Mol. Interv. 5, 94-111
35. Scatena, R., Bottoni, P., Botta, G., Martorana, G. E., and Giardina, B. (2007) Am. J. Physiol. Cell Physiol. 293, 12-21
36. Gutteridge, J. M. (1985) FEBS Lett. 185, 19-23
37. Vasquez-Vivar, J., Kalyanaraman, B., and Kennedy, M. C. (2000) J. Biol. Chem. 275, 14064-14069
38. Cecarini, V., Gee, J., Fioretti, E., Amici, M., Angeletti, M., Eleuteri, A. M., and Keller, J. N. (2007) Biochim. Biophys. Acta 1773, 93-104
39. Parke, D. V. (1983) Vet. Res. Commun. 7, 285-300
40. Reagan-Shaw, S., Nihal, M., and Ahmad, N. (2008) FASEB J. 22, 659-661
41. Center for Drug Evaluation and Research (2005) Guidance for the industry. Estimating the maximum safe starting dose in initial clinical trials for therapeutics in adult volunteers, United States Department of Health and Human Services, Food and Drug Administration Bulletin pp. 6-9, Rockville, MD
42. Insel, P. A. (1991) in Goodman and Gilman's The Pharmacological Basis of Therapeutics (Hardman, J. D., Limbird, L. E., and Gilman, A. G., eds) pp. 638-681, 8th Ed., Pergamon Press, Inc., New York
43. Swift, G. L., Arnold, J., Williams, G. T., Williams, B. D., Rhodes, J., and Khan, F. (1992) Digestion 53, 88-93
44. Larkai, E. N., Smith, J. L., Lidsky, M. D., and Graham, D. Y. (1987) Am. J. Gastroenterol. 82, 1153-1158
45. Takeuchi, Y., Morii, H., Tamura, M., Hayaishi, O., and Watanabe, Y. (1991) Arch. Biochem. Biophys. 289, 33-38
46. Yoshikawa, T., Naito, Y., Kishi, A., Tomii, T., Kaneko, T., Iinuma, S., Ichikawa, H., Yasuda, M., Takahashi, S., and Kondo, M. (1993) Gut 34, 732-737
47. Naito, Y., and Yoshikawa, T. (2006) Redox Rep. 11, 243-253
48. Perry, M. A., Wadhwa, S., Parks, D. A., Pickard, W., and Granger, D. N. (1986) Gastroenterology 90, 362-367
49. Chen, Q., Vazquez, E. J., Moghaddas, S., Hoppel, C. L., and Lesnefsky, E. J. (2003) J. Biol. Chem. 278, 36027-36031
50. Halliwell, B., and Gutteridge, J. M. (1990) Methods Enzymol. 186, 1-85
51. Kussmaul, L., and Hirst, J. (2006) Proc. Natl. Acad. Sci. U. S. A. 103, 7607-7612
52. Muller, F. L., Liu, Y., and Van Remmen, H. (2004) J. Biol. Chem. 279, 49064-49073
53. Chevion, M., Jiang, Y., Har-El, R., Berenshtein, E., Uretzky, G., and Kitrossky, N. (1993) Proc. Natl. Acad. Sci. U. S. A. 90, 1102-1106
54. Porter, D. J., Alston, T. A., and Bright, H. J. (1987) J. Biol. Chem. 262, 6552-6563
55. Schriner, S. E., Linford, N. J., Martin, G. M., Treuting, P., Ogburn, C. E., Emond, M., Coskun, P. E., Ladiges, W., Wolf, N., Van Remmen, H., Wallace, D. C., and Rabinovitch, P. S. (2005) Science 308, 1909-1911
56. Suliman, H. B., Carraway, M. S., and Piantadosi, C. A. (2003) Am. J. Respir. Crit. Care Med. 167, 570-579
57. Ricci, C., Pastukh, V., Leonard, J., Turrens, J., Wilson, G., Schaffer, D., and Schaffer, S. W. (2008) Am. J. Physiol. Cell Physiol. 294, 413-422
58. Kadiiska, M. B., Burkitt, M. J., Xiang, Q. H., and Mason, R. P. (1995) J. Clin. Investig. 96, 1653-1657