Aging augments IL-17 T-cell alloimmune responses

American Journal of Transplantation

Volumn 9, Issue 1, 2009, Pages 54-63

  Tesar, B M ^a   Du, W ^a   Shirali, A C ^a   Walker, W E ^a   Shen, H ^a   Goldstein, D R ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Aging; CD4+ memory T cell; IL 17

Indexed keywords

ALLOANTIGEN; GAMMA INTERFERON; INTERLEUKIN 17; INTERLEUKIN 17 ANTIBODY; INTERLEUKIN 2; INTERLEUKIN 4; PROTEIN ANTIBODY; UNCLASSIFIED DRUG;

ACUTE GRAFT REJECTION; AGED; AGING; ALLOIMMUNITY; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CD4+ T LYMPHOCYTE; CELLULAR IMMUNITY; CONTROLLED STUDY; DENDRITIC CELL; GRAFT SURVIVAL; IN VITRO STUDY; MEMORY T LYMPHOCYTE; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; SKIN ALLOGRAFT; SPLEEN CELL; TH1 CELL;

AGING; ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; ENZYME-LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; GRAFT REJECTION; IMMUNOLOGIC MEMORY; INTERLEUKIN-17; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED C57BL; MICE, INBRED CBA; SKIN TRANSPLANTATION; SPLEEN;

EID: 58049220362     PISSN: 16006135     EISSN: 16006143     Source Type: Journal    
DOI: 10.1111/j.1600-6143.2008.02458.x     Document Type: Article

References (34)

1. Annual report of the U.S. scientific registry for transplant recipients and the organ procurement and transplantation network. Washington, DC : US Department of Health and Human Services 2000.
2. Curtis JJ. Ageism and kidney transplantation. Am J Transplant 2006 6 : 1264 1266.
3. Danovitch GM. A kidney for all ages. Am J Trans 2006 6 : 1267 1268.
4. Miller RA. The aging immune system: Primer and prospectus. Science 1996 273 : 70 74.
5. Yung R. Changes in immune function with age. Rheum Dis Clin N Am 2000 26 : 455 473.
6. Linton P-J, Dorschkind K. Age related changes in lymphocyte development and function. Nat Immunol 2004 5 : 133 139.
7. Fry AM, Shay DK, Holman RC, Curns AT, Anderson LJ. Trends in hospitalizations for pneumonia among persons aged 65 years or older in the United States, 1988-2002. JAMA 2005 294 : 2712 2719.
8. Martins PNA, Pratschke J, Pascher A et al. Age and immune response in organ transplantation. Transplantation 2005 79 : 127 132.
9. Crespo-Leiro MG, Paniagua MJ, Rodriguez JA et al. Morbidity and mortality among heart transplant patients older and younger than 65 years. Transplant Proc 1999 31 : 2537 2538.
10. Pirsch JD, Stratta RJ, Armbrust MJ et al. Cadaveric renal transplantation with cyclosporine in patients more than 60 years of age. Transplantation 1989 47 : 259 261.
11. Baron O, Trochu JN, Treilhaud M et al. Cardiac transplantation in patients over 60 years of age. Transplant Proc 1999 31 : 75 78.
12. Rosenberg A, Sechler J, Horvath J, Maniero T, Bloom E. Assessment of alloreactie T cell subpopulations of aged mice in vivo. CD4+ but not CD8+ T cell mediated rejection response declines with advanced aged. Eur J Immunol 1994 24 : 1312 1316.
13. Thoman ML, Weigle WO. Cell-mediated immunity in aged mice: An underlying lesion in IL 2 synthesis. J Immunol 1982 128 : 2358 2361.
14. Tielen FJ, van Vliet AC, de Geus B, Nagelkerken L, Rozing J. Age-related changes in CD4+ T-cell subsets associated with prolonged skin graft survival in aging rats. Transplant Proc 1993 25 : 2872 2874.
15. Meier-Kriesche HU, Cibrik DM, Ojo AO et al. Interaction between donor and recipient age in determining the risk of chronic renal allograft failure. J Am Geriatr Soc 2002 50 : 14 17.
16. Garcia GG, Miller RA. Single-cell analyses reveal two defects in peptide-specific activation of naive T cells from aged mice. J Immunol 2001 166 : 3151 3157.
17. Miller RA, Garcia G, Kirk CJ, Witkowski JM. Early activation defects in T lymphocytes from aged mice. Immunol Rev 1997 160 : 79 90.
18. Boucher N, Dufeu-Duchesne T, Vicaut E, Farge D, Effros RB, Schachter F. CD28 expression in T cell aging and human longevity. Exp Gerontol 1998 33 : 267 282.
19. Sharma S, Dominguez AL, Lustgarten J. High accumulation of T regulatory cells prevents the activation of immune responses in aged animals. J Immunol 2006 177 : 8348 8355.
20. Brook MO, Wood KJ, Jones ND. The impact of memory T cells on rejection and the induction of tolerance. Transplantation 2006 82 : 1 9.
21. Tesar BM, Zhang J, Li Q, Goldstein DR. TH1 immune responses to fully MHC mismatched allografts are diminished in the absence of MyD88, a toll like receptor signal adaptor protein. Am J Transplant 2004 4 : 1429 1439.
22. Tesar BM, Jiang D, Liang J, Palmer SM, Noble PW, Goldstein DR. The role of hyaluronan degradation products as innate alloimmune agonists. Am J Transplant 2006 6 : 2622 2635.
23. Cong-Qiu C, Swart D, Alcorn D, Tocker J, Elkon KB. Interferon-γ regulates susceptibility to collagen-induced arthritis through suppression of interleukin-17. Arthritis Rheumatism 2007 56 : 1145 1151.
24. Heeger PS, Greenspan NS, Kuhlenschmidt S et al. Pretransplant frequency of donor-specific, IFN-{gamma}-producing lymphocytes is a manifestation of immunologic memory and correlates with the risk of posttransplant rejection episodes. J Immunol 1999 163 : 2267 2275.
25. Aggarwal S, Gurney AL. IL-17: Prototype member of an emerging cytokine family. J Leukoc Biol 2002 71 : 1 8.
26. Laurence A, Tato CM, Davidson TS et al. Interleukin-2 signaling via STAT5 constrains T helper 17 cell generation. Immunity 2007 26 : 371 381.
27. Haynes L, Eaton SM, Burns EM, Randall TD, Swain SL. CD4 T cell memory derived from young naive cells functions well into old age, but memory generated from aged naive cells functions poorly. PNAS 2003 100 : 15053 15058.
28. Poggio ED, Clemente M, Hricik DE, Heeger PS. Panel of reactive T cells as a measurement of primed cellular alloimmunity in kidney transplant candidates. J Am Soc Nephrol 2006 17 : 564 572.
29. Bruunsgard H, Klarlund Pedersen B. Age-related inflammatory cytokines and disease. Immunol Allergy Clin North Am 2003 23 : 15 39.
30. Weaver CT, Harrington LE, Mangan PR, Gavrieli M, Murphy KM. Th17: An effector CD4 T cell lineage with regulatory T cell ties. Immunity 2006 24 : 677 688.
31. Haynes L, Linton P-J, Eaton SM, Tonkonogy SL, Swain SL. Interleukin 2, but not other common {gamma} chain binding cytokines, can reverse the defect in generation of CD4 effector T cells from naive T cells of aged mice. J Exp Med 1999 190 : 1013 1024.
32. Pascher A, Reutzel-Selke A, Jurisch A et al. Alterations of the immune response with increasing recipient age are associated with reduced long-term organ graft function of rat kidney allografts. Transplantation 2003 11 : 1560 1568.
33. Meier-Kriesche HU, Ojo AO, Cibrik DM et al. Relationship of recipient age and development of chronic allograft failure. Transplantation 2000 70 : 306 310.
34. Burlingham WJ, Love RB, Jankowska-Gan E et al. IL-17-dependent cellular immunity to collagen type V predisposes to obliterative bronchiolitis in human lung transplants. J Clin Invest 2008 11 : 3498 3506.