메뉴 건너뛰기




Volumn 115, Issue 4, 2005, Pages 930-939

Age-dependent incidence, time course, and consequences of thymic renewal in adults

Author keywords

[No Author keywords available]

Indexed keywords

CD45 ANTIGEN; PADGEM PROTEIN;

EID: 20144387499     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI200522492     Document Type: Article
Times cited : (314)

References (60)
  • 1
    • 0033951594 scopus 로고    scopus 로고
    • Evidence for thymic function in the elderly
    • Douek, D.C., and Koup, R.A. 2000. Evidence for thymic function in the elderly. Vaccine. 18:1638-1641.
    • (2000) Vaccine , vol.18 , pp. 1638-1641
    • Douek, D.C.1    Koup, R.A.2
  • 2
    • 0033136325 scopus 로고    scopus 로고
    • Generation of functional thymocytes in the human adult
    • Jamieson, B.D., et al. 1999. Generation of functional thymocytes in the human adult. Immunity. 10:569-573.
    • (1999) Immunity , vol.10 , pp. 569-573
    • Jamieson, B.D.1
  • 3
    • 17444372347 scopus 로고    scopus 로고
    • Changes in thymic function with age and during the treatment of HIV infection
    • Douek, D.C., et al. 1998. Changes in thymic function with age and during the treatment of HIV infection. Nature. 396:690-695.
    • (1998) Nature , vol.396 , pp. 690-695
    • Douek, D.C.1
  • 4
    • 0031137735 scopus 로고    scopus 로고
    • Expanded CD4+ and CD8+ T cell clones in elderly humans
    • Schwab, R., et al. 1997. Expanded CD4+ and CD8+ T cell clones in elderly humans. J. Immunol. 158:4493-4499.
    • (1997) J. Immunol. , vol.158 , pp. 4493-4499
    • Schwab, R.1
  • 5
    • 0034124915 scopus 로고    scopus 로고
    • The role of the thymus in immune reconstitution in aging, bone marrow transplantation, and HIV-1 infection
    • Haynes, B.F., Markert, M.L., Sempowski, G.D., Patel, D.D., and Hale, L.P. 2000. The role of the thymus in immune reconstitution in aging, bone marrow transplantation, and HIV-1 infection. Annu. Rev. Immunol. 18:529-560.
    • (2000) Annu. Rev. Immunol. , vol.18 , pp. 529-560
    • Haynes, B.F.1    Markert, M.L.2    Sempowski, G.D.3    Patel, D.D.4    Hale, L.P.5
  • 6
    • 0034651657 scopus 로고    scopus 로고
    • Leukemia inhibitory factor, oncostatin M, IL-6, and stem cell factor mRNA expression in human thymus increases with age and is associated with thymic atrophy
    • Sempowski, G.D., et al. 2000. Leukemia inhibitory factor, oncostatin M, IL-6, and stem cell factor mRNA expression in human thymus increases with age and is associated with thymic atrophy. J. Immunol. 164:2180-2187.
    • (2000) J. Immunol , vol.164 , pp. 2180-2187
    • Sempowski, G.D.1
  • 9
    • 0034698931 scopus 로고    scopus 로고
    • Naive T cells transiently acquire a memory-like phenotype during homeostasis-driven proliferation
    • Goldrath, A.W., Bogatzki, L.Y., and Bevan, M.J. 2000. Naive T cells transiently acquire a memory-like phenotype during homeostasis-driven proliferation. J. Exp. Med. 192:557-564.
    • (2000) J. Exp. Med. , vol.192 , pp. 557-564
    • Goldrath, A.W.1    Bogatzki, L.Y.2    Bevan, M.J.3
  • 10
    • 0028267677 scopus 로고
    • Turnover of naive- and memory-phenotype T cells
    • Tough, D.F., and Sprent, J. 1994. Turnover of naive- and memory-phenotype T cells. J. Exp. Med. 179:1127-1135.
    • (1994) J. Exp. Med. , vol.179 , pp. 1127-1135
    • Tough, D.F.1    Sprent, J.2
  • 11
    • 0038375013 scopus 로고    scopus 로고
    • Proliferation and differentiation potential of human CD8+ memory T-cell subsets in response to antigen or homeostatic cytokines
    • Geginat J., Lanzavecchia, A., and Sallusto, F. 2003. Proliferation and differentiation potential of human CD8+ memory T-cell subsets in response to antigen or homeostatic cytokines. Blood. 101:4260-4266.
    • (2003) Blood , vol.101 , pp. 4260-4266
    • Geginat, J.1    Lanzavecchia, A.2    Sallusto, F.3
  • 12
    • 0035905477 scopus 로고    scopus 로고
    • Cytokine-driven proliferation and differentiation of human naive, central memory, and effector memory CD4(+) T cells J
    • Geginat, J., Sallusco, F., and Lanzavecchia, A. 2001. Cytokine-driven proliferation and differentiation of human naive, central memory, and effector memory CD4(+) T cells J. Exp. Med. 194:1711-1719.
    • (2001) Exp. Med. , vol.194 , pp. 1711-1719
    • Geginat, J.1    Sallusco, F.2    Lanzavecchia, A.3
  • 13
    • 0029943897 scopus 로고    scopus 로고
    • Thymic-independent T cell regeneration occurs via antigen-driven expansion of peripheral T cells resulting in a repertoire that is limited in diversity and prone to skewing
    • Mackall, C.L., et al. 1996. Thymic-independent T cell regeneration occurs via antigen-driven expansion of peripheral T cells resulting in a repertoire that is limited in diversity and prone to skewing. J. Immunol. 156:4609-4616.
    • (1996) J. Immunol. , vol.156 , pp. 4609-4616
    • Mackall, C.L.1
  • 14
    • 0141651729 scopus 로고    scopus 로고
    • Early reconstitution of the T-cell repertoire after non-myeloablative peripheral blood stem cell transplantation is from post-thymic T-cell expansion and is unaffected by graft-versus-host disease or mixed chimaerism
    • Bahceci, E., et al. 2003. Early reconstitution of the T-cell repertoire after non-myeloablative peripheral blood stem cell transplantation is from post-thymic T-cell expansion and is unaffected by graft-versus-host disease or mixed chimaerism. Br. J. Haematol. 122:934-943.
    • (2003) Br. J. Haematol. , vol.122 , pp. 934-943
    • Bahceci, E.1
  • 15
    • 0344465968 scopus 로고    scopus 로고
    • Factors affecting reconstitution of the T cell compartment in allogeneic haematopoietic cell transplant recipients
    • Fallen, P.R., et al. 2003. Factors affecting reconstitution of the T cell compartment in allogeneic haematopoietic cell transplant recipients. Bone Marrow Transplant. 32:1001-1014.
    • (2003) Bone Marrow Transplant , vol.32 , pp. 1001-1014
    • Fallen, P.R.1
  • 16
    • 0030833497 scopus 로고    scopus 로고
    • Constraints on CD4 recovery postchemotherapy in adults: Thymic insufficiency and apoptotic decline of expanded peripheral CD4 cells
    • Hakim, F.T., et al. 1997. Constraints on CD4 recovery postchemotherapy in adults: thymic insufficiency and apoptotic decline of expanded peripheral CD4 cells. Blood. 90:3789-3798.
    • (1997) Blood , vol.90 , pp. 3789-3798
    • Hakim, F.T.1
  • 17
    • 0027488659 scopus 로고
    • T-cell regeneration after bone marrow transplantation: Differential CD45 isoform expression on thymic-derived versus thymic-independent progeny
    • Mackall, C.L., Granger, L., Sheard, M.A., Cepeda, R., and Gress, R.E. 1993. T-cell regeneration after bone marrow transplantation: differential CD45 isoform expression on thymic-derived versus thymic-independent progeny. Blood. 82:2585-2594.
    • (1993) Blood , vol.82 , pp. 2585-2594
    • Mackall, C.L.1    Granger, L.2    Sheard, M.A.3    Cepeda, R.4    Gress, R.E.5
  • 18
    • 0032976288 scopus 로고    scopus 로고
    • Immune reconstitution after bone marrow transplantation for combined immunodeficiencies: Down-modulation of Bcl-2 and high expression of CD95/Fas account for increased susceptibility to spontaneous and activation-induced lymphocyte cell death
    • Brugnoni, D., et al. 1999. Immune reconstitution after bone marrow transplantation for combined immunodeficiencies: down-modulation of Bcl-2 and high expression of CD95/Fas account for increased susceptibility to spontaneous and activation-induced lymphocyte cell death. Bone Marrow Transplant. 23:451-457.
    • (1999) Bone Marrow Transplant , vol.23 , pp. 451-457
    • Brugnoni, D.1
  • 19
    • 0034660623 scopus 로고    scopus 로고
    • Increased apoptosis of peripheral blood T cells following allogeneic hematopoietic cell transplantation
    • Lin, M.T., et al. 2000. Increased apoptosis of peripheral blood T cells following allogeneic hematopoietic cell transplantation. Blood. 95:3832-3839.
    • (2000) Blood , vol.95 , pp. 3832-3839
    • Lin, M.T.1
  • 20
    • 10744226330 scopus 로고    scopus 로고
    • Evidence for adequate thymic function but impaired naive T-cell survival following allogeneic hematopoietic stem cell transplantation in the absence of chronic graft-versus-host disease
    • Poulin, J.F., et al. 2003. Evidence for adequate thymic function but impaired naive T-cell survival following allogeneic hematopoietic stem cell transplantation in the absence of chronic graft-versus-host disease. Blood. 102:4600-4607.
    • (2003) Blood , vol.102 , pp. 4600-4607
    • Poulin, J.F.1
  • 21
    • 0037105537 scopus 로고    scopus 로고
    • Direct evidence for new T-cell generation by patients after either T-cell-depleted or unmodified allogeneic hematopoietic stem cell transplantations
    • Lewin, S.R., et al. 2002. Direct evidence for new T-cell generation by patients after either T-cell-depleted or unmodified allogeneic hematopoietic stem cell transplantations. Blood. 100:2235-2242.
    • (2002) Blood , vol.100 , pp. 2235-2242
    • Lewin, S.R.1
  • 22
    • 0034720664 scopus 로고    scopus 로고
    • Assessment of thymic output in adults after haematopoietic stem-cell transplantation and prediction of T-cell reconstitution
    • Douek, D.C., et al. 2000. Assessment of thymic output in adults after haematopoietic stem-cell transplantation and prediction of T-cell reconstitution. Lancet. 355:1875-1881.
    • (2000) Lancet , vol.355 , pp. 1875-1881
    • Douek, D.C.1
  • 23
    • 18344417656 scopus 로고    scopus 로고
    • Prolonged CD4 depletion after sequential autologous peripheral blood progenitor cell infusions in children and young adults
    • Mackall, C.L., et al. 2000. Prolonged CD4 depletion after sequential autologous peripheral blood progenitor cell infusions in children and young adults. Blood. 96:754-762.
    • (2000) Blood , vol.96 , pp. 754-762
    • Mackall, C.L.1
  • 24
    • 0032726389 scopus 로고    scopus 로고
    • Persistent changes in the immune system 4-10 years after ABMT
    • Nordoy, T., et al. 1999. Persistent changes in the immune system 4-10 years after ABMT. Bone Marrow Transplant. 24:873-878.
    • (1999) Bone Marrow Transplant , vol.24 , pp. 873-878
    • Nordoy, T.1
  • 25
    • 0028812436 scopus 로고
    • Age, thymopoiesis, and CD4+ T-lymphocyte regeneration after intensive chemotherapy
    • Mackall, C.L., et al. 1995. Age, thymopoiesis, and CD4+ T-lymphocyte regeneration after intensive chemotherapy. N. Engl. J. Med. 332:143-149.
    • (1995) N. Engl. J. Med. , vol.332 , pp. 143-149
    • Mackall, C.L.1
  • 26
    • 0032748688 scopus 로고    scopus 로고
    • Thymic hyperplasia after high-dose chemotherapy and autologous stem cell transplantation: Incidence and significance in patients with breast cancer
    • Hara, M., McAdams, H.P., Vredenburgh, J.J., Herndon, J.E., and Patz, E.F., Jr. 1999. Thymic hyperplasia after high-dose chemotherapy and autologous stem cell transplantation: incidence and significance in patients with breast cancer. AJR Am. J. Roentgenol. 173:1341-1344.
    • (1999) AJR Am. J. Roentgenol. , vol.173 , pp. 1341-1344
    • Hara, M.1    McAdams, H.P.2    Vredenburgh, J.J.3    Herndon, J.E.4    Patz Jr., E.F.5
  • 27
    • 0036605699 scopus 로고    scopus 로고
    • Association between larger thymic size and higher thymic output in human immunodeficiency virus-infected patients receiving highly active antiretroviral therapy
    • Kolte, L., et al. 2002. Association between larger thymic size and higher thymic output in human immunodeficiency virus-infected patients receiving highly active antiretroviral therapy. J. Infect. Dis. 185:1578-1585.
    • (2002) J. Infect. Dis. , vol.185 , pp. 1578-1585
    • Kolte, L.1
  • 28
    • 0032104145 scopus 로고    scopus 로고
    • High prevalence of thymic tissue in adults with human immunodeficiency virus-1 infection
    • McCune, J.M., et al. 1998. High prevalence of thymic tissue in adults with human immunodeficiency virus-1 infection. J. Clin. Invest. 101:2301-2308.
    • (1998) J. Clin. Invest. , vol.101 , pp. 2301-2308
    • McCune, J.M.1
  • 29
    • 0033958888 scopus 로고    scopus 로고
    • Thymic size and lymphocyte restoration in patients with human immunodeficiency virus infection after 48 weeks of zidovudine, lamivudine, and ritonavir therapy
    • Smith, K.Y., et al. 2000. Thymic size and lymphocyte restoration in patients with human immunodeficiency virus infection after 48 weeks of zidovudine, lamivudine, and ritonavir therapy. J. Infect. Dis. 181:141-147.
    • (2000) J. Infect. Dis. , vol.181 , pp. 141-147
    • Smith, K.Y.1
  • 30
    • 0034795387 scopus 로고    scopus 로고
    • T-cell recovery in adults and children following umbilical cord blood transplantation
    • Klein, A.K., et al. 2001. T-cell recovery in adults and children following umbilical cord blood transplantation. Biol. Blood Marrow Transplant. 7:454-466.
    • (2001) Biol. Blood Marrow Transplant , vol.7 , pp. 454-466
    • Klein, A.K.1
  • 31
    • 0036566535 scopus 로고    scopus 로고
    • T-cell receptor excision circle and T-cell dynamics after allogeneic stem cell transplantation are related to clinical events
    • Hazenberg, M.D., et al. 2002. T-cell receptor excision circle and T-cell dynamics after allogeneic stem cell transplantation are related to clinical events. Blood. 99:3449-3453.
    • (2002) Blood , vol.99 , pp. 3449-3453
    • Hazenberg, M.D.1
  • 32
    • 0035575775 scopus 로고    scopus 로고
    • Evidence for increased T cell turnover and decreased thymic output in HIV infection
    • Douek, D.C., et al. 2001. Evidence for increased T cell turnover and decreased thymic output in HIV infection. J. Immunol. 167:6663-6668.
    • (2001) J. Immunol. , vol.167 , pp. 6663-6668
    • Douek, D.C.1
  • 33
    • 0035282934 scopus 로고    scopus 로고
    • Factors affecting thymic function after allogeneic hematopoietic stem cell transplantation
    • Weinberg, K., et al. 2001. Factors affecting thymic function after allogeneic hematopoietic stem cell transplantation. Blood. 97:1458-1466.
    • (2001) Blood , vol.97 , pp. 1458-1466
    • Weinberg, K.1
  • 34
    • 0032402158 scopus 로고    scopus 로고
    • Reconstitution of the T-cell compartment after bone marrow transplantation: Restoration of the repertoire by thymic emigrants
    • Dumont-Girard, F., et al. 1998. Reconstitution of the T-cell compartment after bone marrow transplantation: restoration of the repertoire by thymic emigrants. Blood. 92:4464-4471.
    • (1998) Blood , vol.92 , pp. 4464-4471
    • Dumont-Girard, F.1
  • 35
    • 0141502373 scopus 로고    scopus 로고
    • Identification of non-naive CD4+CD45RA+ T cell subsets in adult allogeneic haematopoietic cell transplant recipients
    • Fallen, P.R., et al. 2003. Identification of non-naive CD4+CD45RA+ T cell subsets in adult allogeneic haematopoietic cell transplant recipients. Bone Marrow Transplant. 32:609-616.
    • (2003) Bone Marrow Transplant , vol.32 , pp. 609-616
    • Fallen, P.R.1
  • 36
    • 0028220953 scopus 로고
    • Circulating T cell repertoire complexity in normal individuals and bone marrow recipients analyzed by CDR3 size spectratyping. Correlation with immune status
    • Gorski, J., et al. 1994. Circulating T cell repertoire complexity in normal individuals and bone marrow recipients analyzed by CDR3 size spectratyping. Correlation with immune status. J. Immunol. 152:5109-5119.
    • (1994) J. Immunol. , vol.152 , pp. 5109-5119
    • Gorski, J.1
  • 37
    • 0034019523 scopus 로고    scopus 로고
    • Changes in T cell receptor repertoire associated with graft-versus-tumor effect and graft-versus-host disease in patients with relapsed multiple myeloma after donor lymphocyte infusion
    • Orsini, E., et al. 2000. Changes in T cell receptor repertoire associated with graft-versus-tumor effect and graft-versus-host disease in patients with relapsed multiple myeloma after donor lymphocyte infusion. Bone Marrow Transplant. 25:623-632.
    • (2000) Bone Marrow Transplant , vol.25 , pp. 623-632
    • Orsini, E.1
  • 38
    • 0037082472 scopus 로고    scopus 로고
    • A broad T-cell repertoire diversity and an efficient thymic function indicate a favorable long-term immune reconstitution after cord blood stem cell transplantation
    • Talvensarri, K., et al. 2002. A broad T-cell repertoire diversity and an efficient thymic function indicate a favorable long-term immune reconstitution after cord blood stem cell transplantation. Blood. 99:1458-1464.
    • (2002) Blood , vol.99 , pp. 1458-1464
    • Talvensarri, K.1
  • 39
    • 0034660142 scopus 로고    scopus 로고
    • Longitudinal monitoring of immune reconstitution by CDR3 size spectratyping after T-cell-depleted allogeneic bone marrow transplant and the effect of donor lymphocyte infusions on T-cell repertoire
    • Verfuerth, S., et al. 2000. Longitudinal monitoring of immune reconstitution by CDR3 size spectratyping after T-cell-depleted allogeneic bone marrow transplant and the effect of donor lymphocyte infusions on T-cell repertoire. Blood. 95:3990-3995.
    • (2000) Blood , vol.95 , pp. 3990-3995
    • Verfuerth, S.1
  • 40
    • 2142730100 scopus 로고    scopus 로고
    • Central memory and effector memory T cell subsets: Function, generation, and maintenance
    • Sallusto, F., Geginat, J., and Lanzavecchia, A. 2004. Central memory and effector memory T cell subsets: function, generation, and maintenance. Annu. Rev. Immunol. 22:745-763.
    • (2004) Annu. Rev. Immunol. , vol.22 , pp. 745-763
    • Sallusto, F.1    Geginat, J.2    Lanzavecchia, A.3
  • 41
    • 0036381156 scopus 로고    scopus 로고
    • Changes in thymus volume in adult HIV-infected patients under HAART: Correlation with the T-cell repopulation
    • Rubio, A., et al. 2002. Changes in thymus volume in adult HIV-infected patients under HAART: correlation with the T-cell repopulation. Clin. Exp. Immunol. 130:121-126.
    • (2002) Clin. Exp. Immunol. , vol.130 , pp. 121-126
    • Rubio, A.1
  • 42
    • 0042324110 scopus 로고    scopus 로고
    • Comparison of thymic function-related markers to predict early CD4 T-cell repopulation in adult HIV-infected patients on HAART
    • Ruiz-Mateos, E., et al. 2003. Comparison of thymic function-related markers to predict early CD4 T-cell repopulation in adult HIV-infected patients on HAART. Antivir. Ther. 8:289-294.
    • (2003) Antivir. Ther. , vol.8 , pp. 289-294
    • Ruiz-Mateos, E.1
  • 43
    • 0242580966 scopus 로고    scopus 로고
    • Increases in CD4+ T lymphocytes occur without increases in thymic size in HIV-infected subjects receiving interleukin-2 therapy
    • Lu, A.C., et al. 2003. Increases in CD4+ T lymphocytes occur without increases in thymic size in HIV-infected subjects receiving interleukin-2 therapy. J. Acquir. Immune Defic. Syndr. 34:299-303.
    • (2003) J. Acquir. Immune Defic. Syndr. , vol.34 , pp. 299-303
    • Lu, A.C.1
  • 44
    • 0031869628 scopus 로고    scopus 로고
    • Thymic function in young/old chimeras: Substantial thymic T cell regenerative capacity despite irreversible age-associated thymic involution
    • Mackall, C.L., Punt, J.A., Morgan, P., Farr, A.G., and Gress, R.E. 1998. Thymic function in young/old chimeras: substantial thymic T cell regenerative capacity despite irreversible age-associated thymic involution. Eur. J. Immunol. 28:1886-1893.
    • (1998) Eur. J. Immunol. , vol.28 , pp. 1886-1893
    • Mackall, C.L.1    Punt, J.A.2    Morgan, P.3    Farr, A.G.4    Gress, R.E.5
  • 45
    • 0025688052 scopus 로고
    • In vitro analysis of age-related changes in the developmental potential of bone marrow thymocyre progenitors
    • Sharp, A., Kukulansky, T., and Globerson, A. 1990. In vitro analysis of age-related changes in the developmental potential of bone marrow thymocyre progenitors. Eur. J. Immunol. 20:2541-2546.
    • (1990) Eur. J. Immunol. , vol.20 , pp. 2541-2546
    • Sharp, A.1    Kukulansky, T.2    Globerson, A.3
  • 46
    • 0022515073 scopus 로고
    • Age-related change in the potential of bone marrow cells to repopulate the thymus and splenic T cells in mice
    • Hirokawa, K., Kubo, S., Utsuyama, M., Kurashima, C., and Sado, T. 1986. Age-related change in the potential of bone marrow cells to repopulate the thymus and splenic T cells in mice. Cell. Immunol. 100:443-451.
    • (1986) Cell. Immunol. , vol.100 , pp. 443-451
    • Hirokawa, K.1    Kubo, S.2    Utsuyama, M.3    Kurashima, C.4    Sado, T.5
  • 47
    • 1142275269 scopus 로고    scopus 로고
    • Age-related changes in lymphocyte development and function
    • Linton, P.J., and Dorshkind, K. 2004. Age-related changes in lymphocyte development and function. Nat. Immunol. 5:133-139.
    • (2004) Nat. Immunol. , vol.5 , pp. 133-139
    • Linton, P.J.1    Dorshkind, K.2
  • 48
    • 0036311982 scopus 로고    scopus 로고
    • Molecular characterization of the mouse involuted thymus: Aberrations in expression of transcription regulators in thymocyte and epithelial compartments
    • Ortman, C.L., Dittmar, K.A., Witte, P.L., and Le, P.T. 2002. Molecular characterization of the mouse involuted thymus: aberrations in expression of transcription regulators in thymocyte and epithelial compartments. Int. Immunol. 14:813-822.
    • (2002) Int. Immunol. , vol.14 , pp. 813-822
    • Ortman, C.L.1    Dittmar, K.A.2    Witte, P.L.3    Le, P.T.4
  • 49
    • 0037012030 scopus 로고    scopus 로고
    • Age-associated thymic atrophy is linked to a decline in IL-7 production
    • Andrew, D., and Aspinall, R. 2002. Age-associated thymic atrophy is linked to a decline in IL-7 production. Exp. Gerontol. 37:455-463.
    • (2002) Exp. Gerontol. , vol.37 , pp. 455-463
    • Andrew, D.1    Aspinall, R.2
  • 50
    • 0032946001 scopus 로고    scopus 로고
    • Serum levels of IL-7 in bone marrow transplant recipients: Relationship to clinical characteristics and lymphocyte count
    • Bolotin, E., Annett, G., Parkman, R., and Weinberg, K. 1999. Serum levels of IL-7 in bone marrow transplant recipients: relationship to clinical characteristics and lymphocyte count. Bone Marrow Transplant. 23:783-788.
    • (1999) Bone Marrow Transplant , vol.23 , pp. 783-788
    • Bolotin, E.1    Annett, G.2    Parkman, R.3    Weinberg, K.4
  • 51
    • 0035874499 scopus 로고    scopus 로고
    • A potential role for interleukin-7 in T-cell homeostasis
    • Fry, T.J., et al. 2001. A potential role for interleukin-7 in T-cell homeostasis. Blood. 97:2983-2990.
    • (2001) Blood , vol.97 , pp. 2983-2990
    • Fry, T.J.1
  • 52
  • 53
    • 3843124199 scopus 로고    scopus 로고
    • Exogenous IL-7 increases recent thymic emigrants in peripheral lymphoid tissue without enhanced thymic function
    • Chu, Y.W., et al. 2004. Exogenous IL-7 increases recent thymic emigrants in peripheral lymphoid tissue without enhanced thymic function. Blood. 104:1110-1119.
    • (2004) Blood , vol.104 , pp. 1110-1119
    • Chu, Y.W.1
  • 54
    • 0035253734 scopus 로고    scopus 로고
    • Il-7 and not stem cell factor reverses both the increase in apoptosis and the decline in thymopoiesis seen in aged mice
    • Andrew, D., and Aspinall, R. 2001. Il-7 and not stem cell factor reverses both the increase in apoptosis and the decline in thymopoiesis seen in aged mice. J. Immunol. 166:1524-1530.
    • (2001) J. Immunol. , vol.166 , pp. 1524-1530
    • Andrew, D.1    Aspinall, R.2
  • 55
    • 0035496939 scopus 로고    scopus 로고
    • Administration of interleukin-7 after allogeneic bone marrow transplantation improves immune reconstitution without aggravating graft-versus-host disease
    • Alpdogan, O., et al. 2001. Administration of interleukin-7 after allogeneic bone marrow transplantation improves immune reconstitution without aggravating graft-versus-host disease. Blood. 98:2256-2265.
    • (2001) Blood , vol.98 , pp. 2256-2265
    • Alpdogan, O.1
  • 56
    • 0029794831 scopus 로고    scopus 로고
    • Enhancement of thymopoiesis after bone marrow transplant by in vivo interleukin-7
    • Bolotin, E., Smogorzewska, M., Smith, S., Widmer, M., and Weinberg, K. 1996. Enhancement of thymopoiesis after bone marrow transplant by in vivo interleukin-7. Blood. 88:1887-1894.
    • (1996) Blood , vol.88 , pp. 1887-1894
    • Bolotin, E.1    Smogorzewska, M.2    Smith, S.3    Widmer, M.4    Weinberg, K.5
  • 57
    • 3242747324 scopus 로고    scopus 로고
    • Regulation of thymus size by competition for stromal niches among early T cell progenitors
    • Prockop, S.E., and Petrie, H.T. 2004. Regulation of thymus size by competition for stromal niches among early T cell progenitors. J. Immunol. 173:1604-1611.
    • (2004) J. Immunol. , vol.173 , pp. 1604-1611
    • Prockop, S.E.1    Petrie, H.T.2
  • 58
    • 0343183281 scopus 로고    scopus 로고
    • Stepwise development of thymic microenvironments in vivo is regulated by thymocyte subsets
    • van Ewijk, W., Hollander, G., Terhorst, C., and Wang, B. 2000. Stepwise development of thymic microenvironments in vivo is regulated by thymocyte subsets. Development. 127:1583-1591.
    • (2000) Development , vol.127 , pp. 1583-1591
    • Van Ewijk, W.1    Hollander, G.2    Terhorst, C.3    Wang, B.4
  • 59
    • 0032959111 scopus 로고    scopus 로고
    • Development, organization and function of the thymic medulla in normal, immunodeficient or autoimmune mice
    • Naquet, P., Naspetti, M., and Boyd, R. 1999. Development, organization and function of the thymic medulla in normal, immunodeficient or autoimmune mice. Semin. Immunol. 11:47-55.
    • (1999) Semin. Immunol. , vol.11 , pp. 47-55
    • Naquet, P.1    Naspetti, M.2    Boyd, R.3
  • 60
    • 0032578456 scopus 로고    scopus 로고
    • Interdependence of cortical thymic epithelial cell differentiation and T-lineage commitment
    • Klug, D.B., et al. 1998. Interdependence of cortical thymic epithelial cell differentiation and T-lineage commitment. Proc. Natl. Acad. Sci. U. S. A. 95:11822-11827.
    • (1998) Proc. Natl. Acad. Sci. U. S. A. , vol.95 , pp. 11822-11827
    • Klug, D.B.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.