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Volumn 6, Issue , 2012, Pages 83-91

Aging of the CD4 t cell compartment

Author keywords

Age associated defects; CD4 + T cells

Indexed keywords

APOPTOSIS; ARTICLE; CD4 LYMPHOCYTE COUNT; CD4+ CD25+ T LYMPHOCYTE; CD4+ T LYMPHOCYTE; CELL AGING; CELL COMPARTMENTALIZATION; CELLULAR IMMUNITY; HUMAN; IMMUNOLOGICAL TOLERANCE; IMMUNOREACTIVITY; LYMPHOCYTE DIFFERENTIATION; LYMPHOCYTE PROLIFERATION; MEMORY T LYMPHOCYTE; NONHUMAN; PHENOTYPIC VARIATION; PRIORITY JOURNAL; QUALITATIVE ANALYSIS; QUANTITATIVE ANALYSIS; REGULATORY T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; T LYMPHOCYTE SUBPOPULATION;

EID: 84863922149     PISSN: None     EISSN: 1876326X     Source Type: Journal    
DOI: 10.2174/1876326X01206010083     Document Type: Article
Times cited : (44)

References (100)
  • 1
    • 84863919871 scopus 로고    scopus 로고
    • Administration on Aging [homepage on the internet]. Washington, DC: Department of Health & Human Services.[updated 2010 June 30; cited 2011 Aug 1];Available from
    • Administration on Aging [homepage on the internet]. Washington, DC: Department of Health & Human Services.[updated 2010 June 30; cited 2011 Aug 1];Available from: http://www.aoa.gov/AoARoot/Aging_Statistics/index.aspx
  • 2
    • 67649216901 scopus 로고    scopus 로고
    • Pneumonia in the elderly
    • Cabre M. Pneumonia in the elderly. Curr Opin Pulm Med 2009;15:223-9.
    • (2009) Curr Opin Pulm Med , vol.15 , pp. 223-229
    • Cabre, M.1
  • 3
    • 77955949596 scopus 로고    scopus 로고
    • Adult hospitalizations for laboratory-positive influenza dur-ing the 2005-2006 through 2007-2008 seasons in the United States
    • Dao CN, Kamimoto L, Nowell M, Reingold A, Gershman K, Meek J, et al. Adult hospitalizations for laboratory-positive influenza dur-ing the 2005-2006 through 2007-2008 seasons in the United States. J Infect Dis 2010;202:881-8.
    • (2010) J Infect Dis , vol.202 , pp. 881-888
    • Dao, C.N.1    Kamimoto, L.2    Nowell, M.3    Reingold, A.4    Gershman, K.5    Meek, J.6
  • 4
    • 73949091048 scopus 로고    scopus 로고
    • Impaired immune responses in the lungs of aged mice following influenza infection
    • Toapanta FR, Ross TM. Impaired immune responses in the lungs of aged mice following influenza infection. Respir Res 2009;10:112.
    • (2009) Respir Res , vol.10 , pp. 112
    • Toapanta, F.R.1    Ross, T.M.2
  • 5
    • 79955970125 scopus 로고    scopus 로고
    • Influenza vaccine responses in older adults
    • McElhaney JE. Influenza vaccine responses in older adults. Ageing Res Rev 2011;10:379-88.
    • (2011) Ageing Res Rev , vol.10 , pp. 379-388
    • McElhaney, J.E.1
  • 7
    • 34547816587 scopus 로고    scopus 로고
    • Aging reduces the primary humoral response and the in vitro cytokine production in mice
    • Simioni PU, Costa EH, Tamashiro WM. Aging reduces the primary humoral response and the in vitro cytokine production in mice. Braz J Med Biol Res 2007;40:1111-20.
    • (2007) Braz J Med Biol Res , vol.40 , pp. 1111-1120
    • Simioni, P.U.1    Costa, E.H.2    Tamashiro, W.M.3
  • 8
    • 0025280670 scopus 로고
    • The effect of aging on the induction of humoral and cellular immunity and tolerance in two long-lived mouse strains
    • Gahring LC, Weigle WO. The effect of aging on the induction of humoral and cellular immunity and tolerance in two long-lived mouse strains. Cell Immunol 1990;128:142-51.
    • (1990) Cell Immunol , vol.128 , pp. 142-151
    • Gahring, L.C.1    Weigle, W.O.2
  • 9
    • 0029918498 scopus 로고    scopus 로고
    • Relative contribution of T and B cells to hypermutation and selection of the antibody repertoire in germinal centers of aged mice
    • Yang X, Stedra J, Cerny J. Relative contribution of T and B cells to hypermutation and selection of the antibody repertoire in germinal centers of aged mice. J Exp Med 1996;183:959-70.
    • (1996) J Exp Med , vol.183 , pp. 959-970
    • Yang, X.1    Stedra, J.2    Cerny, J.3
  • 10
    • 0031464890 scopus 로고    scopus 로고
    • Immunosenescence and germinal center reaction
    • Zheng B, Han S, Takahashi Y, Kelsoe G. Immunosenescence and germinal center reaction. Immunol Rev 1997;160:63-77.
    • (1997) Immunol Rev , vol.160 , pp. 63-77
    • Zheng, B.1    Han, S.2    Takahashi, Y.3    Kelsoe, G.4
  • 12
    • 0021365948 scopus 로고
    • Age-associated decline in precursor frequency for different T cell-mediated reactions, with preservation of helper or cytotoxic effect per precursor cell
    • Miller RA. Age-associated decline in precursor frequency for different T cell-mediated reactions, with preservation of helper or cytotoxic effect per precursor cell. J Immunol 1984;132:63-8.
    • (1984) J Immunol , vol.132 , pp. 63-68
    • Miller, R.A.1
  • 13
    • 27144529078 scopus 로고    scopus 로고
    • Age-related differences in phenotype and function of CD4+ T cells are due to a phenotypic shift from naive to memory effector CD4+ T cells
    • Kovaiou RD, Weiskirchner I, Keller M, Pfister G, Cioca DP, Grubeck-Loebenstein B. Age-related differences in phenotype and function of CD4+ T cells are due to a phenotypic shift from naive to memory effector CD4+ T cells. Int Immunol 2005;17:1359-66.
    • (2005) Int Immunol , vol.17 , pp. 1359-1366
    • Kovaiou, R.D.1    Weiskirchner, I.2    Keller, M.3    Pfister, G.4    Cioca, D.P.5    Grubeck-Loebenstein, B.6
  • 14
    • 0024475129 scopus 로고
    • Pgp-1hi T lymphocytes accumu-late with age in mice and respond poorly to concanavalin A
    • Lerner A, Yamada T, Miller RA. Pgp-1hi T lymphocytes accumu-late with age in mice and respond poorly to concanavalin A. Eur J Immunol 1989;19:977-82.
    • (1989) Eur J Immunol , vol.19 , pp. 977-982
    • Lerner, A.1    Yamada, T.2    Miller, R.A.3
  • 15
    • 0028674067 scopus 로고
    • Age-associated changes in human T cell phenotype and function
    • Jackola DR, Ruger JK, Miller RA. Age-associated changes in human T cell phenotype and function. Aging (Milano) 1994;6:25-34.
    • (1994) Aging (Milano) , vol.6 , pp. 25-34
    • Jackola, D.R.1    Ruger, J.K.2    Miller, R.A.3
  • 17
    • 36549039484 scopus 로고    scopus 로고
    • Estimating thymic function through quantification of T-cell receptor excision circles
    • Dion ML, Sekaly RP, Cheynier R. Estimating thymic function through quantification of T-cell receptor excision circles. Methods Mol Biol 2007;380:197-213.
    • (2007) Methods Mol Biol , vol.380 , pp. 197-213
    • Dion, M.L.1    Sekaly, R.P.2    Cheynier, R.3
  • 18
    • 0034651657 scopus 로고    scopus 로고
    • Leukemia inhibitory factor, oncostatin M, IL-6, and stem cell factor mRNA expression in human thymus increases with age and is associated with thymic atrophy
    • Sempowski GD, Hale LP, Sundy JS, Massey JM, Koup RA, Douek DC, et al. Leukemia inhibitory factor, oncostatin M, IL-6, and stem cell factor mRNA expression in human thymus increases with age and is associated with thymic atrophy. J Immunol 2000;164:2180-7.
    • (2000) J Immunol , vol.164 , pp. 2180-2187
    • Sempowski, G.D.1    Hale, L.P.2    Sundy, J.S.3    Massey, J.M.4    Koup, R.A.5    Douek, D.C.6
  • 19
    • 0018833714 scopus 로고
    • Thymus cell migration. Quantitative aspects of cellular traffic from the thymus to the pe-riphery in mice
    • Scollay RG, Butcher EC, Weissman IL. Thymus cell migration. Quantitative aspects of cellular traffic from the thymus to the pe-riphery in mice. Eur J Immunol 1980;10:210-8.
    • (1980) Eur J Immunol , vol.10 , pp. 210-218
    • Scollay, R.G.1    Butcher, E.C.2    Weissman, I.L.3
  • 20
    • 70249143637 scopus 로고    scopus 로고
    • Homeostatic prolifer-ation and survival of naive and memory T cells
    • Boyman O, Letourneau S, Krieg C, Sprent J. Homeostatic prolifer-ation and survival of naive and memory T cells. Eur J Immunol 2009;39:2088-94.
    • (2009) Eur J Immunol , vol.39 , pp. 2088-2094
    • Boyman, O.1    Letourneau, S.2    Krieg, C.3    Sprent, J.4
  • 21
    • 0025902285 scopus 로고
    • Mature murine B and T cells transferred to SCID mice can survive indefinitely and many maintain a virgin phenotype
    • Sprent J, Schaefer M, Hurd M, Surh CD, Ron Y. Mature murine B and T cells transferred to SCID mice can survive indefinitely and many maintain a virgin phenotype. J Exp Med 1991;174:717-28.
    • (1991) J Exp Med , vol.174 , pp. 717-728
    • Sprent, J.1    Schaefer, M.2    Hurd, M.3    Surh, C.D.4    Ron, Y.5
  • 22
    • 0028267677 scopus 로고
    • Turnover of naive-and memory-phenotype T cells
    • Tough DF, Sprent J. Turnover of naive-and memory-phenotype T cells. J Exp Med 1994;179:1127-35.
    • (1994) J Exp Med , vol.179 , pp. 1127-1135
    • Tough, D.F.1    Sprent, J.2
  • 23
    • 57449097558 scopus 로고    scopus 로고
    • Homeostasis of naive and memory T cells
    • Surh CD, Sprent J. Homeostasis of naive and memory T cells. Immunity 2008;29:848-62.
    • (2008) Immunity , vol.29 , pp. 848-862
    • Surh, C.D.1    Sprent, J.2
  • 24
    • 0033555960 scopus 로고    scopus 로고
    • Maturation of CD4+ lymphocytes in the aged microenvironment results in a memory-enriched population
    • Timm JA, Thoman ML. Maturation of CD4+ lymphocytes in the aged microenvironment results in a memory-enriched population. J Immunol 1999;162:711-7.
    • (1999) J Immunol , vol.162 , pp. 711-717
    • Timm, J.A.1    Thoman, M.L.2
  • 25
    • 0032402257 scopus 로고    scopus 로고
    • IL-7-dependent extrathymic expansion of CD45RA+ T cells enables preservation of a naive repertoire
    • Soares MV, Borthwick NJ, Maini MK, Janossy G, Salmon M, Akbar AN. IL-7-dependent extrathymic expansion of CD45RA+ T cells enables preservation of a naive repertoire. J Immunol 1998;161:5909-17.
    • (1998) J Immunol , vol.161 , pp. 5909-5917
    • Soares, M.V.1    Borthwick, N.J.2    Maini, M.K.3    Janossy, G.4    Salmon, M.5    Akbar, A.N.6
  • 27
    • 33845408098 scopus 로고    scopus 로고
    • High accumulation of T regulatory cells prevents the activation of immune responses in aged animals
    • Sharma S, Dominguez AL, Lustgarten J. High accumulation of T regulatory cells prevents the activation of immune responses in aged animals. J Immunol 2006;177:8348-55.
    • (2006) J Immunol , vol.177 , pp. 8348-8355
    • Sharma, S.1    Dominguez, A.L.2    Lustgarten, J.3
  • 28
    • 34249713646 scopus 로고    scopus 로고
    • Changes of CD4+CD25+Foxp3+ regulatory T cells in aged Balb/c mice
    • Zhao L, Sun L, Wang H, Ma H, Liu G, Zhao Y. Changes of CD4+CD25+Foxp3+ regulatory T cells in aged Balb/c mice. J Leukoc Biol 2007;81:1386-94.
    • (2007) J Leukoc Biol , vol.81 , pp. 1386-1394
    • Zhao, L.1    Sun, L.2    Wang, H.3    Ma, H.4    Liu, G.5    Zhao, Y.6
  • 29
    • 49649117750 scopus 로고    scopus 로고
    • Functional regulatory T cells accumulate in aged hosts and promote chronic infectious disease reactivation
    • Lages CS, Suffia I, Velilla PA, Huang B, Warshaw G, Hildeman DA, et al. Functional regulatory T cells accumulate in aged hosts and promote chronic infectious disease reactivation. J Immunol 2008;181:1835-48.
    • (2008) J Immunol , vol.181 , pp. 1835-1848
    • Lages, C.S.1    Suffia, I.2    Velilla, P.A.3    Huang, B.4    Warshaw, G.5    Hildeman, D.A.6
  • 30
    • 37349112715 scopus 로고    scopus 로고
    • Increased Foxp3(+) Treg cell activity reduces dendritic cell co-stimulatory molecule expression in aged mice
    • Chiu BC, Stolberg VR, Zhang H, Chensue SW. Increased Foxp3(+) Treg cell activity reduces dendritic cell co-stimulatory molecule expression in aged mice. Mech Ageing Dev 2007;128:618-27.
    • (2007) Mech Ageing Dev , vol.128 , pp. 618-627
    • Chiu, B.C.1    Stolberg, V.R.2    Zhang, H.3    Chensue, S.W.4
  • 31
    • 34447629515 scopus 로고    scopus 로고
    • Higher frequency of regulatory T cells in the elderly and in-creased suppressive activity in neurodegeneration
    • Rosenkranz D, Weyer S, Tolosa E, Gaenslen A, Berg D, Leyhe T, et al. Higher frequency of regulatory T cells in the elderly and in-creased suppressive activity in neurodegeneration. J Neuroimmunol 2007;188:117-27.
    • (2007) J Neuroimmunol , vol.188 , pp. 117-127
    • Rosenkranz, D.1    Weyer, S.2    Tolosa, E.3    Gaenslen, A.4    Berg, D.5    Leyhe, T.6
  • 32
    • 35048863845 scopus 로고    scopus 로고
    • Age-related changes in the occurrence and characteristics of thymic CD4(+) CD25(+) T cells in mice
    • Kozlowska E, Biernacka M, Ciechomska M, Drela N. Age-related changes in the occurrence and characteristics of thymic CD4(+) CD25(+) T cells in mice. Immunology 2007;122:445-53.
    • (2007) Immunology , vol.122 , pp. 445-453
    • Kozlowska, E.1    Biernacka, M.2    Ciechomska, M.3    Drela, N.4
  • 33
    • 67650705116 scopus 로고    scopus 로고
    • Aging and human CD4(+) regulatory T cells
    • Hwang KA, Kim HR, Kang I. Aging and human CD4(+) regulatory T cells. Mech Ageing Dev 2009;130:509-17.
    • (2009) Mech Ageing Dev , vol.130 , pp. 509-517
    • Hwang, K.A.1    Kim, H.R.2    Kang, I.3
  • 35
    • 11844275234 scopus 로고    scopus 로고
    • Age-related defects in CD4 T cell cognate helper function lead to reduc-tions in humoral responses
    • Eaton SM, Burns EM, Kusser K, Randall TD, Haynes L. Age-related defects in CD4 T cell cognate helper function lead to reduc-tions in humoral responses. J Exp Med 2004;200:1613-22.
    • (2004) J Exp Med , vol.200 , pp. 1613-1622
    • Eaton, S.M.1    Burns, E.M.2    Kusser, K.3    Randall, T.D.4    Haynes, L.5
  • 36
    • 70849110194 scopus 로고    scopus 로고
    • Age-associated increase in lifespan of naive CD4 T cells contributes to T-cell homeostasis but facilitates develop-ment of functional defects
    • Tsukamoto H, Clise-Dwyer K, Huston GE, Duso DK, Buck AL, Johnson LL, et al. Age-associated increase in lifespan of naive CD4 T cells contributes to T-cell homeostasis but facilitates develop-ment of functional defects. Proc Natl Acad Sci U S A 2009;106:18333-8.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 18333-18338
    • Tsukamoto, H.1    Clise-Dwyer, K.2    Huston, G.E.3    Duso, D.K.4    Buck, A.L.5    Johnson, L.L.6
  • 37
    • 78049499052 scopus 로고    scopus 로고
    • Bim dictates naive CD4 T cell lifespan and the development of age-associated functional defects
    • Tsukamoto H, Huston GE, Dibble J, Duso DK, Swain SL. Bim dictates naive CD4 T cell lifespan and the development of age-associated functional defects. J Immunol 2010;185:4535-44.
    • (2010) J Immunol , vol.185 , pp. 4535-4544
    • Tsukamoto, H.1    Huston, G.E.2    Dibble, J.3    Duso, D.K.4    Swain, S.L.5
  • 38
    • 20344375434 scopus 로고    scopus 로고
    • The effect of age on the cognate function of CD4+ T cells
    • Haynes L, Eaton SM. The effect of age on the cognate function of CD4+ T cells. Immunol Rev 2005;205:220-8.
    • (2005) Immunol Rev , vol.205 , pp. 220-228
    • Haynes, L.1    Eaton, S.M.2
  • 39
    • 17144418549 scopus 로고    scopus 로고
    • Newly generated CD4 T cells in aged animals do not exhibit age-related defects in response to antigen
    • Haynes L, Eaton SM, Burns EM, Randall TD, Swain SL. Newly generated CD4 T cells in aged animals do not exhibit age-related defects in response to antigen. J Exp Med 2005;201:845-51.
    • (2005) J Exp Med , vol.201 , pp. 845-851
    • Haynes, L.1    Eaton, S.M.2    Burns, E.M.3    Randall, T.D.4    Swain, S.L.5
  • 40
    • 0029925555 scopus 로고    scopus 로고
    • Changes in lymphocyte subsets, interleukin 2, and sol-uble interleukin 2 receptor in old and very old age
    • Rea IM, Stewart M, Campbell P, Alexander HD, Crockard AD, Morris TC. Changes in lymphocyte subsets, interleukin 2, and sol-uble interleukin 2 receptor in old and very old age. Gerontology 1996;42:69-78.
    • (1996) Gerontology , vol.42 , pp. 69-78
    • Rea, I.M.1    Stewart, M.2    Campbell, P.3    Alexander, H.D.4    Crockard, A.D.5    Morris, T.C.6
  • 41
    • 36749041328 scopus 로고    scopus 로고
    • Interleukin 2: From immunostimulation to immunoregulation and back again
    • Bachmann MF, Oxenius A. Interleukin 2: from immunostimulation to immunoregulation and back again. EMBO Rep 2007;8:1142-8.
    • (2007) EMBO Rep , vol.8 , pp. 1142-1148
    • Bachmann, M.F.1    Oxenius, A.2
  • 42
    • 0033523712 scopus 로고    scopus 로고
    • Inter-leukin 2, but not other common gamma chain-binding cytokines, can reverse the defect in generation of CD4 effector T cells from naive T cells of aged mice
    • Haynes L, Linton PJ, Eaton SM, Tonkonogy SL, Swain SL. Inter-leukin 2, but not other common gamma chain-binding cytokines, can reverse the defect in generation of CD4 effector T cells from naive T cells of aged mice. J Exp Med 1999;190:1013-24.
    • (1999) J Exp Med , vol.190 , pp. 1013-1024
    • Haynes, L.1    Linton, P.J.2    Eaton, S.M.3    Tonkonogy, S.L.4    Swain, S.L.5
  • 43
    • 0026086717 scopus 로고
    • Age-related changes in the activation requirements of human CD4+ T-cell subsets
    • Beckman I, Dimopoulos K, Xu XN, Ahern M, Bradley J. Age-related changes in the activation requirements of human CD4+ T-cell subsets. Cell Immunol 1991;132:17-25.
    • (1991) Cell Immunol , vol.132 , pp. 17-25
    • Beckman, I.1    Dimopoulos, K.2    Xu, X.N.3    Ahern, M.4    Bradley, J.5
  • 44
    • 0012449566 scopus 로고    scopus 로고
    • Proliferative responses of blood mononuclear cells (BMNC) in a cohort of elderly humans: Role of lymphocyte phenotype and cyto-kine production
    • Bruunsgaard H, Pedersen AN, Schroll M, Skinhoj P, Pedersen BK. Proliferative responses of blood mononuclear cells (BMNC) in a cohort of elderly humans: role of lymphocyte phenotype and cyto-kine production. Clin Exp Immunol 2000;119:433-40.
    • (2000) Clin Exp Immunol , vol.119 , pp. 433-440
    • Bruunsgaard, H.1    Pedersen, A.N.2    Schroll, M.3    Skinhoj, P.4    Pedersen, B.K.5
  • 46
    • 0035284902 scopus 로고    scopus 로고
    • Single-cell analyses reveal two defects in peptide-specific activation of naive T cells from aged mice
    • Garcia GG, Miller RA. Single-cell analyses reveal two defects in peptide-specific activation of naive T cells from aged mice. J Im-munol 2001;166:3151-7.
    • (2001) J Im-munol , vol.166 , pp. 3151-3157
    • Garcia, G.G.1    Miller, R.A.2
  • 47
    • 0034254660 scopus 로고    scopus 로고
    • Age-dependent alterations in the assembly of signal transduction complexes at the site of T cell/APC interaction
    • Tamir A, Eisenbraun MD, Garcia GG, Miller RA. Age-dependent alterations in the assembly of signal transduction complexes at the site of T cell/APC interaction. J Immunol 2000;165:1243-51.
    • (2000) J Immunol , vol.165 , pp. 1243-1251
    • Tamir, A.1    Eisenbraun, M.D.2    Garcia, G.G.3    Miller, R.A.4
  • 48
    • 0032883594 scopus 로고    scopus 로고
    • Age-related impair-ments in TCR/CD3 activation of ZAP-70 are associated with re-duced tyrosine phosphorylations of zeta-chains and p59fyn/p56lck in human T cells
    • Whisler RL, Chen M, Liu B, Newhouse YG. Age-related impair-ments in TCR/CD3 activation of ZAP-70 are associated with re-duced tyrosine phosphorylations of zeta-chains and p59fyn/p56lck in human T cells. Mech Ageing Dev 1999;111:49-66.
    • (1999) Mech Ageing Dev , vol.111 , pp. 49-66
    • Whisler, R.L.1    Chen, M.2    Liu, B.3    Newhouse, Y.G.4
  • 49
    • 78650249228 scopus 로고    scopus 로고
    • Age-related defects in the cytoskeleton signaling pathways of CD4 T cells
    • Garcia GG, Miller RA. Age-related defects in the cytoskeleton signaling pathways of CD4 T cells. Ageing Res Rev 2011;10:26-34.
    • (2011) Ageing Res Rev , vol.10 , pp. 26-34
    • Garcia, G.G.1    Miller, R.A.2
  • 50
    • 0032567076 scopus 로고    scopus 로고
    • Analysis of Raf-1 activation in response to TCR activation and costimulation in murine T-lymphocytes: Effect of age
    • Kirk CJ, Miller RA. Analysis of Raf-1 activation in response to TCR activation and costimulation in murine T-lymphocytes: effect of age. Cell Immunol 1998;190:33-42.
    • (1998) Cell Immunol , vol.190 , pp. 33-42
    • Kirk, C.J.1    Miller, R.A.2
  • 51
    • 0029935914 scopus 로고    scopus 로고
    • Age-related decreases in IL-2 production by human T cells are associated with impaired activa-tion of nuclear transcriptional factors AP-1 and NF-AT
    • Whisler RL, Beiqing L, Chen M. Age-related decreases in IL-2 production by human T cells are associated with impaired activa-tion of nuclear transcriptional factors AP-1 and NF-AT. Cell Immunol 1996;169:185-95.
    • (1996) Cell Immunol , vol.169 , pp. 185-195
    • Whisler, R.L.1    Beiqing, L.2    Chen, M.3
  • 52
    • 0031561762 scopus 로고    scopus 로고
    • Impaired induction of c-fos/c-jun genes and of transcriptional regulatory proteins binding distinct c-fos/c-jun promoter elements in activated human T cells during aging
    • Whisler RL, Chen M, Beiqing L, Carle KW. Impaired induction of c-fos/c-jun genes and of transcriptional regulatory proteins binding distinct c-fos/c-jun promoter elements in activated human T cells during aging. Cell Immunol 1997;175:41-50.
    • (1997) Cell Immunol , vol.175 , pp. 41-50
    • Whisler, R.L.1    Chen, M.2    Beiqing, L.3    Carle, K.W.4
  • 53
    • 77953769199 scopus 로고    scopus 로고
    • Contracting the 'mus cells'--does down-sizing suit us for diving into the memory pool?
    • Kurtulus S, Tripathi P, Opferman JT, Hildeman DA. Contracting the 'mus cells'--does down-sizing suit us for diving into the memory pool? Immunol Rev 2010;236:54-67.
    • (2010) Immunol Rev , vol.236 , pp. 54-67
    • Kurtulus, S.1    Tripathi, P.2    Opferman, J.T.3    Hildeman, D.A.4
  • 54
    • 0033558334 scopus 로고    scopus 로고
    • Increased TNF-alpha-induced apoptosis in lymphocytes from aged humans: Changes in TNF-alpha receptor expression and activation of caspases
    • Aggarwal S, Gollapudi S, Gupta S. Increased TNF-alpha-induced apoptosis in lymphocytes from aged humans: changes in TNF-alpha receptor expression and activation of caspases. J Immunol 1999;162: 2154-61.
    • (1999) J Immunol , vol.162 , pp. 2154-2161
    • Aggarwal, S.1    Gollapudi, S.2    Gupta, S.3
  • 55
    • 0032519426 scopus 로고    scopus 로고
    • Increased apoptosis of T cell subsets in aging humans: Altered expression of Fas (CD95), Fas ligand, Bcl-2, and Bax
    • Aggarwal S, Gupta S. Increased apoptosis of T cell subsets in aging humans: altered expression of Fas (CD95), Fas ligand, Bcl-2, and Bax. J Immunol 1998;160:1627-37.
    • (1998) J Immunol , vol.160 , pp. 1627-1637
    • Aggarwal, S.1    Gupta, S.2
  • 56
    • 77958492710 scopus 로고    scopus 로고
    • The many face-lifts of CD4 T helper cells
    • Mucida D, Cheroutre H. The many face-lifts of CD4 T helper cells. Adv Immunol 2010;107:139-52.
    • (2010) Adv Immunol , vol.107 , pp. 139-152
    • Mucida, D.1    Cheroutre, H.2
  • 57
    • 0033975580 scopus 로고    scopus 로고
    • The defects in effector generation associated with aging can be reversed by addition of IL-2 but not other related gamma(c)-receptor binding cytokines
    • Haynes L, Eaton SM, Swain SL. The defects in effector generation associated with aging can be reversed by addition of IL-2 but not other related gamma(c)-receptor binding cytokines. Vaccine 2000;18:1649-53.
    • (2000) Vaccine , vol.18 , pp. 1649-1653
    • Haynes, L.1    Eaton, S.M.2    Swain, S.L.3
  • 60
    • 46749093740 scopus 로고    scopus 로고
    • Nuclear factor-kappaB-dependent reversal of aging-induced alterations in T cell cytokines
    • Huang MC, Liao JJ, Bonasera S, Longo DL, Goetzl EJ. Nuclear factor-kappaB-dependent reversal of aging-induced alterations in T cell cytokines. FASEB J 2008;22:2142-50.
    • (2008) FASEB J , vol.22 , pp. 2142-2150
    • Huang, M.C.1    Liao, J.J.2    Bonasera, S.3    Longo, D.L.4    Goetzl, E.J.5
  • 61
    • 78649960164 scopus 로고    scopus 로고
    • Potentiation of Th17 cytokines in aging process contributes to the development of colitis
    • Ouyang X, Yang Z, Zhang R, Arnaboldi P, Lu G, Li Q, et al. Potentiation of Th17 cytokines in aging process contributes to the development of colitis. Cell Immunol 2011;266:208-17.
    • (2011) Cell Immunol , vol.266 , pp. 208-217
    • Ouyang, X.1    Yang, Z.2    Zhang, R.3    Arnaboldi, P.4    Lu, G.5    Li, Q.6
  • 62
    • 79958772675 scopus 로고    scopus 로고
    • Age-associated alteration in naive and memory Th17 cell response in humans
    • Lee JS, Lee WW, Kim SH, Kang Y, Lee N, Shin MS, et al. Age-associated alteration in naive and memory Th17 cell response in humans. Clin Immunol 2011;140:84-91.
    • (2011) Clin Immunol , vol.140 , pp. 84-91
    • Lee, J.S.1    Lee, W.W.2    Kim, S.H.3    Kang, Y.4    Lee, N.5    Shin, M.S.6
  • 66
    • 2942746461 scopus 로고    scopus 로고
    • Age-associated change in the frequency of memory CD4+ T cells impairs long term CD4+ T cell responses to influenza vaccine
    • Kang I, Hong MS, Nolasco H, Park SH, Dan JM, Choi JY, et al. Age-associated change in the frequency of memory CD4+ T cells impairs long term CD4+ T cell responses to influenza vaccine. J Immunol 2004;173:673-81.
    • (2004) J Immunol , vol.173 , pp. 673-681
    • Kang, I.1    Hong, M.S.2    Nolasco, H.3    Park, S.H.4    Dan, J.M.5    Choi, J.Y.6
  • 67
    • 71049180941 scopus 로고    scopus 로고
    • Naive CD4 T cells from aged mice show enhanced death upon primary activation
    • Mattoo H, Faulkner M, Kandpal U, Das R, Lewis V, George A, et al. Naive CD4 T cells from aged mice show enhanced death upon primary activation. Int Immunol 2009;21:1277-89.
    • (2009) Int Immunol , vol.21 , pp. 1277-1289
    • Mattoo, H.1    Faulkner, M.2    Kandpal, U.3    Das, R.4    Lewis, V.5    George, A.6
  • 68
    • 78649398891 scopus 로고    scopus 로고
    • Nature and nurture: T-cell receptor-dependent and T-cell receptor-independent differentiation cues in the selection of the memory T-cell pool
    • Kim C, Williams MA. Nature and nurture: T-cell receptor-dependent and T-cell receptor-independent differentiation cues in the selection of the memory T-cell pool. Immunology 2010;131:310-7.
    • (2010) Immunology , vol.131 , pp. 310-317
    • Kim, C.1    Williams, M.A.2
  • 69
    • 0344304396 scopus 로고    scopus 로고
    • CD4 T cell memory derived from young naive cells functions well into old age, but memory generated from aged naive cells functions poorly
    • Haynes L, Eaton SM, Burns EM, Randall TD, Swain SL. CD4 T cell memory derived from young naive cells functions well into old age, but memory generated from aged naive cells functions poorly. Proc Natl Acad Sci U S A 2003;100:15053-8.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 15053-15058
    • Haynes, L.1    Eaton, S.M.2    Burns, E.M.3    Randall, T.D.4    Swain, S.L.5
  • 70
    • 58149092081 scopus 로고    scopus 로고
    • Bone marrow precur-sor cells from aged mice generate CD4 T cells that function well in primary and memory responses
    • Eaton SM, Maue AC, Swain SL, Haynes L. Bone marrow precur-sor cells from aged mice generate CD4 T cells that function well in primary and memory responses. J Immunol 2008;181:4825-31.
    • (2008) J Immunol , vol.181 , pp. 4825-4831
    • Eaton, S.M.1    Maue, A.C.2    Swain, S.L.3    Haynes, L.4
  • 72
    • 70349420800 scopus 로고    scopus 로고
    • Advancing age leads to predominance of inhibitory receptor expressing CD4 T cells
    • Channappanavar R, Twardy BS, Krishna P, Suvas S. Advancing age leads to predominance of inhibitory receptor expressing CD4 T cells. Mech Ageing Dev 2009;130:709-12.
    • (2009) Mech Ageing Dev , vol.130 , pp. 709-712
    • Channappanavar, R.1    Twardy, B.S.2    Krishna, P.3    Suvas, S.4
  • 73
    • 67650573171 scopus 로고    scopus 로고
    • Age-associated up-regulation of a negative co-stimulatory re-ceptor PD-1 in mouse CD4+ T cells
    • Shimada Y, Hayashi M, Nagasaka Y, Ohno-Iwashita Y, Inomata M. Age-associated up-regulation of a negative co-stimulatory re-ceptor PD-1 in mouse CD4+ T cells. Exp Gerontol 2009;44:517-22.
    • (2009) Exp Gerontol , vol.44 , pp. 517-522
    • Shimada, Y.1    Hayashi, M.2    Nagasaka, Y.3    Ohno-Iwashita, Y.4    Inomata, M.5
  • 74
    • 78349286392 scopus 로고    scopus 로고
    • Partial restoration of T-cell function in aged mice by in vitro block-ade of the PD-1/ PD-L1 pathway
    • Lages CS, Lewkowich I, Sproles A, Wills-Karp M, Chougnet C. Partial restoration of T-cell function in aged mice by in vitro block-ade of the PD-1/ PD-L1 pathway. Aging Cell 2010;9:785-98.
    • (2010) Aging Cell , vol.9 , pp. 785-798
    • Lages, C.S.1    Lewkowich, I.2    Sproles, A.3    Wills-Karp, M.4    Chougnet, C.5
  • 75
    • 0346422389 scopus 로고    scopus 로고
    • Antigen-specific CD4 T cell clonal expansion and differentiation in the aged lymphoid microenvironment. II. The memory T cell response is diminished
    • Mittler JN, Lee WT. Antigen-specific CD4 T cell clonal expansion and differentiation in the aged lymphoid microenvironment. II. The memory T cell response is diminished. Mech Ageing Dev 2004;125:59-68.
    • (2004) Mech Ageing Dev , vol.125 , pp. 59-68
    • Mittler, J.N.1    Lee, W.T.2
  • 76
    • 0031442280 scopus 로고    scopus 로고
    • Altered expression and function of P-glycoprotein (170 kDa), encoded by the MDR 1 gene, in T cell subsets from aging humans
    • Aggarwal S, Tsuruo T, Gupta S. Altered expression and function of P-glycoprotein (170 kDa), encoded by the MDR 1 gene, in T cell subsets from aging humans. J Clin Immunol 1997;17:448-54.
    • (1997) J Clin Immunol , vol.17 , pp. 448-454
    • Aggarwal, S.1    Tsuruo, T.2    Gupta, S.3
  • 77
    • 0030999692 scopus 로고    scopus 로고
    • Cytokine production by subsets of CD4 memory T cells differing in P-glycoprotein expression: Effects of aging
    • Bining N, Miller RA. Cytokine production by subsets of CD4 memory T cells differing in P-glycoprotein expression: effects of aging. J Gerontol A Biol Sci Med Sci 1997;52:B137-B145.
    • (1997) J Gerontol a Biol Sci Med Sci , vol.52
    • Bining, N.1    Miller, R.A.2
  • 78
    • 0027175441 scopus 로고
    • Increased function of P-glycoprotein in T lymphocyte subsets of aging mice
    • Witkowski JM, Miller RA. Increased function of P-glycoprotein in T lymphocyte subsets of aging mice. J Immunol 1993;150:1296-306.
    • (1993) J Immunol , vol.150 , pp. 1296-1306
    • Witkowski, J.M.1    Miller, R.A.2
  • 79
    • 0348226906 scopus 로고    scopus 로고
    • Age-related changes of the multidrug resistance P-glycoprotein function in normal human peripheral blood T lymphocytes
    • Machado CG, Calado RT, Garcia AB, Falcao RP. Age-related changes of the multidrug resistance P-glycoprotein function in normal human peripheral blood T lymphocytes. Braz J Med Biol Res 2003;36:1653-7.
    • (2003) Braz J Med Biol Res , vol.36 , pp. 1653-1657
    • Machado, C.G.1    Calado, R.T.2    Garcia, A.B.3    Falcao, R.P.4
  • 80
    • 0029125158 scopus 로고
    • Multi-drug transporter P-glycoprotein 170 as a differentiation antigen on normal human lymphocytes and thymocytes: Modulation with dif-ferentiation stage and during aging
    • Pilarski LM, Paine D, McElhaney JE, Cass CE, Belch AR. Multi-drug transporter P-glycoprotein 170 as a differentiation antigen on normal human lymphocytes and thymocytes: modulation with dif-ferentiation stage and during aging. Am J Hematol 1995;49:323-35.
    • (1995) Am J Hematol , vol.49 , pp. 323-335
    • Pilarski, L.M.1    Paine, D.2    McElhaney, J.E.3    Cass, C.E.4    Belch, A.R.5
  • 81
    • 0033197977 scopus 로고    scopus 로고
    • mdr1a-encoded P-glycoprotein is not required for peripheral T cell proliferation, cytokine release, or cy-totoxic effector function in mice
    • Eisenbraun MD, Miller RA. mdr1a-encoded P-glycoprotein is not required for peripheral T cell proliferation, cytokine release, or cy-totoxic effector function in mice. J Immunol 1999;163:2621-7.
    • (1999) J Immunol , vol.163 , pp. 2621-2627
    • Eisenbraun, M.D.1    Miller, R.A.2
  • 82
    • 0033105808 scopus 로고    scopus 로고
    • Calcium signal abnormalities in murine T lymphocytes that express the multidrug transporter P-glycoprotein
    • Witkowski JM, Miller RA. Calcium signal abnormalities in murine T lymphocytes that express the multidrug transporter P-glycoprotein. Mech Ageing Dev 1999;107:165-80.
    • (1999) Mech Ageing Dev , vol.107 , pp. 165-180
    • Witkowski, J.M.1    Miller, R.A.2
  • 83
    • 0028277806 scopus 로고
    • Extrusion of the P glycoprotein substrate rhodamine-123 distinguishes CD4 memory T cell subsets that differ in IL-2-driven IL-4 production
    • Witkowski JM, Li SP, Gorgas G, Miller RA. Extrusion of the P glycoprotein substrate rhodamine-123 distinguishes CD4 memory T cell subsets that differ in IL-2-driven IL-4 production. J Immunol 1994;153:658-65.
    • (1994) J Immunol , vol.153 , pp. 658-665
    • Witkowski, J.M.1    Li, S.P.2    Gorgas, G.3    Miller, R.A.4
  • 84
    • 0034660279 scopus 로고    scopus 로고
    • Altered composition of the immunological synapse in an anergic, age-dependent memory T cell subset
    • Eisenbraun MD, Tamir A, Miller RA. Altered composition of the immunological synapse in an anergic, age-dependent memory T cell subset. J Immunol 2000;164:6105-12.
    • (2000) J Immunol , vol.164 , pp. 6105-6112
    • Eisenbraun, M.D.1    Tamir, A.2    Miller, R.A.3
  • 85
    • 74049164847 scopus 로고    scopus 로고
    • Regulatory T cells exert checks and balances on self tolerance and autoimmunity
    • Wing K, Sakaguchi S. Regulatory T cells exert checks and balances on self tolerance and autoimmunity. Nat Immunol 2010;11:7-13.
    • (2010) Nat Immunol , vol.11 , pp. 7-13
    • Wing, K.1    Sakaguchi, S.2
  • 86
    • 67649160590 scopus 로고    scopus 로고
    • Defective regulatory T cells in patients with severe drug eruptions: Timing of the dysfunction is associated with the pathological phenotype and outcome
    • Takahashi R, Kano Y, Yamazaki Y, Kimishima M, Mizukawa Y, Shiohara T. Defective regulatory T cells in patients with severe drug eruptions: timing of the dysfunction is associated with the pathological phenotype and outcome. J Immunol 2009;182:8071-9.
    • (2009) J Immunol , vol.182 , pp. 8071-8079
    • Takahashi, R.1    Kano, Y.2    Yamazaki, Y.3    Kimishima, M.4    Mizukawa, Y.5    Shiohara, T.6
  • 88
    • 0031821875 scopus 로고    scopus 로고
    • CD4+CD25+ immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting in-terleukin 2 production
    • Thornton AM, Shevach EM. CD4+CD25+ immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting in-terleukin 2 production. J Exp Med 1998;188:287-96.
    • (1998) J Exp Med , vol.188 , pp. 287-296
    • Thornton, A.M.1    Shevach, E.M.2
  • 89
    • 0141481855 scopus 로고    scopus 로고
    • Functional assay for human CD4+CD25+ Treg cells reveals an age-dependent loss of suppressive activity
    • Tsaknaridis L, Spencer L, Culbertson N, Hicks K, LaTocha D, Chou YK, et al. Functional assay for human CD4+CD25+ Treg cells reveals an age-dependent loss of suppressive activity. J Neurosci Res 2003;74:296-308.
    • (2003) J Neurosci Res , vol.74 , pp. 296-308
    • Tsaknaridis, L.1    Spencer, L.2    Culbertson, N.3    Hicks, K.4    Latocha, D.5    Chou, Y.K.6
  • 90
    • 20444497416 scopus 로고    scopus 로고
    • The number of human peripheral blood CD4+ CD25high regulatory T cells increases with age
    • Gregg R, Smith CM, Clark FJ, Dunnion D, Khan N, Chakraverty R, et al. The number of human peripheral blood CD4+ CD25high regulatory T cells increases with age. Clin Exp Immunol 2005;140:540-6.
    • (2005) Clin Exp Immunol , vol.140 , pp. 540-546
    • Gregg, R.1    Smith, C.M.2    Clark, F.J.3    Dunnion, D.4    Khan, N.5    Chakraverty, R.6
  • 91
    • 33646871426 scopus 로고    scopus 로고
    • CD4+CD25+Foxp3+ T cells and CD4+CD25-Foxp3+ T cells in aged mice
    • Nishioka T, Shimizu J, Iida R, Yamazaki S, Sakaguchi S. CD4+CD25+Foxp3+ T cells and CD4+CD25-Foxp3+ T cells in aged mice. J Immunol 2006;176:6586-93.
    • (2006) J Immunol , vol.176 , pp. 6586-6593
    • Nishioka, T.1    Shimizu, J.2    Iida, R.3    Yamazaki, S.4    Sakaguchi, S.5
  • 92
    • 0037442121 scopus 로고    scopus 로고
    • CD4+CD25-T cells in aged mice are hyporesponsive and exhibit suppressive activity
    • Shimizu J, Moriizumi E. CD4+CD25-T cells in aged mice are hyporesponsive and exhibit suppressive activity. J Immunol 2003;170:1675-82.
    • (2003) J Immunol , vol.170 , pp. 1675-1682
    • Shimizu, J.1    Moriizumi, E.2
  • 93
    • 0029788211 scopus 로고    scopus 로고
    • Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulation
    • Asano M, Toda M, Sakaguchi N, Sakaguchi S. Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulation. J Exp Med 1996;184:387-96.
    • (1996) J Exp Med , vol.184 , pp. 387-396
    • Asano, M.1    Toda, M.2    Sakaguchi, N.3    Sakaguchi, S.4
  • 95
    • 0347785480 scopus 로고    scopus 로고
    • Control of regulatory T cell development by the transcription factor Foxp3
    • Hori S, Nomura T, Sakaguchi S. Control of regulatory T cell development by the transcription factor Foxp3. Science 2003;299:1057-61.
    • (2003) Science , vol.299 , pp. 1057-1061
    • Hori, S.1    Nomura, T.2    Sakaguchi, S.3
  • 96
    • 0037385314 scopus 로고    scopus 로고
    • An essential role for Scurfin in CD4+CD25+ T regulatory cells
    • Khattri R, Cox T, Yasayko SA, Ramsdell F. An essential role for Scurfin in CD4+CD25+ T regulatory cells. Nat Immunol 2003;4:337-42.
    • (2003) Nat Immunol , vol.4 , pp. 337-342
    • Khattri, R.1    Cox, T.2    Yasayko, S.A.3    Ramsdell, F.4
  • 97
    • 0037385330 scopus 로고    scopus 로고
    • Foxp3 programs the development and function of CD4+CD25+ regulatory T cells
    • Fontenot JD, Gavin MA, Rudensky AY. Foxp3 programs the development and function of CD4+CD25+ regulatory T cells. Nat Immunol 2003;4:330-6.
    • (2003) Nat Immunol , vol.4 , pp. 330-336
    • Fontenot, J.D.1    Gavin, M.A.2    Rudensky, A.Y.3
  • 100
    • 67649338416 scopus 로고    scopus 로고
    • Age-associated parallel increase of Foxp3(+)CD4(+) regulatory and CD44(+)CD4(+) memory T cells in SJL/J mice
    • Han GM, Zhao B, Jeyaseelan S, Feng JM. Age-associated parallel increase of Foxp3(+)CD4(+) regulatory and CD44(+)CD4(+) memory T cells in SJL/J mice. Cell Immunol 2009;258:188-96.
    • (2009) Cell Immunol , vol.258 , pp. 188-196
    • Han, G.M.1    Zhao, B.2    Jeyaseelan, S.3    Feng, J.M.4


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