A pathogenic role of IL-12 in blood-stage murine malaria lethal strain Plasmodium berghei NK65 infection

Journal of Immunology

Volumn 160, Issue 11, 1998, Pages 5500-5505

  Yoshimoto, Takayuki ^a   Takahama, Yasuhiro ^a   Wang, Chrong Reen ^a   Yoneto, Toshihiko ^a   Waki, Seiji ^b   Nariuchi, Hideo ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b GUNMA PREFECTURAL COLLEGE OF HEALTH SCIENCES   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; FAS LIGAND; GAMMA INTERFERON; INTERLEUKIN 12; NITRIC OXIDE SYNTHASE; PROTEIN P40; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; ENZYME ANALYSIS; FEMALE; IMMUNOPATHOGENESIS; INFECTION RISK; MALARIA; MOUSE; NONHUMAN; PLASMODIUM BERGHEI; PRIORITY JOURNAL; SCORING SYSTEM; SPLEEN CELL;

ANIMALS; ANTIBODIES, MONOCLONAL; FEMALE; INTERFERON TYPE II; INTERLEUKIN-12; LIVER; MALARIA; MICE; MICE, INBRED C57BL; PLASMODIUM BERGHEI; SPLEEN;

EID: 0032103942     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (55)

1. Trinchieri, G. 1994. Interleukin-12: a cytokine produced by antigen-presenting cells with immunoregulatory functions in the generation of T-helper cells type 1 and cytotoxic lymphocytes. Blood 84:4008.
2. Hendrzak, J. A., and M. J. Brunda. 1995. Interleukin-12: biologic activity, therapeutic utility, and role in disease. Lab. Invest. 72:619.
3. Shu, U., M. Kiniwa, C. Y. Wu, C. Maliszewski, N. Vezzio, J. Hakimi, M. Gately, and G. Delespesse. 1995. Activated T cells induce interleukin-12 production by monocytes via CD40-CD40 ligand interaction. Eur. J. Immunol. 25:1125.
4. Kato, T., R. Hakamada, H. Yamane, and H. Nariuchi. 1996. Induction of IL-12 p40 messenger RNA expression and IL-12 production of macrophages via CD40-CD40 ligand interaction. J. Immunol. 156:3932.
5. Heinzel, F. P., D. S. Schoenhaut, R. M. Rerko, L. E. Rosser, and M. K. Gately. 1993. Recombinant interleukin 12 cures mice infected with Leishmania major. J. Exp. Med. 177:1505.
6. Sypek, J. P., C. L. Chung, S. E. Mayor, J. M. Subramanyam, S. J. Goldman, D. S. Sieburth, S. F. Wolf, and R. G. Schaub. 1993. Resolution of cutaneous leishmaniasis: interleukin 12 initiates a protective T helper type 1 immune response. J. Exp. Med. 177:1797.
7. Gazzinelli, R. T., S. Hieny, T. A. Wynn, S. Wolf, and A. Sher. 1993. Interleukin 12 is required for the T-lymphocyte-independent induction of interferon gamma by an intracellular parasite and induces resistance in T-cell-dehcient hosts. Proc. Natl. Acad. Sci. USA 90:6115.
8. Gazzinelli, R. T., M. Wysocka, S. Hayashi, E. Y. Denkers, S. Hieny, P. Caspar, G. Trinchieri, and A. Sher. 1994. Parasite-induced IL-12 stimulates early IFN-gamma synthesis and resistance during acute infection with Toxoplasma gondii. J. Immunol. 153:2533.
9. Orange, J. S., S. F. Wolf, and C. A. Biron. 1994. Effects of IL-12 on the response and susceptibility to experimental viral infections. J. Immunol. 152:1253.
10. Trembleau, S., T. Germann, M. K. Gately, and L. Adorini. 1995. The role of IL-12 in the induction of organ-specific autoimmune diseases. Immunol. Today 16:383.
11. + T cells in the immune response to Plasmodium chabaudi. Parasitol. Today 5:362.
12. + T lymphocytes both contribute to acquired immunity to blood-stage Plasmodium chabaudi AS. Infect. Immun. 59:51.
13. Yap, G. S., P. Jacobs, and M. M. Stevenson. 1994. Th cell regulation of host resistance to blood stage Plasmodium chabaudi AS. Res. Immunol. 145:419.
14. Taylor-Robinson, A. W., R. S. Phillips, A. Severn, S. Moncada, and F. Y. Liew. 1993. The role of TH1 and TH2 cells in a rodent malaria infection. Science 260:1931.
15. Clark, I. A., N. H. Hunt, G. A. Butcher, and W. B. Cowden. 1987. Inhibition of murine malaria (Plasmodium chabaudi) in vivo by recombinant interferon-γ or tumor necrosis factor and its enhancement by butylated hydroxyanisole. J. Immunol. 139:3493.
16. Stevenson, M. M., M. Tam, M. Belosevic, P. H. Van Der Meide, and J. E. Podoba. 1990. Role of endogenous gamma interferon in host response to infection with blood-stage Plasmodium chabaudi AS. Infect. Immun. 58:3225.
17. Meding, S. J., S. C. Cheng, B. Simon-Haarhaus, and J. Langhorne. 1990. Role of endogenous gamma interferon during infection with Plasmodium chabaudi chabaudi. Infect. Immun. 58:3671.
18. Waki, S., J. Tamura, M. Imanaka, S. Ishikawa, and M. Suzuki. 1982. Plasmodium berghei. isolation and maintenance of an irradiation attenuated strain in the nude mouse. Exp. Parasitol. 53:335.
19. Waki, S., S. Uehara, K. Kanbe, K. Ono, M. Suzuki, and H. Nariuchi. 1992. The role of T cells in pathogenesis and protective immunity to murine malaria. Immunology 75:646.
20. Waki, S., S. Uehara, K. Kanbe, H. Nariuch, and M. Suzuki. 1995. Interferon-γ and the induction of protective IgG2a antibodies in non-lethal Plasmodium berghei infections of mice. Parasite Immunol. 17:503.
21. Yoshimolo, T., T. Yoneto, S. Waki, and H. Nariuc. 1998. IL-12 dependent mechanisms in the clearance of blood-stage murine malaria Plasmodium berghei XAT, an attenuated variant of Plasmodium berghei NK65. J. Infect. Din. In press.
22. Chomczynski, P., and N. Sacchi. 1987. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162:156.
23. Reiner, S. L., S. Zheng, D. B. Corry, and R. M. Locksley. 1993. Constructing polycompetitor cDNAs for quantitative PCR. J. Immunol. Methods 165:37.
24. Hino, A., and H. Nariuchi. 1996. Negative feed back mechanism against interleukin 12 production by antigen presenting cells interacted with T helper 2 cells. Eur. J. Immunol. 26:623.
25. Wynn, T. A., I. Eltoum, A. W. Cheever, F. A. Lewis, W. C. Cause, and A. Sher. 1993. Analysis of cytokine mRNA expression during primary granuloma formation induced by eggs of Schistosoma mansoni. J. Immunol. 151:1430.
26. Seguin, M. C., F. W. Klotz. I. Schneider, J. P. Weir, M. Goodbary, M. Slayter, J. J. Raney, J. U. Anigolu, and S. J. Green. 1994. Induction of nitric oxide synthase protects against malaria in mice exposed to irradiated Plasmodium berghei infected mosquitoes: involvement of interferon-γ genes. J. Exp. Med. 180:353.
27. Brossart, P., and M. J. Bevan. 1996. Selective activation of Fas/Fas ligand-mediated cytotoxicity by a self peptide. J. Exp. Med. 183:2449.
28. Yoshimoto, T., E. Yoshimoto, and D. Meruelo. 1992. Enhanced gene expression of murine ecotropic retroviral receptor and its human homologue. J. Virol. 66:4377.
29. Kato, K., O. Shimozato, K. Hoshi, H. Wakimoto, H. Hamada, H. Yagita, and K. Okumura. 1996. Local production of the p40 subunit of imerleukin 12 suppresses T-helper I-mediated immune responses and prevents allogeneic myoblast rejection. Proc. Natl. Acad. Sci. USA 93:9085.
30. Magram, J., S. E. Connaughton, R. R. Warrier, D. M. Carvajal, C. Wu, J. Ferrante, C. Stewart, U. Sarmiento, D. A. Faherty, and M. K. Gately. 1996. IL-12-deficient mice are defective in IFNγ production and type 1 cytokine responses. Immunity 4:471.
31. Cherwinski, H., J. Schumacher, K. Brown, and T. Mosmann. 1987. Two types of mouse helper T cell clone. III. Further differences in lymphokine synthesis between Th1 and Th2 clones revealed by RNA hybridization, functionally monospecific bioassays, and monoclonal antibodies. J. Exp. Med. 166:1229.
32. Gately, M. K., R. R. Warrier, S. Honasoge, D. M. Carvajal, D. A. Faherty, S. E. Connaughton, T. D. Anderson, U. Sarmiento, B. R. Hubbard, and M. Murphy. 1994. Administration of recombinant IL-12 to normal mice enhances cytolytic lymphocyte activity and induces production of IFN-γ in vivo. Int. Immunol. 6:157.
33. Orange, J. S., M. T. Salazar, S. M. Opal, R. L. Spencer, A. H. Miller, B. S. McEwen, and C. A. Biron. 1995. Mechanism of imerleukin 12-mediated toxicities during experimental viral infections: role of tumor necrosis factor and glucocorticoids. J. Exp. Med. 181:901.
34. Tanaka, Y., A. Takahashi, K. Watanabe, K. Takayama, T. Yahata, S. Habu, and T. Nishimura. 1996. A pivotal role of IL-12 in Th1-dependent mouse liver injury. Int. Immunol. 8:569.
35. Toyonaga, T., O. Hino, S. Sugai, S. Wakasugi, K. Abe, M. Shichiri, and K. Yamamura. 1994. Chronic active hepatitis in transgenic mice expressing interferon-γ in the liver. Proc. Natl. Acad. Sci. USA 91:614.
36. -/- mice: role for IFN-γ in activating apoptosis of hepatocytes. J. Immunol. 159:1418.
37. Harbrecht, B. G., M. Di Silvio, A. J. Demetris, R. L. Simmons, and T. R. Billiar. 1994. Tumor necrosis factor-alpha regulates in vivo nitric oxide synthesis and induces liver injury during endotoxemia. Hepatology 20:1055.
38. Clark, I. A., W. B. Cowden, G. A. Butcher, and N. H. Hunt. 1987. Possible roles of tumor necrosis factor in the pathology of malaria. Am. J. Pathol. 129:192.
39. Jacobs, P., D. Radzioch, and M. M. Stevenson. 1995. Nitric oxide expression in the spleen, but not in the liver, correlates with resistance to blood-stage malaria in mice. J. Immunol. 155:5306.
40. Rockett, K. A., M. M. Awburn, E. J. Rockett, W. B. Cowden, and I. A. Clark. 1994. Possible role of nitric oxide in malarial immunosuppression. Parasite Immunol. 16:243.
41. Clark, I. A., K. A. Rockett, and W. B. Cowden. 1991. Proposed link between cytokines, nitric oxide, and human cerebral malaria. Parasitol. Today 7:205.
42. Rockett, K. A., M. M. Awburn, B. B. Aggarwal, W. B. Cowden, and I. A. Clark. 1992. In vivo induction of nitrite and nitrate by tumor necrosis factor, lymphotoxin. and interleukin-1: possible roles in malaria. Infect. Immun. 60:3725.
43. Nagata, S., and P. Golstein. 1995. The Fas death factor. Science 267:1449.
44. Galle, P. R., W. J. Hofmann, H. Walczak, H. Schaller, G. Otto, W. Stremmel, P. H. Krammer, and L. Runkel. 1995. Involvement of the CD95 (APO-1/Fas) receptor and ligand in liver damage. J. Exp. Med. 182:1223.
45. Tanaka, M., T. Suda, T. Yatomi, N. Nakamura, and S. Nagata. 1997. Lethal effect of recombinant human Fas ligand in mice pretreated with Propionibacterium acnes. J. Immunol. 158:2303.
46. cg that complements the gld gene in induction of lymphoadenopathy in the mouse, J. Exp. Med. 171:519.
47. Taylor-Robinson, A. W. 1995. Murine models of cerebral malaria: a qualified defence. Parasitol. Today 11:407.
48. Marsh, K. 1992. Malaria: a neglected disease? Parasitology 104:553.
49. Grau, G. E., L. F. Fajardo, P. F. Piguet, B. Allet, P. H. Lambert, and P. Vassalli. 1987. Tumor necrosis factor (cachectin) as an essential mediator in murine cerebral malaria. Science 237:1210.
50. Grau, G. E., H. Heremans, P. F. Piguet, P. Pointaire, P. H. Lambert, A. Billiau, and P. Vassalli. 1989. Monoclonal antibody against interferon gamma can prevent experimental cerebral malaria and its associated overproduction of tumor necrosis factor. Proc. Natl. Acad. Sci. USA 86:5572.
51. + T lymphocytes play a major role in the pathogenesis of murine cerebral malaria. J. Immunol. 137:2348.
52. Grau, G. E., V. Kindler, P. F. Piguet, P. H. Lambert, and P. Vassalli. 1988. Prevention of experimental cerebral malaria by anticytokine antibodies: interleukin 3 and granulocyte macrophage colony-stimulating factor are intermediates in increased tumor necrosis factor production and macrophage accumulation. J. Exp. Med. 168:1499.
53. Rudin, W., N. Favre, G. Bordmann, and B. Ryffel. 1997. Interferon-γ is essential for the development of cerebral malaria. Eur. J. Immunol. 27:810.
54. Rudin, W., H. P. Eugster, G. Bordmann, J. Bonato, M. Muller, M. Yamage, and B. Ryffel. 1997. Resistance to cerebral malaria in tumor necrosis factor-alpha/beta-deficient mice is associated with a reduction of intercellular adhesion molecule-1 up-regulation and T helper type 1 response. Am. J. Pathol. 150:257.
55. Kamijo, R., J. Le, D. Shapiro, E. A. Havell, S. Huang, M. Aguet, M. Bosland, and J. Vilcek. 1993. Mice that lack the interferon gamma receptor have profoundly altered responses to infection with bacillus Calmette-Guerin and subsequent challenge with lipopolysaccharide. J. Exp. Med. 178:1435.