Synthesis of novel heme-interacting acridone derivatives to prevent free heme-mediated protein oxidation and degradation

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 12, 2011, Pages 3563-3567

  Pal, Chinmay ^a   Kundu, Milan Kumar ^b   Bandyopadhyay, Uday ^a   Adhikari, Susanta ^c  

^a INDIAN INSTITUTE OF CHEMICAL BIOLOGY   (India)

^b UNIVERSITY OF BURDWAN   (India)

^c UNIVERSITY OF CALCUTTA   (India)

Author keywords

Acridones; Arborinine; Heme binding; Oxidative stress; Protein oxidation; Synthesis

Indexed keywords

ACRIDONE DERIVATIVE; ARBORININE; HEME; UNCLASSIFIED DRUG;

ARTICLE; DRUG PROTEIN BINDING; DRUG SYNTHESIS; OXIDATION; PROTEIN DEGRADATION; PROTEIN OXIDATION;

ACRIDINES; HEMEPROTEINS; INHIBITORY CONCENTRATION 50; MODELS, BIOLOGICAL; MOLECULAR STRUCTURE; OXIDATION-REDUCTION; OXIDATIVE STRESS; PROTEIN BINDING;

EID: 79957795889     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.04.127     Document Type: Article

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32. 4 and evaporated to dryness under vacuo. The crude residue was purified by silica gel column chromatography to afford the pure product.
33. +